THE ECONOMICS OF RIPARIAN MANAGEMENT: A LITERATURE REVIEW

Resource /Energy Economics and Policy,

The Physical Characteristics of the Small-Scale Interstellar Structure towards Mu Crucis

We present HST/GHRS echelle observations of multiple interstellar lines of CI, MgI, CrII, and ZnII towards both stars in the mu Cru binary system. Despite large differences in the profiles of the neutral species, no significant variations between the stars are seen in the CrII and ZnII line profiles. In particular, the ZnII absorption observed at -8.6 km/sec towards mu Cru is constant despite greatly enhanced columns of the neutral species at this velocity towards mu^1 Cru. An analysis of the fine-structure excitation of CI in this cloud implies that the density is n_H < 250 cm^{-3}. From the lack of variation in the (optical) NaI D2 line profiles towards mu^1 and mu^2 Cru in spectra taken 21 months apart, we can place a lower limit to the size of the structures of ~10 AU. These results are discussed in the context of recent radio and optical studies of apparently pervasive high density small-scale interstellar structure.Comment: 10 pages, 2 figures, to appear in the Astrophysical Journal (Letters

Therapist empathy and client outcome: an updated meta-analysis

Put simply, empathy refers to understanding what another person is experiencing or trying to express. Therapist empathy has a long history as a hypothesized key change process in psychotherapy. We begin by discussing definitional issues and presenting an integrative definition. We then review measures of therapist empathy, including the conceptual problem of separating empathy from other relationship variables. We follow this with clinical examples illustrating different forms of therapist empathy and empathic response modes. The core of our review is a meta-analysis of research on the relation between therapist empathy and client outcome. Results indicated that empathy is a moderately strong predictor of therapy outcome: mean weighted r= .28 (p< .001; 95% confidence interval: .23 –.33; equivalent of d= .58) for 82 independent samples and 6,138 clients. In general, the empathy-outcome relation held for different theoretical orientations and client presenting problems; however, there was considerable heterogeneity in the effects. Client, observer, and therapist perception measures predicted client outcome better than empathic accuracy measures. We then consider the limitations of the current data. We conclude with diversity considerations and practice recommendations, including endorsing the different forms that empathy may take in therapy

Triggered Star Formation and Dust around Mid-Infrared-Identified Bubbles

We use Two Micron All Sky Survey, GLIMPSE, and MIPSGAL survey data to analyze the young stellar object (YSO) and warm dust distribution around several mid-infrared-identified bubbles. We identify YSOs using J-band to 8 um photometry and correlate their distribution relative to the PDR (as traced by diffuse 8 um emission) which we assume to be associated with and surround a HII region. We find that only 20% of the sample HII regions appear to have a significant number of YSOs associated with their PDRs, implying that triggered star formation mechanisms acting on the boundary of the expanding HII region do not dominate in this sample. We also measure the temperature of dust inside 20 HII regions using 24 um and 70 um MIPSGAL images. In eight circularly symmetric sources we analyze the temperature distribution and find shallower temperature gradients than is predicted by an analytic model. Possible explanations of this shallow temperature gradient are a radially dependent grain-size distribution and/or non-equilibrium radiative processes.Comment: 35 pages, 17 figures, accepted for publication in Ap

Can I have blood tests to check everything is alright?

Patients often request a general check-up with blood tests. In the UK these are often referred to as an MOT, in allusion to the annual motor vehicle check. Some patients may, however, have unrealistic expectations of medical tests1 and underestimate their potential harms. While agreeing to some blood tests can be an easy way out for a busy clinician, it can expose patients to the harms of over-testing and produce extra workload downstream. We provide a framework for navigating these requests constructively, some elements of which are feasible within a 10 minute consultation

Pharmacist-led management of chronic pain in primary care:results from a randomised controlled exploratory trial

To compare the effectiveness of pharmacist medication review, with or without pharmacist prescribing, with standard care, for patients with chronic pain

microRNAs and Esophageal Cancer - Implications for Pathogenesis and Therapy

Author version made available in accordance with the publisher's policy.There are several microRNAs that have been consistently reported to be differentially expressed in esophageal squamous cell carcinoma vs. normal squamous tissue, with prognostic associations for miR-21 (invasion, positive nodes, decreased survival), miR-143 (disease recurrence, invasion depth), and miR-375 (inversely correlated with advanced stage, distant metastasis, poor overall survival, and disease-free survival). There is also evidence that miR-375 regulates gene expression associated with resistance to chemotherapy. Hence, microRNA expression assays have the potential to provide clinically relevant information about prognosis and potential response to chemotherapy in patients with esophageal squamous cell carcinoma. Results are inconsistent, however, for microRNAs across different studies for esophageal adenocarcinoma (EAC) vs. its precursor lesion Barrett’s esophagus. These inconsistencies may partly result from pathological and/or molecular heterogeneity in both Barrett’s esophagus and EAC, but may also result from differences in study designs or different choices of comparator tissues. Despite these inconsistencies, however, several mRNA/protein targets have been identified, the cancer related biology of some of these targets is well understood, and there are clinico-pathological associations for some of these mRNA targets. MicroRNAs also have potential for use in therapy for esophageal cancers. The development of new delivery methods, such as minicells and autologous microvesicles, and molecular modifications such as the addition of aromatic benzene pyridine analogs, have facilitated the exploration of the effects of therapeutic microRNAs in vivo. These approaches are producing encouraging results, with one technology in a phase I/IIa clinical trial

COX-2 mRNA is increased in oesophageal mucosal cells by a proton pump inhibitor

Author version made available in accordance with the publisher's policy.Introduction: Barrett’s oesophagus develops in some individuals with gastro-oesophageal reflux, and is the precursor to oesophageal adenocarcinoma. Proton pump inhibitors (PPIs) suppress gastric acid production and are used to treat reflux. Clinical trials suggest that COX inhibitors might prevent oesophageal cancer, although PPIs could offset this by increasing COX-2 expression in Barrett’s oesophagus. To investigate this, we evaluated the impact of a PPI on COX expression in oesophageal mucosal cells. Methods: The effect of the PPI esomeprazole on COX-1 and COX-2 mRNA levels in oesophageal cells was determined. Oesophageal cell lines OE33 (adenocarcinoma derived) and HET-1A (immortalized squamous cells), and a control intestinal cell line - HT29 (colon carcinoma), were treated for 24 hours with increasing concentrations of the esomeprazole. Results: COX-2, but not COX-1, mRNA levels, dose dependently increased in OE33 and HET-1A cells vs. esomeprazole concentration. COX-2 mRNA levels did not increase in HT29 cells. Conclusions: Exposure to esomeprazole increases COX-2 mRNA in oesophageal cells. This might contribute to the lack of benefit for COX inhibitors for oesophageal cancer prevention in recent clinica

Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation

Background: Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal models of axial pain are not widely available. Accordingly, we developed a mouse model of acute cervical muscle inflammation and assessed the functional properties of superficial dorsal horn (SDH) neurons.&lt;p&gt;&lt;/p&gt; Results: Male C57/Bl6 mice (P24-P40) were deeply anaesthetised (urethane 2.2?g/kg i.p) and the rectus capitis major muscle (RCM) injected with 40??l of 2% carrageenan. Sham animals received vehicle injection and controls remained anaesthetised for 2?hrs. Mice in each group were sacrificed at 2?hrs for analysis. c-Fos staining was used to determine the location of activated neurons. c-Fos labelling in carrageenan-injected mice was concentrated within ipsilateral (87% and 63% of labelled neurons in C1 and C2 segments, respectively) and contralateral laminae I - II with some expression in lateral lamina V. c-Fos expression remained below detectable levels in control and sham animals. In additional experiments, whole cell recordings were obtained from visualised SDH neurons in transverse slices in the ipsilateral C1 and C2 spinal segments. Resting membrane potential and input resistance were not altered. Mean spontaneous EPSC amplitude was reduced by ~20% in neurons from carrageenan-injected mice versus control and sham animals (20.63???1.05 vs. 24.64???0.91 and 25.87???1.32 pA, respectively). The amplitude (238???33 vs. 494???96 and 593???167 pA) and inactivation time constant (12.9???1.5 vs. 22.1???3.6 and 15.3???1.4?ms) of the rapid A type potassium current (IAr), the dominant subthreshold current in SDH neurons, were reduced in carrageenan-injected mice.&lt;p&gt;&lt;/p&gt; Conclusions: Excitatory synaptic drive onto, and important intrinsic properties (i.e., IAr) within SDH neurons are reduced two hours after acute muscle inflammation. We propose this time point represents an important transition period between peripheral and central sensitisation with reduced excitatory drive providing an initial neuroprotective mechanism during the early stages of the progression towards central sensitisation

Molecular biomarkers and ablative therapies for Barrett’s esophagus

Author version made available in accordance with the publisher's policy.Barrett’s esophagus is the major risk factor for esophageal adenocarcinoma. Endoscopic interventions which ablate Barrett’s esophagus mucosa lead to replacement with a new squamous (neosquamous) mucosa, but it can be difficult to achieve complete ablation. Knowing whether cancer is less likely to develop in neosquamous mucosa or residual Barrett’s esophagus after ablation is critical for determining the efficacy of treatment. This issue can be informed by assessing biomarkers that are associated with an increased risk of progression to adenocarcinoma. Although there are few post-ablation biomarker studies, evidence suggests that that neosquamous mucosa may have a reduced risk of adenocarcinoma in patients who have been treated for dysplasia or cancer, but some patients who do not have complete eradication of non-dysplastic Barrett’s esophagus may still be at risk. Biomarkers could be used to optimize endoscopic surveillance strategies following ablation, but this needs to be assessed by clinical studies and economic modeling