Improving the dependability of research in personality and social psychology: recommendations for research and educational practice

pre-printThe Society for Personality and Social Psychology (SPSP) Presidential Task Force on Publication and Research Practices was appointed in response to concerns about the dependability and replicability of research findings in personality and social psychology, a problem that also plagues fields as diverse as physics, economics, biochemistry, medicine and cell biology. In this article the Task Force offers a brief statistical primer and recommendations for improving the dependability of scientific research. Recommendations for research practice include (1) describing and addressing the choice of N (sample size) and consequent issues of statistical power, (2) reporting effect sizes and 95% confidence intervals for findings, (3) avoiding "questionable research practices" that can undermine the assumptions underlying statistical procedures and inflate the probability of Type I error, (4) making available research materials necessary to replicate reported results, (5) adhering to SPSP's data sharing policy, (6) encouraging publication of high quality replication studies, and (7), maintaining flexibility and openness to alternative standards and methods when evaluating research. Recommendations for educational practice include (1) encouraging a culture of "getting it right" rather than "finding significant results," (2) teaching and encouraging transparency of data reporting, (3) improving methodological instruction on topics such as effect size, confidence intervals, statistical power, replication, and the effects of questionable research practices, and (4) modeling sound science and supporting junior researchers who seek to "get it right." The hope is that these recommendations can help lead the way to improved research practices and a more transparent research culture, throughout all of science

Persons, behaviors and situations: An agenda for personality psychology in the postwar era

a b s t r a c t The internecine war over the relative importance of persons and situations, triggered 40 years ago by Walter Mischel's Personality and Assessment, is largely over, so it is time for researchers to develop an agenda for personality psychology in the postwar era. The possibilities include a return to the status quo ante characterized by questionnaire-based research, focusing on narrower trait constructs than the ''global" traits that have undergone so much criticism, and concentrating upon within-person variance (as well as or even instead of between person variance) in behavior. Each of these possibilities offers some promise but also hazards that may be under-appreciated. The present article suggests that personality theory and research be re-organized in terms of the personality triad of persons, behaviors, and situations. A precondition for understanding the elements of this triad is better conceptualization and measurement of behavior and, especially, situations. While the interactions among these elements may turn out to be important, a first order of business is to understand the main effects of each element, a formidable but exciting research agenda that will entail a turn to broadly descriptive research rather than the testing of narrow, isolated hypotheses. Looking further ahead, a post-interactionist personality psychology may someday recognize that personality is a latent construct only indirectly indicated through behavior, and the ultimate understanding of that construct will be empirically tested by the ability to predict behavior in new and unique situations

Regionally acquired intestinal failure data suggest an underestimate in national service requirements

Objectives, setting and patients: With complete case referral for prolonged parenteral nutrition (PN) beyond term equivalent, serving a stable population of 1.25 million people, we describe the long-term outcome and survival of patients referred to an intestinal failure (IF) nutrition support team over the first 8 years of existence at a regional paediatric centre, and extrapolate to potential numbers of national home parenteral nutrition (HPN) cases and intestinal transplantation data. Design and outcome measures: Retrospective analysis detailing patient demographics, interventions, use of HPN, occurrence of intestinal failure-associated liver disease (IFALD), and outcomes of enteral adaptation, survival, and referral for and receipt of organ transplantation. Results: 23 patients were referred over 8 years, 20 being PN dependent within the neonatal period. Diagnoses included short bowel syndrome (SBS) (18), neuromuscular abnormalities (4) and congenital enterocyte disorder (1). 12 696 days of PN were delivered with 314 confirmed episodes of sepsis at a median of 12 episodes per patient. 144 central venous catheters (CVCs) were required at a median of four per patient. IFALD occurred in 17 (73%) patients, with 10 (44%) referred for transplant assessment. Thirteen (56%) children received HPN. Overall mortality was 44%. A significant predictor for survival in the SBS group was residual bowel >40 cm (82% vs 28%, p = 0.049). Conclusions: Survival for IF at 56% was lower than reported from non-UK supra-regional centres, and nationally collected data, possibly reflecting pre-selected referral populations. Data from regional centres with complete ascertainment may be important both when counselling parents and when planning regional and national HPN and IF specialist services

Benefiting From Misfortune: When Harmless Actions Are Judged to Be Morally Blameworthy

Dominant theories of moral blame require an individual to have caused or intended harm. However, the current four studies demonstrate cases where no harm is caused or intended, yet individuals are nonetheless deemed worthy of blame. Specifically, individuals are judged to be blameworthy when they engage in actions that enable them to benefit from another’s misfortune (e.g., betting that a company’s stock will decline or that a natural disaster will occur). Evidence is presented suggesting that perceptions of the actor’s wicked desires are responsible for this phenomenon. It is argued that these results are consistent with a growing literature demonstrating that moral judgments are often the product of evaluations of character in addition to evaluations of acts

Effect of cimetidine, ranitidine, famotidine and omeprazole on hepatocyte proliferation in vitro

Recently reports have indicated that both cimetidine and ranitidine delay cell proliferation in rats following 70% partial hepatectomy and result in an increased mortality following this procedure. The present study was designed to determine whether three H2 blocking agents (cimetidine, ranitidine, famotidine) and a new, powerful antisecretory drug (omeprazole) specifically influence hepatocyte proliferation in primary culture. Hepatocytes were isolated from livers of normal male rats by the standard collagenase perfusion technique. Hepatic DNA synthesis and percent of labelled nuclei were determined after 48 h incubation. Hepatocytes in culture were incubated with the H2 blocking agents and omeprazole or with different concentrations of serum obtained from shamoperated or 70% hepatectomized rats treated or not with the same agents. Rats were injected intraperitoneally at 8:00 a.m. on two consecutive days. In hepatectomized rats, the first dose was injected at 8:00 a.m. immediately after surgery, the second, 24 h later. The serum of sham-operated or 70% hepatectomized rats that did not receive drugs served as control. No changes in DNA synthesis, percentage of labelled nuclei and transaminase were detected when the agents were added to the hepatocytes in culture at concentrations within the effective pharmacological dosage and 30 times higher. Similarly, no changes in these parameters were obtained when different concentrations of serum obtained from sham-operated rats treated with H2 blocking agents or omeprazole were added to the basal culture medium. However, a significant inhibition of DNA synthesis and of percentage of labelled nuclei was observed when hepatocytes were incubated in the presence of serum from 70% hepatectomized rats that had been treated with cimetidine or with ranitidine. The serum of 70% hepatectomized rats treated with famotidine and omeprazole had no effect on hepatocyte proliferation in vitro. No effect on transaminase was found in these conditions. © 1989

Why Has Personality Psychology Played an Outsized Role in the Credibility Revolution?

21 pages. Published at PsychOpen: 10.5964/ps.6001Personality is not the most popular subfield of psychology. But, in one way or another, personality psychologists have played an outsized role in the ongoing “credibility revolution” in psychology. Not only have individual personality psychologists taken on visible roles in the movement, but our field’s practices and norms have now become models for other fields to emulate (or, for those who share Baumeister’s (2016, https://doi.org/10.1016/j.jesp.2016.02.003) skeptical view of the consequences of increasing rigor, a model for what to avoid). In this article we discuss some unique features of our field that may have placed us in an ideal position to be leaders in this movement. We do so from a subjective perspective, describing our impressions and opinions about possible explanations for personality psychology’s disproportionate role in the credibility revolution. We also discuss some ways in which personality psychology remains less-than-optimal, and how we can address these flaws

Evolution of ligand specificity in vertebrate corticosteroid receptors

<p>Abstract</p> <p>Background</p> <p>Corticosteroid receptors include mineralocorticoid (MR) and glucocorticoid (GR) receptors. Teleost fishes have a single MR and duplicate GRs that show variable sensitivities to mineralocorticoids and glucocorticoids. How these receptors compare functionally to tetrapod MR and GR, and the evolutionary significance of maintaining two GRs, remains unclear.</p> <p>Results</p> <p>We used up to seven steroids (including aldosterone, cortisol and 11-deoxycorticosterone [DOC]) to compare the ligand specificity of the ligand binding domains of corticosteroid receptors between a mammal (<it>Mus musculus</it>) and the midshipman fish (<it>Porichthys notatus</it>), a teleost model for steroid regulation of neural and behavioral plasticity. Variation in mineralocorticoid sensitivity was considered in a broader phylogenetic context by examining the aldosterone sensitivity of MR and GRs from the distantly related daffodil cichlid (<it>Neolamprologus pulcher</it>), another teleost model for neurobehavioral plasticity. Both teleost species had a single MR and duplicate GRs. All MRs were sensitive to DOC, consistent with the hypothesis that DOC was the initial ligand of the ancestral MR. Variation in GR steroid-specificity corresponds to nine identified amino acid residue substitutions rather than phylogenetic relationships based on receptor sequences.</p> <p>Conclusion</p> <p>The mineralocorticoid sensitivity of duplicate GRs in teleosts is highly labile in the context of their evolutionary phylogeny, a property that likely led to neo-functionalization and maintenance of two GRs.</p