Autophagy as a promoter of longevity: insights from model organisms.

Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during development and disease, and evidence accumulated over the past decade indicates that autophagy also has a direct role in modulating ageing. In particular, elegant studies using yeasts, worms, flies and mice have demonstrated a broad requirement for autophagy-related genes in the lifespan extension observed in a number of conserved longevity paradigms. Moreover, several new and interesting concepts relevant to autophagy and its role in modulating longevity have emerged. First, select tissues may require or benefit from autophagy activation in longevity paradigms, as tissue-specific overexpression of single autophagy genes is sufficient to extend lifespan. Second, selective types of autophagy may be crucial for longevity by specifically targeting dysfunctional cellular components and preventing their accumulation. And third, autophagy can influence organismal health and ageing even non-cell autonomously, and thus, autophagy stimulation in select tissues can have beneficial, systemic effects on lifespan. Understanding these mechanisms will be important for the development of approaches to improve human healthspan that are based on the modulation of autophagy

Relationship of personal, familial, and abuse-specific factors with outcome following childhood sexual abuse

An examination of the literature on factors related to outcome following child sexual abuse (CSA) revealed many factors that may contribute to symptoms displayed by victims. Factors are divided into three categories: Personal Factors, Familial Factors, and Abuse- Specific Factors. Personal factors are those inherent to the victim, including age, gender, developmental disability, attributions regarding the abuse, and treatment following abuse. Familial factors are defined as those factors associated with other family members. These include parental history of abuse, parental reaction to the disclosure, parental support of the victim, parental mental health, family stress, and treatment following abuse for the parent and other family members. Finally, factors related to the abuse are delineated, including severity of abuse, duration of the abuse, and victim–perpetrator relationship. Directions for future research are discussed

Insight into the microphysics of antigorite deformation from spherical nanoindentation.

The mechanical behaviour of antigorite strongly influences the strength and deformation of the subduction interface. Although there is microstructural evidence elucidating the nature of brittle deformation at low pressures, there is often conflicting evidence regarding the potential for plastic deformation in the ductile regime at higher pressures. Here, we present a series of spherical nanoindentation experiments on aggregates of natural antigorite. These experiments effectively investigate the single-crystal mechanical behaviour because the volume of deformed material is significantly smaller than the grain size. Individual indents reveal elastic loading followed by yield and strain hardening. The magnitude of the yield stress is a function of crystal orientation, with lower values associated with indents parallel to the basal plane. Unloading paths reveal more strain recovery than expected for purely elastic unloading. The magnitude of inelastic strain recovery is highest for indents parallel to the basal plane. We also imposed indents with cyclical loading paths, and observed strain energy dissipation during unloading-loading cycles conducted up to a fixed maximum indentation load and depth. The magnitude of this dissipated strain energy was highest for indents parallel to the basal plane. Subsequent scanning electron microscopy revealed surface impressions accommodated by shear cracks and a general lack of dislocation-induced lattice misorientation. Based on these observations, we suggest that antigorite deformation at high pressures is dominated by sliding on shear cracks. We develop a microphysical model that is able to quantitatively explain Young's modulus and dissipated strain energy data during cyclic loading experiments, based on either frictional or cohesive sliding of an array of cracks contained in the basal plane. This article is part of a discussion meeting issue 'Serpentinite in the earth system'.This work was supported by the Natural Environment Research Councilthrough grant no. NE/M016471/1 to L.N.H. and N.B., and by the European Research Councilunder the European Union’s Horizon 2020 research and innovation programme (project RockDEaF, grant agreement no. 804685)

Superconductivity in NdFe1-xCoxAsO (0.05 < x < 0.20) and rare-earth magnetic ordering in NdCoAsO

The phase diagram of NdFe1-xCoxAsO for low cobalt substitution consists of a superconducting dome (0.05 < x < 0.20) with a maximum critical temperature of 16.5(2) K for x = 0.12. The x = 1 end member, NdCoAsO, is an itinerant ferromagnet (TC = 85 K) with an ordered moment of 0.30(1) BM at 15 K. Below TN = 9 K, Nd spin-ordering results in the antiferromagnetic coupling of the existing ferromagnetic planes. Rietveld analysis reveals that the electronically important two-fold tetrahedral angle increases from 111.4 to 115.9 deg. in this series. Underdoped samples with x = 0.046(2) and x = 0.065(2) show distortions to the orthorhombic Cmma structure at 72(2) and 64(2) K, respectively. The temperature dependences of the critical fields Hc2(T) near Tc are linear with almost identical slopes of 2.3(1) T K-1 for x = 0.065(2), x = 0.118(2) and x = 0.172(2). The estimated critical field Hc2(0) and correlation length for optimally doped samples are 26(1) T and 36(1) Angstrom. A comparison of the maximum reported critical temperatures of well-characterized cobalt doped 122- and 1111-type superconductors is presented.Comment: accepted to PR

A Spectral Method for Elliptic Equations: The Neumann Problem

Let $\Omega$ be an open, simply connected, and bounded region in $\mathbb{R}^{d}$, $d\geq2$, and assume its boundary $\partial\Omega$ is smooth. Consider solving an elliptic partial differential equation $-\Delta u+\gamma u=f$ over $\Omega$ with a Neumann boundary condition. The problem is converted to an equivalent elliptic problem over the unit ball $B$, and then a spectral Galerkin method is used to create a convergent sequence of multivariate polynomials $u_{n}$ of degree $\leq n$ that is convergent to $u$. The transformation from $\Omega$ to $B$ requires a special analytical calculation for its implementation. With sufficiently smooth problem parameters, the method is shown to be rapidly convergent. For $u\in C^{\infty}(\overline{\Omega})$ and assuming $\partial\Omega$ is a $C^{\infty}$ boundary, the convergence of $\Vert u-u_{n}\Vert_{H^{1}}$ to zero is faster than any power of $1/n$. Numerical examples in $\mathbb{R}^{2}$ and $\mathbb{R}^{3}$ show experimentally an exponential rate of convergence.Comment: 23 pages, 11 figure

Management of Potato Leafhopper, Empoasca fabae (Homoptera: Cicadellidae), on Alfalfa with the Aid of Systems Analysis

Efficient management of the potato leafhopper (Homoptera: Cicadellidae) on alfalfa requires a procedure for dealing with the complexities of the ecological and economic system. We developed a mathematical model to represent this agroecosystem and demonstrated how systems analysis can help to make management more efficient and less risky. Our management policies were based on two criteria: annual income calculated from the nutrient yields of three harvests, and level of carbohydrate reserve in the taproots at the end of the season, We determined the dynamic economic thresholds for controlling the leafhoppers as immigrants on each of the cuttings of alfalfa. During development of the thresholds we tested a variety of control tactics, including timing of harvests, We found that, for adult immigrants on the second crop, the economic thresholds increase exponentially as stem height increases, Tactics associated with these thresholds included insecticide treatments and early cutting of the second harvest. The results indicated that temperature pattern has an important effect on the economic thresholds and risk. Evaluation of the model and its results through sensitivity analysis, validation, and a comparison with current recommendations showed that the model can be a useful tool in research and managemen

Studies on Recombination within the Mouse H-2 Gene Complex. III. Further Serological Analyses of the H-2 t Haplotypes *

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66398/1/j.1399-0039.1975.tb00655.x.pd

The Relationship of Personal, Family, and Abuse-Specific Factors to Children’s Clinical Presentation Following Childhood Sexual Abuse

Past literature has proposed potential variables (e.g., age, gender, attributional style) that may relate to clinical presentation following childhood sexual abuse (CSA). However, few studies have tested these relationships. The current study examined multiple factors related to clinical presentation following CSA in 101 children and adolescents presenting for treatment at Project SAFE, a parallel group treatment for children/teens and their nonoffending parents. Using clusters developed in a previous study, relationships between proposed variables and pretreatment clinical presentation were examined. Results indicated that attributions about the abuse, parental mental health, and severity of abuse related to the differentiated clinical presentation. These results are important because pinpointing correlates to clinical presentation following CSA helps elucidate differences among those with a history of CSA and gives greater insight into the impact sexual abuse has on children. Knowing these differences may also benefit treatment providers in the development of individual treatment goals during therapy

Dynamic Electrode-to-Image (DETI) mapping reveals the human brain’s spatiotemporal code of visual information

A number of neuroimaging techniques have been employed to understand how visual information is transformed along the visual pathway. Although each technique has spatial and temporal limitations, they can each provide important insights into the visual code. While the BOLD signal of fMRI can be quite informative, the visual code is not static and this can be obscured by fMRI’s poor temporal resolution. In this study, we leveraged the high temporal resolution of EEG to develop an encoding technique based on the distribution of responses generated by a population of real-world scenes. This approach maps neural signals to each pixel within a given image and reveals location-specific transformations of the visual code, providing a spatiotemporal signature for the image at each electrode. Our analyses of the mapping results revealed that scenes undergo a series of nonuniform transformations that prioritize different spatial frequencies at different regions of scenes over time. This mapping technique offers a potential avenue for future studies to explore how dynamic feedforward and recurrent processes inform and refine high-level representations of our visual world