Interpretative dilemmas

In this paper I claim that the reason we are reluctant to call many informal fallacies fallacies of relevance is because we can interpret them as providing contextual information about how the argument is to be interpreted. This interpretative dilemma is that the logical form is determined in part by whether the analyst wishes to be charitable to the proponent or the opponent. The evaluation of the argument is nonetheless purely logical

The Problem of Modal Upgrading in Aristotle’s Apodictic Syllogistic

This is another contribution to the unending controversy over the two Barbaras. My approach to the problem is hopefully quite new: I wish to view the issue through the prism of modal upgrading. Modal upgrading occurs when a subject term that has only been predicated of assertorically in the premises is predicated of apodictically either: i) in the conclusion of a given syllogism, or; ii) in some proposition that is derived from either the premises of the given syllogism alone or the premises in combination with other propositions that do not refer to the proposition’s subject term. I call the proposition after it has been upgraded the upgraded proposition. When a conclusion is the upgraded proposition, it is obviously a different predicate being predicated than was predicated in the premises. Aristotle endorses this kind of upgrading; it is effectively what happens in any valid mixed modal syllogism when the minor premise is not apodictic (e.g., Barbara LXL). In other cases the upgraded proposition is not a conclusion but still follows from the premises alone. In these cases it is the same predicate being predicated in the upgraded proposition as in the premises, although the quantity of the propositions are different (one is universal, another particular). Aristotle rejects this kind of upgrading and takes its occurrence as sufficient to deny the validity of the given syllogism (e.g., Barbara XLL). I will describe a third type where both the predicate remains the same and the quantity of the proposition remains the same as in the premise, e.g., the upgrading of “All C are B” to “All C are necessarily B”. In these cases it will turn out that the upgraded proposition is not derived from the premises alone, or at least, not syllogistically from the premises alone. This kind of upgrading too is reason for denying the validity of any syllogism from which the upgraded proposition follows as a consequence. I will show that Barbara LXL entails this kind of modal upgrading and should be rejected for this reason. Armed with this notion of modal upgrading I want to attack the problem of the two Barbaras in Aristotle’s apodictic syllogistic. Aristotle himself endorses mixed modal Barbara when the major is necessary and the minor is assertoric, thereby endorsing the first kind of modal upgrading, but rejects Barbara when the minor is necessary and the major is assertoric on the grounds that it leads to the second kind of modal upgrading. Theophrastus endorses the peioram rule which rejects both Barbaras on the grounds that the conclusion can only be as strong as the weakest premise. Łukasiewicz endorses both Barbaras. I will argue that both Barbaras lead to unacceptable modal upgrading and should be taken to be invalid for that reason. Hence, I agree with Theophrastus about the two Barbaras; however, I do not endorse the peioram rule because I think that the negative mixed modal syllogisms generally avoid this problem and is mostly correct

Commentary on: Geoffrey C. Goddu\u27s Why I still do not know what a \u27real\u27 argument is

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A Defence of Broome’s First-Order Model of Practical Reasoning

In this paper I will consider criticisms that have been raised against Broome’s first-order model of practical reasoning by Bratman, Brunero, and Høj. I will modify Broome’s exposition so that it is no longer vulnerable to these objections. The main modification I will make is that I will take the principle Broome dubs the “beliefintention link” to express a pragmatic implicature instead of a material implication, on the basis of which implicatures the process of reasoning Broome describes reaches the conclusion-states Broome desires to reach. This makes a cognitivist account of at least some norms of practical rationality plausible

Toulmin’s logical types

SFRH/BPD/77687/2011 UID/FIL/00183/2013In “The Uses of Argument” Toulmin introduces a number of concepts that have become popular in argumentation theory, such as data, claim, warrant, backing, force, field, and, most fundamentally, the concept of a “logical type”. Toulmin never defines the concept of a logical type or a field very clearly, and different interpretations can be found in the literature, either reconstructing what Toulmin has in mind, or revising his concepts to suit other concerns. A natural history of these concepts is not my concern. I will analyse logical types according to what Toulmin uses this concept for, namely to raise a problem with deductive logic and motivate its replacement with the Toulmin model. I will argue that a logical type and the distinction he draws between different logical types resembles distinctions made in logical positivism between the directly and the indirectly verifiable, and the problem raised is, in essence, the positivist’s problem of how indirect propositions can be justified on the basis of direct propositions. I will show that Toulmin makes a straw man of the positivists’ own solution to the problem and hence does not prove there to be an adequate motivation for replacing deductive logic with the Toulmin model.authorsversionpublishe

On the interaction between human IQGAP1 and actin

DM thanks the School of Biological Sciences, Queen’s University, Belfast for a summer studentship and EH thanks the Department of Employment and Learning, Northern Ireland for a postgraduate studentship. The work was funded in part by grants from the BBSRC (BB/D000394/1 To DJT) and by the Wellcome Trust [grant number GR06281AIA] which funded the purchase of the QStar XL mass spectrometer at the BBSRC Mass Spectrometry and Proteomics Facility, University of St Andrews and funded SLS.IQGAPs are eukaryotic proteins which integrate signals from various sources and pass these on the cytoskeleton. Understanding how they do this requires information on the interfaces between the proteins. Here, it is shown that the calponin homology domain of human IQGAP1 (CHD1) can be crosslinked with α-actin. The stoichiometry of the interaction was 1:1. A molecular model was built of the complex and associated bioinformatics analyses predicted that the interaction is likely to involve an electrostatic interaction between Lys-240 of α-actin and Glu-30 of CHD1. These residues are predicted to be accessible and are not involved in many intra-protein interactions; they are thus available for interaction with binding partners. They are both located in regions of the proteins which are predicted to be flexible and disordered; interactions between signalling molecules often involve flexible, disordered regions. The predicted binding region in CHD1 is well conserved in many eukaryotic IQGAP-like proteins. In some cases (e.g Dictyostelium discoideum and Saccharomyces cerevisiae) protein sequence conservation is weak, but molecular modelling reveals that a region of charged, polar residues in a flexible N-terminus is structurally well conserved. Therefore we conclude that the calponin homology domains of IQGAP1-like proteins interact initially through the electrostatic interaction identified here and that there may be subsequent conformational changes to form the final complex.PostprintPeer reviewe

Risk of Congenital Anomalies after the Opening of Landfill Sites

Concern that living near a particular landfill site in Wales caused increased risk of births with congenital malformations led us to examine whether residents living close to 24 landfill sites in Wales experienced increased rates of congenital anomalies after the landfills opened compared with before they opened. We carried out a small-area study in which expected rates of congenital anomalies in births to mothers living within 2 km of the sites, before and after opening of the sites, were estimated from a logistic regression model fitted to all births in residents living at least 4 km away from these sites and hence not likely to be subject to contamination from a landfill, adjusting for hospital catchment area, year of birth, sex, maternal age, and socioeconomic deprivation score. We investigated all births from 1983 through 1997 with at least one recorded congenital anomaly [International Classification of Diseases, Ninth Revision (ICD-9), codes 7400–7599; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10), codes Q000–Q999]. The ratio of the observed to expected rates of congenital anomalies before landfills opened was 0.87 [95% confidence interval (CI), 0.75–1.00], and this increased to 1.21 (95% CI, 1.04–1.40) after opening, giving a standardized risk ratio of 1.39 (95% CI, 1.12–1.72). Enhanced congenital malformation surveillance data collected from 1998 through 2000 showed a standardized risk ratio of 1.04 (95% CI, 0.88–1.21). Causal inferences are difficult because of possible biases from incomplete case ascertainment, lack of data on individual-level exposures, and other socioeconomic and lifestyle factors that may confound a relationship with area of residence. However, the increase in risk after the sites opened requires continued enhanced surveillance of congenital anomalies, and site-specific chemical exposure studies

Toward the effective surveillance of hypospadias.

Concern about apparent increases in the prevalence of hypospadias--a congenital male reproductive-tract abnormality--in the 1960s to 1980s and the possible connection to increasing exposures to endocrine-disrupting chemicals have underlined the importance of effective surveillance of hypospadias prevalence in the population. We report here the prevalence of hypospadias from 1980 to 1999 in 20 regions of Europe with EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers, 14 of which implemented a guideline to exclude glanular hypospadias. We also report data from the England and Wales National Congenital Anomaly System (NCAS). Our results do not suggest a continuation of rising trends of hypospadias prevalence in Europe. However, a survey of the registers and a special validation study conducted for the years 1994-1996 in nine EUROCAT registers as well as NCAS identified a clear need for a change in the guidelines for registration of hypospadias. We recommend that all hypospadias be included in surveillance, but that information from surgeons be obtained to verify location of the meatus, and whether surgery was performed, in order to interpret trends. Investing resources in repeated special surveys may be more cost-effective than continuous population surveillance. We conclude that it is doubtful whether we have had the systems in place worldwide for the effective surveillance of hypospadias in relation to exposure to potential endocrine-disrupting chemicals

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual\u27s risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig\u27s potential to enhance clinical therapeutic innovation to improve human health. (Figure presented.)

Electrocardiographic Deep Learning for Predicting Post-Procedural Mortality

Background. Pre-operative risk assessments used in clinical practice are limited in their ability to identify risk for post-operative mortality. We hypothesize that electrocardiograms contain hidden risk markers that can help prognosticate post-operative mortality. Methods. In a derivation cohort of 45,969 pre-operative patients (age 59+- 19 years, 55 percent women), a deep learning algorithm was developed to leverage waveform signals from pre-operative ECGs to discriminate post-operative mortality. Model performance was assessed in a holdout internal test dataset and in two external hospital cohorts and compared with the Revised Cardiac Risk Index (RCRI) score. Results. In the derivation cohort, there were 1,452 deaths. The algorithm discriminates mortality with an AUC of 0.83 (95% CI 0.79-0.87) surpassing the discrimination of the RCRI score with an AUC of 0.67 (CI 0.61-0.72) in the held out test cohort. Patients determined to be high risk by the deep learning model's risk prediction had an unadjusted odds ratio (OR) of 8.83 (5.57-13.20) for post-operative mortality as compared to an unadjusted OR of 2.08 (CI 0.77-3.50) for post-operative mortality for RCRI greater than 2. The deep learning algorithm performed similarly for patients undergoing cardiac surgery with an AUC of 0.85 (CI 0.77-0.92), non-cardiac surgery with an AUC of 0.83 (0.79-0.88), and catherization or endoscopy suite procedures with an AUC of 0.76 (0.72-0.81). The algorithm similarly discriminated risk for mortality in two separate external validation cohorts from independent healthcare systems with AUCs of 0.79 (0.75-0.83) and 0.75 (0.74-0.76) respectively. Conclusion. The findings demonstrate how a novel deep learning algorithm, applied to pre-operative ECGs, can improve discrimination of post-operative mortality