Separation and identification of indene-C70 bisadduct isomers.

Following an initial work on the isolation of a single geometric isomer from an indene-C70 bisadduct (IC70BA) mixture, we report the full fractionation and identification of the bisadduct species in the material. Eleven fractions of IC70BA isomers were separated by high-performance liquid chromatography. A number of fractions contained relatively pure isomer species and their configuration were deduced using a variety of analytical techniques including (1)H and (13)C NMR and UV-vis spectroscopy. The electrochemical properties and the organic solar cell device performance were investigated for fractions where a reasonable quantity of sample could be isolated

Long-term efficacy and safety of solifenacin in pediatric patients aged 6 months to 18 years with neurogenic detrusor overactivity: results from two phase 3 prospective open-label studies

Introduction The standard recommended treatment for neurogenic detrusor overactivity (NDO) is clean intermittent catheterization combined with an antimuscarinic agent. However, the adverse systemic side effects of oxybutynin, the most widely used agent, are of concern. Objective To evaluate the efficacy and safety of solifenacin in pediatric patients with NDO, aged 6 months–15 cmH2O), number of overactive detrusor contractions (>15 cmH2O), maximum catheterized volume (MCV)/24 h and incontinence episodes/24 h. Safety parameters were treatment-emergent adverse events (TEAEs), serious adverse events, laboratory variables, vital signs, electrocardiograms, and ocular accommodation and cognitive function assessments. Results After 24 weeks, MCC had significantly increased compared with baseline in patients aged 6 months–<5 years and 5–<18 years (37.0 ml and 57.2 ml, respectively; P < 0.001; Fig.). Improvement was also observed after 52 weeks’ treatment. Significant changes were observed from baseline to week 24 in all secondary endpoints in both age groups: increase in bladder compliance, increase in bladder volume to first detrusor contraction as a percentage of expected bladder capacity, reduction in the number of overactive detrusor contractions, increase in MCV, and decreased incontinence episodes. TEAEs were mostly mild or moderate and there were no new drug-related TEAEs compared with adult studies. Age-related improvements were noted in ocular accommodation and cognitive function. Discussion These long-term multicenter investigations demonstrated the efficacy and safety of solifenacin in pediatric patients with NDO. The observed increases in MCC were clinically relevant and demonstrated that an increase in fluid volume can be accommodated in the bladder prior to reaching intravesical pressures that endanger kidney function and/or are associated with leakage or discomfort. Solifenacin was well tolerated with low incidences of constipation and dry mouth (typically associated with antimuscarinics), central nervous system-related side effects and facial flushing. Conclusion Solifenacin was effective and well tolerated in pediatric patients with NDO, aged 6 months–<18 years, suggesting that it is a viable alternative to oxybutynin, the current standard of care

Expert Consensus on Microtransplant for Acute Myeloid Leukemia in Elderly Patients -Report From the International Microtransplant Interest Group

Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML. Four major issues related to MST for treating EAML were addressed: therapeutic principle of MST (1), candidates for MST (2), induction chemotherapy regimens (3), and post-remission therapy based on MST (4). Others included donor screening, infusion of donor cells, laboratory examinations, and complications of treatment

Alkyl Chain Length‐Dependent Amine‐Induced Crystallization for Efficient Interface Passivation of Perovskite Solar Cells

Abstract Efficient surface passivation of perovskite solar cells (PSC) using treatment with ammonium salts is demonstrated as an efficient method to enhance the device performance, owing to the affinity between the amine group and [PbI6]4− octahedron. However, due to their high solubility in polar solvents (DMF/DMSO), ammonium salts are more difficult to use in passivation of the interface between the electron transport layer and perovskite thin film in n‐i‐p structured PSCs. In this report, this work successfully links the amine group with a fullerene through a series of increasing carbon chain length, from two to twelve methylene units (FC‐X, X = 2, 6, 12), and then introduce the synthesized molecules as interface passivation layers into SnO2‐based planar n‐i‐p PSCs. Results show that the interface passivation effect is highly dependent on the side‐chain length, and the longer chain length amine‐functionalized fullerene is more beneficial for the device performance. A power conversion efficiency as high as 21.2% is achieved by using FC‐12. The surface energy, perovskite crystallite size and electron transfer capacity correlate with the linker chain length. This work develops an amine‐induced anchored crystallization of perovskite to unravel the mechanism of this passivation effect. As expected, enhanced device stability is also observed in the FC‐12 passivated PSCs

Highly Fluorescent Molecularly Insulated Perylene Diimides: Effect of Concentration on Photophysical Properties

A series of four perylene diimide (PDI) chromophores were prepared with increasing steric bulk on the imide substituents with the aim of retarding the effect of concentration quenching on photoluminescence, commonly observed with these dyes. Spectroscopic investigations of the compounds in dilute solution confirmed that the photophysical properties of the PDI core chromophore were not perturbed by the bulky substituents. Solid film samples containing the PDI compounds at various concentrations dispersed in a poly­(methyl methacrylate) (PMMA) matrix were examined and compared to amorphous neat films as well as crystalline samples. The PDI compounds containing di-<i>tert</i>-butylphenyl (bPDI-3) and trityl (bPDI-4) substituents showed near unity photoluminescence quantum yield (PLQY) up to 20 mM in PMMA compared to 10% PLQY for the reference compound (bPDI-1) without molecular insulation. Surprisingly, high concentrations (>40 mM) of a phenyl-substituted PDI compound (bPDI-2) with moderate molecular insulation formed emissive aggregates that showed a higher PLQY compared to the PDI derivatives with greater steric bulk. By examining the molecular structure and solid state packing in conjunction with a series of photophysical measurements, new insights into designing highly fluorescent dyes, particularly in the solid state, were obtained. The trityl-substituted PDI compound (bPDI-4) was used in a luminescent solar concentrator with optical quantum efficiency of 54%, flux gain of 6.4, and geometric gain of 45

Highly Fluorescent Molecularly Insulated Perylene Diimides: Effect of Concentration on Photophysical Properties

A series of four perylene diimide (PDI) chromophores were prepared with increasing steric bulk on the imide substituents with the aim of retarding the effect of concentration quenching on photoluminescence, commonly observed with these dyes. Spectroscopic investigations of the compounds in dilute solution confirmed that the photophysical properties of the PDI core chromophore were not perturbed by the bulky substituents. Solid film samples containing the PDI compounds at various concentrations dispersed in a poly­(methyl methacrylate) (PMMA) matrix were examined and compared to amorphous neat films as well as crystalline samples. The PDI compounds containing di-<i>tert</i>-butylphenyl (bPDI-3) and trityl (bPDI-4) substituents showed near unity photoluminescence quantum yield (PLQY) up to 20 mM in PMMA compared to 10% PLQY for the reference compound (bPDI-1) without molecular insulation. Surprisingly, high concentrations (>40 mM) of a phenyl-substituted PDI compound (bPDI-2) with moderate molecular insulation formed emissive aggregates that showed a higher PLQY compared to the PDI derivatives with greater steric bulk. By examining the molecular structure and solid state packing in conjunction with a series of photophysical measurements, new insights into designing highly fluorescent dyes, particularly in the solid state, were obtained. The trityl-substituted PDI compound (bPDI-4) was used in a luminescent solar concentrator with optical quantum efficiency of 54%, flux gain of 6.4, and geometric gain of 45

Single Isomer of Indene‑C₇₀ BisadductIsolation and Performance in Bulk Heterojunction Solar Cells

Indene-C₇₀ bisadduct (IC₇₀BA) is a high performance electron acceptor material consisting of a mixture of regioisomers. A single isomer of the IC₇₀BA was isolated by careful chromatographic separation. The structure of this isomer was confirmed by various analytical techniques including single crystal X-ray analysis. The isomer showed superior performance to other isomer mixtures of IC₇₀BA in bulk heterojunction solar cells using poly­(3-hexylthiophene) as the donor material