1,345 research outputs found
Finding k-Dissimilar Paths with Minimum Collective Length
Shortest path computation is a fundamental problem in road networks. However,
in many real-world scenarios, determining solely the shortest path is not
enough. In this paper, we study the problem of finding k-Dissimilar Paths with
Minimum Collective Length (kDPwML), which aims at computing a set of paths from
a source s to a target t such that all paths are pairwise dissimilar by at
least \theta and the sum of the path lengths is minimal. We introduce an exact
algorithm for the kDPwML problem, which iterates over all possible s-t paths
while employing two pruning techniques to reduce the prohibitively expensive
computational cost. To achieve scalability, we also define the much smaller set
of the simple single-via paths, and we adapt two algorithms for kDPwML queries
to iterate over this set. Our experimental analysis on real road networks shows
that iterating over all paths is impractical, while iterating over the set of
simple single-via paths can lead to scalable solutions with only a small
trade-off in the quality of the results.Comment: Extended version of the SIGSPATIAL'18 paper under the same titl
Upper Bounding the Graph Edit Distance Based on Rings and Machine Learning
The graph edit distance (GED) is a flexible distance measure which is widely
used for inexact graph matching. Since its exact computation is NP-hard,
heuristics are used in practice. A popular approach is to obtain upper bounds
for GED via transformations to the linear sum assignment problem with
error-correction (LSAPE). Typically, local structures and distances between
them are employed for carrying out this transformation, but recently also
machine learning techniques have been used. In this paper, we formally define a
unifying framework LSAPE-GED for transformations from GED to LSAPE. We also
introduce rings, a new kind of local structures designed for graphs where most
information resides in the topology rather than in the node labels.
Furthermore, we propose two new ring based heuristics RING and RING-ML, which
instantiate LSAPE-GED using the traditional and the machine learning based
approach for transforming GED to LSAPE, respectively. Extensive experiments
show that using rings for upper bounding GED significantly improves the state
of the art on datasets where most information resides in the graphs'
topologies. This closes the gap between fast but rather inaccurate LSAPE based
heuristics and more accurate but significantly slower GED algorithms based on
local search
EpiGEN: an epistasis simulation pipeline
Abstract
Summary
Simulated data are crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only dichotomous phenotypes or depend on proprietary software. In contrast, EpiGEN supports SNP interactions of arbitrary order, produces realistic LD patterns and generates both categorical and quantitative phenotypes.
Availability and implementation
EpiGEN is implemented in Python 3 and is freely available at https://github.com/baumbachlab/epigen.
Supplementary information
Supplementary data are available at Bioinformatics online
Operon conservation and the evolution of trans-splicing in the phylum Nematoda
The nematode Caenorhabditis elegans is unique among model animals in that many of its genes are cotranscribed as polycistronic pre-mRNAs from operons. The mechanism by which these operonic transcripts are resolved into mature mRNAs includes trans-splicing to a family of SL2-like spliced leader exons. SL2-like spliced leaders are distinct from SL1, the major spliced leader in C. elegans and other nematode species. We surveyed five additional nematode species, representing three of the five major clades of the phylum Nematoda, for the presence of operons and the use of trans-spliced leaders in resolution of polycistronic pre-mRNAs. Conserved operons were found in Pristionchus pacificus, Nippostrongylus brasiliensis, Strongyloides ratti, Brugia malayi, and Ascaris suum. In nematodes closely related to the rhabditine C. elegans, a related family of SL2-like spliced leaders is used for operonic transcript resolution. However, in the tylenchine S. ratti operonic transcripts are resolved using a family of spliced leaders related to SL1. Non-operonic genes in S. ratti may also receive these SL1 variants. In the spirurine nematodes B. malayi and A. suum operonic transcripts are resolved using SL1. Mapping these phenotypes onto the robust molecular phylogeny for the Nematoda suggests that operons evolved before SL2-like spliced leaders, which are an evolutionary invention of the rhabditine lineage
Renormalization of Crumpled Manifolds
We consider a model of D-dimensional tethered manifold interacting by
excluded volume in R^d with a single point. By use of intrinsic distance
geometry, we first provide a rigorous definition of the analytic continuation
of its perturbative expansion for arbitrary D, 0 < D < 2. We then construct
explicitly a renormalization operation, ensuring renormalizability to all
orders. This is the first example of mathematical construction and
renormalization for an interacting extended object with continuous internal
dimension, encompassing field theory.Comment: 10 pages (1 figure, included), harvmac, SPhT/92-15
The Role of a Hot Gas Environment on the Evolution of Galaxies
Most spiral galaxies are found in galaxy groups with low velocity
dispersions; most E/S0 galaxies are found in galaxy groups with relatively high
velocity dispersions. The mass of the hot gas we can observe in the E/S0 groups
via their thermal X-ray emission is, on average, as much as the baryonic mass
of the galaxies in these groups. By comparison, galaxy clusters have as much or
more hot gas than stellar mass. Hot gas in S-rich groups, however, is of low
enough temperature for its X-ray emission to suffer heavy absorption due to
Galactic HI and related observational effects, and hence is hard to detect. We
postulate that such lower temperature hot gas does exist in low velocity
dispersion, S-rich groups, and explore the consequences of this assumption. For
a wide range of metallicity and density, hot gas in S-rich groups can cool in
far less than a Hubble time. If such gas exists and can cool, especially when
interacting with HI in existing galaxies, then it can help link together a
number of disparate observations, both Galactic and extragalactic, that are
otherwise difficult to understand.Comment: 16 pages with one figure. ApJ Letters, in pres
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Mortality Rate in Veterans with Multiple Chronic Conditions
Background: Among patients with multiple chronic conditions, there is increasing appreciation of the complex interrelatedness of diseases. Previous studies have focused on the prevalence and economic burden associated with multiple chronic conditions, much less is known about the mortality rate associated with specific combinations of multiple diseases. Objective: Measure the mortality rate in combinations of 11 chronic conditions. Design: Cohort study of veteran health care users. Participants Veterans between 55 and 64 years that used Veterans Health Administration health care services between October 1999 and September 2000. Measurements: Patients were identified as having one or more of the following: COPD, diabetes, hypertension, rheumatoid arthritis, osteoarthritis, asthma, depression, ischemic heart disease, dementia, stroke, and cancer. Mutually exclusive combinations of disease based on these conditions were created, and 5-year mortality rates were determined. Results: There were 741,847 persons included. The number in each group by a count of conditions was: none = 217,944 (29.34%); 1 = 221,111 (29.8%); 2 = 175,228 (23.6%); 3 = 86,447 (11.7%); and 4+ = 41,117 (5.5%). The 5-year mortality rate by the number of conditions was: none = 4.1%; 1 = 6.0%; 2 = 7.8%; 3 = 11.2%; 4+ = 16.7%. Among combinations with the same number of conditions, there was significant variability in mortality rates. Conclusions: Patients with multiple chronic conditions have higher mortality rates. Because there was significant variation in mortality across clusters with the same number of conditions, when studying patients with multiple coexisting illnesses, it is important to understand not only that several conditions may be present but that specific conditions can differentially impact the risk of mortality
Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial
Introduction Congenital heart disease (CHD) is a major cause of infant mortality. Many infants with CHD require corrective surgery with most operations requiring cardiopulmonary bypass (CPB). CPB triggers a systemic inflammatory response which is associated with low cardiac output syndrome (LCOS), postoperative morbidity and mortality. Delivery of nitric oxide (NO) into CPB circuits can provide myocardial protection and reduce bypass-induced inflammation, leading to less LCOS and improved recovery. We hypothesised that using NO during CPB increases ventilator-free days (VFD) (the number of days patients spend alive and free from invasive mechanical ventilation up until day 28) compared with standard care. Here, we describe the NITRIC trial protocol. Methods and analysis The NITRIC trial is a randomised, double-blind, controlled, parallel-group, two-sided superiority trial to be conducted in six paediatric cardiac surgical centres. One thousand three-hundred and twenty infants <2 years of age undergoing cardiac surgery with CPB will be randomly assigned to NO at 20 ppm administered into the CPB oxygenator for the duration of CPB or standard care (no NO) in a 1:1 ratio with stratification by age (<6 and ≥6 weeks), single ventricle physiology (Y/N) and study centre. The primary outcome will be VFD to day 28. Secondary outcomes include a composite of LCOS, need for extracorporeal membrane oxygenation or death within 28 days of surgery; length of stay in intensive care and in hospital; and, healthcare costs. Analyses will be conducted on an intention-to-treat basis. Preplanned secondary analyses will investigate the impact of NO on host inflammatory profiles postsurgery. Ethics and dissemination The study has ethical approval (HREC/17/QRCH/43, dated 26 April 2017), is registered in the Australian New Zealand Clinical Trials Registry (ACTRN12617000821392) and commenced recruitment in July 2017. The primary manuscript will be submitted for publication in a peer-reviewed journal. Trial registration number ACTRN12617000821392.</p
Rapid Responders to Frovatriptan in Acute Migraine Treatment: Results from a Long-Term, Open-Label Study
Background. the Chronic Nature of Migraine and the Reliance on Acute Treatment Constitute the Basis of the Present Long-Term, Open-Label Study. Objectives. First, Assessment of the Tolerability and Safety of Frovatriptan, 2.5-7.5 Mg Taken Orally over 24 Hours, for the Acute Treatment of Migraine, Repeatedly over a 12-Month Period. Second, Assessment of the Efficacy and Tolerability of a Second, Double-Blind Dose of 2.5-Mg Frovatriptan, Compared with Placebo, for Nonresponse at 2 Hours after Treatment of Moderate or Severe Headache with 2.5-Mg Frovatriptan. Results. with Regard to the First Attack Treated, 173 (36%) of the 486 Subjects in the Study Did Not Take a Second Dose at 2 Hours for Nonresponse. at 2 Hours and 4 Hours, These Rapid Responders Experienced a Decrease in Headache Intensity from Moderate or Severe to Mild or No Pain in 84% and 98%, Respectively ( Headache Response ). Six Percent of Them Experienced Recurrence of Moderate or Severe Headache within 24 Hours Following a Response at 4 Hours and 12% Took Rescue Medication. the Response, Measured in Terms of Median Time to Complete Migraine Relief, Was Maintained over 30 Subsequent Migraine Attacks, Treated from Attack 2 Onwards over the Course of 12 Months. Conclusion. Frovatriptan Provides a Remarkably Fast and High Headache Response in a Subgroup of More Than One-Third of Migraineurs, with a Very Low 24-Hour Headache Recurrence and Low Rescue Medication Intake. © 2009 American Academy of Pain Medicine
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