3,067 research outputs found
A Novel, Fast, Reliable, and Data-Driven Method for Simultaneous Single-Trial Mining and Amplitude—Latency Estimation Based on Proximity Graphs and Network Analysis
Both amplitude and latency of single-trial EEG/MEG recordings provide valuable information regarding functionality of the human brain. In this article, we provided a data-driven graph and network-based framework for mining information from multi-trial event-related brain recordings. In the first part, we provide the general outline of the proposed methodological approach. In the second part, we provide a more detailed illustration, and present the obtained results on every step of the algorithmic procedure. To justify the proposed framework instead of presenting the analytic data mining and graph-based steps, we address the problem of response variability, a prerequisite to reliable estimates for both the amplitude and latency on specific N/P components linked to the nature of the stimuli. The major question addressed in this study is the selection of representative single-trials with the aim of uncovering a less noisey averaged waveform elicited from the stimuli. This graph and network-based algorithmic procedure increases the signal-to-noise (SNR) of the brain response, a key pre-processing step to reveal significant and reliable amplitude and latency at a specific time after the onset of the stimulus and with the right polarity (N or P). We demonstrated the whole approach using electroencephalography (EEG) auditory mismatch negativity (MMN) recordings from 42 young healthy controls. The method is novel, fast and data-driven succeeding first to reveal the true waveform elicited by MMN on different conditions (frequency, intensity, duration, etc.). The proposed graph-oriented algorithmic pipeline increased the SNR of the characteristic waveforms and the reliability of amplitude and latency within the adopted cohort. We also demonstrated how different EEG reference schemes (REST vs. average) can influence amplitude-latency estimation. Simulation results revealed robust amplitude-latency estimations under different SNR and amplitude-latency variations with the proposed algorithm
Metallicity gradients in local field star-forming galaxies: Insights on inflows, outflows, and the coevolution of gas, stars and metals
We present metallicity gradients in 49 local field star-forming galaxies. We
derive gas-phase oxygen abundances using two widely adopted metallicity
calibrations based on the [OIII]/Hbeta, [NII]/Halpha and [NII]/[OII] line
ratios. The two derived metallicity gradients are usually in good agreement
within +/-0.14 dex/R25 (R25 is the B-band iso-photoal radius), but the
metallicity gradients can differ significantly when the ionisation parameters
change systematically with radius. We investigate the metallicity gradients as
a function of stellar mass (8<log(M*/Msun)<11) and absolute B-band luminosity
(-16 > MB > -22). When the metallicity gradients are expressed in dex/kpc, we
show that galaxies with lower mass and luminosity, on average, have steeper
metallicity gradients. When the metallicity gradients are expressed in dex/R25,
we find no correlation between the metallicity gradients, and stellar mass and
luminosity. We provide a local benchmark metallicity gradient of field
star-forming galaxies useful for comparison with studies at high redshifts. We
investigate the origin of the local benchmark gradient using simple chemical
evolution models and observed gas and stellar surface density profiles in
nearby field spiral galaxies. Our models suggest that the local benchmark
gradient is a direct result of the coevolution of gas and stellar disk under
virtually closed-box chemical evolution when the stellar-to-gas mass ratio
becomes high (>>0.3). These models imply low current mass accretion rates
(<0.3xSFR), and low mass outflow rates (<3xSFR) in local field star-forming
galaxies.Comment: 25 pages, 21 figures, accepted to MNRA
The Discovery of a Giant H-alpha Filament in NGC 7213
The nearby Seyfert galaxy NGC 7213 has been imaged in H-alpha and HI with the
CTIO 1.5 m telescope and with the Australia Telescope Compact Array (ATCA),
respectively. Optically NGC 7213 looks undisturbed and relatively featureless
but the continuum-subtracted H-alpha image shows a 19 kpc long filament located
approximately 18.6 kpc from the nucleus. The H-alpha filament could be neutral
gas photo-ionized by the active nucleus, as has been suggested for the Seyfert
galaxy NGC 5252, or shock-ionized by a jet interacting with the surrounding HI,
as has been suggested for the radio galaxy PKS 2240-41. The HI map reveals NGC
7213 to be a highly disturbed system suggesting a past merging event.Comment: 14 pages including 4 figures and 1 table. Figures 1-4 are in jpeg
format; Better quality images can be retrieved in postscript format at
ftp://charon.nmsu.edu/pub/shameed/ ; Accepted for publication in ApJ Letter
Global Properties of Neutral Hydrogen in Compact Groups
Compact groups of galaxies provide a unique environment to study the
evolution of galaxies amid frequent gravitational encounters. These nearby
groups have conditions similar to those in the earlier universe when galaxies
were assembled and give us the opportunity to witness hierarchical formation in
progress. To understand how the compact group environment affects galaxy
evolution, we examine the gas and dust in these groups. We present new
single-dish GBT neutral hydrogen (HI) observations of 30 compact groups and
define a new way to quantify the group HI content as the HI-to-stellar mass
ratio of the group as a whole. We compare the HI content with mid-IR indicators
of star formation and optical [g-r] color to search for correlations between
group gas content and star formation activity of individual group members.
Quiescent galaxies tend to live in HI-poor groups, and galaxies with active
star formation are more commonly found in HI-rich groups. Intriguingly, we also
find "rogue" galaxies whose star formation does not correlate with group HI
content. In particular, we identify three galaxies (NGC 2968 in RSCG 34, KUG
1131+202A in RSCG 42, and NGC 4613 in RSCG 64) whose mid-IR activity is
discrepant with the HI. We speculate that this mismatch between mid-IR activity
and HI content is a consequence of strong interactions in this environment that
can strip HI from galaxies and abruptly affect star-formation. Ultimately,
characterizing how and on what timescales the gas is processed in compact
groups will help us understand the interstellar medium in complex, dense
environments similar to the earlier Universe.Comment: Accepted to A
HST/WFC3 Observations of an Off-Nuclear Superbubble in Arp 220
We present a high spatial resolution optical and infrared study of the
circumnuclear region in Arp 220, a late-stage galaxy merger. Narrowband imaging
using HST/WFC3 has resolved the previously observed peak in H+[NII]
emission into a bubble-shaped feature. This feature measures 1.6" in diameter,
or 600 pc, and is only 1" northwest of the western nucleus. The bubble is
aligned with the western nucleus and the large-scale outflow axis seen in
X-rays. We explore several possibilities for the bubble origin, including a jet
or outflow from a hidden active galactic nucleus (AGN), outflows from high
levels of star formation within the few hundred pc nuclear gas disk, or an
ultraluminous X-ray source. An obscured AGN or high levels of star formation
within the inner 100 pc of the nuclei are favored based on the alignment
of the bubble and energetics arguments.Comment: Accepted for publication in ApJ. 12 pages, 10 figure
Post‐traumatic stress disorder and birthweight: methodological challenges
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89463/1/j.1471-0528.2011.03200.x.pd
Looking like a leader-facial shape predicts perceived height and leadership ability.
Judgments of leadership ability from face images predict the outcomes of actual political elections and are correlated with leadership success in the corporate world. The specific facial cues that people use to judge leadership remain unclear, however. Physical height is also associated with political and organizational success, raising the possibility that facial cues of height contribute to leadership perceptions. Consequently, we assessed whether cues to height exist in the face and, if so, whether they are associated with perception of leadership ability. We found that facial cues to perceived height had a strong relationship with perceived leadership ability. Furthermore, when allowed to manually manipulate faces, participants increased facial cues associated with perceived height in order to maximize leadership perception. A morphometric analysis of face shape revealed that structural facial masculinity was not responsible for the relationship between perceived height and perceived leadership ability. Given the prominence of facial appearance in making social judgments, facial cues to perceived height may have a significant influence on leadership selection
Interactive effects of vascular risk burden and advanced age on cerebral blood flow.
Vascular risk factors and cerebral blood flow (CBF) reduction have been linked to increased risk of cognitive impairment and Alzheimer's disease (AD); however the possible moderating effects of age and vascular risk burden on CBF in late life remain understudied. We examined the relationships among elevated vascular risk burden, age, CBF, and cognition. Seventy-one non-demented older adults completed an arterial spin labeling MR scan, neuropsychological assessment, and medical history interview. Relationships among vascular risk burden, age, and CBF were examined in a priori regions of interest (ROIs) previously implicated in aging and AD. Interaction effects indicated that, among older adults with elevated vascular risk burden (i.e., multiple vascular risk factors), advancing age was significantly associated with reduced cortical CBF whereas there was no such relationship for those with low vascular risk burden (i.e., no or one vascular risk factor). This pattern was observed in cortical ROIs including medial temporal (hippocampus, parahippocampal gyrus, uncus), inferior parietal (supramarginal gyrus, inferior parietal lobule, angular gyrus), and frontal (anterior cingulate, middle frontal gyrus, medial frontal gyrus) cortices. Furthermore, among those with elevated vascular risk, reduced CBF was associated with poorer cognitive performance. Such findings suggest that older adults with elevated vascular risk burden may be particularly vulnerable to cognitive change as a function of CBF reductions. Findings support the use of CBF as a potential biomarker in preclinical AD and suggest that vascular risk burden and regionally-specific CBF changes may contribute to differential age-related cognitive declines
Optimization of the Touchscreen-Based Visuomotor Conditional Learning Task in Mice
The translational gap between animal models and clinical trials is a longstanding, yet largely unresolved, limitation in the study of cognition. This discrepancy is largely due to the differences in how cognition is assessed in animal models compared to those in clinical populations. In the stimulus-response (S-R) learning literature, for example, the techniques used to assess the acquisition of habitual behaviour differ greatly across species, leading to poor cross-species translation and often conflicting results. As a result, we set out to optimize a S-R learning task in mice using the touchscreen-based operant technologies. Similar to human studies, this touchscreen technique encourages animals to respond to visual stimuli displayed on a touchscreen according to a specific rule. Allowing for very similar, if not identical, cognitive assays in mice and men, this technique promotes high translational potential and a high degree of standardisation. Originally developed for rats, the Visuomotor Conditional Learning (VMCL) task encourages animals to learn arbitrary associations between visual stimuli and motor responses. In naïve C57BL/6 mice, we sought to optimize VMCL task parameters to promote better and more efficient responding, identifying the length of inter-trial intervals and the limited hold period as two potential candidates. The validation of this task will provide a novel means through which to study the neural correlates of S-R learning, and its use in conjunction with fiber photometry recordings may be provided
Factors affecting the spatial and temporal distribution of E. coli in intertidal estuarine sediments
Funding: University of St Andrews, The James Hutton Institute. DMP received funding from the Marine Alliance for Science and Technology for Scotland (MASTS), funded by the Scottish Funding Council (grant reference HR09011).Microbiological water quality monitoring of bathing waters does not account for faecal indicator organisms in sediments. Intertidal deposits are a significant reservoir of FIOs and this indicates there is a substantial risk to bathers through direct contact with the sediment, or through the resuspension of bacteria to the water column. Recent modelling efforts include sediment as a secondary source of contamination, however, little is known about the driving factors behind spatial and temporal variation in FIO abundance. E. coli abundance, in conjunction with a wide range of measured variables, was used to construct models to explain E. coli abundance in intertidal sediments in two Scottish estuaries. E. coli concentrations up to 6 log10 CFU 100 g dry wt-1 were observed, with optimal models accounting for E. coli variation up to an adjusted R2 of 0.66. Introducing more complex models resulted in overfitting of models, detrimentally effected the transferability of models between datasets. Salinity was the most important single variable, with season, pH, colloidal carbohydrates, organic content, bulk density and maximum air temperature also featuring in optimal models. Transfer of models, using only lower cost variables, between systems explained an average deviance of 42 %. This study demonstrates the potential for cost-effective sediment characteristic monitoring to contribute to FIO fate and transport modelling and consequently the risk assessment of bathing water safety.PostprintPeer reviewe
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