A GIS BASED SPATIAL DECISION SUPPORT SYSTEM FOR LANDSCAPE CHARACTER ASSESSMENT

Landscape Character Assessment (LCA) provides a structured approach to identifying the character and distinctiveness about the landscape. It is a tool used to identify what makes a location unique, a set of techniques and procedures used to map differences between landscapes based on their physical, cultural and historical characteristics. Although the UK has committed to assessing all of its landscapes by signing the European Landscape Convention in 2006, only 60% of coverage has been achieved. The majority of LCAs are carried out by professional environment or landscape consultancies rather than ‘in-house’. Geographical Information Systems are increasingly being used to collate and analyse data and produce character maps. This research presents a Spatial Decision Support System (LCA-SDSS) based in ArcGIS 9.3 that can be used to support decision makers in conducting a LCA. The LCA-SDSS provides a method for storing data, a model base for the assessment of Landform, Ground Type, Land Cover & Cultural attributes and a method for the user to interact with the resulting maps. Using the Tamar Valley Area of Outstanding Natural Beauty (AONB) as a study area the SDSS was developed and tested, resulting in character maps for each stage of the modelling and a final characterisation map. These maps were compared to a LCA conducted by a professional environmental consultant and were found to have produced a good quality assessment as verified by the end user at the Tamar Valley AONB Partnership.Tamar Valley AONB Partnership and University of Plymouth HEIF

Nationhood and Constitutionalism in the Dutch Republic: An Examination of Grotius' Antiquity of the Batavian Republic

The emphasis in contemporary democratic theory and in the history of political thought on the ‘natural rights’ theory of popular sovereignty of Locke, precursors of which are found in the work of Hugo Grotius and others, obscures an important relationship between constitutional self-government and nationalism. Through an examination of the early political writings of Grotius, especially his Antiquity of the Batavian Republic, this essay shows how a national consciousness forged out of memories of native traditions of self-government, and stories of heroic ancestors who successfully defended those traditions against usurpers and tyrants, gives concrete substance to otherwise inchoate theories of constitutional self-government

Who's afraid of the big bad wolf: a prospective paradigm to test Rachman's indirect pathways in children

Rachman's theory [The conditioning theory of fear insition: a critical examination. Behav. Res. Ther. 15 (1977) 375–387] of fear acquisition suggests that fears and phobias can be acquired through three pathways: direct conditioning, vicarious learning and information/instruction. Although retrospective studies have provided some evidence for these pathways in the development of phobias during childhood [see King, Gullone, & Ollendick, Etiology of childhood phobias: current status of Rachman's three pathway's theory. Behav. Res. Ther. 36 (1998) 297–309 for a review], these studies have relied on long-term past memories of adult phobics or their parents. The current study was aimed towards developing a paradigm in which the plausibility of Rachman's indirect pathways could be investigated prospectively. In Experiment 1, children aged between 7 and 9 were presented with two types of information about novel stimuli (two monsters): video information and verbal information in the form of a story. Fear-related beliefs about the monsters changed significantly as a result of verbal information but not video information. Having established an operational paradigm, Experiment 2 looked at whether the source of verbal information had an effect on changes in fear-beliefs. Using the same paradigm, information about the monsters was provided by either a teacher, an adult stranger or a peer, or no information was given. Again, verbal information significantly changed fear-beliefs, but only when the information came from an adult. The role of information in the acquisition of fear and maintenance of avoidant behaviour is discussed with reference to modern conditioning theories of fear acquisition

The effect of a density difference on shear-layer instability

Measurements of mass flow rate and mean density have been made in separated laminar boundary layers with large transverse density gradients. Two-dimensional shear layers were formed by exhausting a half-jet of one gas into a reservoir of another gas with a different molecular weight. Two freons with a density ratio of 1-98 and unusual properties which permitted the measurement of the mass flow rate with a single hot wire were used. A n analysis of the mass flow rate fluctuations showed that a negative density gradient (i.e. light gas flowing into heavy) increases the amplification rate of the instability oscillations and reduces the frequency and wave number. Opposite trends were observed when the density gradient was positive. These findings are in agreement with recent theoretical predictions

Understanding cisplatin resistance using cellular models

Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts. A series of resistant models were developed from CCRF-CEM leukaemia cells with increasing doses of cisplatin from 100 ng/ml. This produced increasing resistance up to 7-fold with a treatment dose of 1.6 μg/ml. Cisplatin resistance in these cells correlated with increases in the antioxidant glutathione, yet treatment with buthionine sulphoximine, an inhibitor of glutathione synthesis, had no effect on resistance, suggesting that the increase in glutathione was not directly involved in cisplatin resistance. Two models were developed from H69 SCLC cells, H69-CP and H69CIS200 using 100 ng/ml or 200 ng/ml cisplatin respectively. Both cell models were 2-4 fold resistant to cisplatin, and have decreased expression of p21 which may increase the cell’s ability to progress through the cell cycle in the presence of DNA damage. Both the H69-CP and H69CIS200 cells showed no decrease in cellular cisplatin accumulation. However, the H69-CP cells have increased levels of cellular glutathione and are cross resistant to radiation whereas the H69CIS200 cells have neither of these changes. This suggests that increases in glutathione may contribute to cross-resistance to other drugs and radiation, but not directly to cisplatin resistance. There are multiple resistance mechanisms induced by cisplatin treatment, even in the same cell type. How then should cisplatin-resistant cancers be treated? Cisplatin-resistant cell lines are often more sensitive to another chemotherapeutic drug paclitaxel (H69CIS200), or are able to be sensitised to cisplatin with paclitaxel pre-treatment (H69-CP). The understanding of this sensitisation by paclitaxel using cell models of cisplatin resistance will lead to improvements in the clinical treatment of cisplatin resistant tumours