Reactive power considerations in reliability analysis of solar photovoltaic systems

Reliability is one of the key aspects of power system operation and therefore reliability analysis techniques are well developed. However reliability analysis conventionally takes into account active power and limited attention has been given to reactive power. Reactive power is very essential in maintaining voltage stability of power systems. The voltage constraint at network can restricts active power delivery to the loads and could result in forced load curtailment. This research investigates the effect of reactive power shortage on reliability of power systems with significant penetration of PV cells. The reactive power issues become more significant in distributed generation using renewable energy sources such as photovoltaic (PV) Cells, which operate mostly at unity power factor. The IEEE 14-Bus system is utilized to perform this study. Twenty four state PV generation model was developed based on 24-hour solar radiation trend. Reliability indices are calculated analytically and verified through simulation without considering reactive power shortage. Next, a measure of Expected Energy Not Supplied (EENS) on account of reactive power shortage and voltage violation in network is calculated. Monte Carlo simulation was performed in MATLAB environment, where simulation results are compared with the case without taking into account reactive power and voltage violation. This research suggests that placement of the PV in the network can greatly reduce active and reactive power shortage during the contingencies. The reactive power is studied here from design and planning perspectives for reliable and stable power system operation when high penetrations of PV energy sources are present

Security Challenges and Policies in Cloud Computing for Services

Cloud computing is becoming most emerging trend in IT industry. With its potential growth and lucrative services cloud computing has acquired mass market in the industry large enterprises running their business on the cloud. A greater acceptance of public cloud by various businesses has given it a wide popularity, strengthening of public cloud security is big milestone. The article talks about cloud computing and its service models and deployment models. Different threats have been discovered in recent years. Database security in public cloud raised some critical issues for cloud service provider.Further, various security issues and policies related to cloud computing also discussed. Findings emphasis that rapid adaptation to the clouds have increased concerns on a critical issue for successive growth of communication technology and information security. From a cloud security perspective, a number of unexplored risks and challenges are faced by cloud because of migration, causing degradation of the effectiveness of traditional protection mechanisms

Feel good in the medical pharmacology

Background: A curriculum is a vision and road map to meet academic objectivities. The major objectives of teaching pharmacology to the medical students is best way of understanding, retaining pharmacological information and to provide a rational basis for choosing drugs skilfully to relieve patient’s ailments. For better understanding of subjects and its correlation the sequential and interdependent schedule achieved through rearrangements of topics. So that earlier chapters of this pattern are arranged in such manner as general consideration of pharmacological principles and physiological topics of treatment part slowly in 3rd term. By the time student of IInd M.B.B.S are familiar with disease conditions from other paraclinical and clinical departments to achieve the goal for understanding of remaining topics. There should be continuous ongoing reforms for discovering, interpreting, revising and delivering the current knowledge of the subject relevant to the needs of society as a part of research.Methods: A structured 16 point questionnaire containing both open and close ended questions regarding reforms and innovation in pharmacology is prepared for opinion poll. The total 289 participant are from III, IV, V, VI, VII and VIII term’s M.B.B.S. students. The participants are also allowed to offer their own suggestions for certain important item regarding modification in teaching curricula of the subjects.Results: Large majority of the students of opinion poll are in favour of reforms and innovations. They also suggested their own suggestions regarding the refreshing of the subjects.Conclusions: The teaching program of pharmacology at regular interval should be researched to discover, interpret, revise and deliver the updates in basic pharmacological knowledge of drugs and its application

Safety and Efficacy of Nimesulide/Paracetamol Fixed-dose Combination in Acute Pain (SAFE Study)

Background: Nimesulide shows preferential inhibition for the cyclooxygenase-2 (COX-2) enzyme, which blocks the formation of prostaglandins critical in pain and inflammatory pathways. Few studies in the past have reported rare and unpredictable hepatic effects with nimesulide. The present study aimed to evaluate the efficacy and safety of nimesulide/paracetamol (100 mg + 325 mg) fixed-dose combination twice a day for 2 weeks in the management of acute pain in Indian population. Materials and methods: This was a multicenter study, performed on 500 patients, by 24 experienced physicians across India. The primary outcome assessed clinical safety at 2 weeks for mild/serious adverse effects (AEs), change in liver function tests (LFTs), serum bilirubin and alkaline phosphatase levels. The secondary outcomes assessed the clinical effectiveness in reduction of pain at rest and at movement. Results: Analysis of LFT at 2 weeks showed a slight increase (mean change) in the aspartate transaminase {-0.73 [95% confidence interval (CI) -1.54, 0.09; p = 0.081]}, alanine transaminase [-1.73 (95% CI -2.82, -0.64; p = 0.002)], serum bilirubin [-0.02 (95% CI -0.04, -0.001; p = 0.018)] and alkaline phosphatase levels [-1.92 (95% CI -5.84, 2; p = 0.336), not exceeding the normal range. Only one in 500 patients reported AEs. The numerical rating scale (NRS) scores for intensity of pain at rest and at movement at 2 weeks, ≤7 days and >7 days were 68.38%, 68.44% and 68.39%; and 65.43%, 64.60% and 66.02%, respectively. An improvement of 96.6% was observed in patient global assessment scale (GAS) and 97.2% in physician GAS. Conclusion: Nimesulide/paracetamol combination was safe, effective and well-tolerated in acute pain conditions and did not lead to clinically significant changes in liver parameters indicating hepatic safety

IN SILICO DESIGN OF POTENTIAL 1, 5-BENZOTHIAZEPINE DERIVATIVES AS AN ANTI - CONVULSANT AGENT BY MOLECULAR DOCKING STUDIES

Epilepsy is characterized by the presence of recurrent seizures. A seizure can be defined as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex”. One in every three patients with epilepsy is probable to be severely disabled. It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. Recently the discovery of benzothiazepine derivatives as an anticonvulsant agent is a significant area for research in medicinal chemistry as it is free from all side effects which is shown by a developed as an anticonvulsant agent. In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. Docking analysis was utilized to predict the mechanism of action of the designed derivatives for anticonvulsant potential. All the molecules exhibited a binding score in the range of -82.61 to - 118.25 kcal/mol. Most active molecules from Series 1, 2 and 3 exhibited hydrogen bond interactions with LEU282B, LEU282B and LEU282B. Also for the selected standard sodium phenytoin showed the hydrogen bond interaction with LYS637A. It was noted that the docking score of 1a to 10a, 101b to 110b and 201c to 210c was almost the same as that of selected standard sodium phenytoin. The protein showed hydrogen bonding with all synthesized compound showed potential against epilepsy with GABA nergic mechanism.  Keywords: Anti-convulsant; 1,5-benzothiazepine; V-Life MDS 4.3

Development and in vitro evaluation of sustained release multiparticulate tablet of freely water soluble drug

Misturas das dispersões aquosas de polímero hidrofóbico e de polímero hidrofílico, a saber, Surelease®: hidroxipropil metilcelulose (Surelease®: HPMC E15), foram utilizadas como material de revestimento para controlar a liberação de fármacos de péletes revestidos de fármaco altamente solúvel, o succinato de metoprolol. Variando as misturas de polímeros, obtiveram-se faixas de padrão de liberação do fármaco em pH 6,8. O presente estudo tratou da difusão do fármaco através de filmes de Surelease®/hidroxipropil metilcelulose(HPMC E15), preparados pelo revestimento do fármaco e dos polímeros em sementes nonpareil, utilizando técnica de solução em camada. A liberação de succinato de metoprolol dos péletes revestidos diminuiu com o aumento da carga de polímero de revestimento. A formulação otimizada foi obtida por planejamento fatorial 3². O perfil de liberação revelou que a formulação otimizada segue a cinética de liberação de ordem zero. Os dados de estabilidade mostraram não haver interação por armazenamento a 25 ºC e umidade relativa de 60%.Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease®: hydroxypropyl methylcellulose (Surelease®: HPMC E15) were used as coating materials to control the drug release from coated pellets of the highly water soluble drug metoprolol succinate. Varying the polymer blends, ranges of drug release patterns were obtained at pH 6.8. The present study dealt with diffusion of drug through plasticized Surelease®/ hydroxypropyl methylcellulose (HPMC E15) films prepared by coating of drug and polymers onto non-pareil seeds using the solution layering technique. The release of metoprolol succinate from coated pellets was decreased with increased coating load of polymer. The optimized formulation was obtained by 3² full factorial design. The release profile revealed that the optimized formulation follows zero order release kinetics. The stability data showed no interaction for storage at 25ºC and 60% relative humidity

Growth Characteristics of Commonly Occurring Fresh Water Chlorophycean Algae for Biodiesel Production.

Liquid biofuels, renewable fuels derived from biomass, are arguably one of the best transition fuels for the near-term and have made a recent resurgence in response to rising oil prices. Biodiesel can be produced from a variety of lipid feedstock, catalysts and alcohols using several possible conversion processes. Microalgae reproduce themselves using photosynthesis to convert sun energy into chemical energy, completing an entire growth cycle every few days. Fresh water chlorophycean algae have great source of lipid content and proving raw material for biodiesel.  This paper focuses the growth behavior of fresh water Chlorophycean algae during mass culture for biodiesel production.&nbsp

An Institutional Collaboration and Application of Lotka’s Law to the Research Output of Rashtrasant Tukadoji Maharaj Nagpur University

The article presents a scientometric picture of Rashtrasant Tukadoji Maharaj Nagpur University. The analysis was carried out on the data extracted in the form of 1908 records extracted from Web of Science during 2001-2019. However for testing of Lotka’s law all the records i.e. 4212 available 1989 were used. An annual growth is highlighted in the study period. The article draws attention to annual growth of publication output, co-authorship network, distribution of publication output on the basis of various subject categories, leading collaborative institutes and countries. Further, the co-authorship network and co-occurrence of keyword analysis have been depicted through VOS-viewer