77 research outputs found
Correlations between chemical macro composition and redox potential for mineral waters from Truskavets deposit = ΠΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Ρ ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ°ΠΊΡΠΎΡΠΎΡΡΠ°Π²ΠΎΠΌ ΠΈ ΡΠ΅Π΄ΠΎΠΊΡΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΡ Π²ΠΎΠ΄ Π’ΡΡΡΠΊΠ°Π²Π΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ
Berezovskyy V. Ya., Datsko O. R., Zukow W. Correlations between chemical macro composition and redox potential for mineral waters from Truskavets deposit = ΠΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ°ΠΊΡΠΎΡΠΎΡΡΠ°Π²ΠΎΠΌ ΠΈ ΡΠ΅Π΄ΠΎΠΊΡΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΡ
Π²ΠΎΠ΄ Π’ΡΡΡΠΊΠ°Π²Π΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ. Journal of Education, Health and Sport. 2015;5(1):139-150. ISSN 2391-8306. DOI: 10.5281/zenodo.14551http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%281%29%3A139-150https://pbn.nauka.gov.pl/works/530956http://dx.doi.org/10.5281/zenodo.14551Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 β 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archiveΒ Deklaracja.Specyfika i zawartoΕΔ merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacjΔ
MNiSW z dnia 2 czerwca 2014 r., ΕΌe w roku 2014 nie bΔdzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktΓ³w co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).Β© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 20.10.2014. Revised 18.01.2015. Accepted: 25.01.2015.Β Β CORRELATIONS BETWEEN CHEMICAL MACRO COMPOSITION AND REDOX POTENTIAL FOR MINERAL WATERS FROM TRUSKAVETS DEPOSITΒ ΠΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ°ΠΊΡΠΎΡΠΎΡΡΠ°Π²ΠΎΠΌ ΠΈ ΡΠ΅Π΄ΠΎΠΊΡΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΡ
Π²ΠΎΠ΄ Π’ΡΡΡΠΊΠ°Π²Π΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡΒ V. Ya. Berezovskyy1, O. R. Datsko1, W. Zukow2Π. Π―. ΠΠ΅ΡΠ΅Π·ΠΎΠ²ΡΠΊΠΈΠΉ1, Π. Π . ΠΠ°ΡΡΠΊΠΎ1, Π. ΠΡΠΊΠΎΠ²2Β 1O.O. Bogomolets Institute Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine1ΠΠ½ΡΡΠΈΡΡΡ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈΠΌ.Π.Π. ΠΠΎΠ³ΠΎΠΌΠΎΠ»ΡΡΠ° ΠΠΠ Π£ΠΊΡΠ°ΠΈΠ½Ρ, ΠΠΈΠ΅Π², Π£ΠΊΡΠ°ΠΈΠ½Π°2Kazimierz Wielki University, Bydgoszcz, Poland2Uniwersytet Kazimierza Wielkiego, Bydgoszcz, PolskaΒ Keywords: oxidation-reduction potential (ORP), potentiometry, chemical macro composition, mineral waters.Β ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» (ΠΠΠ), ΠΏΠΎΡΠ΅Π½ΡΠΈΠΎΠΌΠ΅ΡΡΠΈΡ, Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠ°ΠΊΡΠΎΡΠΎΡΡΠ°Π², ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΠ΅ Π²ΠΎΠ΄Ρ.Β AbstractCorrelations were researched between chemical macro composition and oxidation-reduction potential (ORP) measured by potentiometry for mineral waters from Truskavets deposit.It has been shown that mainly ORP values are correlated satisfactorily with hydrogen sulfide content and dissolved oxygen.Β Π Π΅Π·ΡΠΌΠ΅Β Β Β Β Β Β Β Β Β Β Β ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ°ΠΊΡΠΎΡΠΎΡΡΠ°Π²ΠΎΠΌ ΠΈ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ (ΠΠΠ), ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½Π½ΡΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈ Π΄Π»Ρ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΡ
Π²ΠΎΠ΄ Π’ΡΡΡΠΊΠ°Π²Π΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ.ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΠΠΠ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΡΡ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ ΡΠ΅ΡΠΎΠ²ΠΎΠ΄ΠΎΡΠΎΠ΄Π° ΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°
THE INFLUENCE OF ANTIRETROVIRAL AND ANTITUBERCULOSIS AGENTS ON THE BIOCHEMICAL AND HISTOPATHOLOGICAL INDICES OF LIVER FUNCTION IN RATS
Background. Standard antituberculosis treatment and highly active antiretroviral therapy are frequently associated with hepatotoxicity leading to drugs discontinuation.Objective. This study aimed to assess the signs of hepatotoxicity in albino rats in case of simultaneous usage of tuberculostatics (TBS) and antiretroviral agents (ART).Methods. Healthy rats were divided in 4 groups: 1st control group; 2nd group was given tuberculostatics (isoniazid β 50 mg/kg, rifampicin β 50 mg/kg and pyrazinamide β 1500 mg/kg); 3rd group was given ART (efavirenz β 150 mg/kg and stavudine β 5 mg/kg); 4th group was given TBS and ART. The animals were sacrificed painlessly on the 29th day; blood and liver samples were obtained. The main biochemical and histopathological indices were determined.Conclusions. Comparing with control group, repeated usage of TBS caused the prominent liver injury with cytolysis and cholestasis signs, decreasing of CYP3A and CYP2E1 isozymes activity and dysfunction of protein synthesis by the liver. ART (efavirenz and stavudine) caused the elevation of transaminases activity with the increase of serum bilirubin level at the background of increase in cytochrome 450 isoforms 3A and 2E1 activities and total serum protein. The antiretroviral agents in case of simultaneous administration with the antituberculosis drugs diminished the hepatotoxic effects of first-line drugs for tuberculosis treatment which was confirmed by the study of liver histopathology. Such results of our experimental study give encouragement for further detailed clinical research of drug-drug interaction of both pharmacological groups due to the rising cases of HIV-associated tuberculosis in the whole world.KEY WORDS: Isoniazid, rifampicin, pyrazinamide, efavirenz, stavudine, liver, cytochrome P450
ΠΠΠ Π€ΠΠ€Π£ΠΠΠ¦ΠΠΠΠΠΠ¬ΠΠ ΠΠΠΠΠ Π ΠΠΠΠΠΠ―Π₯ Π’Π ΠΠΠ§ΠΠΠ¦Π Π£ Π ΠΠΠΠΠ ΠΠΠ ΠΠΠ ΠΠΠ‘ΠΠ― Π’Π ΠΠΠΠΠ’ΠΠ§ΠΠΠΠ Π£Π ΠΠΠΠΠΠ― ΠβΠ―ΠΠΠ Π ΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’Π
An urgent issue today is traumatism, which remains an urgent problem in modern medicine, as there are high levels of disability and mortality among trauma victims.
The aim β to study peculiarities of morphological changes in lungs and liver in traumatic muscle injury in experimental study.
Material and Methods. The dynamics of morphological changes were investigated in an experimental model of traumatic muscle injury in 60 adult nonlinear rats, which were divided into two groups: intact and experimental. Morphological changes in lung and liver tissues were investigated in the early post-traumatic period for the first and seventh days.
Results and Discussion. Histological examination of liver and lung tissues on the first day of the post-traumatic period revealed structural changes that were manifested by marked circulatory disorders and with subsequent development of dystrophic-necrotic changes, which reached a maximum by the seventh day of the experiment.
Conclusions. In traumatic muscle lesions in experimental animals, structural changes in the liver and lungs begin to develop from the first day of the experiment throughout the study period and are manifested by marked circulatory disorders and the development of dystrophic-necrotic changes, especially in epithelial maxima, reaching maximal structures.ΠΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½Ρ Π²ΠΎΠΏΡΠΎΡΠΎΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΠ·ΠΌ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΡΡΠ°Π΅ΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΡΠ΅Π΄ΠΈ ΠΏΠΎΡΡΡΠ°Π΄Π°Π²ΡΠΈΡ
Ρ ΡΡΠ°Π²ΠΌΠ°ΠΌΠΈ ΠΎΡΠΌΠ΅ΡΠ°ΡΡΡΡ Π²ΡΡΠΎΠΊΠΈΠ΅ ΡΡΠΎΠ²Π½ΠΈ ΠΈΠ½Π²Π°Π»ΠΈΠ΄Π½ΠΎΡΡΠΈ ΠΈ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ.
Π¦Π΅Π»Ρ β ΠΈΠ·ΡΡΠΈΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² Π»Π΅Π³ΠΊΠΈΡ
ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΏΡΠΈ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΈ ΠΌΡΡΡ Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΈΠ½Π°ΠΌΠΈΠΊΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ Π½Π° ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΌΡΡΡ Ρ 60 Π²Π·ΡΠΎΡΠ»ΡΡ
Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΡΡ
ΠΊΡΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ Π±ΡΠ»ΠΈ ΠΏΠΎΠ΄Π΅Π»Π΅Π½Ρ Π½Π° Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ: ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΡ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΡΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΡΠΊΠ°Π½ΡΡ
Π»Π΅Π³ΠΊΠΈΡ
ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΈ Π² ΡΠ°Π½Π½ΠΈΠΉ ΠΏΠΎΡΡΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ Π½Π° ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΈ ΡΠ΅Π΄ΡΠΌΡΠ΅ ΡΡΡΠΊΠΈ.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΊΠ°Π½Π΅ΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ Π»Π΅Π³ΠΊΠΈΡ
Π² ΠΏΠ΅ΡΠ²ΡΠ΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΡΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° Π²ΡΡΠ²Π»Π΅Π½Ρ ΡΡΡΡΠΊΡΡΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΎΡΠ²Π»ΡΠ»ΠΈΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌΠΈ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π΄ΠΈΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈ-Π½Π΅ΠΊΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ Π΄ΠΎΡΡΠΈΠ³Π°Π»ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΡΠΌΠ° Π½Π° ΡΠ΅Π΄ΡΠΌΡΠ΅ ΡΡΡΠΊΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°.
ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΈ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΈ ΠΌΡΡΡ Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΡΡΡΡΠΊΡΡΡΠ½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΈ Π»Π΅Π³ΠΊΠΈΡ
Π½Π°ΡΠΈΠ½Π°ΡΡ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΡΡ ΡΠΆΠ΅ Ρ ΠΏΠ΅ΡΠ²ΡΡ
ΡΡΡΠΎΠΊ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ Π²ΡΠ΅Π³ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈ ΠΏΡΠΎΡΠ²Π»ΡΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌΠΈ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π΄ΠΈΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈ-Π½Π΅ΠΊΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π² ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΡΡΡΡΠΊΡΡΡΠ°Ρ
, Π΄ΠΎΡΡΠΈΠ³Π°Ρ ΠΌΠ°ΠΊΡΠΈΠΌΡΠΌΠ° Π½Π° ΡΠ΅Π΄ΡΠΌΡΠ΅ ΡΡΡΠΊΠΈ.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΈΠΌ ΠΏΠΈΡΠ°Π½Π½ΡΠΌ ΡΡΠΎΠ³ΠΎΠ΄Π΅Π½Π½Ρ Ρ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΠ·ΠΌ, ΡΠΊΠΈΠΉ Π·Π°Π»ΠΈΡΠ°ΡΡΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΡ ΡΡΡΠ°ΡΠ½ΠΎΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΠΈ, ΠΎΡΠΊΡΠ»ΡΠΊΠΈ ΡΠ΅ΡΠ΅Π΄ ΠΏΠΎΡΡΡΠ°ΠΆΠ΄Π°Π»ΠΈΡ
ΡΠ· ΡΡΠ°Π²ΠΌΠ°ΠΌΠΈ Π²ΡΠ΄Π·Π½Π°ΡΠ°ΡΡΡΡΡ Π²ΠΈΡΠΎΠΊΡ ΡΡΠ²Π½Ρ ΡΠ½Π²Π°Π»ΡΠ΄Π½ΠΎΡΡΡ ΡΠ° ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΡ.
ΠΠ΅ΡΠ° β Π²ΠΈΠ²ΡΠΈΡΠΈ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
Π·ΠΌΡΠ½ Ρ Π»Π΅Π³Π΅Π½ΡΡ
ΡΠ° ΠΏΠ΅ΡΡΠ½ΡΡ ΠΏΡΠΈ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ½ΠΎΠΌΡ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΠΌβΡΠ·ΡΠ² Π² Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ.
ΠΠ°ΡΠ΅ΡΡΠ°Π» Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠΈΠ½Π°ΠΌΡΠΊΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
Π·ΠΌΡΠ½ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π»ΠΈ Π½Π° Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΉ ΠΌΠΎΠ΄Π΅Π»Ρ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΡΠΊΠΎΠ΄ΠΆΠ΅Π½Π½Ρ ΠΌβΡΠ·ΡΠ² Ρ 60 Π΄ΠΎΡΠΎΡΠ»ΠΈΡ
Π½Π΅Π»ΡΠ½ΡΠΉΠ½ΠΈΡ
ΡΡΡΡΠ², ΡΠΊΡ Π±ΡΠ»ΠΈ ΠΏΠΎΠ΄ΡΠ»Π΅Π½Ρ Π½Π° Π΄Π²Ρ Π³ΡΡΠΏΠΈ: ΡΠ½ΡΠ°ΠΊΡΠ½Ρ ΡΠ° Π΄ΠΎΡΠ»ΡΠ΄Π½Ρ. ΠΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π»ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ Π·ΠΌΡΠ½ΠΈ Π² ΡΠΊΠ°Π½ΠΈΠ½Π°Ρ
Π»Π΅Π³Π΅Π½Ρ ΡΠ° ΠΏΠ΅ΡΡΠ½ΠΊΠΈ Π² ΡΠ°Π½Π½ΡΠΉ ΠΏΠΎΡΡΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ½ΠΈΠΉ ΠΏΠ΅ΡΡΠΎΠ΄ Π½Π° ΠΏΠ΅ΡΡΡ ΡΠ° ΡΡΠΎΠΌΡ Π΄ΠΎΠ±ΠΈ.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ. ΠΡΠΈ Π³ΡΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠΌΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΡΠΊΠ°Π½ΠΈΠ½ ΠΏΠ΅ΡΡΠ½ΠΊΠΈ ΡΠ° Π»Π΅Π³Π΅Π½Ρ Π½Π° ΠΏΠ΅ΡΡΡ Π΄ΠΎΠ±Ρ ΠΏΠΎΡΡΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΡΠΎΠ΄Ρ Π²ΠΈΡΠ²Π»Π΅Π½ΠΎ ΡΡΡΡΠΊΡΡΡΠ½Ρ Π·ΠΌΡΠ½ΠΈ, ΡΠΊΡ ΠΏΡΠΎΡΠ²Π»ΡΠ»ΠΈΡΡ Π²ΠΈΡΠ°ΠΆΠ΅Π½ΠΈΠΌΠΈ ΡΠΎΠ·Π»Π°Π΄Π°ΠΌΠΈ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ³Ρ Π· Π½Π°ΡΡΡΠΏΠ½ΠΈΠΌ ΡΠΎΠ·Π²ΠΈΡΠΊΠΎΠΌ Π΄ΠΈΡΡΡΠΎΡΡΡΠ½ΠΎ-Π½Π΅ΠΊΡΠΎΡΠΈΡΠ½ΠΈΡ
Π·ΠΌΡΠ½, ΡΠΊΡ Π΄ΠΎΡΡΠ³Π°Π»ΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΡΠΌΡ Π½Π° ΡΡΠΎΠΌΡ Π΄ΠΎΠ±Ρ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ.
ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΡΠΈ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ½ΠΎΠΌΡ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΠΌβΡΠ·ΡΠ² Ρ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
ΡΠ²Π°ΡΠΈΠ½ ΡΡΡΡΠΊΡΡΡΠ½Ρ Π·ΠΌΡΠ½ΠΈ Π² ΠΏΠ΅ΡΡΠ½ΡΡ ΡΠ° Π»Π΅Π³Π΅Π½ΡΡ
ΠΏΠΎΡΠΈΠ½Π°ΡΡΡ ΡΠΎΠ·Π²ΠΈΠ²Π°ΡΠΈΡΡ ΡΠΆΠ΅ Π· ΠΏΠ΅ΡΡΠΎΡ Π΄ΠΎΠ±ΠΈ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ, ΡΡΠΈΠ²Π°ΡΡΡ ΡΠΏΡΠΎΠ΄ΠΎΠ²ΠΆ ΡΡΡΠΎΠ³ΠΎ ΠΏΠ΅ΡΡΠΎΠ΄Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Ρ ΠΏΡΠΎΡΠ²Π»ΡΡΡΡΡΡ Π²ΠΈΡΠ°ΠΆΠ΅Π½ΠΈΠΌΠΈ ΡΠΎΠ·Π»Π°Π΄Π°ΠΌΠΈ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ³Ρ ΡΠ° ΡΠΎΠ·Π²ΠΈΡΠΊΠΎΠΌ Π΄ΠΈΡΡΡΠΎΡΡΡΠ½ΠΎ-Π½Π΅ΠΊΡΠΎΡΠΈΡΠ½ΠΈΡ
Π·ΠΌΡΠ½, ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎ Π² Π΅ΠΏΡΡΠ΅Π»ΡΠ°Π»ΡΠ½ΠΈΡ
ΡΡΡΡΠΊΡΡΡΠ°Ρ
, Π΄ΠΎΡΡΠ³Π°ΡΡΠΈ ΠΌΠ°ΠΊΡΠΈΠΌΡΠΌΡ Π½Π° ΡΡΠΎΠΌΡ Π΄ΠΎΠ±Ρ
Experimental study of direct photon emission in K- --> pi- pi0 gamma decay using ISTRA+ detector
The branching ratio in the charged-pion kinetic energy region of 55 to 90 MeV
for the direct photon emission in the K- --> pi- pi0 gamma decay has been
measured using in-flight decays detected with the ISTRA+ setup operating in the
25 GeV/c negative secondary beam of the U-70 PS. The value
Br(DE)=[0.37+-0.39(stat)+-0.10(syst)]*10^(-5) obtained from the analysis of 930
completely reconstructed events is consistent with the average value of two
stopped-kaon experiments, but it differs by 2.5 standard deviations from the
average value of three in-flight-kaon experiments. The result is also compared
with recent theoretical predictions.Comment: 13 pages, 8 figure
Observation of the radiative kaon decay K- --> mu-pi0gammanu
Using data collected with the ISTRA+ spectrometer during the 2001 run of the
U-70 proton synchrotron in Protvino, we report the first observation of the
radiative kaon decay K- -->mu-pi0gammanu. We find Br(Kmu3g)/Br(Kmu3) for two
regions 5<Eg<30 and 30<Eg<60 MeV consistent with theoretical predictions. The
measured angular distribution asymmetry for the first region,
0.093+/-0.141, is two standard deviations away from the theoretical
prediction of 0.354. The measured asymmetry in the T-odd variable is
-0.03+/-0.13.Comment: 15 pages, 8 figurs, submitted to Yadernaya Fizik
Dynamic of indices of lipid peroxidation and antioxidant protection in muscular tissue and blood serum of rats with acute ischemia-reperfusion
Acute limb ischemia occurs as a result of sudden decrease in its perfusion, which usually occurs during the obturation of the lumen of large arteries due to acute thrombosis or embolism either impaired of vascular patency caused by trauma or compression (including the application of hemostatic tourniquets). In the case of restoration of blood supply to previously ischemic tissues, there is an ischemic-reperfusion syndrome, in which one of the main pathogenetic links of tissue alteration is the activation of lipid peroxidation.
The content of diene conjugates, triene conjugates, TBA-active products, superoxide dismutase and catalase in homogenate of the muscle tissue and blood serum of 30 white rats under condition of experimental acute ischemia was determined. Acute ischemia was caused by the application of SWAT (Stretch-Wrap-And-Tuck) rubber bundles on the hind limbs of the animals for 2 hours.
It was experimentally found that the maximum increase in the content of diene and triene conjugates in the injured muscle tissue of the animals occurred in the early post-ischemic period on the 2nd hour of reperfusion with a decreaseing on the 1st and 7th day and the subsequent return of indicators in the late postischemic period on the 14th day to the level of control group. The increasing of TBA-active products in the muscle tissue occurred in the first three groups of the rats and peaked in the third group (reperfusion for the 1st day), after which their level decreased in the animals during the late reperfusion period, reaching in the last group on the 14th day of reperfusion indices, close to the values of the control group.
The dynamics of activity of superoxide dismutase and catalase in the muscle homogenate were to a large extent similar (as indicated by the strong positive correlation (+0,99) between them), gradually increasing and reaching the maximum on 7th day of the ischemia-reperfusion symdrome. As a result of the experiment, a decreasing in the antioxidant-prooxidant index in all experimental groups of the rats was also observed in the muscle homogenate, which was the most pronounced on the 1st day of ischemia-reperfusion.
The comparative analysis of the similar parameters of lipid peroxidation and antioxidant protection in the muscle homogenate and blood serum showed a direct correlation in all the studied pairs. The strong and moderate positive correlation between analogous indices of LPO and AOP in muscle homogenate and blood serum in all five studied pairs indicates similar changes of these indicators at the local and systemic levels
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