Reprint of “Chordoma in children: Case-report and review of literature”

We report an exceptional case of a very late local failure in a 9-year-old boy presenting with a chordoma of the cranio-cervical junction. The child was initially treated with a combination of surgical resection followed by high dose photon–proton radiation therapy. This aggressive therapy allowed a 9-year remission with minimal side-effects. Unfortunately, he subsequently presented with a local failure managed with a second full-dose course of protons. The child died one year later from local bleeding of unclear etiology

Chordoma in children: Case-report and review of literature

We report an exceptional case of a very late local failure in a 9-year-old boy presenting with a chordoma of the cranio-cervical junction. The child was initially treated with a combination of surgical resection followed by high dose photon–proton radiation therapy. This aggressive therapy allowed a 9-year remission with minimal side-effects. Unfortunately, he subsequently presented with a local failure managed with a second full-dose course of protons. The child died one year later from local bleeding of unclear etiology

Ten-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy.

PURPOSE: To evaluate the efficacy of irradiation of internal mammary nodes (IMN) on 10-year overall survival in breast cancer patients after mastectomy. METHODS AND PATIENTS: This multicenter phase 3 study enrolled patients with positive axillary nodes (pN+) or central/medial tumors with or without pN+. Other inclusion criteria were age <75 and a Karnofsky index ≥70. All patients received postoperative irradiation of the chest wall and supraclavicular nodes and were randomly assigned to receive IMN irradiation or not. Randomization was stratified by tumor location (medial/central or lateral), axillary lymph node status, and adjuvant therapy (chemotherapy vs no chemotherapy). The prescribed dose of irradiation to the target volumes was 50 Gy or equivalent. The first 5 intercostal spaces were included in the IMN target volume, and two-thirds of the dose (31.5 Gy) was given by electrons. The primary outcome was overall survival at 10 years. Disease-free survival and toxicity were secondary outcomes. RESULTS: T total of 1334 patients were analyzed after a median follow-up of 11.3 years among the survivors. No benefit of IMN irradiation on the overall survival could be demonstrated: the 10-year overall survival was 59.3% in the IMN-nonirradiated group versus 62.6% in the IMN-irradiated group (P=.8). According to stratification factors, we defined 6 subgroups (medial/central or lateral tumor, pN0 [only for medial/central] or pN+, and chemotherapy or not). In all these subgroups, IMN irradiation did not significantly improve overall survival. CONCLUSIONS: In patients treated with 2-dimensional techniques, we failed to demonstrate a survival benefit for IMN irradiation. This study cannot rule out a moderate benefit, especially with more modern, conformal techniques applied to a higher risk population

Projet scientifique et pratiques éditoriales de la Revue d’anthropologie des connaissances

International audienceThis article retraces the scientific and editorial project behind the Revue d’Anthropologie des Connaissances (RAC), launched in 2007, and in particular the convergence of multiple disciplines that promoted the founding of the journal. It then presents the editorial policy, practices and choices having fashioned it and whose procedures are no less important than its content and epistemic focus. These procedures concern reviewing work but also choice of media (online electronic access), article format, publication language, dissemination (open access to readers) and business model

Toward a Research Agenda on Digital Media and Humanity Well-Being

In the 2020s, an American citizen will spend an average of 6h35 a day on social media, compared to 3h35 for television. As for social networks, which were non-existent less than 20 years ago, about 40\% of US citizens use them at least once a week as source of news and they now have an estimated 60-70% penetration rate worldwide.This means that in less than a generation, digital media have radically transformed the way we inform and socialize, and that this transformation is still ongoing as older generations are gradually replaced by digital natives. From a scientific point of view, this transformation generates many phenomena to be studied, and even "unknown unknowns" whose effects will be revealed only with time.This roadmap covers the issues, impacts and future challenges of digital media as they relate to human well-being in the broadest sense, from mental health to the health of democracies.Its objective is to initiate a new interdisciplinary research community in this field, to define a research agenda, to formulate recommendations for future digital media policy and design, and to inspire future EU calls for projects to develop innovative and transdisciplinary research on these societal challenges.The roadmap is the result of the EU-funded project DIGEING conducted by an international consortium with the help of an interdisciplinary advisory group of international experts. Its writing was based on an hybrid methodology developped at CNRS and powered by GarganText, where the advisory group acted both as catalyst and guide for a larger collaborative mapping of the state-of-the-art and identification of challenges of that emerging field. More than forty researchers from fourteen European countries have contributed to the writing of this roadmap.This roadmap is complemented by online interactive maps that can be used by researchers to situate themselves in this evolving scientific landscape and by research funding agencies to launch new calls for projects

Toward a Research Agenda on Digital Media and Humanity Well-Being

In the 2020s, an American citizen will spend an average of 6h35 a day on social media, compared to 3h35 for television. As for social networks, which were non-existent less than 20 years ago, about 40\% of US citizens use them at least once a week as source of news and they now have an estimated 60-70% penetration rate worldwide.This means that in less than a generation, digital media have radically transformed the way we inform and socialize, and that this transformation is still ongoing as older generations are gradually replaced by digital natives. From a scientific point of view, this transformation generates many phenomena to be studied, and even "unknown unknowns" whose effects will be revealed only with time.This roadmap covers the issues, impacts and future challenges of digital media as they relate to human well-being in the broadest sense, from mental health to the health of democracies.Its objective is to initiate a new interdisciplinary research community in this field, to define a research agenda, to formulate recommendations for future digital media policy and design, and to inspire future EU calls for projects to develop innovative and transdisciplinary research on these societal challenges.The roadmap is the result of the EU-funded project DIGEING conducted by an international consortium with the help of an interdisciplinary advisory group of international experts. Its writing was based on an hybrid methodology developped at CNRS and powered by GarganText, where the advisory group acted both as catalyst and guide for a larger collaborative mapping of the state-of-the-art and identification of challenges of that emerging field. More than forty researchers from fourteen European countries have contributed to the writing of this roadmap.This roadmap is complemented by online interactive maps that can be used by researchers to situate themselves in this evolving scientific landscape and by research funding agencies to launch new calls for projects

Toward a Research Agenda on Digital Media and Humanity Well-Being

In the 2020s, an American citizen will spend an average of 6h35 a day on social media, compared to 3h35 for television. As for social networks, which were non-existent less than 20 years ago, about 40\% of US citizens use them at least once a week as source of news and they now have an estimated 60-70% penetration rate worldwide.This means that in less than a generation, digital media have radically transformed the way we inform and socialize, and that this transformation is still ongoing as older generations are gradually replaced by digital natives. From a scientific point of view, this transformation generates many phenomena to be studied, and even "unknown unknowns" whose effects will be revealed only with time.This roadmap covers the issues, impacts and future challenges of digital media as they relate to human well-being in the broadest sense, from mental health to the health of democracies.Its objective is to initiate a new interdisciplinary research community in this field, to define a research agenda, to formulate recommendations for future digital media policy and design, and to inspire future EU calls for projects to develop innovative and transdisciplinary research on these societal challenges.The roadmap is the result of the EU-funded project DIGEING conducted by an international consortium with the help of an interdisciplinary advisory group of international experts. Its writing was based on an hybrid methodology developped at CNRS and powered by GarganText, where the advisory group acted both as catalyst and guide for a larger collaborative mapping of the state-of-the-art and identification of challenges of that emerging field. More than forty researchers from fourteen European countries have contributed to the writing of this roadmap.This roadmap is complemented by online interactive maps that can be used by researchers to situate themselves in this evolving scientific landscape and by research funding agencies to launch new calls for projects