Numerical approach of experimental homogeneisation

Approche expérimentale de l'homogénéisation numériqueNumerical approach of experimental homogeneisatio

Approche expérimentale de l'homogénéisation numérique

Numerical approach of experimental homogeneisationApproche expérimentale de l'homogénéisation numériqu

Approche expérimentale de l'homogénéisation numérique

Numerical approach of experimental homogeneisationApproche expérimentale de l'homogénéisation numériqu

Towards a KUBC homogenization for architected materials by experimental process

International audienc

Towards a KUBC homogenization for architected materials by experimental process

International audienc

Conception d'un dispositif d'homogénéisation expérimentale par KUBC

International audienc

Toward a homogenizing machine

International audienceThe idea of an experimental homogenization device adapted to the case of architectural materials is discussed here. Although more advanced homog-enization schemes exist, the case of average-field homogenization by KUBC within the framework of linear elasticity is studied here because of its (rel-ative!) simplicity of adaptation to an experimental setup. The main idea here is to propose a device that is simple to implement, inexpensive but that allows to apply a load as close as possible to a perfect KUBC thanks to the use of pantographs to distribute the displacements on the edges of the specimen. For the purposes of the design and tests-design, a reduced model of the device has been developed

Conception d'un dispositif d'homogénéisation expérimentale par KUBC

International audienc

Upfront surgery or definitive radiotherapy for p16+ oropharyngeal cancer. A GETTEC multicentric study

International audienceBackground: The aim of this study was to assess the impact of the initial therapeutic strategy on oncologic outcomes in patients with HPV-positive OPSCC.Methods: All p16-positive OPSCCs treated from 2009 to 2014 in 7 centers were retrospectively included and classified according to the therapeutic strategy: surgical strategy (surgery ± adjuvant radiotherapy and chemotherapy) vs. non-surgical strategy (definitive radiotherapy ± chemotherapy). Univariate, multivariate propensity score matching analyses were performed to compare overall (OS), disease-specific (DSS) and recurrence-free survival (RFS).Results: 382 patients were included (surgical group: 144; non-surgical group: 238). Five-year OS, DSS and RFS were 89.2, 96.8 and 83.9% in the surgical group and 84.2, 87.1 and 70.4% in the non-surgical group, respectively. These differences were statistically significant for DSS and RFS after multivariate analysis, but only for RFS after propensity score matching analysis.Conclusion: In p16+ OPSCC patients, upfront surgery results in higher RFS than definitive radiotherapy ± chemotherapy but does not impact OS

Metachronous second primary neoplasia in oropharyngeal cancer patients: Impact of tumor HPV status. A GETTEC multicentric study

International audienceIntroduction: Patients with oropharyngeal squamous cell carcinoma (OPSCC) display a significant risk to develop a metachronous second primary neoplasia (MSPN). HPV and non-HPV-related OPSCC are 2 distinct entities with biological, clinical and prognostic differences. The aims of our study were to analyze the impact of tumor HPV status and other relevant clinical factors, such as tobacco and/or alcohol (T/A) consumption, on the risk and distribution of MSPN in OPSCC patients and to assess the impact of MSPN on patient survival.Material and methods: All OPSCC patients treated from 2009 to 2014 were included in this multicentric retrospective study. P16 immunohistochemical expression was used as a surrogate maker of tumor HPV status. The impact of tumor p16 status on the risk of MSPN was assessed in uni- and multivariate analyses. Overall survival (OS) was determined by Kaplan-Meier analysis.Results: Among the 1291 patients included in this study, 138 (10.7%) displayed a MSPN which was preferentially located in the head and neck area (H&N), lung and esophagus. Multivariate analyses showed that p16- tumor status (p = 0.003), T/A consumption (p = 0.005) and soft palate tumor site (p = 0.009) were significantly associated with a higher risk of MSPN. We found no impact of p16 tumor status on the median time between index OPSCC diagnosis and MSPN development, but a higher proportion of MSPN arising outside the H&N, lung and esophagus was found in p16 + than in p16- patients. MSPN development had an unfavorable impact (p = 0.04) on OS only in the p16 + patient group.Conclusion: P16 tumor status and T/A consumption were the main predictive factors of MSPN in OPSCC patients. This study provides crucial results with a view to tailoring global management and follow-up of OPSCC patients