Variability, correlation and path coefficient analysis in fenugreek (Trigonella foenum- graecum L.) under water limited conditions

Genetic variability, character association and path analysis between yield and its component traits were carried out in 48 genotypes of fenugreek (Trigonella foenum graecum) at Udaipur (Rajasthan). Highly significant differences between genotypes were recorded for all the characters studied. High phenotypic and genotypic coefficient of variation coupled with high heritability and high genetic advance was observed for seed yield plot-1, biological yield plot-1, harvest index and pods plant-1 indicating the importance of additive gene effects for these traits. Biological yield plot-1 and harvest index exhibited positive and significant correlation with seed yield while days to 50% flowering exhibited negative and significant association with seed yield. Path coefficient analysis revealed that biological yield plot-1 had highest positive direct effect on seed yield followed by branches plant-1, pod length and test weight. It was concluded that improvement in the seed yield of fenugreek is possible through selection for biological yield plot-1, harvest index, branches plant-1, pod length and test weight. &nbsp

Variability, correlation and path coefficient analysis in fenugreek (Trigonella foenum- graecum L.) under water limited conditions

Genetic variability, character association and path analysis between yield and its component traits were carried out in 48 genotypes of fenugreek (Trigonella foenum graecum) at Udaipur (Rajasthan). Highly significant differences between genotypes were recorded for all the characters studied. High phenotypic and genotypic coefficient of variation coupled with high heritability and high genetic advance was observed for seed yield plot-1, biological yield plot-1, harvest index and pods plant-1 indicating the importance of additive gene effects for these traits. Biological yield plot-1 and harvest index exhibited positive and significant correlation with seed yield while days to 50% flowering exhibited negative and significant association with seed yield. Path coefficient analysis revealed that biological yield plot-1 had highest positive direct effect on seed yield followed by branches plant-1, pod length and test weight. It was concluded that improvement in the seed yield of fenugreek is possible through selection for biological yield plot-1, harvest index, branches plant-1, pod length and test weight. &nbsp

Comparative evaluation of different reference evapotranspiration models

The study was carried out to select best alternative method for the estimation of reference evapotranspi-ration (ET0). Accurate estimation of potential evapotranspiration is a necessary step in water resource management. Recently, the FAO-56 version of Penman-Monteith equation has been established as a standard for calculating ref-erence evapotranspiration (ET0) which requires measurement of a number of meteorological parameters namely, air temperature, relative humidity, solar radiation, and wind speed which may not be available in most of the meteoro-logical stations. Still there are different approaches (requiring less data) which estimate ET0 closely to Penman- Monteith (P-M) method for different climatological conditions. The present study is based on analysis of long term of 13 years (2000 to 2012) climatic data to calculate monthly reference evapotranspiration for Capsicum production (September–March) and also to compare the performance of evapotranspiration equations for Jhalawar district of Rajasthan with the standard FAO-56 Penman-Monteith method on the basis of the least root mean square error (RMSE) analysis. Hargreaves method and Pan evaporation (E-Pan) method overestimated the values of ETo when compared with FAO-56 Penman-Monteith method. On the basis of lowest value of RMSE, Pan evaporation method is found best alternative method to FAO-56 Penman-Monteith method in the study area

Variablity, correlation and path analysis in fennel (Foeniculum vulgare Mill.)

Forty eight collections of fennel (Foeniculum vulgare) showed significant variability for days to flowering, plant height, branches per plant, umbels per plant, umbellets per umbel, grains per umbel, 1000 seed weight, yield per plant and yield per plot at Jobner, India. The broad sense heritability was high for 1000 seed weight, umbels per plant and grain yield per plant while genetic advance was· high for umbels per plant, yield per plant and yield per plot. Grain yield per plot was significant and positively associated with yield per plant, grains per umbel and umbels per plant. Branches per plant showed a high positive, direct effect on yield per plot followed by grains per umbel and plant height. &nbsp

A guideline for the outpatient management of glycaemic control in people with cancer

Individuals with cancer are at increased risk of developing new onset diabetes mellitus and hyperglycaemia, and an estimated 20% of people with cancer already have an underlying diagnosis of diabetes mellitus. People with both cancer and diabetes may have an increased risk of toxicities, hospital admissions and morbidity, with hyperglycaemia potentially attenuating the efficacy of chemotherapy often secondary to dose reductions and early cessation. Numerous studies have demonstrated that hyperglycaemia is prognostic of worse overall survival and risk of cancer recurrence. These guidelines aim to provide the oncology/haemato-oncology and diabetes multidisciplinary teams with the tools to manage people with diabetes commencing anti-cancer/ glucocorticoid therapy, as well as identifying individuals without a known diagnosis of diabetes who are at risk of developing hyperglycaemia and new onset diabetes

Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y

A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method is based on the formation of a binary complex between the studied drugs and eosin Y in aqueous buffered medium (pH 3.5). Under the optimum conditions, the binary complex showed absorption maxima at 545 nm for tizanidine and 542 nm for orphenadrine. The calibration plots were rectilinear over concentration range of 0.5-8 μg/mL and 1-12 μg/mL with limits of detection of 0.1 μg/mL and 0.3 μg/mL for tizanidine and orphenadrine respectively. The different experimental parameters affecting the development and stability of the complex were studied and optimized. The method was successfully applied for determination of the studied drugs in their dosage forms; and to the content uniformity test of tizanidine in tablets

Enhancing diabetes care for the most vulnerable in the 21st century::Interim findings of the National Advisory Panel on Care Home Diabetes (NAPCHD)

Older adults with diabetes may carry a substantial health burden in Western ageing societies, occupy more than one in four beds in care homes, and are a highly vulnerable group who often require complex nursing and medical care. The global pandemic (COVID-19) had its epicentre in care homes and revealed many shortfalls in diabetes care resulting in hospital admissions and considerable mortality and comorbid illness. The purpose of this work was to develop a national Strategic Document of Diabetes Care for Care Homes which would bring about worthwhile, sustainable and effective quality diabetes care improvements, and address the shortfalls in care provided. A large diverse and multidisciplinary group of stakeholders (NAPCHD) defined 11 areas of interest where recommendations were needed and using a subgroup allocation approach were set tasks to produce a set of primary recommendations. Each subgroup was given 5 starter questions to begin their work and a format to provide responses. During the initial phase, 16 key findings were identified. Overall, after a period of 18 months, 49 primary recommendations were made, and 7 major conclusions were drawn from these. A model of community and integrated diabetes care for care home residents with diabetes was proposed, and a series of 5 ‘quick-wins’ were created to begin implementation of some of the recommendations that would not require significant funding. The work of the NAPCHD is ongoing but we hope that this current resource will help leaders to make these required changes happen

Dendrophthoe pentandra (L.) Miq extract effectively inhibits inflammation, proliferation and induces p53 expression on colitis-associated colon cancer

Background: Indonesian mistletoe grows on various trees. Mango Mistletoes (Dendrophthoe pentandra) is one type of mistletoe that grown on mango tree (.benalu mangga in bahasa Indonesia). Our study used mistletoe as a parasitic plant that has been used for traditional medicine. It has been known that Dendrophtoe pentandra extract (DPE) anti-inflammatory and anticancer. Furthermore, it is necessary to follow-up study in vivo to evaluate the response to treatment of new cancer therapeutic agents. This research aimed to determine the levels of IL-22, myeloperoxide (MPO), proliferation and wild-type p53 expression after the administration of DPE to murine models of CAC. Methods: Mouse colitis associated colon cancer (CAC) was induced firstly by azoxymethane (AOM) and followed by administration of drinking water containing 5 % dextran sodium sulfate (DSS) in a cycle protocol, each cycle consisted of seven days of 5 % DSS in the drinking water and followed by seven days of regular water. This study consists of five treatment groups: I was treated water only (control), II was administrated by (DSS only, without DPE), (III-V) were administrated by DPE (125 mg/kg BW, 250 mg/kg BW and 500 mg/kg BW) respectively. The administrated of DPE were started from the 8th weeks, were continued until 21 weeks. At the end of 21 weeks of the experiment, mice were sacrificed, colon tissue was removed, and then subjected to ELISA, flow cytometry, real-time PCR and histology examination. Results: Administration of DPE 250 mg/kgBW significantly reduce the levels of IL-22 and MPO compared with DSS only group (p < 0.001; p < 0.001). Colonic epithelial cells proliferation of group IV (DPE 250 mg/kgBW) were significantly lower than III and V groups. There was no significant change in the S phase in mice were treated DPE 125 mg/kg BW and 500 mg/kg BW, while administration of DPE 250 mg/kg BW was able to increase the percentage of cells in S phase. The expression of mRNA p53 was up regulated in mice received DPE 125 mg/kg BW. Conclusion: These findings indicate that the DPE could inhibit colonic epithelial cells proliferation through p53 pathway independently. This study also showed that DPE could be potential sources of new therapy

Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma

Craniopharyngiomas are locally aggressive tumors which typically are focused in the sellar and suprasellar region near a number of critical neural and vascular structures mediating endocrinologic, behavioral, and visual functions. The present study aims to summarize and compare the published literature regarding morbidity resulting from treatment of craniopharyngioma. We performed a comprehensive search of the published English language literature to identify studies publishing outcome data of patients undergoing surgery for craniopharyngioma. Comparisons of the rates of endocrine, vascular, neurological, and visual complications were performed using Pearson’s chi-squared test, and covariates of interest were fitted into a multivariate logistic regression model. In our data set, 540 patients underwent surgical resection of their tumor. 138 patients received biopsy alone followed by some form of radiotherapy. Mean overall follow-up for all patients in these studies was 54 ± 1.8 months. The overall rate of new endocrinopathy for all patients undergoing surgical resection of their mass was 37% (95% CI = 33–41). Patients receiving GTR had over 2.5 times the rate of developing at least one endocrinopathy compared to patients receiving STR alone or STR + XRT (52 vs. 19 vs. 20%, χ2P < 0.00001). On multivariate analysis, GTR conferred a significant increase in the risk of endocrinopathy compared to STR + XRT (OR = 3.45, 95% CI = 2.05–5.81, P < 0.00001), after controlling for study size and the presence of significant hypothalamic involvement. There was a statistical trend towards worse visual outcomes in patients receiving XRT after STR compared to GTR or STR alone (GTR = 3.5% vs. STR 2.1% vs. STR + XRT 6.4%, P = 0.11). Given the difficulty in obtaining class 1 data regarding the treatment of this tumor, this study can serve as an estimate of expected outcomes for these patients, and guide decision making until these data are available