In Vitro Cytotoxicity Screening as a Criterion for the Rational Selection of Tear Substitutes

A large number of artificial tears are currently available in the pharmaceutical market. Selecting the right drug for the patient remains a challenge for both the doctor and the patient. Comparing the cytotoxicity of artificial tears is one of the criteria for the rational selection of a drug that promotes maximum clinical efficacy and a higher safety profile. It is known that cells grown in vitro retain many metabolic features of the parent host tissues and at the same time lack tissue and organ interrelations and regulatory effects of the nervous and endocrine systems and have very limited compensatory capabilities. These features of cell cultures provide an opportunity to investigate the interaction of chemical agents directly with the cell itself, to identify changes in cellular and subcellular structures that can be masked in whole-organism settings. This study presents the results of assessing the cytotoxicity of tear substitutes, which demonstrate that these drugs can have a cytostatic effect in vitro and differ in their cytotoxic potential. In recent years, the problem of drug therapy of patients with dry eye syndrome has been attracting increasing attention of ophthalmologists, so screening the cytotoxicity of a wide range of tear substitutes using cell culture-based test systems can promote the rational selection of these drugs

Protective action of water-soluble fullerene adducts on the example of an adduct with L-arginine

We present radioprotective, antiglycating, and photoprotective properties of a water-soluble C60 fullerene derivative with L-arginine (C60-Arg) and composite films based on collagen containing C60-Arg. The synthesis of these materials is described. The identification of the synthesised materials was carried out using modern physicochemical methods of analysis. The physicochemical properties of aqueous solutions of C60-Arg, such as, particle size distribution, zeta potentials, distribution coefficient in the octan-1-ol–water system were measured. The computer simulation of the process of C60-Arg association in aqueous and isotonic solutions was carried out using Molecular Dynamics. Composite films based on collagen containing C60-Arg demonstrate significant improvement in mechanical properties, cell adhesion, and cell proliferation when the nano-modifier is added. This shows high potential for the use of the C60-Arg adduct in biomedicine

COSMOS-Web: An Overview of the JWST Cosmic Origins Survey

We present the survey design, implementation, and outlook for COSMOS-Web, a 255 hour treasury program conducted by the James Webb Space Telescope in its first cycle of observations. COSMOS-Web is a contiguous 0.54 deg$^2$ NIRCam imaging survey in four filters (F115W, F150W, F277W, and F444W) that will reach 5$\sigma$ point source depths ranging $\sim$27.5-28.2 magnitudes. In parallel, we will obtain 0.19 deg$^2$ of MIRI imaging in one filter (F770W). COSMOS-Web will build on the rich heritage of multiwavelength observations and data products available in the COSMOS field. The design of COSMOS-Web is motivated by three primary science goals: (1) to discover thousands of galaxies in the Epoch of Reionization ($64$ and place constraints on the formation of the Universe's most massive galaxies ($M_\star>10^{10}$ M$_\odot$), and (3) directly measure the evolution of the stellar mass to halo mass relation using weak gravitational lensing out to $z\sim2.5$ and measure its variance with galaxies' star formation histories and morphologies. In addition, we anticipate COSMOS-Web's legacy value to reach far beyond these scientific goals, touching many other areas of astrophysics, such as the identification of the first direct collapse black hole candidates, ultracool sub-dwarf stars in the Galactic halo, and possibly the identification of $z>10$ pair-instability supernovae. In this paper we provide an overview of the survey's key measurements, specifications, goals, and prospects for new discovery

COSMOS-Web: An Overview of the JWST Cosmic Origins Survey

We present the survey design, implementation, and outlook for COSMOS-Web, a 255 hour treasury program conducted by the James Webb Space Telescope in its first cycle of observations. COSMOS-Web is a contiguous 0.54 deg$^2$ NIRCam imaging survey in four filters (F115W, F150W, F277W, and F444W) that will reach 5$\sigma$ point source depths ranging $\sim$27.5-28.2 magnitudes. In parallel, we will obtain 0.19 deg$^2$ of MIRI imaging in one filter (F770W). COSMOS-Web will build on the rich heritage of multiwavelength observations and data products available in the COSMOS field. The design of COSMOS-Web is motivated by three primary science goals: (1) to discover thousands of galaxies in the Epoch of Reionization ($64$ and place constraints on the formation of the Universe's most massive galaxies ($M_\star>10^{10}$ M$_\odot$), and (3) directly measure the evolution of the stellar mass to halo mass relation using weak gravitational lensing out to $z\sim2.5$ and measure its variance with galaxies' star formation histories and morphologies. In addition, we anticipate COSMOS-Web's legacy value to reach far beyond these scientific goals, touching many other areas of astrophysics, such as the identification of the first direct collapse black hole candidates, ultracool sub-dwarf stars in the Galactic halo, and possibly the identification of $z>10$ pair-instability supernovae. In this paper we provide an overview of the survey's key measurements, specifications, goals, and prospects for new discovery

COSMOS-Web: An Overview of the JWST Cosmic Origins Survey

We present the survey design, implementation, and outlook for COSMOS-Web, a 255 hour treasury program conducted by the James Webb Space Telescope in its first cycle of observations. COSMOS-Web is a contiguous 0.54 deg$^2$ NIRCam imaging survey in four filters (F115W, F150W, F277W, and F444W) that will reach 5$\sigma$ point source depths ranging $\sim$27.5-28.2 magnitudes. In parallel, we will obtain 0.19 deg$^2$ of MIRI imaging in one filter (F770W). COSMOS-Web will build on the rich heritage of multiwavelength observations and data products available in the COSMOS field. The design of COSMOS-Web is motivated by three primary science goals: (1) to discover thousands of galaxies in the Epoch of Reionization ($64$ and place constraints on the formation of the Universe's most massive galaxies ($M_\star>10^{10}$ M$_\odot$), and (3) directly measure the evolution of the stellar mass to halo mass relation using weak gravitational lensing out to $z\sim2.5$ and measure its variance with galaxies' star formation histories and morphologies. In addition, we anticipate COSMOS-Web's legacy value to reach far beyond these scientific goals, touching many other areas of astrophysics, such as the identification of the first direct collapse black hole candidates, ultracool sub-dwarf stars in the Galactic halo, and possibly the identification of $z>10$ pair-instability supernovae. In this paper we provide an overview of the survey's key measurements, specifications, goals, and prospects for new discovery