OTM Based OxyCombustion for CO{sub 2} Capture from Coal Power Plants

This report outlines accomplishments for the following tasks: Task 1 â Process and Systems Engineering, Task 2 â OTM Performance Improvement, Task 3 â OTM Manufacturing Development, Task 4 - Laboratory Scale Testing and Task 5 â Project Management

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei

A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicromolar range. The most potent was a member of the sulphonepiperazine series with an IC50 of 34 nM. These results identify lead compounds with potential for the development of a novel class of trypanocidal agent