Vertebral fractures and abdominal aortic aneurysm revealing Q fever

International audienc

How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art

International audienceBloodstream infection (BSI) is a major cause of death in developed countries and the detection of microorganisms is essential in managing patients. Despite major progress has been made to improve identification of microorganisms, blood culture (BC) remains the gold standard and the first line tool for detecting BSIs. Consensus guidelines are available to ensure optimal BSI procedures, but BC practices often deviate from the recommendations. This review provides an update on clinical and technical issues related to blood collection and to BC performance, with a special focus on the blood sample strategy to optimize the sensitivity and specificity of BC

Measles inclusion-body encephalitis (MIBE) in a immunocompromised patient

International audienc

A Pilot Study of Tobacco Screening and Referral for Smoking Cessation Program among HIV-Infected Patients in France

International audienceBackground: The prevalence of tobacco smoking is high among patients living with HIV, supporting the need for effectivetargeted interventions. Materials and Methods: All current smokers at our outpatient HIV clinic were invited to participate in asmoking cessation program. Results: Of the 716 patients living with HIV, 280 (39%) reported active smoking and were younger,more recently HIV infected and more frequently infected due to intravenous drug use (IDU). One hundred forty-seven (53%)smokers agreed to participate in the smoking cessation program and had a higher Fagerstro¨m score and were less likely IDU.During follow-up, 41 (28%) smokers withdrew from the program. After 6 months, 60 (57%) of the 106 smokers who completedthe intervention had stopped tobacco smoking and were more likely to use varenicline, adjusting for a history of depression.Conclusion: Our smoking cessation program was feasible. However, strategies to reach and retain in smoking cessationprogram specific groups such as IDU are needed to improve the smoking cessation cascade

Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin

International audienceEnterocytozoon bieneusi microsporidiosis is an emerging disease in immunocompromised patients. We report 2 cases of this disease in allogeneic hematopoietic stem cell transplant patients successfully treated with fumagillin. Thrombocytopenia occurred but without major adverse events. Modifications of immunosuppression could be avoided when E. bieneusi is rapidly identified and fumagillin therapy is started promptly

Real-world 2-year weight changes among people with sustained HIV suppression: A multicenter French retrospective cohort study

Meeting abstract du "19th European AIDS Conference (#EACS2023)", 18-21 Octobre 2023, VarsovieInternational audienc

Four-days-a-week antiretroviral maintenance therapy in virologically controlled HIV-1-infected adults: the ANRS 162-4D trial

International audienceBackground:Intermittent treatment could improve the convenience, tolerability and cost of ART, as well as patients' quality of life. We conducted a 48 week multicentre study of a 4-days-a-week antiretroviral regimen in adults with controlled HIV-1-RNA plasma viral load (VL).Methods:Eligible patients were adults with VL  90%, with a power of 87% and a 5% type 1 error. The study was registered with ClinicalTrials.gov (NCT02157311) and EudraCT (2014-000146-29).Results:One hundred patients (82 men), median age 47 years (IQR 40-53), were included. They had been receiving ART for a median of 5.1 (IQR 2.9-9.3) years and had a median CD4 cell count of 665 (IQR 543-829) cells/mm3. The ongoing regimen included PI/r in 29 cases and NNRTI in 71 cases. At 48 weeks, 96% of participants (95% CI 90%-98%) had no failure while remaining on the 4-days-a-week regimen. Virological failure occurred in three participants, who all resumed daily treatment and became resuppressed. One participant stopped the strategy. No severe treatment-related events occurred.Conclusions:Antiretroviral maintenance therapy 4 days a week was effective for 48 weeks in 96% of patients, leading to potential reduction of long-term toxicities, high adherence to the antiretroviral regimen and drug cost saving