417 research outputs found
Transition to turbulence in particulate pipe flow
We investigate experimentally the influence of suspended particles on the
transition to turbulence. The particles are monodisperse and neutrally-buoyant
with the liquid. The role of the particles on the transition depends both upon
the pipe to particle diameter ratios and the concentration. For large
pipe-to-particle diameter ratios the transition is delayed while it is lowered
for small ratios. A scaling is proposed to collapse the departure from the
critical Reynolds number for pure fluid as a function of concentration into a
single master curve.Comment: 4 pages, 4 figure
The Hudson Bay Lithospheric Experiment (HuBLE) : Insights into Precambrian Plate Tectonics and the Development of Mantle Keels
The UK component of HuBLE was supported by Natural Environment Research Council (NERC) grant NE/F007337/1, with financial and logistical support from the Geological Survey of Canada, Canada–Nunavut Geoscience Office, SEIS-UK (the seismic node of NERC), and First Nations communities of Nunavut. J. Beauchesne and J. Kendall provided invaluable assistance in the field. Discussions with M. St-Onge, T. Skulski, D. Corrigan and M. Sanborne-Barrie were helpful for interpretation of the data. D. Eaton and F. A. Darbyshire acknowledge the Natural Sciences and Engineering Research Council. Four stations on the Belcher Islands and northern Quebec were installed by the University of Western Ontario and funded through a grant to D. Eaton (UWO Academic Development Fund). I. Bastow is funded by the Leverhulme Trust. This is Natural Resources Canada Contribution 20130084 to its Geomapping for Energy and Minerals Program. This work has received funding from the European Research Council under the European Unions Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement no. 240473 ‘CoMITAC’.Peer reviewedPublisher PD
Travelling waves in pipe flow
A family of three-dimensional travelling waves for flow through a pipe of
circular cross section is identified. The travelling waves are dominated by
pairs of downstream vortices and streaks. They originate in saddle-node
bifurcations at Reynolds numbers as low as 1250. All states are immediately
unstable. Their dynamical significance is that they provide a skeleton for the
formation of a chaotic saddle that can explain the intermittent transition to
turbulence and the sensitive dependence on initial conditions in this shear
flow.Comment: 4 pages, 5 figure
Tomographic image of melt storage beneath Askja Volcano, Iceland using local microseismicity
We use P wave and S wave arrivals from microseismic earthquakes to construct 3-D tomographic Vp and Vs images of the magma storage region beneath Askja's central volcano in the Northern Volcanic Zone of Iceland. A distinctive ellipsoidal low-velocity anomaly, with both Vp and Vsvelocities 8-12% below the background, is imaged at 6-11 km depth beneath the caldera. The presence of a shallow magma chamber is corroborated by geodetic and gravity studies. The small Vp/Vs anomaly suggests a lack of pervasive melt. We interpret this anomaly as a region of multiple sills, some frozen but hot, others containing partial melt. A second, smaller low-velocity anomaly beneath the main magma storage region may represent a magma migration pathway. This interpretation is supported by the close proximity to the anomaly of clusters of deep, magmatically induced earthquakes. However, the location and shape of this deep anomaly are poorly constrained by the current data set
Fractal Stability Border in Plane Couette Flow
We study the dynamics of localised perturbations in plane Couette flow with
periodic lateral boundary conditions. For small Reynolds number and small
amplitude of the initial state the perturbation decays on a viscous time scale
. For Reynolds number larger than about 200, chaotic transients
appear with life times longer than the viscous one. Depending on the type of
the perturbation isolated initial conditions with infinite life time appear for
Reynolds numbers larger than about 270--320. In this third regime, the life
time as a function of Reynolds number and amplitude is fractal. These results
suggest that in the transition region the turbulent dynamics is characterised
by a chaotic repeller rather than an attractor.Comment: 4 pages, Latex, 4 eps-figures, submitted to Phys. Rev. Le
Geologic Provinces Beneath the Greenland Ice Sheet Constrained by Geophysical Data Synthesis
Present understanding of Greenland's subglacial geology is derived mostly from interpolation of geologic mapping of its ice‐free margins and unconstrained by geophysical data. Here we refine the extent of its geologic provinces by synthesizing geophysical constraints on subglacial geology from seismic, gravity, magnetic and topographic data. North of 72°N, no province clearly extends across the whole island, leaving three distinct subglacial regions yet to be reconciled with margin geology. Geophysically coherent anomalies and apparent province boundaries are adjacent to the onset of faster ice flow at both Petermann Glacier and the Northeast Greenland Ice Stream. Separately, based on their subaerial expression, dozens of unusually long, straight and sub‐parallel subglacial valleys cross Greenland's interior and are not yet resolved by current syntheses of its subglacial topography
The vertical distribution of biomass burning pollution over tropical South America from aircraft in situ measurements during SAMBBA
This is the final version. Available from the publisher via the DOI in this record.All raw time series data used to derive the
vertical profiles from the FAAM research aircraft are publicly
available from the Centre for Environmental Data Analysis website
(http://www.ceda.ac.uk/, last access: 31 August 2018). Direct links
to the flight data records are given in the reference list (Facility for
Airborne Atmospheric Measurements et al., 2014a, b, c, d, e, f, g
– https://doi.org/10.5285/6034214ae46c48a7835608866a823f56, h,
i, j, k, l – https://doi.org/10.5285/7e7783fcd44e4a3890f3bd67e89e585e,
m, n, o, p, q). Raw active fire and land use data used in the paper
are available publicly from NASA and ESA respectively (see
Acknowledgements). Processed individual and averaged vertical
profiles, data masks, plume composition, model output and
satellite fields are currently available on request from Eoghan Darbyshire. Lidar data are available on request from Franco Marenco
([email protected]).We examine processes driving the vertical distribution of biomass burning pollution following an integrated analysis of over 200 pollutant and meteorological profiles measured in situ during the South AMerican Biomass Burning Analysis (SAMBBA) field experiment. This study will aid future work examining the impact of biomass burning on weather, climate and air quality. During the dry season there were significant contrasts in the composition and vertical distribution of haze between western and eastern regions of tropical South America. Owing to an active or residual convective mixing layer, the aerosol abundance was similar from the surface to ĝ1/41.5 km in the west and ĝ1/43 km in the east. Black carbon mass loadings were double as much in the east (1.7 μg mĝ'3) than the west (0.85 μg mĝ'3), but aerosol scattering coefficients at 550 nm were similar (ĝ1/4120 Mmĝ'1), as too were CO near-surface concentrations (310-340 ppb). We attribute these contrasts to the more flaming combustion of Cerrado fires in the east and more smouldering combustion of deforestation and pasture fires in the west. Horizontal wind shear was important in inhibiting mixed layer growth and plume rise, in addition to advecting pollutants from the Cerrado regions into the remote tropical forest of central Amazonia. Thin layers above the mixing layer indicate the roles of both plume injection and shallow moist convection in delivering pollution to the lower free troposphere. However, detrainment of large smoke plumes into the upper free troposphere was very infrequently observed. Our results reiterate that thermodynamics control the pollutant vertical distribution and thus point to the need for correct model representation so that the spatial distribution and vertical structure of biomass burning smoke is captured. We observed an increase of aerosol abundance relative to CO with altitude both in the background haze and plume enhancement ratios. It is unlikely associated with thermodynamic partitioning, aerosol deposition or local non-fire sources. We speculate it may be linked to long-range transport from West Africa or fire combustion efficiency coupled to plume injection height. Further enquiry is required to explain the phenomenon and explore impacts on regional climate and air quality.Natural Environment Research Council (NERC
A new P-wave tomographic model (cap22) for North America: implications for the subduction and cratonic metasomatic modification history of western Canada and Alaska
Our understanding of the present-day state and evolution of the Canadian and Alaskan mantle is hindered by a lack of absolute P-wavespeed constraints that provide complementary sensitivity to composition in conjunction with existing S-wavespeed models. Consequently, cratonic modification, orogenic history of western North America and complexities within the Alaskan Proto-Pacific subduction system remain enigmatic. One challenge concerns the difficulties in extracting absolute arrival-time measurements from often-noisy data recorded by temporary seismograph networks required to fill gaps in continental and global databases. Using the Absolute Arrival-time Recovery Method (AARM), we extract >180,000 new absolute arrival-time residuals from seismograph stations across Canada and Alaska and combine these data with USArray and global arrival-time data from the contiguous US and Alaska. We develop a new absolute P-wavespeed tomographic model, CAP22, spanning North America that significantly improves resolution in Canada and Alaska over previous models. Slow wavespeeds below the Canadian Cordillera sharply abut fast wavespeeds of the continental interior at the Rocky Mountain Trench in southwest Canada. Slow wavespeeds below the Mackenzie Mountains continue farther inland in northwest Canada, indicating Proterozoic-Archean metasomatism of the Slave craton. Inherited tectonic lineaments colocated with this north-south wavespeed boundary suggest that both the crust and mantle may control Cordilleran orogenic processes. In Alaska, fast upper mantle wavespeeds below the Wrangell Volcanic Field favor a conventional subduction related mechanism for volcanism. Finally, seismic evidence for the subducted Kula and Yukon slabs indicate tectonic reconstructions of western North America may require revision
Interleukin-2 therapy in patients with HIV infection
BACKGROUND
Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known.
METHODS
We conducted two trials: the Subcutaneous Recombinant, Human Interleukin-2 in HIV-Infected Patients with Low CD4+ Counts under Active Antiretroviral Therapy (SILCAAT) study and the Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT). In each, patients infected with the human immunodeficiency virus (HIV) who had CD4+ cell counts of either 50 to 299 per cubic millimeter (SILCAAT) or 300 or more per cubic millimeter (ESPRIT) were randomly assigned to receive interleukin-2 plus antiretroviral therapy or antiretroviral therapy alone. The interleukin-2 regimen consisted of cycles of 5 consecutive days each, administered at 8-week intervals. The SILCAAT study involved six cycles and a dose of 4.5 million IU of interleukin-2 twice daily; ESPRIT involved three cycles and a dose of 7.5 million IU twice daily. Additional cycles were recommended to maintain the CD4+ cell count above predefined target levels. The primary end point of both studies was opportunistic disease or death from any cause.
RESULTS
In the SILCAAT study, 1695 patients (849 receiving interleukin-2 plus antiretroviral therapy and 846 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 202 cells per cubic millimeter were enrolled; in ESPRIT, 4111 patients (2071 receiving interleukin-2 plus antiretroviral therapy and 2040 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 457 cells per cubic millimeter were enrolled. Over a median follow-up period of 7 to 8 years, the CD4+ cell count was higher in the interleukin-2 group than in the group receiving antiretroviral therapy alone--by 53 and 159 cells per cubic millimeter, on average, in the SILCAAT study and ESPRIT, respectively. Hazard ratios for opportunistic disease or death from any cause with interleukin-2 plus antiretroviral therapy (vs. antiretroviral therapy alone) were 0.91 (95% confidence interval [CI], 0.70 to 1.18; P=0.47) in the SILCAAT study and 0.94 (95% CI, 0.75 to 1.16; P=0.55) in ESPRIT. The hazard ratios for death from any cause and for grade 4 clinical events were 1.06 (P=0.73) and 1.10 (P=0.35), respectively, in the SILCAAT study and 0.90 (P=0.42) and 1.23 (P=0.003), respectively, in ESPRIT.
CONCLUSIONS
Despite a substantial and sustained increase in the CD4+ cell count, as compared with antiretroviral therapy alone, interleukin-2 plus antiretroviral therapy yielded no clinical benefit in either study. (ClinicalTrials.gov numbers, NCT00004978 [ESPRIT] and NCT00013611 [SILCAAT study].
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