7 research outputs found
The prevalence of sexual behavior disorders in patients with treated and untreated gastroesophageal reflux disease.
Abstract
Background: Gastroesophageal reflux disease (GERD)
is a chronic disease. Sexual behavior is often altered in
chronic illness. The aim of this study was to evaluate
sexual behavior in patients affected with GERD before
and after medical or surgical treatment in comparison to
healthy controls (HC).
Methods: Upper GI endoscopy and 24-h ambulatory pH
testing were performed to confirm GERD in symptomatic
patients. GERD patients completed an anonymous
questionnaire on sexual life before and after
medical or surgical treatment.
Results: Compared with HC, untreated patients with
GERD showed more frequent difficulty in attaining
orgasm and painful intercourse. GERD patients after
surgical treatment had significantly more difficulty in
attaining orgasm, while after continuous medical treatment
GERD patients compared with HC had significantly
more difficulty in attaining orgasm, higher painful
intercourse, lower sexual desire, and perceived more
frequently that the partner was unhelpful. When compared
with untreated conditions, GERD patients after
surgical treatment had a significant improvement in
attaining orgasm and in painful intercourse but a significant
decrease in sexual desire, a lower satisfaction
with their sexual life, and a higher prevalence of an
unhelpful partner, whereas GERD patients after medical
treatment had a decrease in all indices of sexual
behavior.
Conclusion: Untreated GERD is associated with disorders
in sexual behavior. Compared with HC, only the
surgical group partially improved after treatment
The prevalence of sexual behavior disorders in patients with treated and untreated gastroesophageal reflux disease.
Evaluation of Clensia®, a new low-volume PEG bowel preparation in colonoscopy: Multicentre randomized controlled trial versus 4L PEG
Abstract Background Success of colonoscopy is linked to the adequacy of bowel cleansing. Polyethylene glycol 4 L (PEG 4 L) solutions are widely used for colonic cleansing but with limitations concerning tolerability and acceptability. Aim To demonstrate the equivalence of a new low-volume PEG containing citrates and simeticone (Clensia) versus a standard PEG 4 L. Methods In this, multicentre, randomised, observer-blind trial, patients received either Clensia 2 L or PEG 4 L solution. Primary endpoint was the proportion of patients with colon cleansing evaluated as excellent or good. Results 422 patients received Clensia (n = 213) or PEG 4 L (n = 209). Rate of excellent/good bowel cleansing was 73.6% and 72.3% in Clensia and PEG 4 L group respectively. Clensia was demonstrated to be equivalent to PEG 4 L. No SAEs were observed. Clensia showed better gastrointestinal tolerability (37.0% vs 25.4%). The acceptability was significantly better with Clensia in terms of proportion of subjects who felt no distress (Clensia 72.8% vs PEG 4 L 63%, P = 0.0314) and willingness-to-repeat (93.9% vs 82.2%, P = 0.0002). The rate of optimal compliance was similar with both formulations (91.1% for Clensia vs 90.9% for PEG 4 L, P = 0.9388). Conclusions The low-volume Clensia is equally effective and safe in bowel cleansing compared to the standard PEG 4 L, with better gastrointestinal tolerability and acceptability