Gamma-Rays Produced in Cosmic-Ray Interactions and the TeV-band Spectrum of RX J1713.7-3946

We employ the Monte Carlo particle collision code DPMJET3.04 to determine the multiplicity spectra of various secondary particles (in addition to $\pi^0$'s) with $\gamma$'s as the final decay state, that are produced in cosmic-ray ($p$'s and $\alpha$'s) interactions with the interstellar medium. We derive an easy-to-use $\gamma$-ray production matrix for cosmic rays with energies up to about 10 PeV. This $\gamma$-ray production matrix is applied to the GeV excess in diffuse Galactic $\gamma$-rays observed by EGRET, and we conclude the non-$\pi^0$ decay components are insufficient to explain the GeV excess, although they have contributed a different spectrum from the $\pi^0$-decay component. We also test the hypothesis that the TeV-band $\gamma$-ray emission of the shell-type SNR RX J1713.7-3946 observed with HESS is caused by hadronic cosmic rays which are accelerated by a cosmic-ray modified shock. By the $\chi^2$ statistics, we find a continuously softening spectrum is strongly preferred, in contrast to expectations. A hardening spectrum has about 1% probability to explain the HESS data, but then only if a hard cutoff at 50-100 TeV is imposed on the particle spectrum.Comment: 3 pages; 4 figures; Contribution to the First GLAST Symposium, Standord, 200

Semiflexible polymers: Dependence on ensemble and boundary orientations

We show that the mechanical properties of a worm-like-chain (WLC) polymer, of contour length $L$ and persistence length \l such that t=L/\l\sim{\cal O}(1), depend both on the ensemble and the constraint on end-orientations. In the Helmholtz ensemble, multiple minima in free energy near $t=4$ persists for all kinds of orientational boundary conditions. The qualitative features of projected probability distribution of end to end vector depend crucially on the embedding dimensions. A mapping of the WLC model, to a quantum particle moving on the surface of an unit sphere, is used to obtain the statistical and mechanical properties of the polymer under various boundary conditions and ensembles. The results show excellent agreement with Monte-Carlo simulations.Comment: 15 pages, 15 figures; version accepted for publication in Phys. Rev. E; one new figure and discussions adde

Photoelastic force measurements in granular materials

Photoelastic techniques are used to make both qualitative and quantitative measurements of the forces within idealized granular materials. The method is based on placing a birefringent granular material between a pair of polarizing filters, so that each region of the material rotates the polarization of light according to the amount of local of stress. In this review paper, we summarize past work using the technique, describe the optics underlying the technique, and illustrate how it can be used to quantitatively determine the vector contact forces between particles in a 2D granular system. We provide a description of software resources available to perform this task, as well as key techniques and resources for building an experimental apparatus

Spicules and the effect of rigid rods on enclosing membrane tubes

Membrane tubes (spicules) arise in cells, or artificial membranes, in the nonlinear deformation regime due to, e.g. the growth of microtubules, actin filaments or sickle hemoglobin fibers towards a membrane. We calculate the axial force exerted by the cylindrical membrane tube, and its average radius, by taking into account steric interactions between the fluctuating membrane and the enclosed rod. The force required to confine a fluctuating membrane near the surface of the enclosed rod diverges as the separation approaches zero. This results in a smooth crossover of the axial force between a square root and a linear dependence on the membrane tension as the tension increases and the tube radius shrinks. This crossover can occur at the most physiologically relevant membrane tensions. Our work may be important in (i) interpreting experiments in which axial force is related to the tube radius or membrane tension (ii) dynamical theories for biopolymer growth in narrow tubes where these fluctuation effects control the tube radius.Comment: 10 pages, 1 figur

Segregation by thermal diffusion in granular shear flows

Segregation by thermal diffusion of an intruder immersed in a sheared granular gas is analyzed from the (inelastic) Boltzmann equation. Segregation is induced by the presence of a temperature gradient orthogonal to the shear flow plane and parallel to gravity. We show that, like in analogous systems without shear, the segregation criterion yields a transition between upwards segregation and downwards segregation. The form of the phase diagrams is illustrated in detail showing that they depend sensitively on the value of gravity relative to the thermal gradient. Two specific situations are considered: i) absence of gravity, and ii) homogeneous temperature. We find that both mechanisms (upwards and downwards segregation) are stronger and more clearly separated when compared with segregation criteria in systems without shear.Comment: 8 figures. To appear in J. Stat. Mec

New Discoveries from the Arecibo 327 MHz Drift Pulsar Survey Radio Transient Search

We present Clusterrank, a new algorithm for identifying dispersed astrophysical pulses. Such pulses are commonly detected from Galactic pulsars and rotating radio transients (RRATs), which are neutron stars with sporadic radio emission. More recently, isolated, highly dispersed pulses dubbed fast radio bursts (FRBs) have been identified as the potential signature of an extragalactic cataclysmic radio source distinct from pulsars and RRATs. Clusterrank helped us discover 14 pulsars and 8 RRATs in data from the Arecibo 327 MHz Drift Pulsar Survey (AO327). The new RRATs have DMs in the range $23.5 - 86.6$ pc cm$^{-3}$ and periods in the range $0.172 - 3.901$ s. The new pulsars have DMs in the range $23.6 - 133.3$ pc cm$^{-3}$ and periods in the range $1.249 - 5.012$ s, and include two nullers and a mode-switching object. We estimate an upper limit on the all-sky FRB rate of $10^5$ day$^{-1}$ for bursts with a width of 10 ms and flux density $\gtrsim 83$ mJy. The DMs of all new discoveries are consistent with a Galactic origin. In comparing statistics of the new RRATs with sources from the RRATalog, we find that both sets are drawn from the same period distribution. In contrast, we find that the period distribution of the new pulsars is different from the period distributions of canonical pulsars in the ATNF catalog or pulsars found in AO327 data by a periodicity search. This indicates that Clusterrank is a powerful complement to periodicity searches and uncovers a subset of the pulsar population that has so far been underrepresented in survey results and therefore in Galactic pulsar population models.Comment: 41 pages, 16 figures, 4 tables, accepted by ApJ; added minor corrections to final ApJ proo

Limitations in Predicting Radiation-Induced Pharmaceutical Instability during Long-Duration Spaceflight

As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration spaceflight. Historical missions have relied upon frequent resupply of onboard pharmaceuticals; as a result, there has been little study into the effects of long-term exposure of pharmaceuticals to the space environment. Of particular concern are the long-term effects of space radiation on drug stability, especially as missions venture away from the protective proximity of the Earth. Here we highlight the risk of space radiation to pharmaceuticals during exploration spaceflight, identifying the limitations of current understanding. We further seek to identify ways in which these limitations could be addressed through dedicated research efforts aimed towards the rapid development of an effective pharmacy for future spaceflight endeavors.Comment: in press, Nature Microgravit

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection

Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection. However, the role of astrocytes in innate immune responses of the BBB during viral infection of the CNS remains to be fully elucidated. Here, we have demonstrated that type I IFNAR signaling in astrocytes regulates BBB permeability and protects the cerebellum from infection and immunopathology. Mice with astrocyte-specific loss of IFNAR signaling showed decreased survival after West Nile virus infection. Accelerated mortality was not due to expanded viral tropism or increased replication. Rather, viral entry increased specifically in the hindbrain of IFNAR-deficient mice, suggesting that IFNAR signaling critically regulates BBB permeability in this brain region. Pattern recognition receptors and IFN-stimulated genes had higher basal and IFN-induced expression in human and mouse cerebellar astrocytes than did cerebral cortical astrocytes, suggesting that IFNAR signaling has brain region–specific roles in CNS immune responses. Taken together, our data identify cerebellar astrocytes as key responders to viral infection and highlight the existence of distinct innate immune programs in astrocytes from evolutionarily disparate regions of the CNS