PARÂMETROS CINÉTICOS DE MOAGEM DE ITABIRITOS COMPACTO E FRIÁVEL

Duas amostras de minério de ferro classificadas como itabiritos compacto e friável foram testadas com relação a moabilidade. Os testes foram realizados em um moinho de bolas em escala de laboratório com torquímetro para medição precisa da potência. Os parâmetros cinéticos das amostras foram determinados através do aplicativo Moly-Cop Tools 2.0. Simulações foram realizadas com o mesmo aplicativo para previsão do comportamento do circuito de moagem com cada uma das amostras estudadas. Os resultados indicam que a amostra de itabirito friável possui maior consumo específico de energia, mesmo sendo uma amostra de granulometria mais fina que a amostra de itabirito compacto

U-Pb SHRIMP and Sm-Nd geochronology of the Silvânia Volcanics and Jurubatuba Granite: juvenile Paleoproterozoic crust in the basement of the Neoproterozoic Brasília Belt, Goiás, central Brazil

U-Pb SHRIMP and Sm-Nd isotopic ages were determined for felsic metavolcanic rocks from the Silvânia Sequence and Jurubatuba Granite in the central part of the Brasília Belt. Zircon grains from a metavolcanic sample yielded 2115 ± 23 Ma and from the granite yielded 2089 ± 14 Ma, interpreted as crystallization ages of these rocks. Six metavolcanic samples of the Silvânia Sequence yielded a six-point whole-rock Sm-Nd isochron indicating a crystallization age of 2262 ± 110 Ma and positive epsilonNd(T) = +3.0 interpreted as a juvenile magmatic event. Nd isotopic analyses on samples from the Jurubatuba Granite have Paleoproterozoic T DM model ages between 2.30 and 2.42 Ga and epsilonNd(T) values vary between -0.22 and -0.58. The oldest T DM value refers to a sedimentary xenolith in the granite. These results suggest crystallization ages of Silvânia volcanics and Jurubatuba Granite are the first evidence of a ca. 2.14-2.08 juvenile magmatic event in the basement of the central part of the Brasília Belt that implies the presence of arc/suture hidden in reworked basement of the Brasília Belt.Idades isótopicas U-Pb SHRIMP e Sm-Nd foram determinadas em rochas metavulcânicas félsicas da Seqüência de Silvânia e Granito Jurubatuba na porção central da Faixa Brasília. Grãos de zircão da rocha metavulcânica da Seqüência de Silvânia e do granito forneceram, respectivamente, as idades de 2115 ± 23 Ma e 2089 ± 14 Ma, interpretadas como idades de cristalização destas rochas. Amostras da Seqüência de Silvânia resultaram em isócrona Sm-Nd em rocha total, indicando idade de cristalização de 2262 ± 110 Ma e épsilonNd(T) = +3.0 interpretada como representativa de evento magmático juvenil para estas rochas. Análises isótopicas de Nd em amostras do Granito Jurubatuba resultaram em idades modelo T DM entre 2.30 e 2.42 Ga e valores de épsilonNd(T) variando entre -0.22 e -0.58. O valor mais antigo de idade modelo T DM refere-se a xenólito de rocha metassedimentar no granito. As idades de cristalização paleoproterozóicas da Seqüência de Silvânia e do Granito Jurubatuba são a primeira evidência de evento magmático juvenil ocorrido entre 2.14-2.08 Ga no embasamento da porção central da Faixa Brasília

Experimental Gastric Carcinogenesis in Cebus apella Nonhuman Primates

The evolution of gastric carcinogenesis remains largely unknown. We established two gastric carcinogenesis models in New-World nonhuman primates. In the first model, ACP03 gastric cancer cell line was inoculated in 18 animals. In the second model, we treated 6 animals with N-methyl-nitrosourea (MNU). Animals with gastric cancer were also treated with Canova immunomodulator. Clinical, hematologic, and biochemical, including C-reactive protein, folic acid, and homocysteine, analyses were performed in this study. MYC expression and copy number was also evaluated. We observed that all animals inoculated with ACP03 developed gastric cancer on the 9th day though on the 14th day presented total tumor remission. In the second model, all animals developed pre-neoplastic lesions and five died of drug intoxication before the development of cancer. The last surviving MNU-treated animal developed intestinal-type gastric adenocarcinoma observed by endoscopy on the 940th day. The level of C-reactive protein level and homocysteine concentration increased while the level of folic acid decreased with the presence of tumors in ACP03-inoculated animals and MNU treatment. ACP03 inoculation also led to anemia and leukocytosis. The hematologic and biochemical results corroborate those observed in patients with gastric cancer, supporting that our in vivo models are potentially useful to study this neoplasia. In cell line inoculated animals, we detected MYC immunoreactivity, mRNA overexpression, and amplification, as previously observed in vitro. In MNU-treated animals, mRNA expression and MYC copy number increased during the sequential steps of intestinal-type gastric carcinogenesis and immunoreactivity was only observed in intestinal metaplasia and gastric cancer. Thus, MYC deregulation supports the gastric carcinogenesis process. Canova immunomodulator restored several hematologic measurements and therefore, can be applied during/after chemotherapy to increase the tolerability and duration of anticancer treatments

High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort

Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded from the analyses. Among the remaining 1638 participants who were seronegative at baseline, 214 showed seroconversion at visit 2. The seroconversion incidence was 13·06% (95% CI 11·52–14·79) overall and 6·78% (5·61–8·10) for symptomatic seroconversion, over a median follow-up period of 57 days (IQR 54–61). 48·1% of seroconversion events were estimated to be asymptomatic. The sample had higher proportions of affluent and higher-educated people than those reported for the Manaus city population. In the fully adjusted and corrected model, risk factors for seroconversion before visit 2 were having a COVID-19 case in the household (IRR 1·49 [95% CI 1·21–1·83]), not wearing a mask during contact with a person with COVID-19 (1·25 [1·09–1·45]), relaxation of physical distancing (1·31 [1·05–1·64]), and having flu-like symptoms (1·79 [1·23–2·59]) or a COVID-19 diagnosis (3·57 [2·27–5·63]) between the first and second visits, whereas working remotely was associated with lower incidence (0·74 [0·56–0·97]). Interpretation: An intense infection transmission period preceded the second wave of COVID-19 in Manaus. Several modifiable behaviours increased the risk of seroconversion, including non-compliance with non-pharmaceutical interventions measures such as not wearing a mask during contact, relaxation of protective measures, and non-remote working. Increased testing in high-transmission areas is needed to provide timely information about ongoing transmission and aid appropriate implementation of transmission mitigation measures. Funding: Ministry of Education, Brazil; Fundação de Amparo à Pesquisa do Estado do Amazonas; Pan American Health Organization (PAHO)/WHO.World Health OrganizationRevisión por pare

U-Pb data for granulites of the Anápolis-Itauçu complex: evidence for two high-grade events in the Brasília belt

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PARÂMETROS CINÉTICOS DE MOAGEM DE ITABIRITOS COMPACTO E FRIÁVEL

Duas amostras de minério de ferro classificadas como itabiritos compacto e friável foram testadas com relação a moabilidade. Os testes foram realizados em um moinho de bolas em escala de laboratório com torquímetro para medição precisa da potência. Os parâmetros cinéticos das amostras foram determinados através do aplicativo Moly-Cop Tools 2.0. Simulações foram realizadas com o mesmo aplicativo para previsão do comportamento do circuito de moagem com cada uma das amostras estudadas. Os resultados indicam que a amostra de itabirito friável possui maior consumo específico de energia, mesmo sendo uma amostra de granulometria mais fina que a amostra de itabirito compacto