The energy transition in Europe: a vision of progress

Europe needs a new vision of progress. An energy transition has this potential. It can give the "European idea" a future-oriented content. The goal for 2050 is clear: a Europe without fossil and nuclear energy! This is not a utopia. Studies, resolutions of the EU and some member states prove that this vision is feasible and has many advantages: more jobs, more security of supply, fewer premature deaths due to air pollution, reduction of resource conflicts, falling energy costs. New green lead markets for renewable energies and resource efficiency are emerging. A European energy transition requires an alliance, ideally fuelled by neighbours France and Germany. Many are hoping for Germany as a driver of nuclear and coal phase-out. But deciding on "revolutionary goals" is not enough: finally implementing them is what Germany and Europe are waiting for. This report shows which concrete steps can advance this vision of progress

Giants and dwarfs:the multilevel lobbying strategies of national interest organizations

The article addresses the bias in interest representation within the EU by examining the lobbying strategies of national interest organisations within the EU’s multilevel political system. Both our theoretical framework, which includes the determinants of a national interest organisation's decision to act at the EU level, and the data analysis from the INTEREURO Multi-Level Governance Module (MLG) (www.intereuro.eu) reveal three main findings. Firstly, the greatest differentiation among interest organisations (IOs) appears to be between those IOs from the older member states (Germany, the UK and the Netherlands), which exhibit above-average levels of activity, and those from the newer EU member states (Sweden, Slovenia), which exhibit below-average levels of activity. Secondly, the variations in IO activity levels are much greater from country to country than from one policy field to another. Thirdly, although the IOs from all five countries in our study are more likely to employ media and publishing strategies (information politics) than to mobilise their members and supporters (protest politics), we can still observe national patterns in their selection of strategies and in the intensity of their instrumentalisation

The Effect of AICAR-Induced AMPK Activation on Gene Expression in Sarcopenic Muscle

The loss of muscle mass and function (sarcopenia) afflicts 11-74% of all aging adults, with prevalence increasing with age. Exercise training is clearly effective in preventing or attenuating sarcopenia. The cellular mechanisms of exercise’s protective effects are not entirely clear, but AMP-activated protein kinase (AMPK) is thought to play an important role, in part by regulating gene expression. PURPOSE: To determine the effect of chronic pharmacological AMPK activation on skeletal muscle gene expression in sarcopenic muscle. METHODS: 24-month-old C57Bl/6J mice received either one acute injection or chronic daily saline injections of the AMPK-activating drug AICAR for 31 days. 5-month-old saline-injected mice served as young controls for reference. Treadmill running capacity was measured before and after treatment. Expression of genes relating to mitochondria, muscle size regulation, and inflammation was measured by real-time polymerase chain reaction (RT-PCR). RESULTS: One hour after a single injection of AICAR, raptor phosphorylation was increased in both young and old mice, indicating AMPK activation. Phosphorylation of the mTORC1 targets 4EBP1, and S6k were both elevated in old muscle, consistent with previous reports of hyperactivated mTORC1 in aged muscle. Acute AICAR injection returned 4EBP1 and S6k phosphorylation to young levels. RNA sequencing demonstrated that chronic AICAR injections restored the expression of many genes in old muscle to the levels observed in young muscle. Among these, mitochondrial splicing suppressor 51 (Mss51) expression, which is associated with impaired mitochondrial function and muscle loss, was elevated in sarcopenic muscle but attenuated by AICAR treatment, and this was confirmed by RT-PCR analysis. CONCLUSION: AICAR treatment reverses several critical age-related changes in gene expression and mTORC1 activity. Our findings support further investigation of AMPK activation and Mss51 repression as targets for therapeutic interventions in sarcopenia

Playful mapping in the digital age:The Playful Mapping Collective

From Mah-Jong, to the introduction of Prussian war-games, through to the emergence of location-based play: maps and play share a long and diverse history. This monograph shows how mapping and playing unfold in the digital age, when the relations between these apparently separate tropes are increasingly woven together. Fluid networks of interaction have encouraged a proliferation of hybrid forms of mapping and playing and a rich plethora of contemporary case-studies, ranging from fieldwork, golf, activism and automotive navigation, to pervasive and desktop-based games evidences this trend. Examining these cases shows how mapping and playing can form productive synergies, but also encourages new ways of being, knowing and shaping our everyday lives. The chapters in this book explore how play can be more than just an object or practice, and instead focus on its potential as a method for understanding maps and spatiality. They show how playing and mapping can be liberating, dangerous, subversive and performative

Die Energiewende in Europa : eine Fortschrittsvision

Europa braucht eine neue Fortschrittsvision. Eine Energiewende hat dieses Potenzial. Sie kann der "Europäischen Idee" einen zukunftsorientierten Inhalt geben. Das Ziel für 2050 ist klar: ein Europa ohne fossile und nukleare Energie! Das ist keine Utopie. Studien, Beschlüsse der EU und einiger Mitgliedsländer belegen, dass diese Vision machbar und mit vielen Vorteilen verbunden ist: mehr Jobs, mehr Versorgungssicherheit, weniger vorzeitige Todesfälle durch Luftverschmutzung, Abbau von Ressourcenkonflikten, sinkende Energiekosten. Neue grüne Leitmärkte für erneuerbare Energien und Ressourceneffizienz entstehen. Eine europäische Energiewende erfordert eine Allianz, idealerweise angefeuert durch die Nachbarn Frankreich und Deutschland. Viele hoffen auf Deutschland als Treiber von Atom- und Kohleausstieg. Aber "revolutionäre Ziele" zu beschließen ist nicht genug: Sie endlich umzusetzen - darauf warten Deutschland und Europa. Dieses Buch zeigt, welche konkreten Schritte diese Fortschrittsvision voranbringen werden

The Experimental Regional Ensemble Forecast System (ExREF): Its Use in NWS Forecast Operations and Preliminary Verification

The Experimental Regional Ensemble Forecast (ExREF) system is a tool for the development and testing of new Numerical Weather Prediction (NWP) methodologies. ExREF is run in nearrealtime by the Global Systems Division (GSD) of the NOAA Earth System Research Laboratory (ESRL) and its products are made available through a website, an ftp site, and via the Unidata Local Data Manager (LDM). The ExREF domain covers most of North America and has 9km horizontal grid spacing. The ensemble has eight members, all employing WRFARW. The ensemble uses a variety of initial conditions from LAPS and the Global Forecasting System (GFS) and multiple boundary conditions from the GFS ensemble. Additionally, a diversity of physical parameterizations is used to increase ensemble spread and to account for the uncertainty in forecasting extreme precipitation events. ExREF has been a component of the Hydrometeorology Testbed (HMT) NWP suite in the 20122013 and 20132014 winters. A smaller domain covering just the West Coast was created to minimize bandwidth consumption for the NWS. This smaller domain has and is being distributed to the National Weather Service (NWS) Weather Forecast Office and California Nevada River Forecast Center in Sacramento, California, where it is ingested into the Advanced Weather Interactive Processing System (AWIPS I and II) to provide guidance on the forecasting of extreme precipitation events. This paper will review the cooperative effort employed by NOAA ESRL, NASA SPoRT (Shortterm Prediction Research and Transition Center), and the NWS to facilitate the ingest and display of ExREF data utilizing the AWIPS I and II D2D and GFE (Graphical Software Editor) software. Within GFE is a very useful verification software package called BoiVer that allows the NWS to utilize the River Forecast Center's 4 km gridded QPE to compare with all operational NWP models 6hr QPF along with the ExREF mean 6hr QPF so the forecasters can build confidence in the use of the ExREF in preparing their rainfall forecasts. Preliminary results will be presented

National interest organisations in EU policy-making

Comparative and EU interest group studies are marked by a progression towards theory-driven, large-N empirical studies in the past 20 years. With the study of national interest organisations in EU policy-making, this special issue puts centre stage a theoretically and empirically neglected topic in this research field. The individual contributions include interest group characteristics, institutional contexts as well as issue contexts as explanatory factors in their empirical analyses of multilevel interest representation. They present novel developments in the study of political alignments among interest groups and political institutions, the Europeanisation of domestic interest organisations, and the question of bias in interest group populations. Thereby, they not only contribute to the comparative study of interest groups, but also to the analysis of policy-making, multilevel governance, and political representation in the EU

Development of a Fetal Weight Chart using Serial Trans-Abdominal Ultrasound in an East African Population: A Longitudinal Observational Study.

To produce a fetal weight chart representative of a Tanzanian population, and compare it to weight charts from Sub-Saharan Africa and the developed world. A longitudinal observational study in Northeastern Tanzania. Pregnant women were followed throughout pregnancy with serial trans-abdominal ultrasound. All pregnancies with pathology were excluded and a chart representing the optimal growth potential was developed using fetal weights and birth weights. The weight chart was compared to a chart from Congo, a chart representing a white population, and a chart representing a white population but adapted to the study population. The prevalence of SGA was assessed using all four charts. A total of 2193 weight measurements from 583 fetuses/newborns were included in the fetal weight chart. Our chart had lower percentiles than all the other charts. Most importantly, in the end of pregnancy, the 10(th) percentiles deviated substantially causing an overestimation of the true prevalence of SGA newborns if our chart had not been used. We developed a weight chart representative for a Tanzanian population and provide evidence for the necessity of developing regional specific weight charts for correct identification of SGA. Our weight chart is an important tool that can be used for clinical risk assessments of newborns and for evaluating the effect of intrauterine exposures on fetal and newborn weight

Who says what to whom? Alignments and arguments in EU policy-making

In the EU multilevel polity, domestic interest groups seek to shape EU legislation by accessing both national and EU institutions. Previous studies indicated that institutional and issue contexts, as well as organizational characteristics shape their strategies of interest representation. However, we know much less about how alignments and arguments impact on their participation in EU and national policy consultations. Addressing this gap, we investigate the lobbying strategies of almost 2,900 national interest organizations from five member states (Germany, the Netherlands, Slovenia, Sweden, and the United Kingdom) on 20 EU directive proposals bringing also a new empirical scope to the study of multilevel interest representation. The findings indicate that alignments and arguments shape the participation of domestic interest groups in consultations on EU policies. We infer from our study that some general predictions of interest group behaviour are overstretched and outline four variations of interest representation routines