39 research outputs found

    PROJECT AUTOMATION APPLICATION WITH LEAN PHILOSOPHY AT THE CONSTRUCTION OF OIL REFINING UNIT

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    Increased investment in the oil industry and Brazil gas, led to the improvement in construction and assembly processes of a hydrotreating unit cracked naphtha in oil refining sub-area. Thus, the resutado achieved was mainly credited to the support of automation tools projects and principles of Lean Construction. In this way the study seeks to demonstrate the role of design automation tools, Lean philosophy and trend identified after critical analysis of the empirical study in what should be recommended for future construction and assembly, it is the sustainable logistics. Especially in the historical context of high demand for construction of oil refineries to meet the pre-salt layer in Brazil in the last 10 years. The goal is to demonstrate the results achieved through the visual management of the planning and control of construction with contrutibilidade lean principles and philosophy. This methodology is qualitative predominanemente stamp from exploratory and descriptive analysis, through bibliographic, bibliometric and experimental study in order to show barriers and benefits of utlização automation vinuladas projects tools to Lean Construction of principles with future pespectivas for logistics sustainable in the oil and gas industr

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

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    The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability

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    Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) wide-spread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications

    Subcortical brain volume, regional cortical thickness, and cortical surface area across disorders: findings from the ENIGMA ADHD, ASD, and OCD Working Groups

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    Objective Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positioned to investigate structural brain alterations across these disorders. Methods Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD (n=2,271), ASD (n=1,777), and OCD (n=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. We examined subcortical volume, cortical thickness and surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults using linear mixed-effects models adjusting for age, sex and site (and ICV for subcortical and surface area measures). Results We found no shared alterations among all three disorders, while shared alterations between any two disorders did not survive multiple comparisons correction. Children with ADHD compared to those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller ICV than controls and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared to adult controls and other clinical groups. No OCD-specific alterations across different age-groups and surface area alterations among all disorders in childhood and adulthood were observed. Conclusion Our findings suggest robust but subtle alterations across different age-groups among ADHD, ASD, and OCD. ADHD-specific ICV and hippocampal alterations in children and adolescents, and ASD-specific cortical thickness alterations in the frontal cortex in adults support previous work emphasizing neurodevelopmental alterations in these disorders

    Orbitally Shaken Single-Use Bioreactors

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    In cloud computing, lock-in refers to the difficulty of porting an application from one platform to another. An example of such difficulty can be witnessed when porting an application from Platform-as-a-Service Google App Engine to Microsoft Azure. Differences in their implementations are substantial, yielding non-portable applications. Standardization could address this problem, but existing initiatives are still to be accepted. This paper addresses lock-in by proposing a model-driven engineering design approach that decouples platform specific code from the application logic. The resulting platform-independent models, as well as corresponding model transformations, can be reused to generate distinct platform-specific implementations, hence reducing the programming effort spent coding repetitive tasks. Such transformations can be made available for reuse on a repository for cloud providers. We have implemented transformations to handle persistence for Google App Engine and Azure, and discuss how model-driven engineering can reconcile the differences between features of the persistence models of GAE and Azure.FAPESP (processes 2012/24487-3 and 2012/04549-4)Coordination of Superior Level Staff Improvement - CAPESBrazil-Europe Erasmus Mundus project (process BM13DM0002

    Review of literature of attention-deficit/hyperactivity disorder with comorbid eating disorders Revisão da literatura sobre a comorbidade do transtorno do déficit de atenção e hiperatividade com transtornos alimentares

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    OBJECTIVE: According to studies of prevalence, up to 70% of adults with attention deficit/hyperactivity disorder have at least one psychiatric comorbidity, which leads to diagnostic and therapeutic difficulties as well as more severe functional impairment. There is a paucity of data on the comorbidity of attention deficit/hyperactivity disorder and eating disorders. The objective of this study was to review the literature regarding the attention deficit/hyperactivity disorder/eating disorders comorbidity, performing a critical analysis of relevant data. METHOD: Articles in Medline, Lilacs, SciELO, ISI and PsycINFO databases from 1980 up to 2008, were searched. The references from the articles were used as additional sources of data. RESULTS: Fourteen articles were found: five prevalence studies, four case reports, three case-control studies, one symptom-assessment study of attention deficit/hyperactivity disorder and eating disorders, and one article regarding possible causes of the association between attention deficit/hyperactivity disorder and eating disorders. These articles suggested that adult women with attention deficit/hyperactivity disorder are at higher risk of developing eating disorders, especially bulimia nervosa. Bulimia Nervosa rates found in attention deficit/hyperactivity disorder groups ranged from 1% to 12%, versus 0% to 2% in control groups. CONCLUSIONS: Although there seems to be a relationship between attention deficit/hyperactivity disorder and eating disorders, the reduced number of studies available, with various methodologies, and small sample sizes limit the generalization of the findings.OBJETIVO: De acordo com os estudos de prevalência de comorbidades, até 70% dos adultos com transtorno do déficit de atenção e hiperatividade apresentam pelo menos uma comorbidade psiquiátrica, ocasionando dificuldades diagnósticas e terapêuticas, bem como um maior prejuízo funcional. Existem poucos estudos sobre a comorbidade entre transtorno do déficit de atenção e hiperatividade e transtornos alimentares. O objetivo deste estudo foi realizar uma revisão da literatura sobre a comorbidade transtorno do déficit de atenção e hiperatividade/transtornos alimentares, realizando uma análise crítica dos dados encontrados. MÉTODO: Procedeu-se a uma revisão sistemática da literatura por meio de pesquisa bibliográfica de artigos publicados no período de 1980 a 2008, utilizando as bases de dados Medline, Lilacs, SciELO, ISI e PsycINFO. RESULTADOS: Foram identificados 14 artigos, sendo cinco estudos de prevalência de comorbidades, quatro relatos de casos, três estudos caso-controle, um estudo de avaliação de sintomas de transtorno do déficit de atenção e hiperatividade e de transtornos alimentares e um sobre as possíveis causas da associação entre transtorno do déficit de atenção e hiperatividade e transtornos alimentares. Os artigos identificados evidenciaram maior risco de desenvolvimento de transtornos alimentares, especialmente bulimia nervosa, em mulheres portadoras de transtorno do déficit de atenção e hiperatividade. As taxas de bulimia nervosa encontradas nos grupos com transtorno do déficit de atenção e hiperatividade variaram de 1% a 12%, enquanto que nos grupos controle foram de 0% a 2%. CONCLUSÕES: Embora pareça existir uma relação entre transtorno do déficit de atenção e hiperatividade e transtornos alimentares, a escassez de trabalhos existentes, com metodologias variadas e pequenas amostras avaliadas não permitem a generalização dos resultados

    O uso das terapias Reiki e Floral na melhoria da Qualidade de Vida da Pessoa Vivendo com HIV/Aids: Uma contribuição da Enfermagem.

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    INTRODUÇÃO: O estigma vivenciado por Pessoas Vivendo com HIV/Aids (PVHA) podem interferir diretamente na Qualidade de Vida (QV). A Organização Mundial de Saúde (OMS) diz que QV é a percepção subjetiva do indivíduo quanto aos seus sentimentos e comportamentos no contexto social, familiar e cultural. As Práticas Integrativas e Complementares em Saúde (PICS), utilizam mecanismos complementares que podem ser utilizados de forma auxiliar a terapia tradicional.  O Reiki, com a proposta de reposição energética; e a Terapia Floral, com ação não invasiva e sem princípio ativo, que se utiliza da energia extraídas das flores, a fim de tratar as alterações da personalidade, valorizando a essência humana, são duas destas PICS que podem contribuir para a melhoria na QV. O presente trabalho está vinculado ao projeto de extensão Pessoas vivendo com HIV/Aids e a Terapia Floral: Ações para potencializar a adesão ao tratamento; e, é parte de um dos critérios de avaliação do projeto. OBJETIVOS: Medir a QV das PVHA em uso de Reiki e/ou Floral em atendimento no projeto de extensão. PROCEDIMENTOS METODOLÓGICOS: Este estudo busca trazer subsídios para a avaliação do projeto de extensão ao qual está vinculado. Tem um desenho quantitativo exploratório com 25 PVHA, em auxílio do questionário WHOQOL-HIV BREF da OMS. Todos em tratamento regular em unidade de saúde, informadas e esclarecidas quanto a realização da pesquisa além da assinatura do termo de consentimento livre e esclarecido para participar do projeto. O primeiro autopreenchimento do questionário ocorreu antes de qualquer intervenção, sendo então encaminhadas para a Consulta de Enfermagem e aplicações das terapias. A reaplicação dos demais questionários passou a ser feita trimestralmente. Os dados são tabulados e armazenados em planilha Excel. Os atendimentos aconteceram no espaço PIPA (Programa Integrado Pesquisa-Assistência) na Escola de Enfermagem Anna Nery, quinzenalmente entre os meses Março/2013 a Julho/2015. PRINCIPAIS RESULTADOS: Após análise comparativa entre o primeiro questionário aplicado e o último, foi possível observar que nos domínios contendo questões voltadas especificamente à PVHA: houve uma melhora em 58% dos usuários no domínio Físico; manutenção dos índices positivos prévios por parte de 67% dos usuários no domínio de Crenças e Religiosidade. Até o momento não verificamos alteração no domínio das Relações Sociais. CONCLUSÕES: Como resultado preliminar, podemos verificar que o uso das terapias Reiki e Floral fornecidas pelo projeto favoreceram a melhora da QV das PVHA
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