Project SPACE: Solar Panel Automated Cleaning Environment

The goal of Project SPACE is to create an automated solar panel cleaner that will address the adverse impact of soiling on commercial photovoltaic cells. Specifically, we hoped to create a device that increases the maximum power output of a soiled panel by 10% (recovering the amount of power lost) while still costing under $500 and operating for up to 7.0 years. A successful design should operate without the use of water. This will help solar panel arrays achieve a production output closer to their maximum potential and save companies on costs associated energy generation. The current apparatus utilizes a brush cleaning system that cleans on set cleaning cycles. The device uses the combination of a gear train (with 48 pitch Delrin gears) and a 12V DC motor to spin both a 5.00 foot long, 0.25 inch diameter vacuum brush shaft and drive two sets of two wheels. The power source for the drive train is a 12V deep cycle lead-acid battery. Our light weight design eliminates water usage during cleaning and reduces the potential dangers stemming from manual labor. Our design’s retail price was estimated to be around$700 with a payback period of less than 3.5 years. To date, we have created a device that improves the efficiency of soiled solar panels by 3.5% after two runs over the solar panel. We hope that our final design will continue to expand the growth of solar energy globally

Coastal Capital -- Economic Valuation of Coral Reefs in Tobago and St. Lucia

Presents findings on the economic benefits of coral reefs to the local economies of Tobago and St. Lucia, using a new, broadly applicable methodology that focuses on benefits to tourism, fisheries, and shoreline protection. Includes policy applications

An Examination of Product Hopping by Brand-Name Prescription Drug Manufacturers: The Problem and a Proposed Solution

The balance between incentivizing innovation through exclusivity protection and maintaining competitive market conditions—including prices for consumers—is a difficult line to toe. Product hopping has characteristics that constitute a violation of the Sherman Antitrust Act because companies can maintain monopoly power in the pharmaceutical market. While some monopoly power is justified as an incentive for incredibly costly innovation, extended periods of exclusivity harms consumers by keeping prescription drug prices artificially inflated. Allowing generic drug manufacturers to compete sooner in the prescription drug market by disallowing product hopping by name-brand pharmaceutical drug companies will aid in driving down prices. Courts should adopt the Second Circuit’s test for whether a particular activity by a pharmaceutical drug company is monopolistic and a violation of the Sherman Act

Geophysical Analysis Of The Paleogeothermal Gradient And Heat Flow In The Williston Basin, ND

Past researchers have suggested that elevated heat flow once existed in the Williston Basin during the Eocene Epoch or younger time frame, based on petroleum maturity indices data. Further, they have argued that those attempting to computationally model the region have incorrectly assumed constant heat flow through time. The present work attempts to address the different positions taken by updating geophysical modeling evidence concerning heat flow in the Williston Basin in which paleogeothermal conditions are variable over geologic time. After conducting the investigation, present research demonstrates that elevated heat flow may have existed in the Williston Basin in the geologic past but did not necessarily have to occur during or after the time period suggested. Furthermore, variable radioactivity in the crystalline basement rock demonstrated by the present models can explain the enhanced thermal maturity described by past researchers. Only more detailed study will eventually lead the scientific community to a more precise explanation of the cause and time constraints of such paleogeothermal conditions

A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics.

Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome reduction. However, it remains largely unknown which nutrients they acquire and whether their metabolic dependency can be exploited therapeutically. Here, we describe a genetic rewiring of bacterial isoprenoid biosynthetic pathways in the Rickettsiales that has resulted from reductive genome evolution. Furthermore, we investigated whether the spotted fever group Rickettsia species Rickettsia parkeri scavenges isoprenoid precursors directly from the host. Using targeted mass spectrometry, we found that infection caused decreases in host isoprenoid products and concomitant increases in bacterial isoprenoid metabolites. Additionally, we report that treatment of infected cells with statins, which inhibit host isoprenoid synthesis, prohibited bacterial growth. We show that growth inhibition correlates with changes in bacterial size and shape that mimic those caused by antibiotics that inhibit peptidoglycan biosynthesis, suggesting that statins lead to an inhibition of cell wall synthesis. Altogether, our results describe a potential Achilles' heel of obligate intracellular pathogens that can potentially be exploited with host-targeted therapeutics that interfere with metabolic pathways required for bacterial growth.IMPORTANCE Obligate intracellular pathogens, which include viruses as well as certain bacteria and eukaryotes, are a subset of infectious microbes that are metabolically dependent on and unable to grow outside an infected host cell because they have lost or lack essential biosynthetic pathways. In this study, we describe a metabolic dependency of the bacterial pathogen Rickettsia parkeri on host isoprenoid molecules that are used in the biosynthesis of downstream products, including cholesterol, steroid hormones, and heme. Bacteria make products from isoprenoids, such as an essential lipid carrier for making the bacterial cell wall. We show that bacterial metabolic dependency can represent a potential Achilles' heel and that inhibiting host isoprenoid biosynthesis with the FDA-approved statin class of drugs inhibits bacterial growth by interfering with the integrity of the cell wall. This work supports the potential to treat infections by obligate intracellular pathogens through inhibition of host biosynthetic pathways that are susceptible to parasitism