415 research outputs found
Prevalence, treatment, and control of dyslipidemia in diabetic participants of two Brazilian cohorts: a place far from heaven
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 02/04/2020
- Field of study
Diabetes is one of the leading causes of cardiovascular mortality. Over the last years, mortality has decreased significantly, more in individuals with diabetes than in healthy ones. That is mostly due to the control of other cardiovascular risk factors. The objective of our study was to analyze the dyslipidemia control in two diabetes cohorts. Patients from two distinct cohorts were studied, 173 patients from the BHS (Brasilia Heart Study) and 222 patients from the BDS (Brazilian Diabetes Study). The data on dyslipidemia control were studied in both different populations. All patients had diabetes. There are significant differences concerning comorbidities between the LDL-C and BDS groups. The average glycated hemoglobin is of 8.2 in the LDL-C > 100 group in comparison with 7.7 and 7.5 in the 70-100 and 100 groups (54.3% and 54.9%, respectively; p = 0.005). Diastolic pressure is higher in the group with LDL > 100, with an average of 87 mmHg, in comparison with 82.6 mmHg and 81.9 mmHg in the 70-100 and 100 has the greatest percentage of smokers (8.7%) in comparison with the groups with LDL between 70-100 and 100 groups, respectively (p < 0.001). The data in our study have shown that the dyslipidemia control in diabetic patients is inadequate and there is a tendency of direct association between lack of blood glucose control and lack of dyslipidemia control, in addition to the association with other cardiovascular risk factors, such as diastolic hypertension and smoking. This worsened control might be related to the plateau in the descending curve of mortality, and investments in this regard can improve the cardiovascular health in diabetic patients.6513
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
- Author
- Agrela Marcus V
- Amorim Mariene R
- Bernardes Ana F
- Bispos-dos-Santos Karina
- Bloyet Louis-Marie
- Boldrini Vinicius O
- Brunetti Natalia S
- Buscaratti Lucas I
- Carregari Victor C
- Carvalho Murilo
- Carvalho Robson F
- Castelucci Bianca G
- Castro Icaro MS
- Coimbra Laís D
- Crunfli Fernanda
- Cunha Thiago Mattar
- da Silva Luis LP
- Damasio André
- Davanzo Gustavo G
- de Moraes Diogo
- de Oliveira Eduardo B
- Dias Artur HS
- Dias Marieli MG
- Faca Vitor M
- Farias Alessandro S
- Ferrari Allan JR
- Figueira Ana Carolina M
- Forato Julia
- Gerhardt Jaqueline A
- Gomes Arilson Bernardo SP
- Granja Fabiana
- Knittel Thiago L
- Ludwig Raissa G
- Mansour Eli
- Marques Ana Maria
- Marques Rafael E
- Marques-Souza Henrique
- Martini Matheus Cavalheiro
- Martins-de-Souza Daniel
- Monteiro Lauar B
- Moraes-Vieira Pedro MM
- Moretti Maria Luiza
- Mori Marcelo A
- Munhoz-Alves Natália
- Muraro Stéfanie Primon
- Nakaya Helder I
- Nunes Santos Luana
- Nunes Thyago A
- Palma André C
- Parise Pierina Lorencini
- Pereira Alexandre B
- Pereira Fabricio B
- Pontelli Marjorie C
- Proenca-Modena Jose Luiz
- Profeta Gerson S
- Ribeiro Luciana C
- Rodrigues Patricia B
- Santos Leonilda MB
- Sesti-Costa Renata
- Silva-Costa Lícia C
- Silvestrini Virgínia C
- Simeoni Camila L
- Skaf Munir S
- Souza Gabriela F
- Sposito Andrei C
- Stumpf Spencer
- Tavares Lucas A
- Toledo-Teixeira Daniel A
- Ulaf Raisa G
- Velloso Licio
- Veras Flavio P
- Vieira André S
- Vinolo Marco AR
- Virgílio-da-Silva João Victor
- Wassano Natália S
- Whelan Sean
- Publication venue
- Publication date
- 31/07/2023
- Field of study
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS-CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.</p
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
- Author
- Agrela Marcus V
- Amorim Mariene R
- Bernardes Ana F
- Bispos-dos-Santos Karina
- Bloyet Louis-Marie
- Boldrini Vinicius O
- Brunetti Natalia S
- Buscaratti Lucas I
- Carregari Victor C
- Carvalho Murilo
- Carvalho Robson F
- Castelucci Bianca G
- Castro Icaro MS
- Coimbra Laís D
- Crunfli Fernanda
- Cunha Thiago Mattar
- da Silva Luis LP
- Damasio André
- Davanzo Gustavo G
- de Moraes Diogo
- de Oliveira Eduardo B
- Dias Artur HS
- Dias Marieli MG
- Faca Vitor M
- Farias Alessandro S
- Ferrari Allan JR
- Figueira Ana Carolina M
- Forato Julia
- Gerhardt Jaqueline A
- Gomes Arilson Bernardo SP
- Granja Fabiana
- Knittel Thiago L
- Ludwig Raissa G
- Mansour Eli
- Marques Ana Maria
- Marques Rafael E
- Marques-Souza Henrique
- Martini Matheus Cavalheiro
- Martins-de-Souza Daniel
- Monteiro Lauar B
- Moraes-Vieira Pedro MM
- Moretti Maria Luiza
- Mori Marcelo A
- Munhoz-Alves Natália
- Muraro Stéfanie Primon
- Nakaya Helder I
- Nunes Santos Luana
- Nunes Thyago A
- Palma André C
- Parise Pierina Lorencini
- Pereira Alexandre B
- Pereira Fabricio B
- Pontelli Marjorie C
- Proenca-Modena Jose Luiz
- Profeta Gerson S
- Ribeiro Luciana C
- Rodrigues Patricia B
- Santos Leonilda MB
- Sesti-Costa Renata
- Silva-Costa Lícia C
- Silvestrini Virgínia C
- Simeoni Camila L
- Skaf Munir S
- Souza Gabriela F
- Sposito Andrei C
- Stumpf Spencer
- Tavares Lucas A
- Toledo-Teixeira Daniel A
- Ulaf Raisa G
- Velloso Licio
- Veras Flavio P
- Vieira André S
- Vinolo Marco AR
- Virgílio-da-Silva João Victor
- Wassano Natália S
- Whelan Sean
- Publication venue
- Publication date
- 31/07/2023
- Field of study
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS-CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.</p
Pyoverdine use for the control of passion fruit bacterial blight
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Azimuthal di-hadron correlations in d+Au and Au+Au collisions at sNN=200 GeV from STAR
- Author
- Aggarwal M. M.
- Ahammed Z.
- Alakhverdyants A. V.
- Alekseev I.
- Alford J.
- Anderson B. D.
- Anson Daniel
- Arkhipkin D.
- Averichev G. S.
- Balewski J.
- Barnby L. S.
- Baumgart S.
- Beavis D. R.
- Bellwied R.
- Betancourt M. J.
- Betts R. R.
- Bhasin A.
- Bhati A. K.
- Bichsel H.
- Bielcik J.
- Bielcikova J.
- Biritz B.
- Bland L. C.
- Bonner B. E.
- Bouchet J.
- Braidot E.
- Brandin A. V.
- Bridgeman A.
- Bruna E.
- Bueltmann S.
- Bunzarov I.
- Burton T. P.
- Cai X. Z.
- Caines H.
- Calderon M.
- Catu O.
- Cebra D.
- Cendejas R.
- Cervantes M. C.
- Chajecki Z.
- Chaloupka P.
- Chattopadhyay S.
- Chen H. F.
- Chen J. H.
- Chen J. Y.
- Cheng J.
- Cherney M.
- Chikanian A.
- Choi K. E.
- Christie W.
- Chung P.
- Clarke R. F.
- Codrington M. J. M.
- Corliss R.
- Cramer J. G.
- Crawford H. J.
- Das D.
- Dash S.
- De Silva L. C.
- de Souza R. Derradi
- de Toledo A. Szanto
- Debbe R. R.
- Dedovich T. G.
- Derevschikov A. A.
- Didenko L.
- Djawotho P.
- Dogra S. M.
- Dong X.
- Drachenberg J. L.
- Draper J. E.
- Dunlop J. C.
- Efimov L. G.
- Elhalhuli E.
- Elnimr M.
- Engelage J.
- Eppley G.
- Erazmus B.
- Estienne M.
- Eun L.
- Evdokimov O.
- Fachini P.
- Fatemi R.
- Fedorisin J.
- Fersch R. G.
- Filip P.
- Finch E.
- Fine V.
- Fisyak Y.
- Gagliardi C. A.
- Gangadharan D. R.
- Ganti M. S.
- Garcia-Solis E. J.
- Geromitsos A.
- Geurts F.
- Ghazikhanian V.
- Ghosh P.
- Gorbunov Y. N.
- Gordon A.
- Grebenyuk O.
- Grosnick D.
- Guertin S. M.
- Gupta A.
- Gupta N.
- Guryn W.
- Haag B.
- Hamed A.
- Han L-X.
- Harris J. W.
- Hays-Wehle J. P.
- Heinz M.
- Heppelmann S.
- Hirsch A.
- Hjort E.
- Hoffman A. M.
- Hoffmann G. W.
- Hofman D. J.
- Huang B.
- Huang H. Z.
- Humanic T. J.
- Huo L.
- Igo G.
- Jacobs P.
- Jacobs W. W.
- Jena C.
- Jin F.
- Jones C. L.
- Jones P. G.
- Joseph J.
- Judd E. G.
- Kabana S.
- Kajimoto K.
- Kang K.
- Kapitan J.
- Kauder K.
- Keane D.
- Kechechyan A.
- Kettler D.
- Kikola D. P.
- Kiryluk J.
- Kisiel A.
- Klein S. R.
- Knospe A. G.
- Kocoloski A.
- Koetke D. D.
- Kollegger T.
- Konzer J.
- Koralt I.
- Koroleva L.
- Korsch W.
- Kotchenda L.
- Kouchpil V.
- Kravtsov P.
- Krueger K.
- Krus M.
- Kumar L.
- Kurnadi P.
- Lamont M. A. C.
- Landgraf J. M.
- LaPointe S.
- Lauret J.
- Lebedev A.
- Lednicky R.
- Lee C-H.
- Lee J. H.
- Leight W.
- LeVine M. J.
- Leyva A. Davila
- Li C.
- Li L.
- Li N.
- Li W.
- Li X.
- Li X.
- Li Y.
- Li Z. M.
- Lin G.
- Lindenbaum S. J.
- Lisa M. A.
- Liu F.
- Liu H.
- Liu J.
- Ljubicic T.
- Llope W. J.
- Longacre R. S.
- Love W. A.
- Lu Y.
- Lukashov E. V.
- Luo X.
- Ma G. L.
- Ma Y. G.
- Mahapatra D. P.
- Majka R.
- Mall O. I.
- Mangotra L. K.
- Manweiler R.
- Margetis S.
- Markert C.
- Masui H.
- Matis H. S.
- Matulenko Yu. A.
- Mazumdar M. R. Dutta
- McDonald D.
- McShane T. S.
- Meschanin A.
- Milner R.
- Minaev N. G.
- Mioduszewski S.
- Mischke A.
- Mitrovski M. K.
- Mohanty B.
- Mondal M. M.
- Morozov B.
- Morozov D. A.
- Munhoz M. G.
- Nandi B. K.
- Nattrass C.
- Nayak T. K.
- Nelson J. M.
- Netrakanti P. K.
- Ng M. J.
- Nogach L. V.
- Nurushev S. B.
- Odyniec G.
- Ogawa A.
- Okorokov V.
- Oldag E. W.
- Olson D.
- Pachr M.
- Page B. S.
- Pal S. K.
- Pandit Y.
- Panebratsev Y.
- Pawlak T.
- Peitzmann T.
- Perevoztchikov V.
- Perkins C.
- Peryt W.
- Phatak S. C.
- Pile P.
- Planinic M.
- Ploskon M. A.
- Pluta J.
- Plyku D.
- Poljak N.
- Poskanzer A. M.
- Potukuchi B. V. K. S.
- Powell C. B.
- Prindle D.
- Pruneau C.
- Pruthi N. K.
- Pujahari P. R.
- Putschke J.
- Qiu H.
- Raniwala R.
- Raniwala S.
- Ray R. L.
- Redwine R.
- Reed R.
- Ritter H. G.
- Roberts J. B.
- Rogachevskiy O. V.
- Romero J. L.
- Rose A.
- Roy C.
- Ruan L.
- Sahoo R.
- Sakai S.
- Sakrejda I.
- Sakuma T.
- Salur S.
- Sandweiss J.
- Sangaline E.
- Schambach J.
- Scharenberg R. P.
- Schmitz N.
- Schuster T. R.
- Seele J.
- Seger J.
- Selyuzhenkov I.
- Seyboth P.
- Shahaliev E.
- Shao M.
- Sharma M.
- Shi S. S.
- Sichtermann E. P.
- Simon F.
- Singaraju R. N.
- Skoby M. J.
- Smirnov N.
- Sorensen P.
- Sowinski J.
- Spinka H. M.
- Srivastava B.
- Stanislaus T. D. S.
- STAR Collaboration
- Staszak D.
- Stevens J. R.
- Stock R.
- Strikhanov M.
- Stringfellow B.
- Suaide A. A. P.
- Suarez M. C.
- Subba N. L.
- Sumbera M.
- Sun X. M.
- Sun Y.
- Sun Z.
- Surrow B.
- Svirida D. N.
- Symons T. J. M.
- Takahashi J.
- Tang A. H.
- Tang Z.
- Tarini L. H.
- Tarnowsky T.
- Thein D.
- Thomas J. H.
- Tian J.
- Timmins A. R.
- Timoshenko S.
- Tlusty D.
- Tokarev M.
- Trainor T. A.
- Tram V. N.
- Trentalange S.
- Tribble R. E.
- Tsai O. D.
- Ulery J.
- Ullrich T.
- Underwood D. G.
- Van Buren G.
- van Leeuwen M.
- van Nieuwenhuizen G.
- Vanfossen Jr., J. A.
- Varma R.
- Vasconcelos G. M. S.
- Vasiliev A. N.
- Videbaek F.
- Viyogi Y. P.
- Vokal S.
- Voloshin S. A.
- Wada M.
- Walker M.
- Wang F.
- Wang G.
- Wang H.
- Wang J. S.
- Wang Q.
- Wang X. L.
- Wang Y.
- Webb G.
- Webb J. C.
- Westfall G. D.
- Whitten Jr. C.
- Wieman H.
- Wissink S. W.
- Witt R.
- Wu Y. F.
- Xie W.
- Xu H.
- Xu N.
- Xu Q. H.
- Xu W.
- Xu Y.
- Xu Z.
- Xue L.
- Yang Y.
- Yepes P.
- Yip K.
- Yoo I-K.
- Yue Q.
- Zawisza M.
- Zbroszczyk H.
- Zhan W.
- Zhang J. B.
- Zhang S.
- Zhang W. M.
- Zhang X. P.
- Zhang Y.
- Zhang Z. P.
- Zhao J.
- Zhong C.
- Zhou J.
- Zhou W.
- Zhu X.
- Zhu Y. H.
- Zoulkarneev R.
- Zoulkarneeva Y.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2010
- Field of study
Yields, correlation shapes, and mean transverse momenta \pt{} of charged
particles associated with intermediate to high-\pt{} trigger particles (2.5 <
\pt < 10 \GeVc) in d+Au and Au+Au collisions at \snn=200 GeV are presented.
For associated particles at higher \pt \gtrsim 2.5 \GeVc, narrow correlation
peaks are seen in d+Au and Au+Au, indicating that the main production mechanism
is jet fragmentation. At lower associated particle \pt < 2 \GeVc, a large
enhancement of the near- (\dphi \sim 0) and away-side (\dphi \sim \pi)
associated yields is found, together with a strong broadening of the away-side
azimuthal distributions in Au+Au collisions compared to d+Au measurements,
suggesting that other particle production mechanisms play a role. This is
further supported by the observed significant softening of the away-side
associated particle yield distribution at \dphi \sim \pi in central Au+Au
collisions.Comment: 16 pages, 11 figures, updated after journal revie
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
- Abdul Manap H.
- Abdul Rahim A. A.
- Abdulkader F.
- Abdulla A. H. K.
- AbdulWahab M. Z.
- Abduvalieva V.
- Abele S.
- Aboyans V.
- Abreu P. E.
- Adam-Blanpain M.
- Adamaszek K.
- Adamczyk-Kot D.
- Adamkiewicz-Piejko A.
- Adda M.
- Aftab A.
- Agrawal A.
- Aguiar C.
- Ahuad Guerrero A.
- Ahuja R.
- Ai F.
- Aimouch N.
- Aiyegbayo O.
- Ajani A.
- Akbar M.
- Aksyutina N.
- Al Dhanki M.
- Al Ghool S.
- Al Kandari F.
- Al Lawati A.
- Al Mahmeed W.
- Al Radaideh G.
- Al Rashdan I.
- Al Sousi A.
- Al Suwaidi J.
- Al Tamimi F.
- Al Wahshi Y.
- Al Yazeedi J.
- Al Zaibag M.
- Al-Baker H.
- Al-Faleh H.
- Al-Hersi A.
- Al-Khalidi B.
- Al-Shamiri M.
- Al-Zaibag M.
- Alam A.
- Alanazy M.
- Alanbaei M.
- Albero Martinez V.
- Alberto Ramirez Reyes H.
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- Alekseenko V.
- Alekseeva T.
- Alexanderson E.
- Alexopoulos I.
- Alford K.
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- Alizon F.
- Allcock A.
- Almeida Fernandez C. A.
- Altevogt B. -M.
- Altmann U.
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- Angela R.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Long-range angular correlations on the near and away side in p–Pb collisions at
- Author
- Abdiel Ramirez Reyes
- Adam Ryszard Kisiel
- Adam Tomasz Matyja
- Adam Wlodzimierz Jacholkowski
- Adam Szczepankiewicz
- Adela Kravcakova
- Aditya Nath Mishra
- Adrian Sevcenco
- Adriana Telesca
- Airton Deppman
- Ajay Kumar Dash
- Alberica Toia
- Alberto Baldisseri
- Alberto Collu
- Alberto Gago
- Alberto Masoni
- Alejandro Szanto de Toledo
- Alessandra Maria Mazzoni
- Alessandra Fantoni
- Alessandro De Falco
- Alessandro Feliciello
- Alessandro Grelli
- Alessandro Pesci
- Alexander Philipp Kalweit
- Alexander Akindinov
- Alexander Borissov
- Alexander Hansen
- Alexander Kluge
- Alexander Mamonov
- Alexander Nedosekin
- Alexander Ochirov
- Alexander Vinogradov
- Alexander Vodopianov
- Alexander Wilk
- Alexandr Tumkin
- Alexandre Alarcon do Passo Suaide
- Alexandre Nyanin
- Alexandre Rachevski
- Alexandre Shabetai
- Alexandru Florin Dobrin
- Alexandru Bercuci
- Alexei Kaidalov
- Alexei Khanzadeev
- Alexei Pavlinov
- Alexey Bogdanov
- Alexey Kuryakin
- Alexey Vyushin
- Alexis Jean Michel Mas
- Alfonso Tarazona Martinez
- Alfredo Musso
- Alice Zimmermann
- Alina Gabriela Grigoras
- Alis Rodriguez Manso
- Alla Maevskaya
- Alphonse Rademakers
- Amalia Pop
- Amaya Ofelia Casanova Diaz
- Ana Maria Marin
- Anais Annick Erica Bergognon
- Anand Kumar Dubey
- Anatoly Kolojvari
- Anders Garritt Knospe
- Anders Nils Erik Oskarsson
- Andras Gabor Agocs
- Andre Augustinus
- Andre Mischke
- Andrea Agostinelli
- Andrea Alici
- Andrea Dainese
- Andrea Danu
- Andrea Dubla
- Andrea Festanti
- Andrea Francescon
- Andrea Rossi
- Andreas Arend
- Andreas Morsch
- Andrei Geae Gheata
- Andrei Ionut Herghelegiu
- Andres Sandoval
- Andrew Marshall Adare
- Andrey Ivanov
- Andrey Kazantsev
- Andrey Reshetin
- Andrey Vasiliev
- Andrey Zarochentsev
- Andry Malala Rakotozafindrabe
- Andrzej Deloff
- Andrzej Rybicki
- Andzhey Asryan
- Angela Badala
- Anik Gupta
- Anitha Nyatha
- Anju Bhasin
- Ankita Goswami
- Anna Rita Reolon
- Annalisa De Caro
- Annalisa Mastroserio
- Annika Passfeld
- Anselmo Margotti
- Ante Bilandzic
- Anthony Timmins
- Antoine Xavier Lardeux
- Anton Alkin
- Anton Andronic
- Anton Jusko
- Antonin Maire
- Antonino Zichichi
- Antonio Carlos Oliveira Da Silva
- Antonio Di Mauro
- Antonio Juan Rubio Montero
- Antonio Ortiz Velasquez
- Antonio Uras
- Ara Grigoryan
- Armando Palmeri
- Arnaldi Roberta
- Arnulfo Martinez Davalos
- Arsen Hayrapetyan
- Arshad Ahmad
- Artem Konevskih
- Artur Krzysztof Szostak
- Arturo Alejandro Menchaca Rocha
- Arturo Fernandez Tellez
- Arturo Tauro
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- Ashok Kumar Bhati
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- Barbara Guerzoni
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- Bastian Bathen
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- Benjamin Donigus
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- Beomsu Chang
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- Pedro Luis Manuel Podesta Lerma
- Per Ivar Loenne
- Peter Braun Munzinger
- Peter Graham Jones
- Peter Zahariev Hristov
- Peter Chochula
- Peter Christiansen
- Peter Glassel
- Peter Jacobs
- Peter Kalinak
- Peter Levai
- Peter Malzacher
- Peter Strmen
- Petr Nomokonov
- Petr Zavada
- Petra Riedler
- Philipp Luettig
- Philippe Crochet
- Philippe Gros
- Philippe Pillot
- Philippe Rosnet
- Pier Giaio Innocenti
- Piergiaio Cerello
- Pierre Vande Vyvre
- Pierre Zelnicek
- Pietro Antonioli
- Pietro Cortese
- Piotr Krystian Ostrowski
- Plamen Rumenov Petrov
- Podist Kurashvili
- Pradip Kumar Roy
- Pradip Kumar Sahu
- Predrag Buncic
- Premomoy Ghosh
- Rachid Guernane
- Radek Smakal
- Radiy Ilkaev
- Raffaele Grosso
- Raghava Varma
- Raghunath Sahoo
- Raimond Snellings
- Rainer Arno Ernst Renfordt
- Rainer Martin Schicker
- Ralf Peter Averbeck
- Ralf Keidel
- Rama Chandra Baral
- Rama Narayana Singaraju
- Ramello Luciano
- Ramni Gupta
- Ramon Gomez
- Ramona Lea
- Ranbir Singh
- Raoul Stefan de Rooij
- Raphael Noel Tieulent
- Raphaelle Marie Bailhache
- Raphaelle Ichou
- Rashmi Raniwala
- Raul Tonatiuh Jimenez Bustamante
- Rebecca Scott
- Renato Angelo Ricci
- Renaud Vernet
- Rene Bellwied
- Rene Brun
- Renu Bala
- Renzhuo Wan
- Rigoberto Cruz Albino
- Rinaldo Baldini Ferroli
- Rinaldo Rui
- Rishat Sultanov
- Robert Grajcarek
- Roberto Barbera
- Roberto Divia
- Roberto Preghenella
- Roger Worsley Fearick
- Rohini Sharma
- Rolf Paul Scharenberg
- Roman Lietava
- Romualdo Santoro
- Ron Ariel Soltz
- Rongrong Ma
- Rosa Romita
- Rosario Nania
- Rosario Turrisi
- Rosi Jan Reed
- Ruben Shahoyan
- Rudiger Haake
- Rudolf Janik
- Rune Langoy
- Russo Riccardo
- Sabyasachi Siddhanta
- Sadhana Dash
- Saehanseul Oh
- Salvatore De Pasquale
- Sami Sakari Rasanen
- Sandra Moretto
- Sandro Bjelogrlic
- Sandun Jayarathna
- Sang Un Ahn
- Sanjeev Singh Sambyal
- Sanjib Muhuri
- Sanshiro Mizuno
- Sara Vallero
- Sarah Louise La Pointe
- Sarah Porteboeuf Houssais
- Satish Sharma
- Satyajit Jena
- Scomparin Enrico
- Se Yong Kim
- Sean Murray
- Sebastian Kalcher
- Sedat Altinpinar
- Serge Kox
- Sergey Filchagin
- Sergey Fokin
- Sergey Gorbunov
- Sergey Kiselev
- Sergey Nazarenko
- Sergey Nikolaev
- Sergey Nikulin
- Sergey Sadovsky
- Sergey Voloshin
- Sergey Zaporozhets
- Sergio Di Liberto
- Sergio Serci
- Sergio Vergara
- Serhiy Senyukov
- Shiming Yang
- Shingo Sakai
- Shinichi Esumi
- Shinichi Hayashi
- Shtejer Diaz Katherin
- Shuaib Ahmad Khan
- Shuang Li
- Sidharth Kumar Prasad
- Siegfried Valentin Foertsch
- Silvia Arcelli
- Silvia Masciocchi
- Simone Schuchmann
- Sitta Mario
- Smbat Grigoryan
- Sona Pochybova
- Sorin Ion Zgura
- Stanislav Yasnopolsky
- Stefan Thomas Heckel
- Stefan Boettger
- Stefan Kirsch
- Stefan Rossegger
- Stefano Piano
- Subhash Singha
- Subhasis Chattopadhyay
- Subikash Choudhury
- Sudhir Raniwala
- Sudipan De
- Suh Urk Chung
- Sukalyan Chattopadhyay
- Sul Ah Ahn
- Sumit Basu
- Sun Kun Oh
- Sung Chul Lee
- Supriya Das
- Susanta Kumar Pal
- Svein Lindal
- Sven Gotovac
- Svetlana Kushpil
- Sylvain Chapeland
- Tadeusz Antoni Dobrowolski
- Taebong Moon
- Taesoo Kim
- Takafumi Niida
- Taku Gunji
- Tapan Kumar Nayak
- Tatiana Karavicheva
- Tatjana Susa
- Tatsuya Chujo
- Teodor Siemiarczuk
- Terry Awes
- Thanushan Kugathasan
- Theo Alexander Broker
- Thomas Michael Cormier
- Thomas Dietel
- Thomas Humanic
- Thomas Peitzmann
- Thorsten Kollegger
- Tim Schuster
- Timo Gunther Breitner
- Timothy Symons
- Timur Pocheptsov
- Tinku Sinha
- Tiziano Virgili
- Tobias Krawutschke
- Tomas Robert Aronsson
- Tomasz Jan Pawlak
- Tome Anticic
- Tomi Samuli Raiha
- Tomoya Tsuji
- Torsten Alt
- Toru Sugitate
- Trine Spedstad Tveter
- Tuomo Esa Aukusti Kalliokoski
- Tuva Richert
- Tyler Allen Browning
- Udo Wolfgang Kebschull
- Ulrich Michael Frankenfeld
- Ulrich Fuchs
- Uwe Westerhoff
- Valentina Zaccolo
- Valeria Muccifora
- Valerie Barret
- Valerio Altini
- Valery Kondratiev
- Valery Punin
- Vardanush Papikyan
- Vasco Miguel Chibante Barroso
- Vasile Catanescu
- Vasily Kushpil
- Vedran Nikolic
- Venelin Anguelov
- Vera Loggins
- Vercellin Ermanno
- Veronica Canoa Roman
- Victor Trubnikov
- Vikas Singhal
- Vincenzo Paticchio
- Vitaly Loginov
- Vito Lenti
- Vito Manzari
- Vladimir Ivanov
- Vladimir Kaplin
- Vladimir Kovalenko
- Vladimir Nikulin
- Vladimir Peskov
- Vladimir Pospisil
- Vladimir Samsonov
- Vladimir Vechernin
- Vladimir Wagner
- Vladislav Grigoriev
- Vladislav Manko
- Vojtech Petracek
- Volker Lindenstruth
- Weilin Yu
- Werner Riegler
- Wiktor Stanislaw Peryt
- Wisla Carena
- Wladyslaw Henryk Trzaska
- Woo Jin Park
- Xavier Bernard Lopez
- Xianbao Yuan
- Xiangrong Zhu
- Xianguo Lu
- Xiaoming Zhang
- Xitzel Sanchez Castro
- Yaldo Chris G.
- Yannick Denis Zoccarato
- Yaping Wang
- Yaroslav Berdnikov
- Yasuo Miake
- Yasuto Hori
- Yaxian Mao
- Yevgen Martynov
- Yifei Wang
- Yogendra Viyogi
- Yong Wook Baek
- Yorito Yamaguchi
- You Zhou
- Youngil Kwon
- Yury Kharlov
- Yury Kucheriaev
- Yury Pestov
- Yury Sibiriak
- Yury Vinogradov
- Yves Roland Schutz
- Yvonne Chiara Pachmayer
- Zabulon Vilakazi
- Zaida Conesa del Valle
- Zhongbao Yin
- Zubayer Ahammed
- Zuzana Harmanova
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
EFEITO DE ALTAS TEMPERATURAS NA GERMINAÇÃO DE SEMENTES DE Plathymenia reticulata Benth. E Dalbergia miscolobium Benth.
- Author
- AGUIAR I.B.
- ANDRADE A.C.S
- ANDRADE L.A.Z.
- BELL D.T.
- BORGHETTI F.
- BRAGA L.L
- CARVALHO P.G.B.
- CASTRO E.A.
- CASTRO-NEVES B.M.
- CIRNE P.
- COUTINHO L.M.
- Daniel de Alencastro Bouchardet
- DELGADO J.A.
- FERRAZ-VICENTINI K.R.
- FICHINO B.
- FRANÇA H.
- GASHAW M.
- GLEADOW R.M.
- GUEDES D.M.
- HANLEY M.E.
- Heloisa Sinatora Miranda
- Isadora Matos Ribeiro
- JONES T.A.
- JUDD T.S.
- LABOURIAU L.G.
- LACERDA D.R.
- LAHOREAU G.
- LANDIM M.F.
- LOPES R.M.F.
- LORENZI H.
- MIRANDA H.S.
- MUNHOZ C.B.R.
- Nayara de Almeida de Sousa
- OVERBECK G.E.
- PALERMO A.C.
- PIÑA-RODRIGUES F.C.M.
- POPINIGIS F.
- RAMOS A.E.
- RIBEIRO M.L.
- SANTANA D.G.
- SASSAKI R.M.
- SATO M.N.
- SCHMIDT I.B.
- SILVA JÚNIOR M.C.
- Stefano Salvo Aires
- ZAIDAN L.B.P.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Flagellin and GroEL mediates in vitro binding of an atypical enteropathogenic Escherichia coli to cellular fibronectin
- Author
- A Berndt
- AE Jerse
- AG Abreu
- AG Torres
- AL Berrier
- AL Erdem
- AQ Abbady
- AS Barbosa
- B Henderson
- B Walia
- C Chagnot
- CA Magalhães
- CJ Braga
- Claudia T. P. Moraes
- CM Abe
- CT Parker
- CW Dorsey
- Daniel C. Pimenta
- Danielle D. Munhoz
- DE Andreev
- DI Oliveira-Garcia De
- DL Swenson
- E Allen-Vercoe
- F Hayashi
- Fernando H. Martins
- GA O'Toole
- GW Clark
- H Zhu
- HC Ramos
- HJ Taguchi
- IN Baranova
- J Bruyn
- J Cleary
- J Sambrock
- JA Girón
- JA Girón
- JA Mendoza
- JA Westerlund
- JB Kaper
- JF Sinclair
- JM Nara
- Juliana M. Polatto
- LR Trabulsi
- M Ensgraber
- MA Vieira
- Mariana Izquierdo
- Mauricio J. Farfan
- ME Konke
- MJ Farfan
- MJ Farfan
- MM Muza-Moons
- P Kuusela
- PI Fields
- R Pankov
- RC Edgar
- RC Ruiz
- RM Piazza
- RM Ragione
- Roxane M. F. Piazza
- RT Hernandes
- RT Hernandes
- SA Beatson
- Sarita S. Rossato
- SC Sampaio
- SD Reid
- SK Arora
- SS Zulfakar
- TK Chaudhuri
- U Schwarz-Linek
- WA Fenton
- Waldir P. Elias
- Y Bao
- Ângela S. Barbosa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis
- Author
- Akena Dickens
- Arroll Bruce
- Ayalon Liat
- Azar Marleine
- Baradaran Hamid R
- Baron Murray
- Benedetti Andrea
- Bombardier Charles H
- Boruff Jill
- Butterworth Peter
- Carter Gregory
- Chagas Marcos H
- Chan Juliana C N
- Chiovitti Matthew J
- Clover Kerrie
- Conwell Yeates
- Cuijpers Pim
- de Man-van Ginkel Janneke M
- Delgadillo Jaime
- Fann Jesse R
- Fischer Felix H
- Fung Daniel
- Gelaye Bizu
- Gilbody Simon
- Goodyear-Smith Felicity
- Greeno Catherine G
- Hall Brian J
- Hambridge John
- Harrison Patricia A
- Hegerl Ulrich
- Hides Leanne
- Hobfoll Stevan E
- Hudson Marie
- Härter Martin
- Inagaki Masatoshi
- Ioannidis John P.A.
- Ismail Khalida
- Jetté Nathalie
- Khamseh Mohammad E
- Kiely Kim M
- Kloda Lorie A
- Kwan Yunxin
- Levis Alexander W
- Levis Brooke
- Liu Shen-Ing
- Lotrakul Manote
- Loureiro Sonia R
- Löwe Bernd
- Marsh Laura
- McGuire Anthony
- McMillan Dean
- Mohd Sidik Sherina
- Munhoz Tiago N
- Muramatsu Kumiko
- Osório Flávia L
- Patel Vikram
- Patten Scott B
- Pence Brian W
- Persoons Philippe
- Picardi Angelo
- Reuter Katrin
- Rice Danielle B
- Riehm Kira E
- Rooney Alasdair G
- Saadat Nazanin
- Sanchez Tatiana A
- Santos Iná S
- Shaaban Juwita
- Shrier Ian
- Sidebottom Abbey
- Simning Adam
- Stafford Lesley
- Sung Sharon C
- Tan Pei Lin Lynnette
- Thombs Brett D
- Turner Alyna
- Van Der Feltz-Cornelis Christina Maria
- van Weert Henk C P M
- Vöhringer Paul A
- White Jennifer
- Whooley Mary A
- Winkley Kirsty
- Yamada Mitsuhiko
- Zhang Yuying
- Ziegelstein Roy C
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2019
- Field of study
Objective: To determine the accuracy of the Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression.
Design: Individual participant data meta-analysis.
Data sources: Medline, Medline In-Process and Other Non-Indexed Citations, PsycINFO, and Web of Science (January 2000-February 2015).
Inclusion criteria: Eligible studies compared PHQ-9 scores with major depression diagnoses from validated diagnostic interviews. Primary study data and study level data extracted from primary reports were synthesized. For PHQ-9 cut-off scores 5-15, bivariate random effects meta-analysis was used to estimate pooled sensitivity and specificity, separately, among studies that used semistructured diagnostic interviews, which are designed for administration by clinicians; fully structured interviews, which are designed for lay administration; and the Mini International Neuropsychiatric (MINI) diagnostic interviews, a brief fully structured interview. Sensitivity and specificity were examined among participant subgroups and, separately, using meta-regression, considering all subgroup variables in a single model.
Results: Data were obtained for 58 of 72 eligible studies (total n=17 357; major depression cases n=2312). Combined sensitivity and specificity was maximized at a cut-off score of 10 or above among studies using a semistructured interview (29 studies, 6725 participants; sensitivity 0.88, 95% confidence interval 0.83 to 0.92; specificity 0.85, 0.82 to 0.88). Across cut-off scores 5-15, sensitivity with semistructured interviews was 5-22% higher than for fully structured interviews (MINI excluded; 14 studies, 7680 participants) and 2-15% higher than for the MINI (15 studies, 2952 participants). Specificity was similar across diagnostic interviews. The PHQ-9 seems to be similarly sensitive but may be less specific for younger patients than for older patients; a cut-off score of 10 or above can be used regardless of age..
Conclusions: PHQ-9 sensitivity compared with semistructured diagnostic interviews was greater than in previous conventional meta-analyses that combined reference standards. A cut-off score of 10 or above maximized combined sensitivity and specificity overall and for subgroups.
Registration: PROSPERO CRD42014010673
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