Interpretation of a Regularity in the Behavior of M2

macroeconomics

Next steps in children and young people’s research, participation and protection from the perspective of young researchers

Purpose The purpose of this paper is to explore young researchers perspectives on children and young people’s research, participation and protection. Design/methodology/approach The paper is co-authored by young people and academics involved in a young researcher group. This paper provides a brief introduction from the young researchers and some academic context to their work, then the young researcher group’s contribution. Their contribution is followed by a brief discussion of the issues they raise in the light of current academic debate. Findings This paper contains our critical reflection on participation and protection. Originality/value The paper presents a unique contribution capturing children and young people’s perspectives on the journal’s theme and other contributions to i

An illustrated anatomical ontology of the developing mouse lower urogenital tract

Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. Representative illustrations, detailed text descriptions and molecular markers that selectively label muscle, nerves/ganglia and epithelia of the lower urogenital system are also presented. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation

Participation, Citizenship and Intergenerational Relations in Children and Young People's Lives: Children and Adults in Conversation

In 2012, over 200 academics who are active in international childhood and youth research gathered together alongside young people for a unique ICYRNet conference where they debated and discussed participatory approaches. Participation, Citizenship and Intergenerational Relations in Children and Young People's Lives continues the dialogue between young people and adults that started then. This edited collection draws together work from six countries about participatory research and intergenerational relations. Adopting participatory techniques, the editors worked with children and young people to co–author three chapters that each reflect young people's interpretations of three chapters written by adults. This provides a unique insight into how children and young people view research which is about them as well as highlighting their perspectives on research which resonates with their own life experiences. The book includes reference to a wealth of supplementary visual and audio materials which are available on the conference website at www.dvigc.com

Mutations In Cspp1 Cause Primary Cilia Abnormalities And Joubert Syndrome With Or Without Jeune Asphyxiating Thoracic Dystrophy

Joubert syndrome (JBTS) is a recessive ciliopathy in which a subset of affected individuals also have the skeletal dysplasia Jeune asphyxiating thoracic dystrophy (JATD). Here, we have identified biallelic truncating CSPP1 (centrosome and spindle pole associated protein 1) mutations in 19 JBTS-affected individuals, four of whom also have features of JATD. CSPP1 mutations explain similar to 5% of JBTS in our cohort, and despite truncating mutations in all affected individuals, the range of phenotypic severity is broad. Morpholino knockdown of cspp1 in zebrafish caused phenotypes reported in other zebrafish models of JBTS (curved body shape, pronephric cysts, and cerebellar abnormalities) and reduced ciliary localization of Arl13b, further supporting loss of CSPP1 function as a cause of JBTS. Fibroblasts from affected individuals with CSPP1 mutations showed reduced numbers of primary cilia and/or short primary cilia, as well as reduced axonemal localization of ciliary proteins ARL13B and adenylyl cyclase III. In summary, CSPP1 mutations are a major cause of the Joubert-Jeune phenotype in humans; however, the mechanism by which these mutations lead to both JBTS and JATD remains unknown.WoSScopu

The Arabidopsis Cell Division Cycle

Plant cells have evolved a complex circuitry to regulate cell division. In many aspects, the plant cell cycle follows a basic strategy similar to other eukaryotes. However, several key issues are unique to plant cells. In this chapter, both the conserved and unique cellular and molecular properties of the plant cell cycle are reviewed. In addition to division of individual cells, the specific characteristic of plant organogenesis and development make that cell proliferation control is of primary importance during development. Therefore, special attention should be given to consider plant cell division control in a developmental context. Proper organogenesis depends on the formation of different cell types. In plants, many of the processes leading to cell differentiation rely on the occurrence of a different cycle, termed the endoreplication cycle, whereby cells undergo repeated full genome duplication events in the absence of mitosis and increase their ploidy. Recent findings are focusing on the relevance of changes in chromatin organization for a correct cell cycle progression and, conversely, in the relevance of a correct functioning of chromatin remodelling complexes to prevent alterations in both the cell cycle and the endocycle