La Importancia del sector Minero para el Perú

El Perú es uno de los principales exportadores de minerales a nivel mundial. En el cuadro 1 se puede apreciar que es el sexto productor de oro, tercer productor de plata, segundo productor de cobre, cuarto productor de plomo y tercer productor de zinc. Las exportaciones mineras peruanas representan aproximadamente el 60% de las exportaciones del país contribuyendo a la generación de divisas y permitiendo realizar importaciones que son necesarias para el crecimiento de la economía: vehículos, alimentos, artículos farmacéuticos, combustibles, y maquinaria y equipos, entre otros.El Perú es uno de los principales exportadores de minerales a nivel mundial. En el cuadro 1 se puede apreciar que es el sexto productor de oro, tercer productor de plata, segundo productor de cobre, cuarto productor de plomo y tercer productor de zinc. Las exportaciones mineras peruanas representan aproximadamente el 60% de las exportaciones del país contribuyendo a la generación de divisas y permitiendo realizar importaciones que son necesarias para el crecimiento de la economía: vehículos, alimentos, artículos farmacéuticos, combustibles, y maquinaria y equipos, entre otros

La Importancia del sector Minero para el Perú

El Perú es uno de los principales exportadores de minerales a nivel mundial. En el cuadro 1 se puede apreciar que es el sexto productor de oro, tercer productor de plata, segundo productor de cobre, cuarto productor de plomo y tercer productor de zinc. Las exportaciones mineras peruanas representan aproximadamente el 60% de las exportaciones del país contribuyendo a la generación de divisas y permitiendo realizar importaciones que son necesarias para el crecimiento de la economía: vehículos, alimentos, artículos farmacéuticos, combustibles, y maquinaria y equipos, entre otros

Gated communities: Definitions, causes and consequences

Gated communities became an 'object of study' in the 1990s as social scientists observed their growth in several cities; they are now a feature of the urban landscape in most cities around the world. The expansion of gated communities has led to prolific research, examining different aspects of this type of residential development and providing evidence from case studies worldwide. This paper reviews how gated communities are conceptualised according to the literature and identifies the main factors influencing their development. It also considers spatial, economic, political and social consequences of the development of gated communities. These elements should be taken into account by planners and policymakers to minimise their negative impacts and maximise the positive consequences of a residential option that is likely to be part of the urban landscape for a long time

Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer

Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. Here, we provide further evidence that current anti-RET drugs may not be potent enough to induce durable responses in such tumors. We report that potent inhibitors such as AD80 or ponatinib that stably bind in the DFG-out conformation of RET may overcome these limitations and selectively kill RET-rearranged tumors. Using chemical genomics in conjunction with phosphoproteomic analyses in RET-rearranged cells we identify the CCDC6-RETI788N mutation and drug-induced MAPK pathway reactivation as possible mechanisms, by which tumors may escape the activity of RET inhibitors. Our data provide mechanistic insight into the druggability of RET kinase fusions that may be of help for the development of effective therapies targeting such tumors

Mind the gaps! A research agenda for urban interstices

Processes of urbanisation can hardly be considered without reference to the spaces that lie between developments. However, the literature on such interstitial spaces is fragmentary. In this paper we draw together insights from the extant literature into a research agenda on urban interstices. We propose a research agenda centred on four themes: the multiple geographic scales at which the interstitial spaces of urban sprawl might be analysed; the pending nature of such spaces; their planned or unplanned character and their relational properties. We develop these themes, briefly illustrating them with reference to the case of metropolitan area of Santiago de Chile. In conclusion, we emphasise some of the implications of interstitial spaces for theories of urban politics and their value in forcing inter-disciplinarity in urban studies

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

Kinase inhibitors suppress the growth of oncogene driven cancer but also enforce the selection of treatment resistant cells that are thought to promote tumor relapse in patients. Here, we report transcriptomic and functional genomics analyses of cells and tumors within their microenvironment across different genotypes that persist during kinase inhibitor treatment. We uncover a conserved, MAPK/IRF1-mediated inflammatory response in tumors that undergo stemness- and senescence-associated reprogramming. In these tumor cells, activation of the innate immunity sensor RIG-I via its agonist IVT4, triggers an interferon and a pro-apoptotic response that synergize with concomitant kinase inhibition. In humanized lung cancer xenografts and a syngeneic Egfr-driven lung cancer model these effects translate into reduction of exhausted CD8(+) T cells and robust tumor shrinkage. Overall, the mechanistic understanding of MAPK/IRF1-mediated intratumoral reprogramming may ultimately prolong the efficacy of targeted drugs in genetically defined cancer patients

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.

Kinase inhibitors suppress the growth of oncogene driven cancer but also enforce the selection of treatment resistant cells that are thought to promote tumor relapse in patients. Here, we report transcriptomic and functional genomics analyses of cells and tumors within their microenvironment across different genotypes that persist during kinase inhibitor treatment. We uncover a conserved, MAPK/IRF1-mediated inflammatory response in tumors that undergo stemness- and senescence-associated reprogramming. In these tumor cells, activation of the innate immunity sensor RIG-I via its agonist IVT4, triggers an interferon and a pro-apoptotic response that synergize with concomitant kinase inhibition. In humanized lung cancer xenografts and a syngeneic Egfr-driven lung cancer model these effects translate into reduction of exhausted CD8+ T cells and robust tumor shrinkage. Overall, the mechanistic understanding of MAPK/IRF1-mediated intratumoral reprogramming may ultimately prolong the efficacy of targeted drugs in genetically defined cancer patients