Big Data Assurance Evaluation: An SLA-Based Approach.

The Big Data community has started noticing that there is the need to complete Big Data platforms with assurance techniques proving the correct behavior of Big Data analytics and management. In this paper, we propose a Big Data assurance solution based on Service-Level Agreements (SLAs), focusing on a platform providing Model-based Big Data Analytics-as-a-Service (MBDAaaS)

Solar particle effects on minor components of the Polar atmosphere

Abstract. Solar activity can influence the Earth's environment, and in particular the ozone layer, by direct modulation of the e.m. radiation or through variability of the incoming cosmic ray flux (solar and galactic particles). In particular, solar energetic particles (SEPs) provide additional external energy to the terrestrial environment; they are able to interact with the minor constituents of the atmospheric layer and produce ionizations, dissociations, dissociative ionizations and excitations. This paper highlights the SEP effects on the chemistry of the upper atmosphere by analysing some SEP events recorded during 2005 in the descending phase of the current solar cycle. It is shown that these events can lead to short- (hours) and medium- (days) term ozone variations through catalytic cycles (e.g. HOx and NOx increases). We focus attention on the relationship between ozone and OH data (retrieved from MLS EOS AURA) for four SEP events: 17 and 20 January, 15 May and 8 September. We confirm that SEP effects are different on the night and day hemispheres at high latitudes.</p

La Diana of Montemayor as Social and Religious Teaching

Jorge de Montemayor’s great pastoral novel La Diana (1559), one of the fountainheads of Spanish Renaissance literature, has often been regarded as a work written merely to amuse an effete courtly world. Bruno M. Damiani argues here that, far from being simply a “pastoral dream,” Diana has profound socio-historical and religious dimensions, and that Montemayor’s intentions in it were largely moral and instructive. The timeless, idyllic nature which forms the essence of the pastoral is, in the case of Diana, inextricably bound up with the grace and sophistication of urban Spanish culture. Indeed, this study shows, Montemayor’s shepherds and shepherdesses exist not in an imaginary Arcadian land but in the very real Spain and Portugal of their author’s own time, and many of the characters are disguises for actual persons of the Spanish court, including perhaps the author himself. Similarly, the philosophical and religious concerns of Renaissance Spain are fully explored in the lives of Montemayor’s sorrowing rustics. Symbolically they are sinners who have fallen from grace and must undertake a spiritual pilgrimage, one which ultimately leads them to an understanding of the Christian virtues of faith, hope, and charity. Mustering a wealth of classical, biblical, medieval, and Renaissance sources, the author reveals the underlying fabric of Diana, an inter-twining of allegory, symbolism, and imagery intended to instruct Monte-mayor’s readers in the path of virtue. Damiani’s analysis of this important work offers us a clearer view of the intellectual life of Renaissance Spain. Bruno M. Damiani is professor of romance languages at the Catholic University of America. He is the general editor of Studia Humanitatis and a widely published authority on Spanish literature of the Renaissance.https://uknowledge.uky.edu/upk_spanish_literature/1010/thumbnail.jp

Checkpoint Inhibitors in Acute Myeloid Leukemia

The prognosis of acute myeloid leukemia (AML) remains unsatisfactory. Among the reasons for the poor response to therapy and high incidence of relapse, there is tumor cell immune escape, as AML blasts can negatively influence various components of the immune system, mostly weakening T-cells. Since leukemic cells can dysregulate immune checkpoints (ICs), receptor-based signal transductors that lead to the negative regulation of T-cells and, eventually, to immune surveillance escape, the inhibition of ICs is a promising therapeutic strategy and has led to the development of so-called immune checkpoint inhibitors (ICIs). ICIs, in combination with conventional chemotherapy, hypomethylating agents or targeted therapies, are being increasingly tested in cases of AML, but the results reported are often conflicting. Here, we review the main issues concerning the immune system in AML, the main pathways leading to immune escape and the results obtained from clinical trials of ICIs, alone or in combination, in newly diagnosed or relapsed/refractory AML

Present and Future Role of Immune Targets in Acute Myeloid Leukemia

It is now well known that the bone marrow (BM) cell niche contributes to leukemogenesis, but emerging data support the role of the complex crosstalk between AML cells and the BM microenvironment to induce a permissive immune setting that protects leukemic stem cells (LSCs) from therapy-induced death, thus favoring disease persistence and eventual relapse. The identification of potential immune targets on AML cells and the modulation of the BM environment could lead to enhanced anti-leukemic effects of drugs, immune system reactivation, and the restoration of AML surveillance. Potential targets and effectors of this immune-based therapy could be monoclonal antibodies directed against LSC antigens such as CD33, CD123, and CLL-1 (either as direct targets or via several bispecific T-cell engagers), immune checkpoint inhibitors acting on different co-inhibitory axes (alone or in combination with conventional AML drugs), and novel cellular therapies such as chimeric antigen receptor (CAR) T-cells designed against AML-specific antigens. Though dozens of clinical trials, mostly in phases I and II, are ongoing worldwide, results have still been negatively affected by difficulties in the identification of the optimal targets on LSCs

ATP-Binding Cassette Subfamily G Member 2 in Acute Myeloid Leukemia: A New Molecular Target?

Despite the progress in the knowledge of disease pathogenesis and the identification of many molecular markers as potential targets of new therapies, the cure of acute myeloid leukemia remains challenging. Disease recurrence after an initial response and the development of resistance to old and new therapies account for the poor survival rate and still make allogeneic stem cell transplantation the only curative option. Multidrug resistance (MDR) is a multifactorial phenomenon resulting from host-related characteristics and leukemia factors. Among these, the overexpression of membrane drug transporter proteins belonging to the ABC (ATP-Binding Cassette)-protein superfamily, which diverts drugs from their cellular targets, plays an important role. Moreover, a better understanding of leukemia biology has highlighted that, at least in cancer, ABC protein’s role goes beyond simple drug transport and affects many other cell functions. In this paper, we summarized the current knowledge of ABCG2 (formerly Breast Cancer Resistance Protein, BCRP) in acute myeloid leukemia and discuss the potential ways to overcome its efflux function and to revert its ability to confer stemness to leukemia cells, favoring the persistence of leukemia progenitors in the bone marrow niche and justifying relapse also after therapy intensification with allogeneic stem cell transplantation

A new eclipsing binary system with a pulsating component detected by CoRoT

We report the discovery of CoRoT 102980178 (R.A.= 06:50:12.10, Dec.= -02:41:21.8, J2000) an Algol-type eclipsing binary system with a pulsating component (oEA). It was identified using a publicly available 55 day long monochromatic lightcurve from the CoRoT initial run dataset (exoplanet field). Eleven consecutive 1.26m deep total primary and the equal number of 0.25m deep secondary eclipses (at phase 0.50) were observed. The following light elements for the primary eclipse were derived: HJD_MinI= 2454139.0680 + 5.0548d x E. The lightcurve modeling leads to a semidetached configuration with the photometric mass ratio q=0.2 and orbital inclination i=85 deg. The out-of-eclipse lightcurve shows ellipsoidal variability and positive O'Connell effect as well as clear 0.01m pulsations with the dominating frequency of 2.75 c/d. The pulsations disappear during the primary eclipses, which indicates the primary (more massive) component to be the pulsating star. Careful frequency analysis reveals the second independent pulsation frequency of 0.21 c/d and numerous combinations of these frequencies with the binary orbital frequency and its harmonics. On the basis of the CoRoT lightcurve and ground based multicolor photometry, we favor classification of the pulsating component as a gamma Doradus type variable, however, classification as an SPB star cannot be excluded.Comment: 16 pages, 7 figures, 3 tables, accepted to Communications in Asteroseismolog

Low mass star formation and subclustering in the HII regions RCW 32, 33 and 27 of the Vela Molecular Ridge. A photometric diagnostics to identify M-type stars

Most stars born in clusters and recent results suggest that star formation (SF) preferentially occurs in subclusters. Studying the morphology and SF history of young clusters is crucial to understanding early SF. We identify the embedded clusters of young stellar objects (YSOs) down to M stars, in the HII regions RCW33, RCW32 and RCW27 of the Vela Molecular Ridge. Our aim is to characterise their properties, such as morphology and extent of the clusters in the three HII regions, derive stellar ages and the connection of the SF history with the environment. Through public photometric surveys such as Gaia, VPHAS, 2MASS and Spitzer/GLIMPSE, we identify YSOs with IR, Halpha and UV excesses, as signature of circumstellar disks and accretion. In addition, we implement a method to distinguish M dwarfs and giants, by comparing the reddening derived in several optical/IR color-color diagrams, assuming suitable theoretical models. Since this diagnostic is sensitive to stellar gravity, the procedure allows us to identify pre-main sequence stars. We find a large population of YSOs showing signatures of circumstellar disks with or without accretion. In addition, with the new technique of M-type star selection, we find a rich population of young M stars with a spatial distribution strongly correlated to the more massive population. We find evidence of three young clusters, with different morphology. In addition, we identify field stars falling in the same region, by securely classifying them as giants and foreground MS stars. We identify the embedded population of YSOs, down to about 0.1 Msun, associated with the HII regions RCW33, RCW32 and RCW27 and the clusters Vela T2, Cr197 and Vela T1, respectively, showing very different morphologies. Our results suggest a decreasing SF rate in Vela T2 and triggered SF in Cr197 and Vela T1.Comment: Accepted for publication in A&A; 20 pages, 22 figures, 6 table