Toot Your Horn Kid, You\u27re In A Fog

https://digitalcommons.library.umaine.edu/mmb-vp/6293/thumbnail.jp

In the Heart of the City (That Has No Heart) / music by Joseph M. Daly; words by Thos. S. Allen

Cover: drawing of a lone woman walking a dark city; photo inset of Jerome Tobin; Publisher: Daly Music Publisher (Boston)https://egrove.olemiss.edu/sharris_c/1058/thumbnail.jp

Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis

Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal fluid (CSF)). Currently, staging relies upon detecting the very low number of parasites or elevated white blood cell numbers in CSF. Improved staging is desirable, as is the elimination of the need for lumbar puncture. Here we use metabolomics to probe samples of CSF, plasma and urine from 40 Angolan patients infected with Trypanosoma brucei gambiense, at different disease stages. Urine samples provided no robust markers indicative of infection or stage of infection due to inherent variability in urine concentrations. Biomarkers in CSF were able to distinguish patients at stage 1 or advanced stage 2 with absolute specificity. Eleven metabolites clearly distinguished the stage in most patients and two of these (neopterin and 5-hydroxytryptophan) showed 100% specificity and sensitivity between our stage 1 and advanced stage 2 samples. Neopterin is an inflammatory biomarker previously shown in CSF of stage 2 but not stage 1 patients. 5-hydroxytryptophan is an important metabolite in the serotonin synthetic pathway, the key pathway in determining somnolence, thus offering a possible link to the eponymous symptoms of “sleeping sickness”. Plasma also yielded several biomarkers clearly indicative of the presence (87% sensitivity and 95% specificity) and stage of disease (92% sensitivity and 81% specificity). A logistic regression model including these metabolites showed clear separation of patients being either at stage 1 or advanced stage 2 or indeed diseased (both stages) versus control

Chicken Reel

A woman and a man dancing in a large room with many other couples / Starmer ; photograph inset of Ben Linn.https://scholarsjunction.msstate.edu/cht-sheet-music/4058/thumbnail.jp

Chicken Reel or Performer\u27s Buck

Illustration of white and green floral motifs on pink backgroundhttps://scholarsjunction.msstate.edu/cht-sheet-music/4027/thumbnail.jp

Turkey Trot

Illustration of two turkeyshttps://scholarsjunction.msstate.edu/cht-sheet-music/3974/thumbnail.jp

Yankee tar

A sailor of the early 20th century.https://scholarsjunction.msstate.edu/cht-sheet-music/3842/thumbnail.jp

Miss Liberty

Illustration of the Statue of Liberty set agains at pale red, white, and blue sky.https://scholarsjunction.msstate.edu/cht-sheet-music/3893/thumbnail.jp

Cabaret Rag

Illustration of purple and blue circles with red triangleshttps://scholarsjunction.msstate.edu/cht-sheet-music/4015/thumbnail.jp

Too Much Ginger : One Step

Text only; Blue backgroundhttps://scholarsjunction.msstate.edu/cht-sheet-music/3982/thumbnail.jp