Effects of Symmetry Breaking on the Strong and Electroweak Interactions of the Vector Nonet

Starting from a chiral invariant and quark line rule conserving Lagrangian of pseudoscalar and vector nonets we introduce first and second order symmetry breaking as well as quark line rule violating terms and fit the parameters, at tree level, to many strong and electroweak processes. A number of predictions are made. The electroweak interactions are included in a manifestly gauge invariant manner. The resulting symmetry breaking pattern is discussed in detail. Specifically, for the ``strong'' interactions, we study all the vector meson masses and V -> \phi \phi decays, including isotopic spin violations. In the electroweak sector we study the { rho^0 , omega , phi } -> e^+e^- decays, { pi^+ , K^+ , K^0 } ``charge radii'', K_{l3} ``slope factor'' and the overall e^+e^- -> pi^+ pi^- process. It is hoped that the resulting model may be useful as a reasonable description of low energy physics in the range up to about 1 GeV.Comment: 43 pages (LaTeX), 5 PostScript figures are included as uuencoded-compressed-tar file at the en

The secondary KIT mutation p.Ala510Val in a cutaneous mast cell tumour carrying the activating mutation p.Asn508Ile confers resistance to masitinib in dogs

Background: Gain-of-function mutations in KIT are driver events of oncogenesis in mast cell tumours (MCTs) affecting companion animals. Somatic mutations of KIT determine the constitutive activation of the tyrosine kinase receptor leading to a worse prognosis and a shorter survival time than MCTs harbouring wild-type KIT. However, canine MCTs carrying KIT somatic mutations generally respond well to tyrosine kinase inhibitors; hence their presence represents a predictor of treatment effectiveness, and its detection allows implementing a stratified medical approach. Despite this, veterinary oncologists experience treatment failures, even with targeted therapies whose cause cannot be elucidated. The first case of an MCT-affected dog caused by a secondary mutation in the tyrosine kinase domain responsible for resistance has recently been reported. The knowledge of this and all the other mutations responsible for resistance would allow the effective bedside implementation of a deeply stratified and more effective medical approach. Case presentation: The second case of a canine MCT carrying a different resistance mutation is herein described. The case was characterised by aggressive behaviour and early metastasis unresponsive to both vinblastine- and masitinib-based treatments. Molecular profiling of the tumoural masses revealed two different mutations; other than the already known activating mutation p.Asn508Ile in KIT exon 9, which is tyrosine kinase inhibitor-sensitive, a nearly adjacent secondary missense mutation, p.Ala510Val, which had never before been described, was detected. In vitro transfection experiments showed that the secondary mutation did not cause the constitutive activation by itself but played a role in conferring resistance to masitinib. Conclusions: This study highlighted the importance of the accurate molecular profiling of an MCT in order to improve understanding of the molecular mechanism underlying tumourigenesis and reveal chemoresistance in MCTs for more effective therapies. The detection of the somatic mutations responsible for resistance should be included in the molecular screening of MCTs, and a systematic analysis of all the cases characterised by unexpected refractoriness to therapies should be investigated in depth at both the genetic and the phenotypic level

'I make up a silly name': Understanding Children's Perception of Privacy Risks Online

Children under 11 are often regarded as too young to comprehend the implications of online privacy. Perhaps as a result, little research has focused on younger kids' risk recognition and coping. Such knowledge is, however, critical for designing efficient safeguarding mechanisms for this age group. Through 12 focus group studies with 29 children aged 6-10 from UK schools, we examined how children described privacy risks related to their use of tablet computers and what information was used by them to identify threats. We found that children could identify and articulate certain privacy risks well, such as information oversharing or revealing real identities online; however, they had less awareness with respect to other risks, such as online tracking or game promotions. Our findings offer promising directions for supporting children's awareness of cyber risks and the ability to protect themselves online

Pion and Kaon Vector Form Factors

We develop a unitarity approach to consider the final state interaction corrections to the tree level graphs calculated from Chiral Perturbation Theory ($\chi PT$) allowing the inclusion of explicit resonance fields. The method is discussed considering the coupled channel pion and kaon vector form factors. These form factors are then matched with the one loop $\chi PT$ results. A very good description of experimental data is accomplished for the vector form factors and for the $\pi\pi$ P-wave phase shifts up to $\sqrt{s}\lesssim 1.2$ GeV, beyond which multiparticle states play a non negligible role. In particular the low and resonance energy regions are discussed in detail and for the former a comparison with one and two loop $\chi PT$ is made showing a remarkable coincidence with the two loop $\chi PT$ results.Comment: 20 pages, 7 figs, to appear in Phys. Rev.

Constraining the low energy pion electromagnetic form factor with space-like data

The pionic contribution to the g-2 of the muon involves a certain integral over the the modulus squared of F_\pi(t), the pion electromagnetic form factor. We extend techniques that use cut-plane analyticity properties of F_\pi(t) in order to account for present day estimates of the pionic contribution and experimental information at a finite number of points in the space-like region. Using data from several experiments over a large kinematic range for |t|, we find bounds on the expansion coefficients of F_\pi(t), sub-leading to the charge radius. The value of one of these coefficients in chiral perturbation theory respects these bounds. Furthermore, we present a sensitivity analysis to the inputs. A brief comparison with results in the literature that use observables other than the g-2 and timelike data is presented.Comment: 11 pages in EPJ journal style, to appear in European Physical Journal

Form factors of pion and kaon

An addtional intrinsic form factors of pion and kaons have been studied.Comment: 14 pages and 10 figure

Light-cone QCD Sum Rules for the Λ\Lambda Baryon Electromagnetic Form Factors and its magnetic moment

We present the light-cone QCD sum rules up to twist 6 for the electromagnetic form factors of the $\Lambda$ baryon. To estimate the magnetic moment of the baryon, the magnetic form factor is fitted by the dipole formula. The numerical value of our estimation is $\mu_\Lambda=-(0.64\pm0.04)\mu_N$, which is in accordance with the experimental data and the existing theoretical results. We find that it is twist 4 but not the leading twist distribution amplitudes that dominate the results.Comment: 13 page, 7 figures, accepted for publication in Euro. Phys. J.