Inequality, Nonhomothetic Preferences, And Trade: A Gravity Approach

We construct the first direct classification of goods as luxuries or necessities that is compatible with international trade data. We then use it to test an idea that has not been tested directly in the literature: countries income distributions are important determinants of their import demand, and in particular of the difference in their import demands of luxuries versus necessities. We interpret this result with the aid of a model in which preferences are nonhomothetic, thus relaxing a long-held and standard but empirically dubious assumption in the theory of international trade. Our model is strongly borne out by the results: imports of luxuries increase with importing countrys inequality, and imports of necessities decrease with it. Our calculations imply that if income distribution in the United States became as equal as in Canada, the US would import about 9 13% less in luxury goods and 13 19% more in necessity goods.nonhomothetic tastes, gravity equation, inequality, luxuries, necessities

Inequality, Nonhomothetic Preferences, and Trade: A Gravity Approach

In this paper, we show that inequality is an important determinant of import demand, in that it augments the standard gravity model in a significant way. We interpret this result with the aid of a model in which tastes are nonhomothetic. Classification of products, based on the correlation between household budget shares in the US and income, into "luxuries" and "necessities," works very well in our analysis when we restrict the analysis to developed importing countries. While the imports of luxuries increase with the importing country's inequality, imports of necessities decrease with it. Furthermore, we find that an increase in the level of inequality in the importing country generally leads to an increase in imports from developed countries, and to a reduction in imports from low-income countries.

Collaborative Information Literacy Practices to Connect Theory to Practice in Rehabilitation Counseling Students

The authors offer this case study of collaborating to scaffold information literacy learning into a semester-long research assignment within an undergraduate rehabilitation services course. The goal of the partnership was to teach students to research a rehabilitation theory/intervention in the professional literature and connect the evidence to rehabilitation services available locally for individuals with disabilities. Specific collaborative practices are identified as essential to the success of this pedagogical project, specifically the giving of time, the scaffolding of learning, and the continual return to reflection in the teaching and learning process, which are all enabled by the sharing of expertise between partners. The authors affirm that collaboration between librarians and course faculty in the counseling and human services fields improves outcomes for connecting theory to practice. This is an important component of evidence-based practice to develop in students the essential dispositions of more mindful and ethical future human services professionals

Inequality, Nonhomothetic Preferences, And Trade: A Gravity Approach

We construct the first direct classification of goods as luxuries or necessities that is compatible with international trade data. We then use it to test an idea that has not been tested directly in the literature: countries' income distributions are important determinants of their import demand, and in particular of the difference in their import demands of luxuries versus necessities. We interpret this result with the aid of a model in which preferences are nonhomothetic, thus relaxing a long-held and standard - but empirically dubious - assumption in the theory of international trade. Our model is strongly borne out by the results: imports of luxuries increase with importing country's inequality, and imports of necessities decrease with it. Our calculations imply that if income distribution in the United States became as equal as in Canada, the US would import about 9 - 13% less in luxury goods and 13 - 19% more in necessity goods

Identification and Characterization of Renal Cell Carcinoma Gene Markers

Microarray gene expression profiling has been used to distinguish histological subtypes of renal cell carcinoma (RCC), and consequently to identify specific tumor markers. The analytical procedures currently in use find sets of genes whose average differential expression across the two categories differ significantly. In general each of the markers thus identified does not distinguish tumor from normal with 100% accuracy, although the group as a whole might be able to do so. For the purpose of developing a widely used economically viable diagnostic signature, however, large groups of genes are not likely to be useful. Here we use two different methods, one a support vector machine variant, and the other an exhaustive search, to reanalyze data previously generated in our Lab (Lenburg et al. 2003). We identify 158 genes, each having an expression level that is higher (lower) in every tumor sample than in any normal sample, and each having a minimum differential expression across the two categories at a significance of 0.01. The set is highly enriched in cancer related genes (p = 1.6 × 10−12), containing 43 genes previously associated with either RCC or other types of cancer. Many of the biomarkers appear to be associated with the central alterations known to be required for cancer transformation. These include the oncogenes JAZF1, AXL, ABL2; tumor suppressors RASD1, PTPRO, TFAP2A, CDKN1C; and genes involved in proteolysis or cell-adhesion such as WASF2, and PAPPA

Data Perturbation Independent Diagnosis and Validation of Breast Cancer Subtypes Using Clustering and Patterns

Molecular stratification of disease based on expression levels of sets of genes can help guide therapeutic decisions if such classifications can be shown to be stable against variations in sample source and data perturbation. Classifications inferred from one set of samples in one lab should be able to consistently stratify a different set of samples in another lab. We present a method for assessing such stability and apply it to the breast cancer (BCA) datasets of Sorlie et al. 2003 and Ma et al. 2003. We find that within the now commonly accepted BCA categories identified by Sorlie et al. Luminal A and Basal are robust, but Luminal B and ERBB2+ are not. In particular, 36% of the samples identified as Luminal B and 55% identified as ERBB2+ cannot be assigned an accurate category because the classification is sensitive to data perturbation. We identify a “core cluster” of samples for each category, and from these we determine “patterns” of gene expression that distinguish the core clusters from each other. We find that the best markers for Luminal A and Basal are (ESR1, LIV1, GATA-3) and (CCNE1, LAD1, KRT5), respectively. Pathways enriched in the patterns regulate apoptosis, tissue remodeling and the immune response. We use a different dataset (Ma et al. 2003) to test the accuracy with which samples can be allocated to the four disease subtypes. We find, as expected, that the classification of samples identified as Luminal A and Basal is robust but classification into the other two subtypes is not

A New Approach to Blood Parameters in Dogs with Hemorrhagic Enteritis

Background: Some blood parameters have diagnostic and prognostic importance for the infections in human medicine. However, there is insufficient research regarding the importance of blood parameters and their correlations in veterinary medicine. Increased blood cell distribution width (RDW) and platelet activity can link with the important inflammatory markers. The main objective of the present study was the evaluation of the relationship among some important blood parameters namely RDW, platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), their potential usage in the diagnosis and determination of the clinical severity in dogs with hemorrhagic enteritis.Materials, Methods & Results: In this study, the case records of 29 dogs with hemorrhagic enteritis were evaluated and the records of 10 healthy dogs were used as controls. The animals of the study group were presented at the Ondokuz Mayis University, Veterinary Internal Medicine Clinic. The complete blood count (CBC), which includes the total WBC, RBC, hematocrit (HCT), hemoglobin concentration (Hgb), MCV, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RDW, PLT, MPV, PCT, and PDW, was determined. Significant positive correlations between RDW and RBC, HCT, MCHC, PLT and PDW, and a negative correlation with MCV, were determined. PDW was positively correlated with the lymphocyte count, MCHC and RDW, and negatively correlated with PCT. PLT was negatively correlated with MCV and MPV and positively correlated with RBC and RDW. In addition, MPV was positively correlated with MCV and MCH, and negatively correlated with PLT. Furthermore, there were significant differences between the granulocyte, WBC, HCT, RDW and PDW values (P < 0.001) and monocyte count, Hgb and MCV (P < 0.05), of the study and control groups.Discussion: Acute hemorrhagic enteritis has various causes in dogs such as idiopathic hemorrhagic gastroenteritis and a number of viral, bacterial and parasitic agents. Hematological and biochemical parameters are not specific to enteric diseases, but these paremeters can provide clinically helpful information for differential diagnosis, response to treatment, and prognosis. In this frame, the evaluation of MCV and RDW in combination, and the determination of the mean red cell size and the extent of heterogeneity of the red cell population, can be especially useful to the diagnosis of different red blood cell disorders. In the present study, differences in RDW and MCV values were statistically significant between the study and control groups (P < 0.05). Increased RDW and decreased MCV can be good indicators of hemorragic diseases and in the present study, in addition to these findings, decreased Hgb and Hct confirmed anemia in dogs with hemorrhagic enteritis. The other key findings of this study were statistically significant relationships between RDW, PLT and PDW, which could be important indicators of inflammation in dogs with hemorrhagic enteritis. These parameters should be evaluated carefully in clinical cases of hemorrhagic enteritis. However, due to nature of retrospective studies, there were some limitations (the lack of another control group of dogs suffering from other hemorrhagic diseases) lack of serial measurements of the blood parameters and further studies should be carried out on dogs with hemorrhagic enteritis for a more detailed evaluation and confirmation of the findings of this study

Reconstructing ‘the Alcoholic’: Recovering from Alcohol Addiction and the Stigma this Entails

Public perception of alcohol addiction is frequently negative, whilst an important part of recovery is the construction of a positive sense of self. In order to explore how this might be achieved, we investigated how those who self-identify as in recovery from alcohol problems view themselves and their difficulties with alcohol and how they make sense of others’ responses to their addiction. Semi-structured interviews with six individuals who had been in recovery between 5 and 35 years and in contact with Alcoholics Anonymous were analysed using Interpretative Phenomenological Analysis. The participants were acutely aware of stigmatising images of ‘alcoholics’ and described having struggled with a considerable dilemma in accepting this identity themselves. However, to some extent they were able to resist stigma by conceiving of an ‘aware alcoholic self’ which was divorced from their previously unaware self and formed the basis for a new more knowing and valued identity

Systematic review of beliefs, behaviours and influencing factors associated with disclosure of a mental health problem in the workplace

Stigma and discrimination present an important barrier to finding and keeping work for individuals with a mental health problem. This paper reviews evidence on: 1) employment-related disclosure beliefs and behaviours of people with a mental health problem; 2) factors associated with the disclosure of a mental health problem in the employment setting; 3) whether employers are less likely to hire applicants who disclose a mental health problem; and 4) factors influencing employers' hiring beliefs and behaviours towards job applicants with a mental health problem