On the spatial distributions of stars and gas in numerical simulations of molecular clouds

We compare the spatial distribution of stars which form in hydrodynamical simulations to the spatial distribution of the gas, using the $\mathcal{Q}$-parameter. The $\mathcal{Q}$-parameter enables a self-consistent comparison between the stars and gas because it uses a pixelated image of the gas as a distribution of points, in the same way that the stars (sink particles in the simulations) are a distribution of points. We find that, whereas the stars have a substructured, or hierarchical spatial distribution ($\mathcal{Q} \sim 0.4 - 0.7$), the gas is dominated by a smooth, concentrated component and typically has $\mathcal{Q} \sim 0.9$. We also find no statistical difference between the structure of the gas in simulations that form with feedback, and those that form without, despite these two processes producing visually different distributions. These results suggest that the link between the spatial distributions of gas, and the stars which form from them, is non-trivial

Did the Solar System form in a sequential triggered star formation event?

The presence and abundance of the short-lived radioisotopes (SLRs) $^{26}$Al and $^{60}$Fe during the formation of the Solar System is difficult to explain unless the Sun formed in the vicinity of one or more massive star(s) that exploded as supernovae. Two different scenarios have been proposed to explain the delivery of SLRs to the protosolar nebula: (i) direct pollution of the protosolar disc by supernova ejecta and (ii) the formation of the Sun in a sequential star formation event in which supernovae shockwaves trigger further star formation which is enriched in SLRs. The sequentially triggered model has been suggested as being more astrophysically likely than the direct pollution scenario. In this paper we investigate this claim by analysing a combination of $N$-body and SPH simulations of star formation. We find that sequential star formation would result in large age spreads (or even bi-modal age distributions for spatially coincident events) due to the dynamical relaxation of the first star-formation event(s). Secondly, we discuss the probability of triggering spatially and temporally discrete populations of stars and find this to be only possible in very contrived situations. Taken together, these results suggest that the formation of the Solar System in a triggered star formation event is as improbable, if not more so, than the direct pollution of the protosolar disc by a supernova

The dynamical evolution of molecular clouds near the Galactic Centre -- III. Tidally--induced star formation in protocluster clouds

As part of a series of papers aimed at understanding the evolution of the Milky Way's Central Molecular Zone (CMZ), we present hydrodynamical simulations of turbulent molecular clouds orbiting in an accurate model of the gravitational potential extant there. We consider two sets of model clouds differing in the energy content of their velocity fields. In the first, self--virialised set, the turbulent kinetic energies are chosen to be close in magnitude to the clouds' self--gravitational potential energies. Comparison with isolated clouds evolving without an external potential shows that the self--virialised clouds are unable to withstand the compressive tidal field of the CMZ and rapidly collapse, forming stars much faster and reaching gas exhaustion after a small fraction of a Galactocentric orbit. In the second, tidally--virialised, set of simulations, the clouds' turbulent kinetic energies are in equilibrium with the external tidal field. These models are better supported against the field and the stronger turbulence suppresses star formation. Our results strongly support the inference that anomalously low star formation rates in the CMZ are due primarily to high velocity dispersions in the molecular gas. The clouds follow open, eccentric orbits oscillating in all three spatial coordinates. We examine the consequences of the orbital dynamics, particularly pericentre passage, by performing companion simulations of clouds on circular orbits. The increased tidal forces at pericentre produce transient accelerations in star formation rates of at most a factor of 2.7. Our results demonstrate that modelling star formation in galactic centres requires the inclusion of tidal forces

Which feedback mechanisms dominate in the high-pressure environment of the Central Molecular Zone?

Supernovae (SNe) dominate the energy and momentum budget of stellar feedback, but the efficiency with which they couple to the interstellar medium (ISM) depends strongly on how effectively early, pre-SN feedback clears dense gas from star-forming regions. There are observational constraints on the magnitudes and timescales of early stellar feedback in low ISM pressure environments, yet no such constraints exist for more cosmologically typical high ISM pressure environments. In this paper, we determine the mechanisms dominating the expansion of HII regions as a function of size-scale and evolutionary time within the high-pressure (P/k_\rm{B}~$10^{7-8}$K cm$^{-3}$) environment in the inner 100pc of the Milky Way. We calculate the thermal pressure from the warm ionised (P_\rm{HII}; 10$^{4}$K) gas, direct radiation pressure (P_\rm{dir}), and dust processed radiation pressure (P_\rm{IR}). We find that (1) P_\rm{dir} dominates the expansion on small scales and at early times (0.01-0.1pc; $0.1$pc; $>1$Myr); (3) during the first ~1Myr of growth, but not thereafter, either $P_{\rm IR}$ or stellar wind pressure likely make a comparable contribution. Despite the high confining pressure of the environment, natal star-forming gas is efficiently cleared to radii of several pc within ~2Myr, i.e. before the first SNe explode. This `pre-processing' means that subsequent SNe will explode into low density gas, so their energy and momentum will efficiently couple to the ISM. We find the HII regions expand to a radius of 3pc, at which point they have internal pressures equal with the surrounding external pressure. A comparison with HII regions in lower pressure environments shows that the maximum size of all HII regions is set by pressure equilibrium with the ambient ISM

A novel isolator-based system promotes viability of human embryos during laboratory processing

In vitro fertilisation (IVF) and related technologies are arguably the most challenging of all cell culture applications. The starting material is a single cell from which one aims to produce an embryo capable of establishing a pregnancy eventually leading to a live birth. Laboratory processing during IVF treatment requires open manipulations of gametes and embryos, which typically involves exposure to ambient conditions. To reduce the risk of cellular stress, we have developed a totally enclosed system of interlinked isolator-based workstations designed to maintain oocytes and embryos in a physiological environment throughout the IVF process. Comparison of clinical and laboratory data before and after the introduction of the new system revealed that significantly more embryos developed to the blastocyst stage in the enclosed isolator-based system compared with conventional open-fronted laminar flow hoods. Moreover, blastocysts produced in the isolator-based system contained significantly more cells and their development was accelerated. Consistent with this, the introduction of the enclosed system was accompanied by a significant increase in the clinical pregnancy rate and in the proportion of embryos implanting following transfer to the uterus. The data indicate that protection from ambient conditions promotes improved development of human embryos. Importantly, we found that it was entirely feasible to conduct all IVF-related procedures in the isolator-based workstations

Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection.

A majority of individuals infected with human immunodeficiency virus (HIV) have inadequate access to antiretroviral therapy and ultimately develop debilitating oral infections that often correlate with disease progression. Due to the impracticalities of conducting host-microbe systems-based studies in HIV infected patients, we have evaluated the potential of simian immunodeficiency virus (SIV) infected rhesus macaques to serve as a non-human primate model for oral manifestations of HIV disease. We present the first description of the rhesus macaque oral microbiota and show that a mixture of human commensal bacteria and "macaque versions" of human commensals colonize the tongue dorsum and dental plaque. Our findings indicate that SIV infection results in chronic activation of antiviral and inflammatory responses in the tongue mucosa that may collectively lead to repression of epithelial development and impact the microbiome. In addition, we show that dysbiosis of the lingual microbiome in SIV infection is characterized by outgrowth of Gemella morbillorum that may result from impaired macrophage function. Finally, we provide evidence that the increased capacity of opportunistic pathogens (e.g. E. coli) to colonize the microbiome is associated with reduced production of antimicrobial peptides

The properties, origin and evolution of stellar clusters in galaxy simulations and observations

Published onlineWe investigate the properties and evolution of star particles in two simulations of isolated spiral galaxies, and two galaxies from cosmological simulations. Unlike previous numerical work, where typically each star particle represents one ‘cluster’, for the isolated galaxies we are able to model features we term ‘clusters’ with groups of particles. We compute the spatial distribution of stars with different ages, and cluster mass distributions, comparing our findings with observations including the recent LEGUS survey. We find that spiral structure tends to be present in older (100s Myr) stars and clusters in the simulations compared to the observations. This likely reflects differences in the numbers of stars or clusters, the strength of spiral arms, and whether the clusters are allowed to evolve. Where we model clusters with multiple particles, we are able to study their evolution. The evolution of simulated clusters tends to follow that of their natal gas clouds. Massive, dense, long-lived clouds host massive clusters, whilst short-lived clouds host smaller clusters which readily disperse. Most clusters appear to disperse fairly quickly, in basic agreement with observational findings. We note that embedded clusters may be less inclined to disperse in simulations in a galactic environment with continuous accretion of gas on to the clouds than isolated clouds and correspondingly, massive young clusters which are no longer associated with gas tend not to occur in the simulations. Caveats of our models include that the cluster densities are lower than realistic clusters, and the simplistic implementation of stellar feedback.We thank the referee for a useful report. The calculations for this paper were performed primarily on the DiRAC machine ‘Complexity’, as well as the supercomputer at Exeter, which is jointly funded by STFC, the Large Facilities Capital Fund of BIS, and the University of Exeter. We would like to thank Michele Fumagalli for work putting together the LEGUS cluster catalogues. CLD and CGF acknowledge funding from the European Research Council for the FP7 ERC starting grant project LOCALSTAR. CGF thanks Ben Thompson for performing data reduction. DG kindly acknowledges financial support by the German Research Foundation (DFG) through grant GO 1659/3-2. Figures in this paper were produced using splash (Price 2007)

Tobacco use and asking prices of used cars: prevalence, costs, and new opportunities for changing smoking behavior

Secondhand smoke (SHS) causes premature death and disease in children and adults, and the scientific evidence indicates that there is no risk-free level of exposure to SHS. Smoking tobacco in a car can pollute the microenvironment of the car with residual SHS, leaving telltale signs to potential buyers (e.g., odor, used ash tray). This study examined (a) the proportion of used cars sold in the private party market that may be polluted with tobacco smoke and (b) whether asking prices of smoker and nonsmoker cars differed for cars of otherwise equivalent value. A random sample of 1,642 private party sellers were interviewed by telephone, and content analyses of print advertisements were conducted. Findings indicate that 22% of used cars were advertised by smokers or had been smoked in during the previous year. Among nonsmokers, 94% did not allow smoking in their car during the past year. Only 33% of smokers had the same restrictions. The smoking status of the seller and tobacco use in the car were significantly (p < .01) associated with the asking price independent of a car's Kelley Blue Book value (KBB). Used nonsmoker cars were offered at a considerable premium above their KBB value (>11%) and above comparable smoker cars (7–9%). These findings suggest that community preferences are affecting the value of smoke-free cars. New directions for research, tobacco control policies, and health education are discussed to further reduce smoking behavior, to help consumers make informed purchasing decisions, and to protect nonsmokers from SHS exposure

Towards integration of general practitioner posts and accident and emergency departments: a case study of two integrated emergency posts in the Netherlands

<p>Abstract</p> <p>Background</p> <p>Accident and emergency (A&E) departments and general practitioner (GP) posts are often used inappropriately, leading to overcrowding. In the Netherlands, increasingly more integrated emergency posts (IEPs) are being created, integrating the care provided by GP posts and A&E departments, in order to improve the provision of the emergency care.</p> <p>Methods</p> <p>This explorative study compares the efficiency and patient and employee satisfaction in IEPs with those in two GP posts and two A&E departments. To this end, information was retrieved from hospital and GP patient records for the first quarter of the year before and of the year after the creation of IEPs. Patients and employees were sent a questionnaire to measure their satisfaction. Lastly, groups of hospital doctors, GPs, GP assistants, and nurses were interviewed.</p> <p>Results</p> <p>After the creation of IEPs, there was a shift of more than fifteen percent from secondary care to primary care for emergency consultations and waiting/consultation times were shortened by more than ten percent. Compared with the control settings, patients were more satisfied about telephone contact with an IEP, but professionals working at the IEP were less satisfied with several aspects of their work.</p> <p>Conclusion</p> <p>IEPs could be a promising innovation to organize emergency care more efficiently; however, it might take time to convince professionals of the possible advantages. Studies involving more IEPs and longer follow-up times are needed to determine whether such integration should be stimulated.</p

Access to communication technologies in a sample of cancer patients: an urban and rural survey

BACKGROUND: There is a growing awareness among providers of the symptom burden experienced by cancer patients. Systematic symptom screening is difficult. Our plan was to evaluate a technology-based symptom screening process using touch-tone telephone and Internet in our rural outreach cancer program in Indiana. Would rural patients have adequate access to technologies for home-based symptom reporting? OBJECTIVES: 1) To determine access to touch-tone telephone service and Internet for patients in urban and rural clinics; 2) to determine barriers to access; 3) to determine willingness to use technology for home-based symptom reporting. METHODS: Patients from representative clinics (seven rural and three urban) in our network were surveyed. Inclusion criteria were age greater than 18, able to read, and diagnosis of malignancy. RESULTS: The response rate was 97%. Of 416 patients completing the survey (230 rural, 186 urban), 95% had access to touch-tone telephone service, while 46% had Internet access (56% of urban patients, 38% of rural patients). Higher rates of Internet access were related to younger patient age, current employment, and higher education and income. The primary barrier to Internet access was lack of interest. Use of the Internet for health related activities was less than 50%. The preferred means of symptom reporting in patients with internet access were the touch-tone telephone (70%), compared to reporting by the Internet (28%). CONCLUSION: Access to communication technologies appears adequate for home-based symptom reporting. The use of touch-tone telephone and Internet reporting, based upon patient preference, has the potential of enhancing symptom detection among cancer patients that is not dependent solely upon clinic visits and clinician inquiry