A New Transcoding Scheme for Scalable Video Coding to H.264/AVC

Requests from various video terminals push video servers to equip with scalability for video contents distribution in different ways. Scalable Video Coding (SVC) as the extension of H.264/AVC standard can provide the scalability for video servers by encoding videos into one base layer and several enhancement layers. To enable mobile devices without scalability receive videos at their best extent, converting bit-streams from SVC into H.264/AVC becomes the key technique. Bit-stream rewriting is the simplest way without quality loss. However, rewriting is not a real transcoding scheme, since it needs to modify SVC encoders. This paper proposes a novel transcoding approach to support spatial scalability by minimizing the distortions generated from re-encoding process. The proposed scheme keeps the input bit-streams’ information at maximum and adopts the hybrid upsampling method to do residue scaling, which can reduce the transcoding distortion into minimization. Experimental results demonstrate that the loss of the rate-distortion (RD) performance of the proposed transcoding scheme is better than Full Decoding Re-encoding (FDR) which can get the highest video quality in general sense, by achieving up to 0.9 dB Y-PSNR gain while saving 95%~97% processing time

Construction of three-dimensional, homogeneous regenerative cartilage tissue based on the ECG-DBM complex

Introduction: The feasibility of using a steel decalcified bone matrix (DBM)-reinforced concrete engineered cartilage gel (ECG) model concept for in vivo cartilage regeneration has been demonstrated in preliminary experiments. However, the regenerated cartilage tissue contained an immature part in the center. The present study aimed to achieve more homogeneous regenerated cartilage based on the same model concept.Methods: For this, we optimized the culture conditions for the engineered cartilage gel-decalcified bone matrix (ECG-DBM) complex based on the previous model and systematically compared the in vitro chondrogenic abilities of ECG in the cartilage slice and ECG-DBM complex states. We then compared the in vivo cartilage regeneration effects of the ECG-DBM complex with those of an equivalent volume of ECG and an equivalent ECG content.Results and discussion: Significant increases in the DNA content and cartilage-specific matrix content were observed for the ECG-DBM complex compared with the ECG cartilage slice, suggesting that the DBM scaffold significantly improved the quality of ECG-derived cartilage regeneration in vitro. In the in vivo experiments, high-quality cartilage tissue was regenerated in all groups at 8 weeks, and the regenerated cartilage exhibited typical cartilage lacunae and cartilage-specific extracellular matrix deposition. Quantitative analysis revealed a higher chondrogenic efficiency in the ECG-DBM group. Specifically, the ECG-DBM complex achieved more homogeneous and stable regenerated cartilage than an equivalent volume of ECG and more mature regenerated cartilage than an equivalent ECG content. Compared with ECG overall, ECG-DBM had a more controllable shape, good morphology retention, moderate mechanical strength, and high cartilage regeneration efficiency. Further evaluation of the ECG-DBM complex after in vitro culture for 7 and 14 days confirmed that an extended in vitro preculture facilitated more homogeneous cartilage regeneration

Characteristics of Xiao Chai Hu decoction based on randomized controlled trials: A bibliometric analysis

Objective: To explore the characteristics of Xiao Chai Hu (XCH) decoction in randomized controlled trials (RCTs) using a bibliometric method. Methods: Seven databases including PubMed, Web of Science, Embase, Cochrane library, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP) and Wanfang database were retrieved from inception to May 27, 2022. In the study, XCH decoction (or modified) used alone or combined with conventional Western medicine as an intervention measure was included. The basic characteristics, funding support, relevant diseases, intervention methods, and adverse events (AEs) were analyzed. Data analysis was performed using SPSS 26.0 software. Results: A total of 813 RCTs were included, published from 1989 to 2022. There was only one English-language literature with the recent impact factor of 5.374. There were 147 studies were from Chinese-language core journals, with the highest impact factor of 2.414. Only 6.15% of the literatures mentioned funding support. 96.31% of the included literature reported the statistical significance of using XCH decoction. The diseases treated mainly included chronic hepatitis B (9.35%), cough variant asthma (5.66%), dizziness (5.54%), bile reflux gastritis (4.43%), and fever (4.18%). However, the overall research design of the included literature was poor, and large sample size, multicenter RCTs are needed. The incidence of AEs of XCH decoction alone was 8.86%, which was significantly lower than that of conventional Western medicine treatment. The combination of XCH decoction and conventional Western medicine treatment could reduce the incidence of AEs, and no serious adverse event was reported. Conclusion: Although the included studies show that XCH decoction is widely used, and has good efficacy and few AEs. Due to the low quality of the included RCTs, there may be some bias, and its rational use based on the specific conditions is recommended in clinical practice

Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress- and Ca2+ Imbalance-Mediated Endoplasmic Reticulum Stress

Excessive drinking can damage brain tissue and cause cognitive dysfunction. Studies have found that the early stage of neurodegenerative disease is closely related to heavy drinking. Acetaldehyde (ADE) is the main toxic metabolite of alcohol. However, the exact mechanisms of ADE-induced neurotoxicity are not fully clear. In this article, we studied the cytotoxic effect of ADE in HT22 cells and primary cultured cortical neuronal cells. We found that ADE exhibited cytotoxicities against HT22 cells and primary cultured cortical neuronal cells in dose-dependent manners. Furthermore, ADE induced apoptosis of HT22 cells by upregulating the expression of caspase family proapoptotic proteins. Moreover, ADE treatment could significantly increase the intracellular Ca2+ and reactive oxygen species (ROS) levels and activate endoplasmic reticulum stress (ERS) in HT22 cells. ADE upregulated ERS-related CHOP expression dose-dependently in primary cultured cortical neuronal cells. In addition, inhibition of ROS with antioxidant N-acetyl-L-cysteine (NAC) reduced the accumulation of ROS and reversed ADE-induced increase of ERS-related protein and apoptosis-related protein levels. Mitigation of ERS with ERS inhibitor 4-PBA obviously suppressed ADE-induced apoptosis and the expression of ERS-related proteins. Therefore, ADE induces neurotoxicity of HT22 cells via oxidative stress- and Ca2+ imbalance-mediated ERS