Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299

Pseudonocardians A–C (2–4), three new diazaanthraquinone derivatives, along with a previously synthesized compound deoxynyboquinone (1), were produced by the strain SCSIO 01299, a marine actinomycete member of the genus Pseudonocardia, isolated from deep-sea sediment of the South China Sea. The structures of compounds 1–4 were determined by mass spectrometry and NMR experiments (1H, 13C, HSQC, and HMBC). The structure of compound 1, which was obtained for the first time from a natural source, was confirmed by X-ray analysis. Compounds 1–3 exhibited potent cytotoxic activities against three tumor cell lines of SF-268, MCF-7 and NCI-H460 with IC50 values between 0.01 and 0.21 μm, and also showed antibacterial activities on Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Bacillus thuringensis SCSIO BT01, with MIC values of 1–4 μg mL−1

Process-Oriented Evaluation of Climate and Weather Forecasting Models

Realistic climate and weather prediction models are necessary to produce confidence in projections of future climate over many decades and predictions for days to seasons. These models must be physically justified and validated for multiple weather and climate processes. A key opportunity to accelerate model improvement is greater incorporation of process-oriented diagnostics (PODs) into standard packages that can be applied during the model development process, allowing the application of diagnostics to be repeatable across multiple model versions and used as a benchmark for model improvement. A POD characterizes a specific physical process or emergent behavior that is related to the ability to simulate an observed phenomenon. This paper describes the outcomes of activities by the Model Diagnostics Task Force (MDTF) under the NOAA Climate Program Office (CPO) Modeling, Analysis, Predictions and Projections (MAPP) program to promote development of PODs and their application to climate and weather prediction models. MDTF and modeling center perspectives on the need for expanded process-oriented diagnosis of models are presented. Multiple PODs developed by the MDTF are summarized, and an open-source software framework developed by the MDTF to aid application of PODs to centers’ model development is presented in the context of other relevant community activities. The paper closes by discussing paths forward for the MDTF effort and for community process-oriented diagnosis

Preface

This book presents the most recent advances in the research and applications of reconfigurable mechanisms and robots. It collects 93 independently reviewed papers presented at the Third ASME/IFToMM International Conference on Reconfigurable Mechanisms and Robots (ReMAR 2015) held in Beijing, China, 20-22 July 2015. The conference papers are organized into seven parts to cover the reconfiguration theory, topology, kinematics and design of reconfigurable mechanisms including reconfigurable parallel mechanisms. The most recent results on reconfigurable robots are presented including their analysis, design, simulation and control. Bio-inspired mechanisms are also explored in the challenging fields of rehabilitation and minimally invasive surgery. This book further addresses deployable mechanisms and origami-inspired mechanisms and showcases a wide range of successful applications of reconfigurable mechanisms and robots. Advances in Reconfigurable Mechanisms and Robots II should be of interest for researchers, engineers and postgraduate students in mechanical engineering, electrical engineering, computer science and mathematics. 

Advances in Reconfigurable Mechanisms and Robots I

Advances in Reconfigurable Mechanisms and Robots I provides a selection of key papers presented in The Second ASME/IFToMM International Conference on Reconfigurable Mechanisms and Robots (ReMAR 2012) held on 9th -11th  July 2012 in Tianjin, China. This ongoing series of conferences will be covered in this ongoing collection of books.   A total of seventy-eight papers are divided into seven parts to cover the topology, kinematics and design of reconfigurable mechanisms with the reconfiguration theory, analysis and synthesis, and present the current research and development in the field of reconfigurable mechanisms including reconfigurable parallel mechanisms. In this aspect, the recent study and development of reconfigurable robots are further presented with the analysis and design and with their control and development. The bio-inspired mechanisms and subsequent reconfiguration are explored in the challenging fields of rehabilitation and minimally invasive surgery. Advances in Reconfigurable Mechanisms and Robots I further extends the study to deployable mechanisms and foldable devices and introduces applications of reconfigurable mechanisms and robots.   The rich-content of Advances in Reconfigurable Mechanisms and Robots I brings together new developments in reconfigurable mechanisms and robots and presents a new horizon for future development in the field of reconfigurable mechanisms and robots

Rescheduling Oriented Dependent Tasks Spread Domain Computing

Abstract: To narrow the scope of rescheduling tasks is one of the effective ways to improve the grid dependent tasks rescheduling efficiency. For how to determine the scope which should improve the efficiency of rescheduling problem as far as possible without affecting the application performance, this paper proposed the rescheduling tasks spread domain concept and its method of computation. Beginning with a minimum tasks set to rescheduling, the computing process is oriented by resource share conflict and data transmission dependent of tasks, and limited by the degree of task to optimize the performance of the whole application. Experimentation results show that static scheduling strategy could maintain the performance advantages compare with the dynamic strategy, thus the efficiency of proposed rescheduling tasks spread domain is validated

Rescheduling Oriented Dependent Tasks Spread Domain Computing

To narrow the scope of rescheduling tasks is one of the effective ways to improve the grid dependent tasks rescheduling efficiency. For how to determine the scope which should improve the efficiency of rescheduling problem as far as possible without affecting the application performance, this paper proposed the rescheduling tasks spread domain concept and its method of computation. Beginning with a minimum tasks set to rescheduling, the computing process is oriented by resource share conflict and data transmission dependent of tasks, and limited by the degree of task to optimize the performance of the whole application. Experimentation results show that static scheduling strategy could maintain the performance advantages compare with the dynamic strategy, thus the efficiency of proposed rescheduling tasks spread domain is validated

Does Education Influence Life-Course Depression in Middle-Aged and Elderly in China? Evidence from the China Health and Retirement Longitudinal Study (CHARLS)

Mental health problems have become a major public health problem worldwide and are more common among middle-aged and elderly people in China. Research on the effect of education on depression is limited, and whether the relationship between education and depression changes over the life course remains unclear. This study was based on the cross-sectional data of 15,767 middle-aged and elderly individuals in the 2018 tracking survey (Wave 4) of the China Health and Retirement Longitudinal Study (CHARLS) database. Multiple linear regression and bootstrap methods were developed to detect the mediating effect of education on depression. In all samples or different age groups, education was significantly positively associated with depression. Three mediators (economic level, health-related lifestyle, and cognitive level) were significantly positively associated with depression, and cognitive level had a greater effect on depression than economic level and health-related lifestyle. The total, direct, and indirect effects of the whole samples and elderly samples were significant; however, the direct effect of the middle-aged samples was insignificant, and the total and indirect effects of the three mediating pathways were all significant, that is, economic level, health-related lifestyle, and cognitive level should produce complete mediation. The multiple linear regression and bootstrap methods could successfully detect the mediating effect of education on depression. On the basis of the education, economic level, health-related lifestyle, cognitive level, and depression of middle-aged and elderly people, we established and compared the total, direct, and mediating effects of education on depression under the life course. The mediating variables should be further increased, and the measurement methods of depression should be developed to improve the credibility of the research results