17 research outputs found
Total synthesis and biological evaluation of the tetramic acid based natural product harzianic acid and its stereoisomers
Financial support for this project was provided by Cancer Research UK (Grant No. C21383/A6950)The bioactive natural product harzianic acid was prepared for the first time in just six steps (longest linear sequence) with an overall yield of 22%. The identification of conditions to telescope amide bond formation and a Lacey-Dieckmann reaction into one pot proved important. The three stereoisomers of harzianic acid were also prepared, providing material for comparison of their biological activity. While all of the isomers promoted root growth, improved antifungal activity was unexpectedly associated with isomers in the enantiomeric series opposite that of harzianic acid.Publisher PDFPeer reviewe
Silphiperfolene-Type Terpenoids and Other Metabolites from Cultures of the Tropical Ascomycete Hypoxylon rickii (Xylariaceae)
Zopfiellamides A and B, antimicrobial pyrrolidinone derivatives from the marine fungus Zopfiella latipes
Two new antimicrobial metabolites, zopfiellamides A (1) and B (2) were isolated from fermentations of the facultative marine fungus Zopfiella latipes CBS 611.97. Their structures were elucidated by spectroscopic techniques, and they are pyrrolidinone derivatives. (C) 2002 Elsevier Science Ltd. All rights reserved
Die sekundäre Varusdislokation nach winkelstabiler Plattenosteosynthese der proximalen Humerusfraktur - Zwangsläufig ein schlechtes Outcome?
Konservative versus operative Behandlung der Skapulafraktur mit Beteiligung der Fossa glenoidalis (Euler u. Rüedi Typ D2) - Klinische und radiologische Langzeitergebnisse mit einem min. Follow-up von 10 Jahren
Versagensmuster der winkelstabilen Plattenosteosynthese nach Versorgung dislozierter proximaler Humerusfrakturen - Definition, zeitliches Auftreten und Komplikationsmanagement
Funktionelles Outcome nach winkelstabiler Plattenosteosynthese proximaler Humerusfrakturen - eine Auswertung von 557 Fällen nach einem mittleren Follow-Up Zeitraum von 4 Jahren
Harzianic Acid, an Antifungal and Plant Growth Promoting Metabolite from Trichoderma harzianum
Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus
Supporting Information Available: 1D and 2D NMR spectra for
terretonins E and F. This material is available free of charge via the
Internet at http://pubs.acs.org.[EN] Two new meroterpenoids, terretonins E and F (1, 2), together with three known compounds, aurantiamine (3), linoleic acid, and uridine, were isolated as fermentation products of the marine-derived fungus Aspergillus insuetus, which was associated with the sponge Petrosia ficiformis. Structures of all isolates were elucidated employing spectroscopic methods, mainly by two-dimensional NMR techniques. Compounds 1-3 showed activity as inhibitors of the mammalian mitochondrial respiratory chain.We acknowledge ICB and ITQ NMR Service (D. Melck and E. Mateos) and E. Estornell and V. Romero for biological assay support. We would like to thank the R&D&I Linguistic Assistance Office, Universidad Politecnica de Valencia (Spain), for granting financial support for the linguistic revision of this paper. This work has been supported through European Social Fund (ESF).López Gresa, MP.; Cabedo Escrig, N.; Gonzalez-Mas, MC.; Ciavatta, ML.; Avila, C.; Primo Millo, J. (2009). Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus. Journal of Natural Products. 72(7):1348-1351. doi:10.1021/np900085nS1348135172