136 research outputs found

    Mobile Health Information Technology and Patient Care: Methods, Themes, and Research Gaps

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    The focus of the healthcare industry on delivering Patient-Centered Care (PCC) using Mobile Health Information Technologies (MHIT) is rapidly increasing, yet this critical area is still under-researched in the IS/IT literature despite the fact that mobile devices and their applications are widely spread and are likely to change the way of using and applying healthcare services. In this study we further analyze the literature reviewed in Dadgar et al (2013) to uncover research gaps in the area of MHIT which needs further attention. This work posits a preliminary research agenda, in forms of gaps, which can help propel future work in the field of MHIT for patient centered care

    Ear and Face Mucormycosis; A Case Report.

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    peer reviewedMucormycosis is an invasive fungal infection belonging to order of Mucorales which causes a high rate of mortality. This infection is mostly common in the immunosuppression conditions such as diabetes mellitus, chemotherapy, organ transplantation and hematologic malignancies

    Feasibility studies for imaging e+^{+}e−^{-} annihilation with modular multi-strip detectors

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    Studies based on imaging the annihilation of the electron (e−^{-}) and its antiparticle positron (e+^{+}) open up several interesting applications in nuclear medicine and fundamental research. The annihilation process involves both the direct conversion of e+^{+}e−^{-} into photons and the formation of their atomically bound state, the positronium atom (Ps), which can be used as a probe for fundamental studies. With the ability to produce large quantities of Ps, manipulate them in long-lived Ps states, and image their annihilations after a free fall or after passing through atomic interferometers, this purely leptonic antimatter system can be used to perform inertial sensing studies in view of a direct test of Einstein equivalence principle. It is envisioned that modular multistrip detectors can be exploited as potential detection units for this kind of studies. In this work, we report the results of the first feasibility study performed on a e+^{+} beamline using two detection modules to evaluate their reconstruction performance and spatial resolution for imaging e+^{+}e−^{-} annihilations and thus their applicability for gravitational studies of Ps

    Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

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    We sought to determine the mechanisms underlying failure of muscle regeneration that is observed in dystrophic muscle through hypothesis generation using muscle profiling data (human dystrophy and murine regeneration). We found that transforming growth factor β-centered networks strongly associated with pathological fibrosis and failed regeneration were also induced during normal regeneration but at distinct time points. We hypothesized that asynchronously regenerating microenvironments are an underlying driver of fibrosis and failed regeneration. We validated this hypothesis using an experimental model of focal asynchronous bouts of muscle regeneration in wild-type (WT) mice. A chronic inflammatory state and reduced mitochondrial oxidative capacity are observed in bouts separated by 4 d, whereas a chronic profibrotic state was seen in bouts separated by 10 d. Treatment of asynchronously remodeling WT muscle with either prednisone or VBP15 mitigated the molecular phenotype. Our asynchronous regeneration model for pathological fibrosis and muscle wasting in the muscular dystrophies is likely generalizable to tissue failure in chronic inflammatory states in other regenerative tissues
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