Flight control electronics reliability/maintenance study

Collection and analysis of data are reported that concern the reliability and maintenance experience of flight control system electronics currently in use on passenger carrying jet aircraft. Two airlines B-747 airplane fleets were analyzed to assess the component reliability, system functional reliability, and achieved availability of the CAT II configuration flight control system. Also assessed were the costs generated by this system in the categories of spare equipment, schedule irregularity, and line and shop maintenance. The results indicate that although there is a marked difference in the geographic location and route pattern between the airlines studied, there is a close similarity in the reliability and the maintenance costs associated with the flight control electronics

Spectral estimates of bed shear stress using suspended-sediment concentrations in a wave-current boundary layer

High-resolution time series of suspended-sediment profiles have been obtained using an acoustic backscatter system at an inner shelf site (North Carolina) where flows are dominated by wind-driven currents and waves. We analyzed the spatial and temporal structure of near-bed turbulence in particle-transporting flows and scalar-like fluctuations of suspended-sediment concentrations. An important element of our analysis is a new inertial dissipation method for passive tracers to estimate the shear stress acting on the seabed, using the spectral properties of suspended sediment concentrations observed by acoustic backscatter sensors. In flows that provide adequate separation of the scales of turbulence production and dissipation, a sufficiently thick constant stress wall layer, and significant sediment suspension, frequency (or associated wave number) spectra of near-bed sediment concentration exhibit a -5/3 slope in the inertial subrange that spans frequencies of order 1 Hz. This observation suggests that the suspended sediment is effectively a passive tracer of turbulent fluid motions. Inversion of the relevant, Kolmogorov scaling equations yields estimates of the shear velocity that agree reasonably well with other, independent and widely used measures. High- and low-frequency limits on application of the inertial dissipation method to sediment concentration are related to the inertial response time of sediment particles and the sediment settling timescale. We propose that, in future applications, the inertial dissipation method for passive tracers can be used to estimate either the shear velocity, effective settling velocity of suspended sediment (or equivalent particle size) or dynamic bed roughness if two of these three quantities are independently known

Surficial Redistribution of Fallout 131iodine in a Small Temperate Catchment

Isotopes of iodine play significant environmental roles, including a limiting micronutrient (127I), an acute radiotoxin (131I), and a geochemical tracer (129I). But the cycling of iodine through terrestrial ecosystems is poorly understood, due to its complex environmental chemistry and low natural abundance. To better understand iodine transport and fate in a terrestrial ecosystem, we traced fallout 131iodine throughout a small temperate catchment following contamination by the 11 March 2011 failure of the Fukushima Daiichi nuclear power facility. We find that radioiodine fallout is actively and efficiently scavenged by the soil system, where it is continuously focused to surface soils over a period of weeks following deposition. Mobilization of historic (pre-Fukushima) 137cesium observed concurrently in these soils suggests that the focusing of iodine to surface soils may be biologically mediated. Atmospherically deposited iodine is subsequently redistributed from the soil system via fluvial processes in a manner analogous to that of the particle-reactive tracer 7beryllium, a consequence of the radionuclides’ shared sorption affinity for fine, particulate organic matter. These processes of surficial redistribution create iodine hotspots in the terrestrial environment where fine, particulate organic matter accumulates, and in this manner regulate the delivery of iodine nutrients and toxins alike from small catchments to larger river systems, lakes and estuaries

The Ideal Intersection Property for Groupoid Graded Rings

We show that if a groupoid graded ring has a certain nonzero ideal property, then the commutant of the center of the principal component of the ring has the ideal intersection property, that is it intersects nontrivially every nonzero ideal of the ring. Furthermore, we show that for skew groupoid algebras with commutative principal component, the principal component is maximal commutative if and only if it has the ideal intersection property

Associations between the gut microbiome and metabolome in early life

Background: The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the taxonomic composition of the microbiome and its metabolic phenotype is undefined and complicated by redundancies in the taxon-function relationship within microbial communities. To inform a more mechanistic understanding of the relationship between the microbiome and health, we performed an integrative statistical and machine learning-based analysis of microbe taxonomic structure and metabolic function in order to characterize the taxa-function relationship in early life. Results: Stool samples collected from infants enrolled in the New Hampshire Birth Cohort Study (NHBCS) at approximately 6-weeks (n = 158) and 12-months (n = 282) of age were profiled using targeted and untargeted nuclear magnetic resonance (NMR) spectroscopy as well as DNA sequencing of the V4-V5 hypervariable region from the bacterial 16S rRNA gene. There was significant inter-omic concordance based on Procrustes analysis (6 weeks: p = 0.056; 12 months: p = 0.001), however this association was no longer significant when accounting for phylogenetic relationships using generalized UniFrac distance metric (6 weeks: p = 0.376; 12 months: p = 0.069). Sparse canonical correlation analysis showed significant correlation, as well as identifying sets of microbe/metabolites driving microbiome-metabolome relatedness. Performance of machine learning models varied across different metabolites, with support vector machines (radial basis function kernel) being the consistently top ranked model. However, predictive R2 values demonstrated poor predictive performance across all models assessed (avg: − 5.06% -- 6 weeks; − 3.7% -- 12 months). Conversely, the Spearman correlation metric was higher (avg: 0.344–6 weeks; 0.265–12 months). This demonstrated that taxonomic relative abundance was not predictive of metabolite concentrations. Conclusions: Our results suggest a degree of overall association between taxonomic profiles and metabolite concentrations. However, lack of predictive capacity for stool metabolic signatures reflects, in part, the possible role of functional redundancy in defining the taxa-function relationship in early life as well as the bidirectional nature of the microbiome-metabolome association. Our results provide evidence in favor of a multi-omic approach for microbiome studies, especially those focused on health outcomes

Towards a molecular definition of worker sterility: differential gene expression and reproductive plasticity in honey bees

We show that differences in the reproductive development of honey bee workers are associated with locus-specific changes to abundance of messenger RNA. Using a cross-fostering field experiment to control for differences related to age and environment, we compared the gene expression profiles of functionally sterile workers (wild-type) and those from a mutant strain in which workers are reproductively active (anarchist). Among the set of three genes that are significantly differentially expressed are two major royal jelly proteins that are up-regulated in wild-type heads. This discovery is consistent with sterile workers synthesizing royal jelly as food for developing brood. Likewise, the relative underexpression of these two royal jellies in anarchist workers is consistent with these workers’ characteristic avoidance of alloparental behaviour, in favour of selfish egg-laying. Overall, there is a trend for the most differentially expressed genes to be up-regulated in wild-type workers. This pattern suggests that functional sterility in honey bee workers may generally involve the expression of a suite of genes that effectively ‘switch’ ovaries off, and that selfish reproduction in honey bee workers, though rare, is the default developmental pathway that results when ovary activation is not suppressed

Post-Trial Feedback Alters Landing Performance in Adolescent Female Athletes Using a Portable Feedback System

# Background Post-performance verbal and visual feedback based on data collected via lab-based instruments have been shown to improve landing patterns related to non-contact ACL injury. Biomechanical methods are often complex, difficult to transport and utilize in field settings, and costly, which limits their use for injury prevention. Developing systems that can readily provide feedback outside of the lab setting may support large scale use of feedback training for ACL injury prevention. # Purpose/Hypothesis The purpose of this study was to investigate the effectiveness of a single training session using a custom portable feedback training system that provides performance cues to promote changes in impact kinetics and lower extremity position during landing in female athletes. # Study Design Repeated measures # Methods One hundred fifty female athletes (ages 13-18 years old) landed from a 50 cm platform with and without feedback related to vertical ground reaction force (vGRF), vGRF symmetry and lower extremity position. Feedback was provided via a portable, low-cost system that included two custom-built force plates interfaced with a digital camera. Each athlete performed six pre-test trials followed by two blocks of six trials where they received visual feedback from the training system and individualized verbal cues from an investigator. Following training blocks, athletes completed six post-test trials without feedback and then six dual-task trials where a ball was randomly thrown to the performer during the landing (transfer task). vGRF and knee to ankle (K:A) separation ratio were measured and the average responses were reported for each trial block. # Results Differences in vGRF between baseline, post-test and transfer task trial blocks were observed (F(2,298)=181.68, p < .0001). Mean (SD) peak vGRF (body weight) were 4.43 (0.90), 3.28 (0.61), and 3.80 (0.92), respectively. Differences in K:A ratio between baseline, post-test and transfer task trial blocks were shown (F(2,298)=68.47, p < .0001). Mean (SD) K:A ratio were 0.87 (0.21), 0.98 (0.19), and 0.92 (0.19), respectively. # Conclusion A portable feedback system may be effective in reducing peak vGRFs and promoting a more desirable K:A ratio during landing and transfer task landing in adolescent female athletes. # Level of Evidence 3

Design and modelling of an engineered bacteria-based, pressure-sensitive soil.

In this paper, we describe the first steps in the design of a synthetic biological system based on the use of genetically modified bacteria to detect elevated pressures in soils and respond by cementing soil particles. Such a system might, for example, enable a self- constructed foundation to form in response to load using engineered bacteria which could be seeded and grown in the soils. This process would reduce the need for large-scale excavations and may be the basis for a new generation of self-assembling and responsive bio-based materials. A prototype computational model is presented which integrates experimental data from a pressure sensitive gene within Escherichia coli bacteria with geotechnical models of soil loading and pore water pressure. The results from the integrated model are visualised by mapping expected gene expression values onto the soil volume. We also use our experimental data to design a two component system where one type of bacteria acts as a sensor and signals to another material synthesis bacteria. The simulation demonstrates the potential of computational models which integrate multiple scales from macro stresses in soils to the expression of individual genes to inform new types of design process. The work also illustrates the combination of in silico (silicon based computing) computation with in vivo (in the living) computation