Validity and reliability of the Serbian version of Patient-Reported Impact of Spasticity Measure in multiple sclerosis

The Patient-Reported Impact of Spasticity Measure (PRISM) has been developed recently to assess the impact of spasticity on quality of life after spinal cord injury. Although PRISM may also be useful in patients with multiple sclerosis (MS), its psychometric properties in MS have not been established and PRISM is currently available only in English. The aims of this cross-sectional study were to translate PRISM into the Serbian language (PRISMSR) and examine its validity (construct, convergent, divergent) and reliability (internal consistency, test-retest reliability) in 48 patients with spasticity because of MS diagnosed at least 1 year earlier and in remission at least 3 months. PRISMSR was administered twice 3 days apart. The validity of seven PRISMSR subscales was examined against the Modified Ashworth Scale (MAS), the Numerical Rating Scale (NRS) for spasticity, sex, and education. Internal consistency was assessed with Cronbach α and test-retest reliability with intraclass correlation coefficient for agreement (ICC2,1). During the forward-backward translation, only one PRISM item required minor cultural adaption. Almost all PRISMSR scores correlated significantly with MAS and NRS scores (r=0.29-0.51, 0.001≤P≤0.043). They were all significantly higher for MAS≥2 group versus the MAS<2 group (0.003≤P≤0.035) and for the NRS≥7 group versus the NRS<7 group (0.001≤P≤0.042), except for the Social Embarrassment subscale (P=0.083). The PRISMSR scores were not significantly different between sexes (P≥0.104) or those with high school versus college degree (P≥0.139). Both Cronbach α (0.78-0.93) and test-retest ICC2,1 (0.82-0.90) were high. The original PRISM may be translated successfully into other languages. PRISMSR shows adequate validity and reliability for assessing the impact of spasticity on quality of life in patients with MS

Validation of the Serbian Version of Multiple Sclerosis Spasticity Scale 88 (MSSS-88).

Multiple Sclerosis Spasticity Scale (MSSS)-88 has been developed for self-assessment of spasticity symptoms in patients with multiple sclerosis (MS). The objective of this study was to validate MSSS-88 and evaluate the psychometric properties in patients with MS in Serbia.The study comprised 65 MS patients with spasticity. MSSS-88 consists of 88 items grouped in eight sections. Internal consistency of the MSSS-88SR subscales was determined using Cronbach's alpha coefficient. Test/retest reliability with an intra-class correlation coefficient (ICC) for each MSSS-88SR subscale was performed. Clinical validity of MSSS-88SR was determined by correlations with the Numeric Rating Scale (NRS) and the Modified Ashworth Scale (MAS).The range of Cronbach's alpha for all scales and ICC was 0.91-0.96 and 0.84-0.91, respectively. All ICCs were statistically significant (p<0.05). All evaluated subscales of MSSS-88 were significantly correlated with the NRS scale. The highest correlation coefficients were registered between the WL subscale and the EDSS and MAS, while the strongest relationship was observed between the MSS subscale and the NRS.The Serbian translated version of this instrument may be useful as a clinical measure for spasticity and functionality in patients with MS

MSJ787347_supplementary_figure – Supplemental material for Dynamic volumetric changes of hippocampal subfields in clinically isolated syndrome patients: A 2-year MRI study

<p>Supplemental material, MSJ787347_supplementary_figure for Dynamic volumetric changes of hippocampal subfields in clinically isolated syndrome patients: A 2-year MRI study by Laura Cacciaguerra, Elisabetta Pagani, Sharlota Mesaros, Jelena Dackovic, Irena Dujmovic-Basuroski, Jelena Drulovic, Paola Valsasina, Massimo Filippi and Maria Assunta Rocca in Multiple Sclerosis Journal</p

MSJ787347_supplementary_MRI_details – Supplemental material for Dynamic volumetric changes of hippocampal subfields in clinically isolated syndrome patients: A 2-year MRI study

<p>Supplemental material, MSJ787347_supplementary_MRI_details for Dynamic volumetric changes of hippocampal subfields in clinically isolated syndrome patients: A 2-year MRI study by Laura Cacciaguerra, Elisabetta Pagani, Sharlota Mesaros, Jelena Dackovic, Irena Dujmovic-Basuroski, Jelena Drulovic, Paola Valsasina, Massimo Filippi and Maria Assunta Rocca in Multiple Sclerosis Journal</p

The correlation analysis of MSSS-88 subscales with the EDSS, MAS and NRS scales scores.

<p>The correlation analysis of MSSS-88 subscales with the EDSS, MAS and NRS scales scores.</p

Differences in MSSS-88 subscale scores between test and retest.

<p>Differences in MSSS-88 subscale scores between test and retest.</p