Teaching Medical Students about Communicating with Patients with Major Mental Illness

Persons with major mental illness often have chronic diseases and poor physical health. Therefore, all practicing physicians should learn about communicating effectively with these patients. Few efforts to teach medical students communication skills have specifically targeted patients with major mental illness. Indeed, most of the limited literature on this topic is decades old, predating significant scientific advances in cognitive neuroscience and psychiatric therapeutics and changes in social policies regarding major mental illness. To gather preliminary insight into training needs, we interviewed 13 final-year students from 2 Boston medical schools. Students' observations coalesced around 4 themes: fears and anxieties about interacting with persons with major mental illness; residents “protecting” students from patients with major mental illness; lack of clinical maturity; and barriers to learning during psychiatry rotations. Educational researchers must explore ways to better prepare young physicians to communicate effectively with patients with major mental illness

Porous organic molecules

Most synthetic materials that show molecular-scale porosity consist of one-, two- or three-dimensional networks. Porous metal-organic frameworks in particular have attracted a lot of recent attention. By contrast, discrete molecules tend to pack efficiently in the solid state, leaving as little empty space as possible, which leads to non-porous materials. This Perspective discusses recent developments with discrete organic molecules that are porous in the solid state. Such molecules, which may be either crystalline or amorphous, can be categorized as either intrinsically porous (containing permanent covalent cavities) or extrinsically porous (inefficiently packed). We focus on the possible advantages of organic molecules over inorganic or hybrid systems in terms of molecular solubility, choice of components and functionalities, and structural mobility and responsiveness in non-covalent extended solids. We also highlight the potential for 'undiscovered' porous systems among the large number of cage-like organic molecules that are already known

UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication

<div><p>Positive-strand RNA virus infections can induce the stress-related unfolded protein response (UPR) in host cells. This study found that enterovirus A71 (EVA71) utilizes host UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1), a key endoplasmic reticulum protein (ER) involved in UPR, to enhance viral replication and virulence. EVA71 forms replication complexes (RCs) on cellular membranes that contain a mix of host and viral proteins to facilitate viral replication, but the components and processes involved in the assembly and function of RCs are not fully understood. Using EVA71 as a model, this study found that host UGGT1 and viral 3D polymerase co-precipitate along with other factors on membranous replication complexes to enhance viral replication. Increased UGGT1 levels elevated viral growth rates, while viral pathogenicity was observed to be lower in heterozygous knockout mice (Uggt1 +/- mice). These findings provide important insight on the role of UPR and host UGGT1 in regulating RNA virus replication and pathogenicity.</p></div

Systematik vermeidungsorientierter Produktnutzungskonzepte - Optimierung der Produktnutzung als Beitrag zum Umweltschutz

During the last few decades, the world has witnessed a dual democratic transformation. On the one hand and beginning with the fall of communism, the number of electoral democracies worldwide almost doubled between 1989 and 2011 (Freedom House, 2012). The victory of democracy and capitalism may not have marked the “end of history” (Fukuyama, 1992), but today there is no alternative political system that enjoys the same worldwide support and legitimacy as democracy (Inglehart & Welzel, 2005; Inglehart, 2003). On the other hand, many established democracies have witnessed a transformation towards increasing complexity, less deferential and increasingly critical and dissatisfied citizens (Norris, 2011), lower electoral turnout and trust in politicians and political institutions (Franklin, 2004; Norris, 1999), and increasingly autonomous, market-driven and critical media (Hallin & Mancini, 2004; Hamilton, 2004; Patterson, 1993). National political institutions and actors thus find themselves under increasing pressure from both citizens and the media, while the need to find solutions to major challenges such as global warming, rising inequalities, weak growth and increasing deficits appears both more urgent and more difficult to tackle

Innate immunity in inflammation

A fine balance between prompt response to pathogens and avoidance of unregulated inflammation, as well as that between protection and self-damage drives the complexity of the immune system, at the same time pointing out the challenge for effective and safe immunopharmacological intervention. A wide variety of clinically relevant drugs are currently used in the treatment of human inflammatory and immune-system associated disorders. Classical therapeutic approaches are now integrated with emerging strategies that largely derive from advances in signalling and regulatory networks and the pathological consequences of their dysregulation in the field of innate immunity. This chapter provides an account of: (i) the interplay between innate immunity and inflammation; (ii) main immune signalling molecules in inflammation including cytokines, prostanoids and cancer-related immune response, and the main aspects of pharmacological control thereof; and (iii) emerging options for therapeutic interventions on cells of innate immunity

Offshore and Multi-Use Aquaculture with Extractive Species: Seaweeds and Bivalves

Aquaculture of extractive species, such as bivalves and macroalgae, already supplies a large amount of the production consumed worldwide, and further production is steadily increasing. Moving aquaculture operations off the coast as well as combining various uses at one site, commonly called multi-use aquaculture, is still in its infancy. Various projects worldwide, pioneered in Germany and later accompanied by other European projects, such as in Belgium, The Netherlands, Norway, as well as other international projects in the Republic of Korea and the USA, to name a few, started to invest in robust technologies and to investigate in system design needed that species can be farmed to market size in high energy environments. There are a few running enterprises with extractive species offshore, however, multi-use scenarios as well as offshore IMTA concepts are still on project scale. This will change soon as the demand is dramatically increasing and space is limited