1-(2-Furo­yl)-3-(o-tol­yl)thio­urea

The title compound, C13H12N2O2S, was synthesized from furoyl isothio­cyanate and o-toluidine in dry acetone. The thio­urea group is in the thio­amide form. The central thio­urea fragment makes dihedral angles of 2.6 (1) and 22.4 (1)° with the ketofuran group and the benzene ring, respectively. The mol­ecular structure is stabilized by N—H⋯O hydrogen bonds. In the crystal structure, centrosymmetrically related mol­ecules are linked by a pair of N—H⋯S hydrogen bonds to form a dimer with an R 2 2(6) ring motif

High-quality genome-scale metabolic modelling of \u3ci\u3ePseudomonas putida\u3c/i\u3e highlights its broad metabolic capabilities

Genome-scale reconstructions of metabolism are computational species-specific knowledge bases able to compute systemic metabolic properties. We present a comprehensive and validated reconstruction of the biotechnologically relevant bacterium Pseudomonas putida KT2440 that greatly expands computable predictions of its metabolic states. The reconstruction represents a significant reactome expansion over available reconstructed bacterial metabolic networks. Specifically, iJN1462 (i) incorporates several hundred additional genes and associated reactions resulting in new predictive capabilities, including new nutrients supporting growth; (ii) was validated by in vivo growth screens that included previously untested carbon (48) and nitrogen (41) sources; (iii) yielded gene essentiality predictions showing large accuracy when compared with a knock-out library and Bar-seq data; and (iv) allowed mapping of its network to 82 P. putida sequenced strains revealing functional core that reflect the large metabolic versatility of this species, including aromatic compounds derived from lignin. Thus, this study provides a thoroughly updated metabolic reconstruction and new computable phenotypes for P. putida, which can be leveraged as a first step toward understanding the pan metabolic capabilities of Pseudomonas

Neuropatía autonómica cardíaca diabética

La neuropatía autonómica cardíaca es una complicación frecuente y subdiagnosticada de la diabetes, se asocia con una mayor mortalidad por causas cardiovasculares e incapacidad física. El tratamiento actual está basado en recomendaciones de expertos y experiencias locales, debido a la falta de estudios de alto peso epidemiológico que orienten el manejo de estos pacientes. Con esta revisión se busca generar conciencia a la comunidad médica acerca de la importancia de esta entidad, de su reconocimiento temprano, formas de diagnóstico y tratamiento disponibles con la evidencia actual

N-(2-Furylcarbon­yl)piperidine-1-carbo­thio­amide

The title compound, C11H14N2O2S, was synthesized from furoyl isothio­cyanate and piperidine in dry acetone. The thio­urea group is in the thio­amide form. The thio­urea group makes a dihedral angle of 53.9 (1)° with the furan carbonyl group. In the crystal structure, mol­ecules are linked by inter­molecular N—H⋯O hydrogen bonds, forming one-dimensional chains along the c axis. An intramolecular N—H⋯O hydrogen bond is also present

Why could Electron Spin Resonance be observed in a heavy fermion Kondo lattice?

We develop a theoretical basis for understanding the spin relaxation processes in Kondo lattice systems with heavy fermions as experimentally observed by electron spin resonance (ESR). The Kondo effect leads to a common energy scale that regulates a logarithmic divergence of different spin kinetic coefficients and supports a collective spin motion of the Kondo ions with conduction electrons. We find that the relaxation rate of a collective spin mode is greatly reduced due to a mutual cancelation of all the divergent contributions even in the case of the strongly anisotropic Kondo interaction. The contribution to the ESR linewidth caused by the local magnetic field distribution is subject to motional narrowing supported by ferromagnetic correlations. The developed theoretical model successfully explains the ESR data of YbRh2Si2 in terms of their dependence on temperature and magnetic field.Comment: 5pages, 1 Figur

Half-metallic finite zigzag single-walled carbon nanotubes from first principles

Density-functional calculations predict half-metallicity in zigzag single-walled carbon nanotubes of finite length with the two ends saturated with hydrogen. We have analyzed the change of the β- and α-spin electronic gaps under the influence of an electric field applied along the nanotube axis. The half-metallic behavior, in which the electronic gap is zero for one spin flavor and nonzero for the other, is obtained for a critical electric field of 3.0/w V/Å, where w is the length of the nanotube. This critical field is the same as that predicted for graphene nanoribbons. By a detailed analysis of the spin structure of the ground state, we show the relevance of the edge states, electronic states spatially localized at the carbon atoms of the nanotube boundaries, on the on-set of half-metallicity, and on the magnetic properties of the finite semiconducting zigzag nanotubes

1-Furoyl-3-[3-(trifluoro­meth­yl)phen­yl]thio­urea

The title compound, C13H9F3N2O2S, crystallizes with two independent mol­ecules in the asymmetric unit. The central thio­urea core is roughly coplanar with the furan and benzene rings, showing O—C—N—C(S) torsion angles of 2.3 (4) and −11.4 (2)° and (S)C—N—C—C torsion angles of −2.4 (4) and −28.8 (4)°, respectively, in the two independent mol­ecules. The trans–cis geometry of the thio­urea fragment is stabilized by an intra­molecular N—H⋯O hydrogen bond between the H atom of the cis thio­amide and the carbonyl O atom. In the crystal structure, inter­molecular N—H⋯S hydrogen bonds form centrosymmetric dimers extending along the b axis