La métallurgie du fer : technique, symbolique et sémantique : symbolique obstétrique et dynamique de la contradiction en Afrique centrale

Les métallurgistes africains accordent une grande importance à ce qui est convenu d'appeler des procédures magiques. La variété des gestes symboliques révélée par notre inventaire bibliographique repose sur une base commune, l'activité sémantique, entendue comme production de sens pour orienter l'action. La métaphore obstétrique, toujours présente, ne doit pas occulter le travail sémantique dont elle est issue. L'efficacité technique apparaît sous-entendue par une dynamique de la contradiction qui rapproche temporairement des éléments définis comme distincts et opposés dans la vie ordinaire. (Résumé d'auteur

Glucagon-like peptide 1 improved glycemic control in type 1 diabetes

BACKGROUND: Glucagon-like peptide-1 (GLP-1) and its agonists are under assessment in treatment of type 2 diabetes, by virtue of their antidiabetic actions, which include stimulation of insulin secretion, inhibition of glucagon release, and delay of gastric emptying. We examined the potential of GLP-1 to improve glycemic control in type 1 diabetes with no endogenous insulin secretion. METHODS: Dose-finding studies were carried out to establish mid range doses for delay of gastric emptying indicated by postponement of pancreatic polypeptide responses after meals. The selected dose of 0.63 micrograms/kg GLP-1 was administered before breakfast and lunch in 8-hour studies in hospital to establish the efficacy and safety of GLP-1. In outside-hospital studies, GLP-1 or vehicle was self-administered double-blind before meals with usual insulin for five consecutive days by five males and three females with well-controlled C-peptide-negative type 1 diabetes. Capillary blood glucose values were self-monitored before meals, at 30 and 60 min after breakfast and supper, and at bedtime. Breakfast tests with GLP-1 were conducted on the day before and on the day after 5-day studies. Paired t-tests and ANOVA were used for statistical analysis. RESULTS: In 8-hour studies time-averaged incremental (delta) areas under the curves(AUC) for plasma glucose through 8 hours were decreased by GLP-1 compared to vehicle (3.2 ± 0.9, mean ± se, vs 5.4 ± 0.8 mmol/l, p < .05), and for pancreatic polypeptide, an indicator of gastric emptying, through 30 min after meals (4.0 ± 3.1 vs 37 ± 9.6 pmol/l, p < .05) with no adverse effects. Incremental glucagon levels through 60 min after meals were depressed by GLP-1 compared to vehicle (-3.7 ± 2.5 vs 3.1 ± 1.9 ng/l, p < .04). In 5-day studies, AUC for capillary blood glucose levels were lower with GLP-1 than with vehicle (-0.64 ± 0.33 vs 0.34 ± 0.26 mmol/l, p < .05). No assisted episode of hypoglycaemia or change in insulin dosage occurred. Breakfast tests on the days immediately before and after 5-day trials showed no change in the effects of GLP-1. CONCLUSION: We have demonstrated that subcutaneous GLP-1 can improve glucose control in type 1 diabetes without adverse effects when self-administered before meals with usual insulin during established intensive insulin treatment programs

Study of the pitch change of carbon coils during their growth

AbstractIn the present paper, carbon coils (CCs) were prepared by CVD. Their morphology, particularly pitch changes of the carbon coils prepared in different conditions were observed. It was found that the carbon source flow plays an important role in carbon coil growth and its morphology evolution. The appropriate atmosphere and flow rate is beneficial to the steady reactivity of catalyst particles. As such each carbon coil can grow well and have an exact growth rate. When the carbon supply is sufficient, the CCs exhibit close spiral and small coil diameter. When carbon supply decreases, small carbon supply leads to large pitch and coil diameter. CCs can be synthesized with different coil pitch under different carbon supply. This may be of great significance for the controllable preparation of carbon coil and its application

Phase Transition in a Model with Non-Compact Symmetry on Bethe Lattice and the Replica Limit

We solve $O(n,1)$ nonlinear vector model on Bethe lattice and show that it exhibits a transition from ordered to disordered state for $0 \leq n < 1$. If the replica limit $n\to 0$ is taken carefully, the model is shown to reduce to the corresponding supersymmetric model. The latter was introduced by Zirnbauer as a toy model for the Anderson localization transition. We argue thus that the non-compact replica models describe correctly the Anderson transition features. This should be contrasted to their failure in the case of the level correlation problem.Comment: 21 pages, REVTEX, 2 Postscript figures, uses epsf styl

Epistemic policy networks in the European Union’s CBRN risk mitigation policy

This paper offers insights into an innovative and currently flagship approach of the European Union (EU) to the mitigation of chemical, biological, radiological, and nuclear (CBRN) risks. Building on its long-time experience in the CBRN field, the EU has incorporated methods familiar to the students of international security governance: it is establishing regional networks of experts and expertise. CBRN Centers of Excellence, as they are officially called, aim to contribute to the security and safety culture in different parts of Africa, the Middle East, South East Asia, and South East Europe, in the broadly construed CBRN area. These regional networks represent a modern form of security cooperation, which can be conceptualized as an epistemic policy networks approach. It offers flexibility to the participating states, which have different incentives to get involved. At the same, however, the paper identifies potential limitations and challenges of epistemic policy networks in this form

Effect of permafrost thawing on organic carbon and trace element colloidal speciation in the thermokarst lakes of western Siberia

To examine the mechanisms of carbon mobilization and biodegradation during permafrost thawing and to establish a link between organic carbon (OC) and other chemical and microbiological parameters in forming thermokarst (thaw) lakes, we studied the biogeochemistry of OC and trace elements (TEs) in a chronosequence of small lakes that are being formed due to permafrost thawing in the northern part of western Siberia. Twenty lakes and small ponds of various sizes and ages were sampled for dissolved and colloidal organic carbon, metals and culturable heterotrophic bacterial cell number. We observed a sequence of ecosystems from peat thawing and palsa degradation due to permafrost subsidence in small ponds to large, km-size lakes that are subject to drainage to, finally, the khasyrey (drained lake) formation. There is a systematic evolution of both total dissolved and colloidal concentration of OC and TEs in the lake water along with the chronosequence of lake development that may be directly linked to the microbial mineralization of dissolved organic matter and the liberation of the inorganic components (Fe, Al, and TEs) from the organo-mineral colloids. &lt;br&gt;&lt;br&gt; In this chronosequence of lake development, we observed an apparent decrease in the relative proportion of low molecular weight &lt;1 kDa (1 kDa ~ 1 nm) OC concentration along with a decrease in the concentration of total dissolved (&lt;0.45 μm) OC. This decrease was accompanied by an increase in the small size organic ligands (probably autochthonous exometabolites produced by the phytoplankton) and a simultaneous decrease in the proportion of large-size organic (humic) complexes of allochthonous (soil) origin. This evolution may be due to the activity of heterotrophic bacterioplankton that use allochthonous organic matter and dissolved nutrients originating from peat lixiviation. Most insoluble TEs demonstrate a systematic decrease in concentration during filtration (5 μm, 0.45 μm) exhibiting a similar pattern among different samples. At the same time, there is an increase in the relative proportion of large size particles over the &lt;1 kDa fraction for most insoluble elements along the chronosequence of lake evolution. TEs are likely to be bound to colloidal OC and coprecipitate with the mineral (Fe, Al) part of the colloids. Upon progressive consumption of dissolved OC by the heterotrophic bacteria, there is liberation of Fe, Al, and insoluble TEs in the water column that may be subjected to coagulation in the form of particles or large-size mineral colloids