PLoS One

[This corrects the article DOI: 10.1371/journal.pone.0196711.]

Microorganisms

The indoor microbial community is a mixture of microorganisms resulting from outdoor ecosystems that seed the built environment. However, the biogeography of the indoor microbial community is still inadequately studied. Dust from more than 3000 dwellings across France was analyzed by qPCR using 17 targets: 10 molds, 3 bacteria groups, and 4 mites. Thus, the first spatial description of the main indoor microbial allergens on the French territory, in relation with biogeographical factors influencing the distribution of microorganisms, was realized in this study. Ten microorganisms out of 17 exhibited increasing abundance profiles across the country: Five microorganisms (Dermatophagoïdes pteronyssinus, Dermatophagoïdes spp., Streptomyces spp., Cladosporium sphaerospermum, Epicoccum nigrum) from northeast to southwest, two (Cryptococcus spp., Alternaria alternata) from northwest to southeast, Mycobacteria from east to west, Aspergillus fumigatus from south to north, and Penicillium chrysogenum from south to northeast. These geographical patterns were partly linked to climate and land cover. Multivariate analysis showed that composition of communities seemed to depend on landscapes, with species related to closed and rather cold and humid landscapes (forests, located in the northeast) and others to more open, hot, and dry landscapes (herbaceous and coastal regions, located in the west). This study highlights the importance of geographical location and outdoor factors that shape communities. In order to study the effect of microorganisms on human health (allergic diseases in particular), it is important to identify biogeographic factors that structure microbial communities on large spatial scales and to quantify the exposure with quantitative tools, such as the multi-qPCR approach

Diagnosis and management of Silver–Russell syndrome: first international consensus statement

This Consensus Statement summarizes recommendations for clinical diagnosis, investigation and management of patients with Silver–Russell syndrome (SRS), an imprinting disorder that causes prenatal and postnatal growth retardation. Considerable overlap exists between the care of individuals born small for gestational age and those with SRS. However, many specific management issues exist and evidence from controlled trials remains limited. SRS is primarily a clinical diagnosis; however, molecular testing enables confirmation of the clinical diagnosis and defines the subtype. A 'normal' result from a molecular test does not exclude the diagnosis of SRS. The management of children with SRS requires an experienced, multidisciplinary approach. Specific issues include growth failure, severe feeding difficulties, gastrointestinal problems, hypoglycaemia, body asymmetry, scoliosis, motor and speech delay and psychosocial challenges. An early emphasis on adequate nutritional status is important, with awareness that rapid postnatal weight gain might lead to subsequent increased risk of metabolic disorders. The benefits of treating patients with SRS with growth hormone include improved body composition, motor development and appetite, reduced risk of hypoglycaemia and increased height. Clinicians should be aware of possible premature adrenarche, fairly early and rapid central puberty and insulin resistance. Treatment with gonadotropin-releasing hormone analogues can delay progression of central puberty and preserve adult height potential. Long-term follow up is essential to determine the natural history and optimal management in adulthood

TREPS, a tool for coordinate and time transformations in space physics

International audienc

Joining the yellow hub: Uses of the Simple Application Messaging Protocol in Space Physics analysis tools

International audienceThe interest for data communication between analysis tools in planetary sciences and space physics is illustrated is this paper via several examples of the uses of SAMP. The Simple Application Messaging Protocol is developed in the frame of the IVOA from an earlier protocol called PLASTIC. SAMP enables easy communication and interoperability between astronomy software, stand-alone and web-based; it is now increasingly adopted by the planetary sciences and space physics community. Its attractiveness is based, on one hand, on the use of common file formats for exchange and, on the other hand, on established messaging models. Examples of uses at the CDPP and elsewhere are presented. The CDPP (Centre de Données de la Physique des Plasmas, http://cdpp.eu/), the French data center for plasma physics, is engaged for more than a decade in the archiving and dissemination of data products from space missions and ground observatories. Besides these activities, the CDPP developed services like AMDA (Automated Multi Dataset Analysis, http://amda.cdpp.eu/) which enables in depth analysis of large amount of data through dedicated functionalities such as: visualization, conditional search, cataloguing, etc. Besides AMDA, the 3DView (http://3dview.cdpp.eu/) tool provides immersive visualisations and is further developed to include simulation and observational data. These tools and their interactions with each other, notably via SAMP, are presented via science cases of interest to planetary sciences and space physics communities

Planetary data distribution by the French Plasma Physics Data Centre (CDPP): the example of Rosetta Plasma Consortium in the perspective of Solar Orbiter, Bepi-Colombo and JUICE

International audienceThe French Plasma Physics Data Centre (CDPP, http://www.cdpp.eu/ ) has been addressing for almost the past 20 years all issues pertaining to natural plasma data distribution and valorization. Initially established by CNES and CNRS on the ground of a solid data archive, CDPP activities diversified with the advent of broader networks and interoperability standards, and through fruitful collaborations (e.g. with NASA/PDS). Providing access to remote data, designing and building science driven analysis tools then became at the forefront of CDPP developments. In the frame of data distribution, the CDPP has provided to the Rosetta Plasma Consortium (RPC), a suite of five different plasma sensors, with the possibility to visualize plasma data acquired by the Rosetta mission through its data analysis tool AMDA. AMDA was used during the operational phase of the Rosetta mission, facilitating data access between different Rosetta PI sensor teams, thus allowing 1/ a more efficient instruments operation planning and 2/ a better understanding of single instrument observations in the context of other sensor measurements and of more global observations. The data are now getting open to the public via the AMDA tool as they are released to the ESA/PSA. These in-situ data are complemented by model data, for instance, a solar wind propagation model (see http://heliopropa.irap.omp.eu ) or illumination maps of 67P (available through http://vespa.obspm.fr ). The CDPP also proposes 3D visualization tool for planetary / heliospheric environments which helps putting data in context (http://3dview.cdpp.eu ); for instance all comets and asteroids in a given volume and for a given time interval can be searched and displayed. From this fruitful experience the CDPP intends to play a similar role for the forthcoming data of the Solar Orbiter, Bepi-Colombo and JUICE missions as it is officially part of several instrument consortia. Beside highlighting the current database and products, the presentation will show how these future data could be presented and valorized through a combined use of the tools and models provided by the CDPP

Planetary data distribution by the French Plasma Physics Data Centre (CDPP): the example of Rosetta Plasma Consortium in the perspective of Solar Orbiter, Bepi-Colombo and JUICE

International audienceThe French Plasma Physics Data Centre (CDPP, http://www.cdpp.eu/ ) has been addressing for almost the past 20 years all issues pertaining to natural plasma data distribution and valorization. Initially established by CNES and CNRS on the ground of a solid data archive, CDPP activities diversified with the advent of broader networks and interoperability standards, and through fruitful collaborations (e.g. with NASA/PDS). Providing access to remote data, designing and building science driven analysis tools then became at the forefront of CDPP developments. In the frame of data distribution, the CDPP has provided to the Rosetta Plasma Consortium (RPC), a suite of five different plasma sensors, with the possibility to visualize plasma data acquired by the Rosetta mission through its data analysis tool AMDA. AMDA was used during the operational phase of the Rosetta mission, facilitating data access between different Rosetta PI sensor teams, thus allowing 1/ a more efficient instruments operation planning and 2/ a better understanding of single instrument observations in the context of other sensor measurements and of more global observations. The data are now getting open to the public via the AMDA tool as they are released to the ESA/PSA. These in-situ data are complemented by model data, for instance, a solar wind propagation model (see http://heliopropa.irap.omp.eu ) or illumination maps of 67P (available through http://vespa.obspm.fr ). The CDPP also proposes 3D visualization tool for planetary / heliospheric environments which helps putting data in context (http://3dview.cdpp.eu ); for instance all comets and asteroids in a given volume and for a given time interval can be searched and displayed. From this fruitful experience the CDPP intends to play a similar role for the forthcoming data of the Solar Orbiter, Bepi-Colombo and JUICE missions as it is officially part of several instrument consortia. Beside highlighting the current database and products, the presentation will show how these future data could be presented and valorized through a combined use of the tools and models provided by the CDPP

Planetary data distribution by the French Plasma Physics Data Centre (CDPP): the example of Rosetta Plasma Consortium in the perspective of Solar Orbiter, Bepi-Colombo and JUICE

International audienceThe French Plasma Physics Data Centre (CDPP, http://www.cdpp.eu/ ) has been addressing for almost the past 20 years all issues pertaining to natural plasma data distribution and valorization. Initially established by CNES and CNRS on the ground of a solid data archive, CDPP activities diversified with the advent of broader networks and interoperability standards, and through fruitful collaborations (e.g. with NASA/PDS). Providing access to remote data, designing and building science driven analysis tools then became at the forefront of CDPP developments. In the frame of data distribution, the CDPP has provided to the Rosetta Plasma Consortium (RPC), a suite of five different plasma sensors, with the possibility to visualize plasma data acquired by the Rosetta mission through its data analysis tool AMDA. AMDA was used during the operational phase of the Rosetta mission, facilitating data access between different Rosetta PI sensor teams, thus allowing 1/ a more efficient instruments operation planning and 2/ a better understanding of single instrument observations in the context of other sensor measurements and of more global observations. The data are now getting open to the public via the AMDA tool as they are released to the ESA/PSA. These in-situ data are complemented by model data, for instance, a solar wind propagation model (see http://heliopropa.irap.omp.eu ) or illumination maps of 67P (available through http://vespa.obspm.fr ). The CDPP also proposes 3D visualization tool for planetary / heliospheric environments which helps putting data in context (http://3dview.cdpp.eu ); for instance all comets and asteroids in a given volume and for a given time interval can be searched and displayed. From this fruitful experience the CDPP intends to play a similar role for the forthcoming data of the Solar Orbiter, Bepi-Colombo and JUICE missions as it is officially part of several instrument consortia. Beside highlighting the current database and products, the presentation will show how these future data could be presented and valorized through a combined use of the tools and models provided by the CDPP

HST auroral campaign observations of Jupiter and Saturn enabled by the CDPP/AMDA and IVOA/Aladin tools

International audienceThe Plasma Physics thematic node of IDIS (http://europlanet-plasmanode.oeaw.ac.at/) is established in close cooperation between the IWF Graz (http://www.iwf.oeaw.ac.at/) and CDPP Toulouse (http://cdpp.cesr.fr/). These last years, CDPP has developed a new service, AMDA (Automated Multi-Dataset Analysis, http://cdpp-amda.cesr.fr/), which is a web-based facility for on line analysis of space physics data (heliosphere, magnetospheres, planetary environments) coming from either its local database or distant ones, such as the Cassini/MAPSKP, VEX/MAG at IWF/Graz or the CDAWeb (http://cdaweb.gsfc.nasa.gov/). These last years, a large campaignof remote high resolution imaging of Jupiter and Saturn aurorae has been undertaken using the Hubble Space Telescope, in association with in situ measurements of local solar wind and magnetospheric plasma conditions using several different spacecraft (including Galileo, Cassini and New Horizons). The coordinated scientific exploitation of all these data is a major technical challenge, since it requires accessing heterogeneous data from diverse origins to perform an integrated study combining different software tools appropriate for the analysis of the solar wind, magnetospheric, ionospheric and atmospheric phenomena observed.In the context of our IDIS activities, we will detail our prototype service connecting the CDPP/AMDA service with the IVOA (http://www.ivoa.net/) tool Aladin (http://aladin.u-strasbg.fr/), which is an interactive software that enable the user to visualize digitized astronomical images of Jupiter and Saturn aurorae in combination with solar wind and magnetospheric data reachable via AMDA