Proopiomelanocortin Neurons in Nucleus Tractus Solitarius Are Activated by Visceral Afferents: Regulation by Cholecystokinin and Opioids

The nucleustractus solitarius (NTS) receives dense terminations from cranial visceral afferents, including those from the gastrointestinal (GI) system. Although the NTS integrates peripheral satiety signals and relays this signal to central feeding centers, little is known about which NTS neurons are involved or what mechanisms are responsible. Proopiomelanocortin (POMC) neurons are good candidates for GI integration, because disruption of the POMC gene leads to severe obesity and hyperphagia. Here, we used POMC– enhanced green fluorescent protein (EGFP) transgenic mice to identify NTS POMC neurons. Intraperitoneal administration of cholecystokinin (CCK) induced c-fos gene expression in NTS POMC–EGFP neurons, suggesting that they are activated by afferents stimulated by the satiety hormone. We tested the synaptic relationship of these neurons to visceral afferents and their modulation by CCK and opioids using patch recordings in horizontal brain slices. Electrical activation of the solitary tract (ST) evoked EPSCs in NTS POMC–EGFP neurons. The invariant latencies, low failure rates, and substantial paired-pulse depression of the ST-evoked EPSCs indicate that NTS POMC–EGFP neurons are second-order neurons directly contacted by afferent terminals. The EPSCs were blocked by the glutamate antagonist 2,3- dihydroxy-6-nitro-7-sulfonyl-benzo[f]quinoxaline. CCK increased the amplitude of the ST-stimulated EPSCs and the frequency of miniature EPSCs, effects attenuated by the CCK1 receptor antagonist lorglumide. In contrast, the orexigenic opioid agonists [D-Ala(2), N-Me-Phe(4), Gly-ol(5)]-enkephalin and met-enkephalin inhibited both ST-stimulated EPSCs and the frequency of miniature EPSCs. These findings identify a potential satiety pathway in which visceral afferents directly activate NTS POMC–EGFP neurons with excitatory inputs that are appropriately modulated by appetite regulators

Cold War I, Post-Cold War, and Cold War II: The Overarching Contexts for Peacekeeping, Human Rights, and NATO

Peacekeeping, human rights, and the North Atlantic Treaty Organization (NATO) have flourished in complementary contrast with each other. Their relationship has reflected the constraints and opportunities provided by three geopolitical eras since World War II. The first (the first Cold War) began in about 1948 and lasted until 1988; the second (the Post-Cold War Liberal Primacy) ran from 1989 to around 2012; finally, since 2012 the world has been threatened with the emergence of a second Cold War. During the first geopolitical era, NATO was the centerpiece of the Western Cold War alliance. However, its importance declined when the Cold War waned. Thereafter, during the Post-Cold War liberal primacy, human rights and peacekeeping flourished. In our current geopolitical era, both human rights and peacekeeping are under stress, yet it is not clear that these new forces are strengthening NATO

The UN Charter – A Global Constitution?

Is the UN Charter a constitution? Answering that question depends on what we mean by a constitution and to what alternative we are contrasting a constitution. If the relevant contrast is to the U.S. Constitution – the constitution of a sovereign state – the answer is clearly no. The United Nations was not intended to create a world state. As the Charter\u27s preamble announces, it was created for ambitious but specific purposes: “to save succeeding generations from the scourge of war,” to “reaffirm faith in fundamental human rights,” to “establish conditions under which justice and respect for the obligations arising from treaties and other sources of international law can be maintained,” and to “promote social progress and better standards of life in larger freedom.” The United Nations, moreover, is an organization based on the “sovereign equality of all its members” (art. 2.1), its membership being open to all “peace-loving states” (art. 4.1). This contrasts strikingly with the U.S. Constitution\u27s much more general, sovereign-creating purposes: “to form a more perfect union, establish justice, insure domestic tranquility, provide for the common defence, promote the general welfare and secure the blessings of liberty to ourselves and our posterity.” The UN Charter lacks at least two of the three key attributes that the Constitutional Court of South Africa identified as essential to a constitution. In Pharmaceutical, the court averred that a constitution is a unified system of law: “There is only one system of law

Spectroscopy of formaldehyde in the 30140-30790cm^-1 range

Room-temperature absorption spectroscopy of formaldehyde has been performed in the 30140-30790cm^-1 range. Using tunable ultraviolet continuous-wave laser light, individual rotational lines are well resolved in the Doppler-broadened spectrum. Making use of genetic algorithms, the main features of the spectrum are reproduced. Spectral data is made available as Supporting Information

Responsibility Sharing and the Global Compact on Refugees

Strengthening the Refugee Regime calls for enhancing responsibility sharing. Responsibility sharing was a central commitment in the New York Declaration for Refugees and Migrants. It also is a key commitment in the preamble to the landmark 1951 Refugee Convention. Countries of first refuge are promised that their providing refuge will be met by “international cooperation,” though without specifying its content. Yet, just as the 1951 Refugee Convention failed to define what international cooperation meant; so too the New York Declaration is – as was the Humanitarian Summit before it - long on principles; and short on specific commitments. Today, therefore, responsibility sharing, as Peter Sutherland has so aptly characterized it, amounts to “Responsibility by Proximity.” Neighboring countries such as Syria’s neighbors, Turkey, Lebanon and Jordan overwhelmingly serve as the refuge for Syrians who have managed to flee its devastating civil war. This means that globally the developing world, both relatively poor and home to so many of the world’s armed conflicts, also serves as the refuge for 86% of the world’s refugees … and it does so without adequate international funding (only 40% of the UNHCR appeal for the region was met in 2016)

Kepler Eclipsing Binary Stars. II. 2165 Eclipsing Binaries in the Second Data Release

The Kepler Mission provides nearly continuous monitoring of ~156 000 objects with unprecedented photometric precision. Coincident with the first data release, we presented a catalog of 1879 eclipsing binary systems identified within the 115 square degree Kepler FOV. Here, we provide an updated catalog augmented with the second Kepler data release which increases the baseline nearly 4-fold to 125 days. 386 new systems have been added, ephemerides and principle parameters have been recomputed. We have removed 42 previously cataloged systems that are now clearly recognized as short-period pulsating variables and another 58 blended systems where we have determined that the Kepler target object is not itself the eclipsing binary. A number of interesting objects are identified. We present several exemplary cases: 4 EBs that exhibit extra (tertiary) eclipse events; and 8 systems that show clear eclipse timing variations indicative of the presence of additional bodies bound in the system. We have updated the period and galactic latitude distribution diagrams. With these changes, the total number of identified eclipsing binary systems in the Kepler field-of-view has increased to 2165, 1.4% of the Kepler target stars.Comment: 29 pages, 12 figures. Submitted to the AJ. An online version of the catalog is maintained at http://keplerEBs.villanova.edu

The u'g'r'i'z' Standard Star Network

We present the 158 standard stars that define the u'g'r'i'z' photometric system. These stars form the basis for the photometric calibration of the Sloan Digital Sky Survey (SDSS). The defining instrument system and filters, the observing process, the reduction techniques, and the software used to create the stellar network are all described. We briefly discuss the history of the star selection process, the derivation of a set of transformation equations for the UBVRcIc system, and plans for future work.Comment: References to URLs in paper have been updated to reflect moved website. Accepted by AJ. 50 pages, including 20 pages of text, 9 tables, and 15 figures. Plain ASCII text versions of Tables 8 and 9 can be found at http://home.fnal.gov/~dtucker/ugriz/index.html (new URL

Kepler-16: A Transiting Circumbinary Planet

We report the detection of a planet whose orbit surrounds a pair of low-mass stars. Data from the Kepler spacecraft reveal transits of the planet across both stars, in addition to the mutual eclipses of the stars, giving precise constraints on the absolute dimensions of all three bodies. The planet is comparable to Saturn in mass and size, and is on a nearly circular 229-day orbit around its two parent stars. The eclipsing stars are 20% and 69% as massive as the sun, and have an eccentric 41-day orbit. The motions of all three bodies are confined to within 0.5 degree of a single plane, suggesting that the planet formed within a circumbinary disk.Comment: Science, in press; for supplemental material see http://www.sciencemag.org/content/suppl/2011/09/14/333.6049.1602.DC1/1210923.Doyle.SOM.pd

Characteristics of Kepler Planetary Candidates Based on the First Data Set: The Majority are Found to be Neptune-Size and Smaller

In the spring of 2009, the Kepler Mission commenced high-precision photometry on nearly 156,000 stars to determine the frequency and characteristics of small exoplanets, conduct a guest observer program, and obtain asteroseismic data on a wide variety of stars. On 15 June 2010 the Kepler Mission released data from the first quarter of observations. At the time of this publication, 706 stars from this first data set have exoplanet candidates with sizes from as small as that of the Earth to larger than that of Jupiter. Here we give the identity and characteristics of 306 released stars with planetary candidates. Data for the remaining 400 stars with planetary candidates will be released in February 2011. Over half the candidates on the released list have radii less than half that of Jupiter. The released stars include five possible multi-planet systems. One of these has two Neptune-size (2.3 and 2.5 Earth-radius) candidates with near-resonant periods.Comment: Paper to accompany Kepler's June 15, 2010 data release; submitted to Astrophysical Journal Figures 1,2,& 3 revised. Improved labeling on all figures. Slight changes to planet frequencies in result

Kepler eclipsing binary stars. VII. the catalogue of eclipsing binaries found in the entire Kepler data set

The primary Kepler Mission provided nearly continuous monitoring of ~200,000 objects with unprecedented photometric precision. We present the final catalog of eclipsing binary systems within the 105 deg2 Kepler field of view. This release incorporates the full extent of the data from the primary mission (Q0-Q17 Data Release). As a result, new systems have been added, additional false positives have been removed, ephemerides and principal parameters have been recomputed, classifications have been revised to rely on analytical models, and eclipse timing variations have been computed for each system. We identify several classes of systems including those that exhibit tertiary eclipse events, systems that show clear evidence of additional bodies, heartbeat systems, systems with changing eclipse depths, and systems exhibiting only one eclipse event over the duration of the mission. We have updated the period and galactic latitude distribution diagrams and included a catalog completeness evaluation. The total number of identified eclipsing and ellipsoidal binary systems in the Kepler field of view has increased to 2878, 1.3% of all observed Kepler targets