The macroecology of chemical communication in lizards: do climatic factors drive the evolution of signalling glands?

Chemical communication plays a pivotal role in shaping sexual and ecological interactions among animals. In lizards, fundamental mechanisms of sexual selection such as female mate choice have rarely been shown to be influenced by quantitative phenotypic traits (e.g., ornaments), while chemical signals have been found to potentially influence multiple forms of sexual and social interactions, including mate choice and territoriality. Chemical signals in lizards are secreted by glands primarily located on the edge of the cloacae (precloacal glands, PG) and thighs (femoral glands), and whose interspecific and interclade number ranges from 0 to >100. However, elucidating the factors underlying the evolution of such remarkable variation remains an elusive endeavour. Competing hypotheses suggest a dominant role for phylogenetic conservatism (i.e., species within clades share similar numbers of glands) or for natural selection (i.e., their adaptive diversification results in deviating numbers of glands from ancestors). Using the prolific Liolaemus lizard radiation from South America (where precloacal glands vary from 0-14), we present one of the largest-scale tests of both hypotheses to date. Based on climatic and phylogenetic modelling, we show a clear role for both phylogenetic inertia and adaptation underlying gland variation: (i) solar radiation, net primary productivity, topographic heterogeneity and precipitation range have a significant effect on number of PG variation, (ii) humid and cold environments tend to concentrate species with a higher number of glands, (iii) there is a strong phylogenetic signal that tends to conserve the number of PG within clades. Collectively, our study confirms that the inertia of niche conservatism can be broken down by the need of species facing different selection regimes to adjust their glands to suit the demands of their specific environments

Constructing a WISE High Resolution Galaxy Atlas

After eight months of continuous observations, the Wide-field Infrared Survey Explorer (WISE) mapped the entire sky at 3.4 {\mu}m, 4.6 {\mu}m, 12 {\mu}m and 22 {\mu}m. We have begun a dedicated WISE High Resolution Galaxy Atlas (WHRGA) project to fully characterize large, nearby galaxies and produce a legacy image atlas and source catalogue. Here we summarize the deconvolution technique used to significantly improve the spatial resolution of WISE imaging, specifically designed to study the internal anatomy of nearby galaxies. As a case study, we present results for the galaxy NGC 1566, comparing the WISE super-resolution image processing to that of Spitzer, GALEX and ground-based imaging. The is the first paper in a two part series; results for a much larger sample of nearby galaxies is presented in the second paper.Comment: Published in the AJ (2012, AJ, 144, 68

Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: Cytological studies and chemical investigations

Context: Fitzroya cupressoides (Molina) I. M. Johnst. and Austrocedrus chilensis (D. Don) Pic.Serm. & Bizzarri are two Chilean Cupressaceae that are naturally resistant to biodegradation. Secondary metabolites from these species display a variety of biological activities. Objective: To evaluate the antiproliferative activity of two lignans, a diterpene and a flavonol isolated from A. chilensis and F. cupressoides, to elucidate their cytological effects on P3X murine myeloma cells. Materials and methods: The antiproliferative activity of yatein, isotaxiresinol, ferruginol, and isorhamnetin was evaluated in vitro using the MTT assay. The effect of yatein at the cellular level, due to its high antiproliferative activity was evaluated. P3X cells treated for 24 h with 12.5 and 25 \u3bcg/mL of yatein were also examined at the cytological level using immunofluorescence and scanning and transmission electron microscopy. Results: Yatein, a lignan isolated from A. chilensis, potentially inhibited P3X murine myeloma cell proliferation, resulting in approximately 75% cell death in response to a 25 \u3bcg/mL treatment with the lignan. P3X cells lost membrane integrity at the nuclear and cytoplasmic levels, including organelles, in response to yatein treatment (12.5 \u3bcg/mL), and we observed changes in the cytoplasmic organization and distribution of microtubules. The other compounds tested had low activity. Discussion and conclusions: Yatein is a lignan precursor of podophyllotoxin, a key agent in anticancer drugs. Due to its structural similarities to podophyllotoxin, yatein could have similar cytoplasmic target(s), such as the microtubular apparatus. These findings suggest that yatein may be of potential pharmacological interest and warrants further investigation in human cell lines

Extending the Nearby Galaxy Heritage with WISE: First Results from the WISE Enhanced Resolution Galaxy Atlas

The Wide-field Infrared Survey Explorer (WISE) mapped the entire sky at mid-infrared wavelengths 3.4 μm, 4.6 μm, 12 μm, and 22 μm. The mission was primarily designed to extract point sources, leaving resolved and extended sources, for the most part, unexplored. Accordingly, we have begun a dedicated WISE Enhanced Resolution Galaxy Atlas (WERGA) project to fully characterize large, nearby galaxies and produce a legacy image atlas and source catalog. Here we demonstrate the first results of the WERGA project for a sample of 17 galaxies, chosen to be of large angular size, diverse morphology, and covering a range in color, stellar mass, and star formation. It includes many well-studied galaxies, such as M 51, M 81, M 87, M 83, M 101, and IC 342. Photometry and surface brightness decomposition is carried out after special super-resolution processing, achieving spatial resolutions similar to that of Spitzer Infrared Array Camera. The enhanced resolution method is summarized in the first paper of this two-part series. In this second work, we present WISE, Spitzer, and Galaxy Evolution Explorer (GALEX) photometric and characterization measurements for the sample galaxies, combining the measurements to study the global properties. We derive star formation rates using the polycyclic aromatic hydrocarbon sensitive 12 μm (W3) fluxes, warm-dust sensitive 22 μm (W4) fluxes, and young massive-star sensitive ultraviolet (UV) fluxes. Stellar masses are estimated using the 3.4 μm (W1) and 4.6 μm (W2) measurements that trace the dominant stellar mass content. We highlight and showcase the detailed results of M 83, comparing the WISE/Spitzer results with the Australia Telescope Compact Array H I gas distribution and GALEX UV emission, tracing the evolution from gas to stars. In addition to the enhanced images, WISE's all-sky coverage provides a tremendous advantage over Spitzer for building a complete nearby galaxy catalog, tracing both stellar mass and star formation histories. We discuss the construction of a complete mid-infrared catalog of galaxies and its complementary role of studying the assembly and evolution of galaxies in the local universe

White book on physical and rehabilitation medicine (PRM) in Europe. Chapter 10. Science and research in PRM: Specificities and challenges

In the context of the White Book of Physical and Rehabilitation Medicine (PRM), this paper deals with Research, the future of PRM. PRM students and specialists are mainly involved in biomedical research, investigating the biological processes, the causes of diseases, their medical diagnosis, the evaluation of their consequences on functioning, disability and health and the effects of health interventions at an individual and a societal level. Most of the current PRM research, often interdisciplinary, originates from applied research which, using existing knowledge, is directed towards specific goals. Translational medical research, research and development, implementation research and clinical impact research are in this field. PRM physicians, mainly master or PhD students, are nowadays increasing their participation in basic research and in pre-clinical trials. PRM physicians are involved in primary research, which is an original first hand research, but also in secondary research, which is the analysis and interpretation of primary research publications in a field, with a specific methodology. Secondary research remains an important activity of the UEMS PRM section and it will be the field of the new created Cochrane Rehabilitation. Secondary research with interest for persons with disabilities, will be developed world wide on the basis of evidence based medicine, with the participation of PRM physicians and of all other health and social professionals involved in rehabilitation. The development of research activities with interest for PRM in Europe is a challenge for the future, which has to be faced now. The European PRM schools, the European master and PhD program with their supporting research and clinical facilities, the European PRM organizations with their websites, the PRM scientific journals and European congresses are a strong basis to develop research activities, together with the development of Cochrane Rehabilitation field and of our cooperation with European high level research facilities, European and international scientific societies in different fields. PRM will be a leader in this field of research

Atomic motion in magneto-optical double-well potentials: A new testing ground for quantum chaos

We have identified ultra-cold atoms in magneto-optical double-well potentials as a very clean setting in which to study the quantum and classical dynamics of a nonlinear system with multiple degrees of freedom. In this system, entanglement at the quantum level and chaos at the classical level arise from nonseparable couplings between the atomic spin and its center of mass motion. The main features of the chaotic dynamics are analyzed using action-angle variables and Poincare surfaces of section. We show that for the initial state prepared in current experiments [D. J. Haycock et al., Phys. Rev. Lett. 85, 3365 (2000)], the classical and quantum dynamics diverge, and the observed experimental dynamics are best described by quantum mechanics. Furthermore, the motion corresponds to tunneling through a dynamical potential barrier. The coupling between the spin and the motional subsystems, which are very different in nature from one another, leads to new questions regarding the transition from regular quantum dynamics to chaotic classical motion.Comment: 36 pages including 6 pages of figures. To be published in PRE Nov. 1st, 2001. Revised version contains a discussion and extra figure (Fig 5) related to gauge potentials, plus added refernce

Controlling Groundwater Exploitation Through Economic Instruments: Current Practices, Challenges and Innovative Approaches

Groundwater can be considered as a common-pool resource, is often overexploited and, as a result, there are growing management pressures. This chapter starts with a broad presentation of the range of economic instruments that can be used for groundwater management, considering current practices and innovative approaches inspired from the literature on Common Pool Resources management. It then goes on with a detailed presentation of groundwater allocation policies implemented in France, the High Plains aquifer in the USA, and Chile. The chapter concludes with a discussion of social and political difficulties associated with implementing economic instruments for groundwater management