Clinical experiences in primary retroperitoneal tumors

Amaç: Bu çalışmada Selçuk Üniversitesi Tıp Fakültesi 2011-2013 tarihleri arasında Çocuk Onkoloji Anabilim Dalı’nda takipli ve Çocuk Cerrahisi Kliniğince opere edilen toplam 22 retroperitoneal tümörlü hastaların kayıtları retrospektif olarak değerlendirildi. Olgular ve Yöntem: Retroperitoneal tümör nedeniyle 2011-2013 arasında cerrahi girişim yapılan olgular geriye dönük olarak incelendi. Primer retroperitoneal tümörü kontrol altına alınan, başka uzak organ metastazı olmayan cerrahi tedavi uygulanan olgular çalışmaya dahil edildi. Yaş, cinsiyet, primer tanı anında tümör evresi, cerrahi tedavi yöntemi, patolojik tanı ve takip açısından olguların dosyaları retrospektif olarak değerlendirildi. Bulgular: Olgularımızın 9’u (%40) erkek, 13’ü (%60) kızdı. Ortalama yaş erkeklerde 71 ay (3-132), kızlarda 37 ay (6-204) idi. Histopatolojik olarak olguların 15 (%68)’i nöroblastom, 4’ü (%18.5) wilms tümörü, 1’i (%4.5) embriyonal rabdomyosarkom, 1’i (%4.5) berrak hücreli sarkom, 1’i (%4.5) malign sinir kılıfı tümörü olarak değerlendirildi. Tanı anında olguların 8’i (%36) evre I, 7’si (%32) Evre III, 7’si (%32) evre IV safhasındaydı. Sonuç: Olgularımızın %68’i nöroblastom olup, tanı anında hastaların %64’ü evre III ve evre IV idi. Anatomik lokalizasyonları nedeniyle ileri evrelere kadar sessiz tümörler olan retroperitoneal tümörlerin çoğu nöroblastomdur ve genellikle ileri evrelerde tanı alırlar.Objective: In this study, Selcuk University Faculty of Medicine between 2011 - 2013 follow-up at the Department of Pediatric Oncology and Pediatric Surgery clinic was operated by a total of 22 patients with retroperitoneal tumors were evaluated retrospectively . Patients and Method: Retroperitoneal tumors were evaluated retrospectively during 2011-2013. The cases treated with primary retroperitoneal tumor, surgical treatment without other distant organ metastasis were included in the study. The files of the cases were primary diagnosis in terms of age, sex, tumor stage at the time of diagnosis, surgical treatment method, pathological diagnosis and follow-up reviewed retrospectively. Results: 9 out of 22 cases (40%) male and 13 (60%) were female. Male mean age of 71 months ( 3-132 ) in the girls 37 months ( 6-204 ) . The histological results, 15 (68%) of neuroblastoma , 4 (18.5%) Wilms, 1 (4.5% ) Embryonal Rhabdomyosarcoma , 1 (4.5% ) Clear cell sarcoma , 1 (4.5% ) malignant nerve sheath tumors were evaluated . Eight of the cases (36%) were stage I, 7 (32%) were stage III, 7 (32%) stage IV. Conclusion: In conclusion, 68% of our cases were neuroblastoma and 64% of the patients were stage III and stage IV at the time of diagnosis. Retroperitoneal tumors are generally diagnosed in advanced stages. We think that this is due to the anatomical localizations and the silent as far as the clinically advanced stage

Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:

Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced. .Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design:Animal experimentation.Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day. Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively). Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features

Procalcitonin and other acute phase reactants in patients with chronic obstructive pulmonary disease exacerbation

The aim of this study was to investigate the correlation between procalcitonin and other acute phase reactants, and also analyze their relationship with clinical situation in chronic obstructive pulmonary disease (COPD) acute exacerbations.Materials and methods: The study was made with 122 acute COPD exacerbated patients, who were admitted to emergency service. Patients with below 0.25 ng/ml PCT value included Group 1, and the patients with PCT values ≥ 0.25 ng/ml Group 2. Serum procalcitonin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) values and white blood cell (WBC) counts were measured. Also, patients hospitalization time and mortality rates were recorded and compared with PCT.Results: Patients were divided in 3 groups according to their clinical diagnosis; Pneumonia (n=27), Mycoplasma-Chlamydia pneumonia (n=11) and the patients with only COPD exacerbation(n=84). Mean PCT values according to the groups were 9.47 ± 8.1 ng/ml, 0.41 ± 0.2 ng/ml, and 0.21 ± 0.05 ng/ml respectively. The relationship between PCT with CRP and white blood cell has been found between significiant (p=0.001, p=0.005 respectively), whereas the relationship between PCT and ESR was nonsignificant (p=0.55). Procalcitonin and CRP had a positive correlation with the hospitalization time (p=0.034, p=0.022 respectively). The mean ± standard error of PCT for the patients who died was 28.3 ± 27.5 ng/ml, and the difference between patients who died or were discharged was statistically significant (p= 0.012).Conclusion: PCT can be a useful indicator for morbidity and prognosis in COPD patients

Examination of the Relationship between Umbilical Cord Blood Gas Values and Hearing Function in Neonates

Objective: The aim of the present study was to examine the relationship between the results of the transient otoacoustic emission (TEOAE) test used in neonatal hearing screening and the results of the umbilical cord blood (UCB) analysis in neonates.Methods: This retrospective study included 209 neonates born in the obstetric unit at the 37th gestational week. Based on the results of the TEOAE test, the neonates included in the study were divided into two groups as the study group composed of those “REFER” (n=141) and the control group consisting those “PASS” (n=68) the test. The UCB sampling procedure was performed on all neonates. In the blood samples, the pH parameters were evaluated by using glass electrodes, and the pCO2 and pO2 parameters were evaluated directly by using sensitive electrodes.Results: When the additional maternal diseases were compared with the TEOAE results, the ratio of hypothyroidism was found to be statistically higher in the study group (p0.05).Conclusion: The results of the present study showed that there was no statistically significant difference between the results of UCB analysis and the TEOAE test. However, we believe that conducting a larger study evaluating other parameters and employing UCB analysis would be useful, and UCB evaluation, which is an inexpensive, easy and effective method in determining hypoxia in neonates, might be a significant marker in cases at risk of hearing loss

The efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population

WOS: 000393291900012OBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. in this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients. MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. the patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). the patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months. RESULTS: the levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p< 0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month). CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population

Zeugma kazısına ait kemiklerin ve dişin elektron spin rezonans yöntemiyle radyasyon miktarının belirlenmesi ve tarihlendirilmesi

TEZ5327Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2004.Kaynakça (s. 64-69) var.viii, 69 s. ; 30 cm.

Bio-inpired all-polymer 2d photonic crystal fibers = Doğadan esinlenilmiş tamamen polimer 2B fotonik kristal fiberleri

Ankara : The Graduate School of Engineering and Science of Bilkent University, 2014.Thesis (Master's) -- Bilkent University, 2014.Includes bibliographical references leaves 56-65.Photonic crystals are essential part of the integrated systems which require manipulation of light in a manner that all-optical polarization and re ection properties are completely calibrated to necessary levels. However, beyond scienti c development of photonic crystals, biological systems also provided inspiration for the eld since they perfected the mechanisms in terms of coloration over millions of years. In addition, natural samples are also observed to serve and function for more than single purpose, and this further illuminates the technological designs so as to develop multifunctional structures. Anas Platyrhynchos L. (mallard) is one of the natural examples and detailed investigations yield that its neck feathers have structural coloration, iridescence and hydrophobicity. Being inspired form mallard duck, two-dimensional photonic crystal bers are produced to imitate coloration and surface architecture. The fabrication is established by iterative size reduction technique which, as a top-down method, enables design of nano-scale materials from macro-scale structures. To accurately imitate duck feathers, polycarbonate (PC) and polyvinyldi uoride (PVDF), are characterized and selected for their thermal compatibility and dielectric properties among number of polymers. Produced 2D photonic crystal bers have been demonstrated to re ect color of green like duck feathers, and also shown to have iridescence by optical means. Besides single coloration, all colors of visible spectrum are also obtained to attest potential applicability of fabrication technique and produced bers. It is also substantiated that all colors can be obtained in a single ber by tapering a thick ber. In addition, last but not least, 2D photonic crystal bers are carefully designed to have surface roughness which promoted hydrophobic feature of PVDF and provided better hydrophobicity than natural counterparts. Manufactured structures are also the rst demonstration for production of all-polymer two dimensional photonic crystal bers which may be used in textile or ltering technologies.Doğan, TamerM.S

Paleoseismological analysis in East Anatolia Fault System (EAFS) using Optical Stimulated Luminescence (OSL) dating technique.

TEZ8254Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2010.Kaynakça (s. 157-169) var.xix, 171 s. : res., tablo ; 29 cm.Optical Stimulated Luminescence (OSL) dating technique has been used to obtain the ages of sediment samples collected from four trenches in the Türkoğlu-Antakya segment of the East Anatolian Fault System (EAFS). For the calculation of the ages of the samples the equivalent doses (ED) were measured by using Double Single Aliquot Regenerative Dose (D-SAR) protocol. It is concluded that the D-SAR procedure has proved to be a very powerful approach for determining the equivalent dose using quartz OSL signals. The annual doses (AD) were obtained by various techniques. K concentrations were measured by X-ray fluorescence (XRF) and atomic absorption (AAS) analysis. U and Th concentrations were measured using thick-source alpha counting. dose rate was used as 0.04±0.01 in calculations. The annual gamma dose rates were determined using TLD detectors ( -Al2O3:C) buried in-situ positions for a period of six months. Concentrations and activities were converted to dose rates using the conversion factors of Aitken, 1985. The ages of the samples were found as 4542±392 a, 2911±255 a, 2314±308 a and 2601±202 a.Yapılan çalışmada Doğu Anadolu Fay Sisteminin (DAFS), Türkoğlu-Antakya segmetinde açılan Kıranyurdu, Ortabel hendeklerinden ve Malzeme Ocağı kazı alanından toplanan bazı sediment örnekleri Optiksel Uyarılmayla Lüminesans (OSL) yöntemiyle tarihlendirilmiştir. Bu yöntemi uygulamak amacıyla İkili Tek Tablet Yeniden Oluşturma (D-SAR) protokolünün adımları takip edilmiştir. İnce tanecik yöntemiyle analiz edilen örnekler için eşdeğer doz miktarları elde edilmiştir. Çalışılan sediment örneklerinin toplandığı kazı alanlarının yıllık doz miktarını belirlemek amacıyla değişik yöntemler uygulanmıştır. K konsantrasyonları X-ışını floresans (XRF) ve Atomik Soğurma (AAS) yöntemleriyle ölçülmüştür. U ve Th konsantrasyonları kalın kaynak alfa sayımıyla ölçülmüştür. Gama dozları açılan hendek civarına ?-Al2O3:C dozimetreleri gömülüp burada 6 ay süreyle bekletilerek ölçülmüştür. Yaş formülünde alfa verimlilik faktörü a değeri 0.04±0.01 alınarak hesaplar yapılmıştır. Konsantrasyonlar ve aktiviteler, doz oranlarına Aitken (1985)'in çevirme faktörleriyle çevrilmiştir. Yaş hesabı ""Normal Dağılım Yaklaşımı"" yöntemi uygulanarak çalışılan dört örnek için 4542±392 yıl, 2911±255 yıl, 2314±308 yıl ve 2601±202 yıl olarak bulunmuştur.Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje No: FEF2007D24

Fuzzy Clustering of ECG Beats Using a New Metaheuristic Approach

Abstract. This study proposes a new single-solution based metaheuristic, namely the Vortex Search algorithm (VS), for fuzzy clustering of ECG beats. The newly proposed metaheuristic is quite simple and highly competitive when compared to the population-based metaheuristics. In order to study the performance of the proposed method a number of experiments are performed over a dataset which is created by using the records selected from MIT-BIH arrhythmia database. The selected records includes six type of beats, namely, Normal Beat (N), Premature Ventricular Contraction (PVC), Fusion of Ventricular and Normal Beat (F), Atrial Premature Beat (A), Right Bundle Branch Block Beat (R) and Fusion of Paced and Normal Beat (f). The records are first preprocessed and then four morphological features are extracted for each beat type to form the training and test sets. By using the newly proposed method, fuzzy cluster centers of the training set is found. By using these clusters&apos; centers a supervised classification method is then classified the test set to evaluate the clustering performance of the method. The results are compared to the fuzzy c-means algorithm (FCM), fuzzy c-means algorithm with particle swarm optimization (FCM-PSO2011) and fuzzy c-means algorithm with artificial bee colony (FCM-ABC). It is shown that, in spite of its simplicity, the newly proposed metaheuristic with fuzzy c-means algorithm (FCM-VS) is highly competitive and performs quite well when compared to FCM-PSO2011 and FCM-ABC methods