5,339 research outputs found
EVALUATING HAIR GROWTH POTENTIAL OF SOME TRADITIONAL HERBS
Herbal, traditional drugs are frequently used in therapeutics; more often their chief principles are employed in a more specific manner. Theseprinciples are known as derivatives or extractions. Centella asiatica, Cyperus rotundus, and Emblica officinalis alcoholic and aqueous extractwere evaluated for the hair growth properties using albino rats. The hair growth formulation was formulated as hair oil and applied topicallyon shaved skin of rats. Primary skin irritation test, hair length, hair density test were performed. The hair growth-promoting efficacies wereevaluated at 0 day, 10 days, 15 days, and 20 days after the application through the hair re-growth area significant hair growth was observed. Theresult revealed that the hair growth activity of each drug was found proportional to the concentration range tested and compared with standard(2% minoxidil ethanolic solution) by an enlargement of follicular size and prolongation of the anagen phase. It holds the promise of potent herbalalternative for minoxidil. Excellent results of hair growth were seen in formulation prepared by cloth pouch decoction method of oils preparationtechnique.Keywords: Centella asiatica, Cyperus rotundus, Emblica officinalis, Hair oil, Hair growth, Hair length, % minoxidil
Mining and Analyzing the Italian Parliament: Party Structure and Evolution
The roll calls of the Italian Parliament in the XVI legislature are studied
by employing multidimensional scaling, hierarchical clustering, and network
analysis. In order to detect changes in voting behavior, the roll calls have
been divided in seven periods of six months each. All the methods employed
pointed out an increasing fragmentation of the political parties endorsing the
previous government that culminated in its downfall. By using the concept of
modularity at different resolution levels, we identify the community structure
of Parliament and its evolution in each of the considered time periods. The
analysis performed revealed as a valuable tool in detecting trends and drifts
of Parliamentarians. It showed its effectiveness at identifying political
parties and at providing insights on the temporal evolution of groups and their
cohesiveness, without having at disposal any knowledge about political
membership of Representatives.Comment: 27 pages, 14 figure
Spectral weight transfer in a disorder-broadened Landau level
In the absence of disorder, the degeneracy of a Landau level (LL) is
, where is the magnetic field, is the area of the sample
and is the magnetic flux quantum. With disorder, localized states
appear at the top and bottom of the broadened LL, while states in the center of
the LL (the critical region) remain delocalized. This well-known phenomenology
is sufficient to explain most aspects of the Integer Quantum Hall Effect (IQHE)
[1]. One unnoticed issue is where the new states appear as the magnetic field
is increased. Here we demonstrate that they appear predominantly inside the
critical region. This leads to a certain ``spectral ordering'' of the localized
states that explains the stripes observed in measurements of the local inverse
compressibility [2-3], of two-terminal conductance [4], and of Hall and
longitudinal resistances [5] without invoking interactions as done in previous
work [6-8].Comment: 5 pages 3 figure
High-altitude population neonatal and maternal phenotypes associated with birthweight protection.
BACKGROUND: States which reduce foetal oxygen delivery are associated with impaired intrauterine growth. Hypoxia results when barometric pressure falls with ascent to altitude, and with it the partial pressure of inspired oxygen ('hypobaric hypoxia'). birthweight is reduced when native lowlanders gestate at such high altitude (HA)-an effect mitigated in native (millennia) HA populations. Studying HA populations offer a route to explore the mechanisms by which hypoxia impacts foetal growth. METHODS: Between February 2017 and January 2019, we prospectively studied 316 pregnant women, in Leh, Ladakh (altitude 3524 m, where oxygen partial pressure is reduced by 1/3) and 101 pregnant women living in Delhi (low altitude, 216 m above sea level). RESULTS: Of Ladakhi HA newborns, 14% were small for gestational age (10th weight centile. CONCLUSIONS: This study showed that Ladakhi offspring birthweight is relatively spared from the expected adverse HA effects. Furthermore, maternal body composition and greater UtA size may be physiological HA adaptations and warrant further study, as they offer potential mechanisms to overcome hypoxia-related growth issues. IMPACT: Reduced foetal oxygen delivery seen in native lowlanders who gestate at HA causes foetal growth restriction-an effect thought to be mitigated in native HA populations. We found that greater maternal body mass and UtA diameter were associated with increased offspring birthweight in a (Ladakh) HA population. This supports a role for them as physiological mediators of adaptation and provides insights into potential mechanisms that may treat hypoxia-related growth issues
Random Planar Lattices and Integrated SuperBrownian Excursion
In this paper, a surprising connection is described between a specific brand
of random lattices, namely planar quadrangulations, and Aldous' Integrated
SuperBrownian Excursion (ISE). As a consequence, the radius r_n of a random
quadrangulation with n faces is shown to converge, up to scaling, to the width
r=R-L of the support of the one-dimensional ISE. More generally the
distribution of distances to a random vertex in a random quadrangulation is
described in its scaled limit by the random measure ISE shifted to set the
minimum of its support in zero.
The first combinatorial ingredient is an encoding of quadrangulations by
trees embedded in the positive half-line, reminiscent of Cori and Vauquelin's
well labelled trees. The second step relates these trees to embedded (discrete)
trees in the sense of Aldous, via the conjugation of tree principle, an
analogue for trees of Vervaat's construction of the Brownian excursion from the
bridge.
From probability theory, we need a new result of independent interest: the
weak convergence of the encoding of a random embedded plane tree by two contour
walks to the Brownian snake description of ISE.
Our results suggest the existence of a Continuum Random Map describing in
term of ISE the scaled limit of the dynamical triangulations considered in
two-dimensional pure quantum gravity.Comment: 44 pages, 22 figures. Slides and extended abstract version are
available at http://www.loria.fr/~schaeffe/Pub/Diameter/ and
http://www.iecn.u-nancy.fr/~chassain
The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies
The development of therapeutic monoclonal antibodies (mAbs) can be hindered by their tendency to aggregate throughout their lifetime, which can illicit immunogenic responses and render mAb manufacturing unfeasible. Consequently, there is a need to identify mAbs with desirable thermodynamic stability, solubility, and lack of self‐association. These behaviors are assessed using an array of in silico and in vitro assays, as no single assay can predict aggregation and developability. We have developed an extensional and shear flow device (EFD), which subjects proteins to defined hydrodynamic forces which mimic those experienced in bioprocessing. Here, we utilize the EFD to explore the aggregation propensity of 33 IgG1 mAbs, whose variable domains are derived from clinical antibodies. Using submilligram quantities of material per replicate, wide‐ranging EFD‐induced aggregation (9‐81% protein in pellet) was observed for these mAbs, highlighting the EFD as a sensitive method to assess aggregation propensity. By comparing the EFD‐induced aggregation data to those obtained previously from 12 other biophysical assays, we show that the EFD provides distinct information compared with current measures of adverse biophysical behavior. Assessing a candidate's liability to hydrodynamic force thus adds novel insight into the rational selection of developable mAbs that complements other assays
Language Model Co-occurrence Linking for Interleaved Activity Discovery
As ubiquitous computer and sensor systems become abundant, the potential for automatic identification and tracking of human behaviours becomes all the more evident. Annotating complex human behaviour datasets to achieve ground truth for supervised training can however be extremely labour-intensive, and error prone. One possible solution to this problem is activity discovery: the identification of activities in an unlabelled dataset by means of an unsupervised algorithm. This paper presents a novel approach to activity discovery that utilises deep learning based language production models to construct a hierarchical, tree-like structure over a sequential vector of sensor events. Our approach differs from previous work in that it explicitly aims to deal with interleaving (switching back and forth between between activities) in a principled manner, by utilising the long-term memory capabilities of a recurrent neural network cell. We present our approach and test it on a realistic dataset to evaluate its performance. Our results show the viability of the approach and that it shows promise for further investigation. We believe this is a useful direction to consider in accounting for the continually changing nature of behaviours
Fractional quantum Hall effect in the absence of Landau levels
It has been well-known that topological phenomena with fractional
excitations, i.e., the fractional quantum Hall effect (FQHE) \cite{Tsui1982}
will emerge when electrons move in Landau levels. In this letter, we report the
discovery of the FQHE in the absence of Landau levels in an interacting fermion
model. The non-interacting part of our Hamiltonian is the recently proposed
topologically nontrivial flat band model on the checkerboard lattice
\cite{sun}. In the presence of nearest-neighboring repulsion (), we find
that at 1/3 filling, the Fermi-liquid state is unstable towards FQHE. At 1/5
filling, however, a next-nearest-neighboring repulsion is needed for the
occurrence of the 1/5 FQHE when is not too strong. We demonstrate the
characteristic features of these novel states and determine the phase diagram
correspondingly.Comment: 6 pages and 4 figure
Composite Fermion Metals from Dyon Black Holes and S-Duality
We propose that string theory in the background of dyon black holes in
four-dimensional anti-de Sitter spacetime is holographic dual to conformally
invariant composite Dirac fermion metal. By utilizing S-duality map, we show
that thermodynamic and transport properties of the black hole match with those
of composite fermion metal, exhibiting Fermi liquid-like. Built upon
Dirac-Schwinger-Zwanziger quantization condition, we argue that turning on
magnetic charges to electric black hole along the orbit of Gamma(2) subgroup of
SL(2,Z) is equivalent to attaching even unit of statistical flux quanta to
constituent fermions. Being at metallic point, the statistical magnetic flux is
interlocked to the background magnetic field. We find supporting evidences for
proposed holographic duality from study of internal energy of black hole and
probe bulk fermion motion in black hole background. They show good agreement
with ground-state energy of composite fermion metal in Thomas-Fermi
approximation and cyclotron motion of a constituent or composite fermion
excitation near Fermi-point.Comment: 30 pages, v2. 1 figure added, minor typos corrected; v3. revised
version to be published in JHE
Outlier Edge Detection Using Random Graph Generation Models and Applications
Outliers are samples that are generated by different mechanisms from other
normal data samples. Graphs, in particular social network graphs, may contain
nodes and edges that are made by scammers, malicious programs or mistakenly by
normal users. Detecting outlier nodes and edges is important for data mining
and graph analytics. However, previous research in the field has merely focused
on detecting outlier nodes. In this article, we study the properties of edges
and propose outlier edge detection algorithms using two random graph generation
models. We found that the edge-ego-network, which can be defined as the induced
graph that contains two end nodes of an edge, their neighboring nodes and the
edges that link these nodes, contains critical information to detect outlier
edges. We evaluated the proposed algorithms by injecting outlier edges into
some real-world graph data. Experiment results show that the proposed
algorithms can effectively detect outlier edges. In particular, the algorithm
based on the Preferential Attachment Random Graph Generation model consistently
gives good performance regardless of the test graph data. Further more, the
proposed algorithms are not limited in the area of outlier edge detection. We
demonstrate three different applications that benefit from the proposed
algorithms: 1) a preprocessing tool that improves the performance of graph
clustering algorithms; 2) an outlier node detection algorithm; and 3) a novel
noisy data clustering algorithm. These applications show the great potential of
the proposed outlier edge detection techniques.Comment: 14 pages, 5 figures, journal pape
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