On the Distribution of Salient Objects in Web Images and its Influence on Salient Object Detection

It has become apparent that a Gaussian center bias can serve as an important prior for visual saliency detection, which has been demonstrated for predicting human eye fixations and salient object detection. Tseng et al. have shown that the photographer's tendency to place interesting objects in the center is a likely cause for the center bias of eye fixations. We investigate the influence of the photographer's center bias on salient object detection, extending our previous work. We show that the centroid locations of salient objects in photographs of Achanta and Liu's data set in fact correlate strongly with a Gaussian model. This is an important insight, because it provides an empirical motivation and justification for the integration of such a center bias in salient object detection algorithms and helps to understand why Gaussian models are so effective. To assess the influence of the center bias on salient object detection, we integrate an explicit Gaussian center bias model into two state-of-the-art salient object detection algorithms. This way, first, we quantify the influence of the Gaussian center bias on pixel- and segment-based salient object detection. Second, we improve the performance in terms of F1 score, Fb score, area under the recall-precision curve, area under the receiver operating characteristic curve, and hit-rate on the well-known data set by Achanta and Liu. Third, by debiasing Cheng et al.'s region contrast model, we exemplarily demonstrate that implicit center biases are partially responsible for the outstanding performance of state-of-the-art algorithms. Last but not least, as a result of debiasing Cheng et al.'s algorithm, we introduce a non-biased salient object detection method, which is of interest for applications in which the image data is not likely to have a photographer's center bias (e.g., image data of surveillance cameras or autonomous robots)

Resistive switching and threshold switching behaviors in La 0.1Bi 0.9Fe 1-xCo xO 3 ceramics

The effects of cobalt doping on the electrical conductivity of La 0.1Bi 0.9Fe 1-xCo xO 3 (LBFCO, x=0, 0.01, 0.03) ceramics were investigated. It is found that the leakage current increases with cobalt dopant concentration in LBFCO. On the application of bias voltage LBFCO ceramics with cobalt doping exhibits resistive switching effects at room temperature and threshold switching effects at elevated temperatures (50°C and 80°C). X-ray photoelectron spectroscopy of LBFCO ceramics show that cobalt dopant is bivalent as an acceptor, which induces an enhancement of oxygen vacancy concentration in LBFCO ceramics. Possible mechanisms for both resistive switching and threshold switching effects are discussed on the basis of the interplay of bound ferroelectric charges and mobile charged defects. © 2012 American Institute of Physics.published_or_final_versio

Simulated runoff responses to land use in the middle and upstream reaches of Taoerhe River basin, Northeast China, in wet, average and dry years

Study on runoff variations and responses can lay a foundation for flood control, water allocation and integrated river basin management. This study applied the Soil and Water Assessment Tool model to simulate the effects of land use on annual and monthly runoff in the Middle and Upstream Reaches of Taoerhe River basin, Northeast China, under the wet, average and dry climate conditions through scenario analysis. The results showed that from the early 1970s to 2000, land use change with an increase in farmland (17.0%) and decreases in forest (10.6%), grassland (4.6%) and water body (3.1%) caused increases in annual and monthly runoff. This effect was more distinct in the wet season or in the wet year, suggesting that land use change from the early 1970s to 2000 may increase the flood potential in the wet season. Increases in precipitation and air temperature from the average to wet year led to annual and monthly (March and from June to December) runoff increases, while a decrease in precipitation and an increase in air temperature from the average to dry year induced decreases in annual and monthly (all months except March) runoff, and moreover, these effects were more remarkable in the wet season than those in the dry season. Due to the integrated effects of changing land use and climate conditions, the annual runoff increased (decreased) by 70.1mm (25.2mm) or 197.4% (71.0%) from the average to wet (dry) year. In conclusion, climate conditions, especially precipitation, played an important role in runoff variations while land use change was secondary over the study area, and furthermore, the effects of changes in land use and/or climate conditions on monthly runoff were larger in the wet season. Copyright (c) 2012 John Wiley & Sons, Ltd.Study on runoff variations and responses can lay a foundation for flood control, water allocation and integrated river basin management. This study applied the Soil and Water Assessment Tool model to simulate the effects of land use on annual and monthly runoff in the Middle and Upstream Reaches of Taoerhe River basin, Northeast China, under the wet, average and dry climate conditions through scenario analysis. The results showed that from the early 1970s to 2000, land use change with an increase in farmland (17.0%) and decreases in forest (10.6%), grassland (4.6%) and water body (3.1%) caused increases in annual and monthly runoff. This effect was more distinct in the wet season or in the wet year, suggesting that land use change from the early 1970s to 2000 may increase the flood potential in the wet season. Increases in precipitation and air temperature from the average to wet year led to annual and monthly (March and from June to December) runoff increases, while a decrease in precipitation and an increase in air temperature from the average to dry year induced decreases in annual and monthly (all months except March) runoff, and moreover, these effects were more remarkable in the wet season than those in the dry season. Due to the integrated effects of changing land use and climate conditions, the annual runoff increased (decreased) by 70.1mm (25.2mm) or 197.4% (71.0%) from the average to wet (dry) year. In conclusion, climate conditions, especially precipitation, played an important role in runoff variations while land use change was secondary over the study area, and furthermore, the effects of changes in land use and/or climate conditions on monthly runoff were larger in the wet season. Copyright (c) 2012 John Wiley & Sons, Ltd

Oxygen as a Driver of Early Arthropod Micro-Benthos Evolution

BACKGROUND: We examine the physiological and lifestyle adaptations which facilitated the emergence of ostracods as the numerically dominant Phanerozoic bivalve arthropod micro-benthos. METHODOLOGY/PRINCIPAL FINDINGS: The PO(2) of modern normoxic seawater is 21 kPa (air-equilibrated water), a level that would cause cellular damage if found in the tissues of ostracods and much other marine fauna. The PO(2) of most aquatic breathers at the cellular level is much lower, between 1 and 3 kPa. Ostracods avoid oxygen toxicity by migrating to waters which are hypoxic, or by developing metabolisms which generate high consumption of O(2). Interrogation of the Cambrian record of bivalve arthropod micro-benthos suggests a strong control on ecosystem evolution exerted by changing seawater O(2) levels. The PO(2) of air-equilibrated Cambrian-seawater is predicted to have varied between 10 and 30 kPa. Three groups of marine shelf-dwelling bivalve arthropods adopted different responses to Cambrian seawater O(2). Bradoriida evolved cardiovascular systems that favoured colonization of oxygenated marine waters. Their biodiversity declined during intervals associated with black shale deposition and marine shelf anoxia and their diversity may also have been curtailed by elevated late Cambrian (Furongian) oxygen-levels that increased the PO(2) gradient between seawater and bradoriid tissues. Phosphatocopida responded to Cambrian anoxia differently, reaching their peak during widespread seabed dysoxia of the SPICE event. They lacked a cardiovascular system and appear to have been adapted to seawater hypoxia. As latest Cambrian marine shelf waters became well oxygenated, phosphatocopids went extinct. Changing seawater oxygen-levels and the demise of much of the seabed bradoriid micro-benthos favoured a third group of arthropod micro-benthos, the ostracods. These animals adopted lifestyles that made them tolerant of changes in seawater O(2). Ostracods became the numerically dominant arthropod micro-benthos of the Phanerozoic. CONCLUSIONS/SIGNIFICANCE: Our work has implications from an evolutionary context for understanding how oxygen-level in marine ecosystems drives behaviour

Characterisation of the bacterial and fungal communities associated with different lesion sizes of Dark Spot Syndrome occurring in the Coral Stephanocoenia intersepta

The number and prevalence of coral diseases/syndromes are increasing worldwide. Dark Spot Syndrome (DSS) afflicts numerous coral species and is widespread throughout the Caribbean, yet there are no known causal agents. In this study we aimed to characterise the microbial communities (bacteria and fungi) associated with DSS lesions affecting the coral Stephanocoenia intersepta using nonculture molecular techniques. Bacterial diversity of healthy tissues (H), those in advance of the lesion interface (apparently healthy AH), and three sizes of disease lesions (small, medium, and large) varied significantly (ANOSIM R = 0.052 p,0.001), apart from the medium and large lesions, which were similar in their community profile. Four bacteria fitted into the pattern expected from potential pathogens; namely absent from H, increasing in abundance within AH, and dominant in the lesions themselves. These included ribotypes related to Corynebacterium (KC190237), Acinetobacter (KC190251), Parvularculaceae (KC19027), and Oscillatoria (KC190271). Furthermore, two Vibrio species, a genus including many proposed coral pathogens, dominated the disease lesion and were absent from H and AH tissues, making them candidates as potential pathogens for DSS. In contrast, other members of bacteria from the same genus, such as V. harveyii were present throughout all sample types, supporting previous studies where potential coral pathogens exist in healthy tissues. Fungal diversity varied significantly as well, however the main difference between diseased and healthy tissues was the dominance of one ribotype, closely related to the plant pathogen, Rhytisma acerinum, a known causal agent of tar spot on tree leaves. As the corals’ symbiotic algae have been shown to turn to a darker pigmented state in DSS (giving rise to the syndromes name), the two most likely pathogens are R. acerinum and the bacterium Oscillatoria, which has been identified as the causal agent of the colouration in Black Band Disease, another widespread coral disease

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology

Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is unknown. To study this issue, here we develop a model of human central metabolism that incorporates a solvent capacity constraint of metabolic enzymes and mitochondria, accounting for their occupied volume densities, while assuming glucose and/or fatty acid utilization. The model demonstrates that activation of aerobic glycolysis is favored above a threshold metabolic rate in both rapidly proliferating cells and heavily contracting muscles, because it provides higher ATP yield per volume density than mitochondrial oxidative phosphorylation. In the case of muscle physiology, the model also predicts that before the lactate switch, fatty acid oxidation increases, reaches a maximum, and then decreases to zero with concomitant increase in glucose utilization, in agreement with the empirical evidence. These results are further corroborated by a larger scale model, including biosynthesis of major cell biomass components. The larger scale model also predicts that in proliferating cells the lactate switch is accompanied by activation of glutaminolysis, another distinctive feature of the Warburg effect. In conclusion, intracellular molecular crowding is a fundamental constraint for cell metabolism in both rapidly proliferating- and non-proliferating cells with high metabolic demand. Addition of this constraint to metabolic flux balance models can explain several observations of mammalian cell metabolism under steady state conditions

SH3 Domain-Peptide Binding Energy Calculations Based on Structural Ensemble and Multiple Peptide Templates

SH3 domains mediate signal transduction by recognizing short peptides. Understanding of the driving forces in peptide recognitions will help us to predict the binding specificity of the domain-peptide recognition and to understand the molecular interaction networks of cells. However, accurate calculation of the binding energy is a tough challenge. In this study, we propose three ideas for improving our ability to predict the binding energy between SH3 domains and peptides: (1) utilizing the structural ensembles sampled from a molecular dynamics simulation trajectory, (2) utilizing multiple peptide templates, and (3) optimizing the sequence-structure mapping. We tested these three ideas on ten previously studied SH3 domains for which SPOT analysis data were available. The results indicate that calculating binding energy using the structural ensemble was most effective, clearly increasing the prediction accuracy, while the second and third ideas tended to give better binding energy predictions. We applied our method to the five SH3 targets in DREAM4 Challenge and selected the best performing method

Four Generations: SUSY and SUSY Breaking

We revisit four generations within the context of supersymmetry. We compute the perturbativity limits for the fourth generation Yukawa couplings and show that if the masses of the fourth generation lie within reasonable limits of their present experimental lower bounds, it is possible to have perturbativity only up to scales around 1000 TeV. Such low scales are ideally suited to incorporate gauge mediated supersymmetry breaking, where the mediation scale can be as low as 10-20 TeV. The minimal messenger model, however, is highly constrained. While lack of electroweak symmetry breaking rules out a large part of the parameter space, a small region exists, where the fourth generation stau is tachyonic. General gauge mediation with its broader set of boundary conditions is better suited to accommodate the fourth generation.Comment: 27 pages, 5 figure

Modulating signaling networks by CRISPR/Cas9-mediated transposable element insertion

In a recent past, transposable elements (TEs) were referred to as selfish genetic components only capable of copying themselves with the aim of increasing the odds of being inherited. Nonetheless, TEs have been initially proposed as positive control elements acting in synergy with the host. Nowadays, it is well known that TE movement into host genome comprises an important evolutionary mechanism capable of increasing the adaptive fitness. As insights into TE functioning are increasing day to day, the manipulation of transposition has raised an interesting possibility of setting the host functions, although the lack of appropriate genome engineering tools has unpaved it. Fortunately, the emergence of genome editing technologies based on programmable nucleases, and especially the arrival of a multipurpose RNA-guided Cas9 endonuclease system, has made it possible to reconsider this challenge. For such purpose, a particular type of transposons referred to as miniature inverted-repeat transposable elements (MITEs) has shown a series of interesting characteristics for designing functional drivers. Here, recent insights into MITE elements and versatile RNA-guided CRISPR/Cas9 genome engineering system are given to understand how to deploy the potential of TEs for control of the host transcriptional activity.Fil: Vaschetto, Luis Maria Benjamin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Diversidad Animal I; Argentin