Recognising Beach Kindy as a Pedagogical Approach for Critical Agents of Change Within Early Childhood Education

Research (Davis, Elliot, Hagglung, Johansson, Ritchie, Miller, Inoue, Chua, Sageidet, Young, Cutter-Mackenzie, Ji, Stuhmcke, Mackey, Ohillips, Enggahl, Arlemalm-Hagser, Barrat, Barrat-Hacking, Black, Chawla, Rivkin, Gorman, Sundberg, Ottander, Gilbert, Fuller, Palmer, Rose, Farrell, Danby,2014) has indicated that very young children are capable of supporting the Agenda for Global Action through transformative and creative pedagogical approaches utilised through their environments, that are informed and practiced by knowledgeable early education practitioners and leaders. The early years offers multiple opportunities to surround young children with the awe and wonder of their world, linking to their local cultures, as they seek to question, challenge and access possibilities to transform their families and communities. Beach Kindy utilises the natural environment of the coastline, at sites that demonstrate the biodiversity of the planet. Water, for example, is recognised not only as an effective medium and tool for education for sustainable development but also its immense capacity to support holistic, interconnected areas within early childhood education. However, it is acknowledged that this approach is not without challenges. The four home nations that make up the United Kingdom (England, Northern Ireland Scotland and Wales) have distinct early years curriculum frameworks and this paper focuses on the English framework, The Early Years Foundation Stage (The Department of Education (DfE) 2014).The DfE (2014) imposes what is perceived by many as a linear statutory framework and policy makers must try to move towards embedding education for sustainable development and encourage more flexible, creative approaches to learning. The English Early Years Foundation Stage (EYFS, DFE, 2014) statutory guidance, focuses on three Prime areas, (Communication and Language, Personal, Social and Emotional Development and Physical Development and four Specific areas including, Understanding the World (UW). This Specific area (UW), presents a renewed emphasis on a ‘concentric approach to learning’ (Tickell, 2011, p.104) where children are guided to ‘make sense of their physical world and their community through opportunities to explore, observe and find out about people, places, technology and the environment’ (DfE, 2014, p8). Children can become young scientists, utilising the coastlines and becoming “ocean literate”. Early education Practitioners can thus provide “a platform to channel their infinite capacities for activism into the creation of a better world.” (2015, p.12). This paper seeks to explore how Beach Kindy can help implement both the Sustainable Development Goals and the scientific approaches embedded within UW, whilst also recognising the challenges that it may bring

A Critical Analysis of Concepts Associated with Sustainability in Early Childhood Curriculum Frameworks Across Five National Contexts

Curriculum frameworks have an important role in providing guidance to early childhood practitioners on how to integrate knowledge about sustainability into their practice. This article examines how ideas about sustainability are integrated in the early childhood curricula for Australia, England, Norway, Sweden and the USA. The analyses were guided by critical inquiry and a cross-national dialogue and focused on four aspects of the curricula: sustainability presence, views of the child, human–environment relationship and philosophical/theoretical underpinnings on ideas expressed about sustainability. Ideas about sustainability were more implicitly present than explicitly stated in most curricula. It was not evident that children were viewed as world citizens with agency to help foster sustainability. With respect to human–environmental relationship, the framework from Australia expressed greater reciprocity and entanglement, while other frameworks were more anthropocentric despite the variation among curricula. All five frameworks embodied a sociocultural, human development approach with respect to the philosophical and theoretical underpinnings. There is a need to consider alternative frameworks that offer broader and more inclusive worldviews about sustainability that includes embracing human, non-human and other species within an assemblage of common worlds

Watery Webs of Interconnectedness: Waterways as Pedagogical Sites

Despite the ever-growing body of knowledge about human impacts on river and coastal ecosystems, and the need to work towards sustainable futures, young children's participation in environmental action initiatives in aquatic habitats remains low. This signifies an urgency for educators to support young children's relationship with freshwater and marine environments so they can acquire the skills and dispositions to become 'agents for change' for the environment. Guided by Deleuzian ideas of being and becoming, and ecologies of knowledges, this paper considers three exploratory case studies from England, the United States and Australia that investigated early childhood teachers' practices of using waterways as pedagogical sites. Data were collected through ethnographic methods of observations and interviews. Findings revealed that early childhood teachers viewed such habitats as spaces where action initiatives for sustainability can be conceived and incorporated as "webs of interconnectedness" into the curriculum. We conclude this study has the potential to expand understandings of under-utilized pedagogical spaces, such as natural water and marine habitats, where adults and children have permission to learn together to cultivate a more intimate relationship with the earth

The role of clathrin in post-golgi trafficking in toxoplasma gondii

Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion. In contrast, the role of the endosomal system is poorly understood in these parasites. With many typical endocytic factors missing, we speculated that endocytosis depends exclusively on a clathrin-mediated mechanism. Intriguingly, in Toxoplasma gondii we were only able to observe the endogenous clathrin heavy chain 1 (CHC1) at the Golgi, but not at the parasite surface. For the functional characterisation of Toxoplasma gondii CHC1 we generated parasite mutants conditionally expressing the dominant negative clathrin Hub fragment and demonstrate that CHC1 is essential for vesicle formation at the trans-Golgi network. Consequently, the functional ablation of CHC1 results in Golgi aberrations, a block in the biogenesis of the unique secretory microneme and rhoptry organelles, and of the pellicle. However, we found no morphological evidence for clathrin mediating endocytosis in these parasites and speculate that they remodelled their vesicular trafficking system to adapt to an intracellular lifestyle

Canalization of the evolutionary trajectory of the human influenza virus

Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. Antigenic evolution occurs in the context of a two-dimensional 'antigenic map', while genetic evolution shows a characteristic ladder-like genealogical tree. Here, we use a large-scale individual-based model to show that evolution in a Euclidean antigenic space provides a remarkable correspondence between model behavior and the epidemiological, antigenic, genealogical and geographic patterns observed in influenza virus. We find that evolution away from existing human immunity results in rapid population turnover in the influenza virus and that this population turnover occurs primarily along a single antigenic axis. Thus, selective dynamics induce a canalized evolutionary trajectory, in which the evolutionary fate of the influenza population is surprisingly repeatable and hence, in theory, predictable.Comment: 29 pages, 5 figures, 10 supporting figure

Relationship between effects on time-to-disease progression and overall survival in studies of metastatic breast cancer

The relationship between overall survival (OS) and disease progression end points has been demonstrated in colorectal, colon, and non-small cell lung cancers. We assessed the association between OS and time-to-progression (TTP) or progression-free survival (PFS) in metastatic breast cancer (MBC) studies. A literature search retrieved all randomised controlled trials since 1994 in patients with MBC in which OS and either TTP or PFS were reported. Summary data on trial and patient characteristics were abstracted. Study effect sizes were derived as the ratio of median progression (or survival) times, which approximates the hazard ratio. Effects were centred at zero for regression analyses weighted by sample size. Numerous treatments were represented in 67 studies (17 081 patients). Modeling showed a positive association between outcomes for progression and survival (R2=0.30) with a slope of 0.32 (P<0.001) and a non-significant intercept. Thus, a treatment effect on TTP/PFS translated into a concordant effect on OS, but with attenuated effect size. Similar results were found in models of subsets and sensitivity analyses. These results demonstrate that treatment effects on progression end points in MBC trials are expected to result in treatment differences on OS that are smaller yet consistently in the same direction

Characterization of Shewanella oneidensis MtrC: a cell-surface decaheme cytochrome involved in respiratory electron transport to extracellular electron acceptors

MtrC is a decaheme c-type cytochrome associated with the outer cell membrane of Fe(III)-respiring species of the Shewanella genus. It is proposed to play a role in anaerobic respiration by mediating electron transfer to extracellular mineral oxides that can serve as terminal electron acceptors. The present work presents the first spectropotentiometric and voltammetric characterization of MtrC, using protein purified from Shewanella oneidensis MR-1. Potentiometric titrations, monitored by UV–vis absorption and electron paramagnetic resonance (EPR) spectroscopy, reveal that the hemes within MtrC titrate over a broad potential range spanning between approximately +100 and approximately -500 mV (vs. the standard hydrogen electrode). Across this potential window the UV–vis absorption spectra are characteristic of low-spin c-type hemes and the EPR spectra reveal broad, complex features that suggest the presence of magnetically spin-coupled low-spin c-hemes. Non-catalytic protein film voltammetry of MtrC demonstrates reversible electrochemistry over a potential window similar to that disclosed spectroscopically. The voltammetry also allows definition of kinetic properties of MtrC in direct electron exchange with a solid electrode surface and during reduction of a model Fe(III) substrate. Taken together, the data provide quantitative information on the potential domain in which MtrC can operate

Hyeropic shift after LASIK induced Diffuse lamellar keratitis

BACKGROUND: Diffuse lamellar keratitis (DLK) is a relatively new syndrome that is increasingly being reported after LASIK. We have observed that a hyperopic shift may be associated with the occurrence of this diffuse lamellar keratitis. CASE PRESENTATION: A 26 year old man developed bilateral diffuse lamellar keratitis (DLK) following myopic LASIK. The residual refractive error was +0.5D OD and +0.25D OS at the end of the first week. The sterile infiltrates resolved over a period of 4–6 weeks on topical steroid therapy. A progressive hyperopic shift was noted in the right eye with an error +4.25Dsph/+0.25Dcyl 20 at the final follow up 6 months post surgery. CONCLUSION: Diffuse lamellar keratitis after LASIK may be associated with a significant hyperopic shift