13,241 research outputs found
Raising activity levels as a health risk reduction intervention in Hong Kong children
published_or_final_versio
Let me Google that for you:a time series analysis of seasonality in internet search trends for terms related to foot and ankle pain
BACKGROUND: The analysis of internet search traffic may present the opportunity to gain insights into general trends and patterns in information seeking behaviour related to medical conditions at a population level. For prevalent and widespread problems such as foot and ankle pain, this information has the potential to improve our understanding of seasonality and trends within these conditions and their treatments, and may act as a useful proxy for their true incidence/prevalence characteristics. This study aimed to explore seasonal effects, general trends and relative popularity of internet search terms related to foot and ankle pain over the past decade. METHODS: We used the Google Trends tool to obtain relative search engine traffic for terms relating to foot and ankle pain and common treatments from Google search and affiliated pages for major northern and southern hemisphere English speaking nations. Analysis of overall trends and seasonality including summer/winter differences was carried out on these terms. RESULTS: Searches relating to general foot pain were on average 3.4 times more common than those relating to ankle pain, and twice as common as searches relating to heel pain. Distinct seasonal effects were seen in the northern hemisphere, with large increases in search volumes in the summer months compared to winter for foot (p = 0.004, 95 % CI [22.2–32.1]), ankle (p = 0.0078, 95 % CI [20.9–35.5]), and heel pain (p = 0.004, 95 % CI [29.1–45.6]). These seasonal effects were reflected by data from Australia, with the exception of ankle pain. Annual seasonal effects for treatment options were limited to terms related to foot surgery and ankle orthoses (p = 0.031, 95 % CI [3.5–20.9]; p = 0.004, 95 % CI [7.6–25.2] respectively), again increasing in the summer months. CONCLUSIONS: A number of general trends and annual seasonal effects were found in time series internet search data for terms relating to foot and ankle pain. This data may provide insights into these conditions at population levels. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13047-015-0074-9) contains supplementary material, which is available to authorized users
Effects of Epistasis and Pleiotropy on Fitness Landscapes
The factors that influence genetic architecture shape the structure of the
fitness landscape, and therefore play a large role in the evolutionary
dynamics. Here the NK model is used to investigate how epistasis and pleiotropy
-- key components of genetic architecture -- affect the structure of the
fitness landscape, and how they affect the ability of evolving populations to
adapt despite the difficulty of crossing valleys present in rugged landscapes.
Populations are seen to make use of epistatic interactions and pleiotropy to
attain higher fitness, and are not inhibited by the fact that valleys have to
be crossed to reach peaks of higher fitness.Comment: 10 pages, 6 figures. To appear in "Origin of Life and Evolutionary
Mechanisms" (P. Pontarotti, ed.). Evolutionary Biology: 16th Meeting 2012,
Springer-Verla
Recent progress in treatment of pulmonary arterial hypertension due to congenital heart disease
Crystallization and preliminary crystallographic studies of an antimicrobial protein from Pharbitis nil
An antimicrobial protein from seeds of Pharbitis nil (Pn-AMP) which shows an antifungal activity towards several agriculturally important plant pathogens has been crystallized in the presence of equimolar N-acetylglucosamine with sodium citrate as precipitant. The crystal belongs to the hexagonal space group P6(1)22 (or P6(5)22), with unit-cell parameters a = b = 29.33 (5), c = 133.44 (12) Angstrom. Native data were collected using a crystal at 100 K to a resolution of 1.78 Angstrom.open2
Structural synthesis considering mixed discrete-continuous design variables: A Bayesian framework
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors. An important mechanism for the rapid desensitization of betaAR function is agonist-stimulated receptor phosphorylation by the betaAR kinase (betaARK1), an enzyme known to be elevated in failing human heart tissue. To investigate whether alterations in betaAR function contribute to the development of myocardial failure, transgenic mice with cardiac-restricted overexpression of either a peptide inhibitor of betaARK1 or the beta2AR were mated into a genetic model of murine heart failure (MLP-/-). In vivo cardiac function was assessed by echocardiography and cardiac catheterization. Both MLP-/- and MLP-/-/beta2AR mice had enlarged left ventricular (LV) chambers with significantly reduced fractional shortening and mean velocity of circumferential fiber shortening. In contrast, MLP-/-/betaARKct mice had normal LV chamber size and function. Basal LV contractility in the MLP-/-/betaARKct mice, as measured by LV dP/dtmax, was increased significantly compared with the MLP-/- mice but less than controls. Importantly, heightened betaAR desensitization in the MLP-/- mice, measured in vivo (responsiveness to isoproterenol) and in vitro (isoproterenol-stimulated membrane adenylyl cyclase activity), was completely reversed with overexpression of the betaARK1 inhibitor. We report here the striking finding that overexpression of this inhibitor prevents the development of cardiomyopathy in this murine model of heart failure. These findings implicate abnormal betaAR-G protein coupling in the pathogenesis of the failing heart and point the way toward development of agents to inhibit betaARK1 as a novel mode of therapy
The connection between superconducting phase correlations and spin excitations in YBaCuO: A magnetic field study
One of the most striking universal properties of the
high-transition-temperature (high-) superconductors is that they are all
derived from the hole-doping of their insulating antiferromagnetic (AF) parent
compounds. From the outset, the intimate relationship between magnetism and
superconductivity in these copper-oxides has intrigued researchers. Evidence
for this link comes from neutron scattering experiments that show the
unambiguous presence of short-range AF correlations (excitations) in cuprate
superconductors. Even so, the role of such excitations in the pairing mechanism
and superconductivity is still a subject of controversy. For
YBaCuO, where controls the hole-doping level, the most
prominent feature in the magnetic excitations spectra is the ``resonance''.
Here we show that for underdoped YBaCuO, where and
are below the optimal values, modest magnetic fields suppress the resonance
significantly, much more so for fields approximately perpendicular rather than
parallel to the CuO planes. Our results indicate that the resonance
measures pairing and phase coherence, suggesting that magnetism plays an
important role in the superconductivity of cuprates. The persistence of a field
effect above favors mechanisms with preformed pairs in the normal state
of underdoped cuprates.Comment: 12 pages, 4 figures, Nature (in press
Dynamics of fully coupled rotators with unimodal and bimodal frequency distribution
We analyze the synchronization transition of a globally coupled network of N
phase oscillators with inertia (rotators) whose natural frequencies are
unimodally or bimodally distributed. In the unimodal case, the system exhibits
a discontinuous hysteretic transition from an incoherent to a partially
synchronized (PS) state. For sufficiently large inertia, the system reveals the
coexistence of a PS state and of a standing wave (SW) solution. In the bimodal
case, the hysteretic synchronization transition involves several states.
Namely, the system becomes coherent passing through traveling waves (TWs), SWs
and finally arriving to a PS regime. The transition to the PS state from the SW
occurs always at the same coupling, independently of the system size, while its
value increases linearly with the inertia. On the other hand the critical
coupling required to observe TWs and SWs increases with N suggesting that in
the thermodynamic limit the transition from incoherence to PS will occur
without any intermediate states. Finally a linear stability analysis reveals
that the system is hysteretic not only at the level of macroscopic indicators,
but also microscopically as verified by measuring the maximal Lyapunov
exponent.Comment: 22 pages, 11 figures, contribution for the book: Control of
Self-Organizing Nonlinear Systems, Springer Series in Energetics, eds E.
Schoell, S.H.L. Klapp, P. Hoeve
- …