Doença Meningocócica Invasiva: Aplicação do Base Excess and Platelets Score numa Unidade de Cuidados Intensivos Pediátricos Portuguesa

INTRODUCTION: Meningococcal infection has a high mortality and morbidity. Recently a new prognostic scoring system was developed for paediatric invasive meningococcal disease, based on platelet count and base excess â base excess and platelets score. The main objective of this study was to evaluate the accuracy of base excess and platelets score to predict mortality in children admitted to intensive care due to invasive meningococcal disease. MATERIAL AND METHODS: Observational study, with retrospective data collection, during a 13.5 years period (01/2000 to 06/2013). Mortality by invasive meningococcal disease and related factors (organ dysfunction and multi-organ failure) were analysed. The base excess and platelets score was calculated retrospectively, to evaluate its accuracy in predicting mortality and compared with Paediatric Risk of Mortality and Paediatric Index of Mortality2. RESULTS: Were admitted 76 children with invasive meningococcal disease. The most frequent type of dysfunction was cardiovascular (92%), followed by hematologic (55%). Of the total, 47 patients (62%) had criteria for multi-organ failure. The global mortality was 16%. Neurologic and renal dysfunction showed the strongest association with mortality, adjusted odds ratio 315 (26 - 3 804) and 155 (20 - 1 299). After application of receiver operating characteristic curves, Base Excess and Platelets score had an area under curve of 0.81, Paediatric Index of Mortality2 of 0.91 and Paediatric Risk of Mortality of 0.96. DISCUSSION: The Base Excess and Platelets score showed good accuracy, although not as high as Paediatric Risk of Mortality or Paediatric Index of Mortality 2. CONCLUSIONS: The Base Excess and Platelets score may be useful tool in invasive meningococcal disease because is highly sensitive and specific and is objectively measurable and readily available at presentation

Enhanced optical gain clamping for upstream packet based traffic on hybrid WDM/TDM-PON using fiber bragg grating

In this paper, we propose a method to mitigate the temporal power transients arising from Erbium doped fiber amplifiers (EDFAs) on packeted/bursty scenario. The technique, applicable on hybrid WDM/TDM-PON for extended reach, is based on a low power clamping provided by a distributed feedback (DFB) laser and a fiber Bragg grating (FBG). An mprovement in the data signal Q factor was achieved keeping the clamping control signal with a low power, accompanied by a maximum reduction in the gain excursion of 1.12 d

Indicadores de qualidade de solos em área de mineração e metalurgia de chumbo. I - Microrganismos.

Os microrganismos são os mais numerosos da fração biológica do solo e estão sujeitos a alterações em sua abundância e nas relações metabólicas em função de mudanças ambientais, como o aporte de poluentes ao solo. O objetivo deste trabalho foi avaliar a atividade microbiana de solos da área de mineração e metalurgia de chumbo (Pb), no município de Adrianópolis (PR), a fim de gerar indicadores biológicos da qualidade desses solos. Os solos foram amostrados (0 a 5 e 5 a 10 cm) em cinco locais e em quatro épocas do ano (maio, setembro, novembro e janeiro). Os teores totais de Pb e Zn do solo foram determinados por espectroscopia de emissão atômica com plasma acoplado indutivamente, após digestão das amostras com HF e HNO3 concentrados e H2O2 30 % (v/v) em forno de micro-ondas. Para extração de formas mais disponíveis de Pb e Zn foi empregada a solução de HNO3 0,5 mol L-1 fervente. Foram estimados os seguintes atributos microbiológicos dos solos: contagem de bactérias totais (BT); contagem de bactérias esporuláveis (BESP); percentagem de bactérias esporuláveis em relação à BT; contagem de fungos; relação entre fungos e bactérias totais; respiração microbiana; biomassa microbiana; percentagem do carbono microbiano em relação ao C orgânico total do solo; e quociente metabólico. Utilizaram-se três métodos para o tratamento estatístico dos dados: diferenciação dos solos por meio da análise de componentes principais (ACP); obtenção de índice de qualidade ambiental relativo aos atributos microbiológicos (IQAMi); e análise de correlação simples. A elevada fertilidade dos solos tornou menos expressivo o efeito prejudicial dos metais pesados sobre os microrganismos. Contudo, no mês de maior estresse climático para os organismos (maio - menor temperatura), solos com maiores teores de Pb apresentaram menor população e atividade microbiana, ou seja, nessas condições as bactérias e fungos foram bons indicadores de qualidade do solo. A maior proporção de BESP nos solos mais contaminados por Pb no mês mais frio (correlação de 0,95* para maio) pode ser interpretada como mecanismo de resistência desses organismos. O IQAMi na camada de 0 a 5 cm foi mais eficiente que a ACP na separação dos solos contaminados com metais pesados: os valores decresceram em sentido oposto ao aumento nos teores de Pb dos solos. Já na profundidade de 5 a 10 cm a ACP foi mais eficiente para esse propósito

Skeletal quality in Senegalese sole: characterization of fish resulting from environmental and nutritional trials

The Senegalese sole (Solea senegalensis) is characteristic from southern Europe and Mediterranean. It has recently been adapted for aquaculture production since it is well accepted by consumers and reaches high commercial values. After the initial description of the ontogenic events of skeletogenesis, systematic evaluation of the incidence of skeletal malformations by several groups revealed high levels of skeletal deformities reaching up to 90% of the population

Durability assessment of external thermal insulation composite systems in urban and maritime environments

Funding Information: The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for funding the research project PTDC/ECI-EGC/30681/2017 (WGB_Shield – Shielding building facades for cities revitalization. Triple resistance to water, graffiti and biocolonization of external thermal insulation systems), the research units CERIS ( UIDB/04625/2020 ), CERENA ( UIDB/04028/2020 ) and iBB ( UIDP/04565/2020 ), the Associate Laboratory Institute for Health and Bioeconomy – i4HB ( LA/P/0140/2020 ), and the Ph.D. scholarship 2020.05180.BD (J. L. Parracha). The authors also acknowledge CIN, Saint-Gobain and Secil for the material supply and the Portuguese Institute for Sea and Atmosphere (IPMA) for the meteorological data. Funding Information: The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for funding the research project PTDC/ECI-EGC/30681/2017 (WGB_Shield – Shielding building facades for cities revitalization. Triple resistance to water, graffiti and biocolonization of external thermal insulation systems), the research units CERIS (UIDB/04625/2020), CERENA (UIDB/04028/2020) and iBB (UIDP/04565/2020), the Associate Laboratory Institute for Health and Bioeconomy – i4HB (LA/P/0140/2020), and the Ph.D. scholarship 2020.05180.BD (J. L. Parracha). The authors also acknowledge CIN, Saint-Gobain and Secil for the material supply and the Portuguese Institute for Sea and Atmosphere (IPMA) for the meteorological data. Publisher Copyright: © 2022 Elsevier B.V.External Thermal Insulation Composite Systems (ETICS) are multilayer solutions which provide an enhanced thermal performance to the building envelope. However, significant anomalies can be detected on ETICS facades, in some cases shortly after the application of these systems. This study intends to evaluate and compare the durability of six commercially available ETICS after two years of outdoor exposure at both urban and maritime conditions in Portugal. The systems were characterized by means of non-destructive testing (i.e., visual and microscopic assessment, water transport properties, thermal conductivity, surface roughness), thus allowing to evaluate the performance loss throughout natural aging. The bio-susceptibility and aesthetic properties (color and gloss) were also investigated. Results showed that the performance and durability of the complete system is significantly affected by the rendering system formulation. The lime-based specimens obtained the highest rate of mold development after one year of aging in a maritime environment, becoming considerably darker and with lower surface gloss. Fungal analysis of this darkish stained area indicated the presence of mold species of the genera Alternaria, Didymella, Cladosporium and Epicoccum, and yeasts of the genera Vishniacozyma and Cystobasidium. An increase of both capillary water absorption and water vapor permeability was also registered for the aged lime-based specimens. Acrylic-based systems obtained lower capillary water absorption after aging and greater dirt deposition on their surfaces, especially in urban conditions. These systems had also higher color variation and surface gloss decrease and slightly higher mold growth, when compared with those aged in a maritime environment. Finally, no mold growth was detected on the silicate-based specimens after two years of aging. However, these specimens obtained higher capillary water absorption and lower vapor permeability after aging, possibly leading to moisture accumulation within the system. Results contribute towards the development of ETICS with enhanced performance and durability.publishersversionpublishe

Development of a Cyclic Voltammetry-Based Method for the Detection of Antigens and Antibodies as a Novel Strategy for Syphilis Diagnosis

54/2017). Publisher Copyright: © 2022 by the authors.The improvement of laboratory diagnosis is a critical step for the reduction of syphilis cases around the world. In this paper, we present the development of an impedance-based method for detecting T. pallidum antigens and antibodies as an auxiliary tool for syphilis laboratory diagnosis. We evaluate the voltammetric signal obtained after incubation in carbon or gold nanoparticle-modified carbon electrodes in the presence or absence of Poly-L-Lysine. Our results indicate that the signal obtained from the electrodes was sufficient to distinguish between infected and non-infected samples immediately (T0′) or 15 min (T15′) after incubation, indicating its potential use as a point-of-care method as a screening strategy.publishersversionpublishe

Development of technologies to support the diagnosis of infectious diseases and cancer to support the primary health care

54/2017). Publisher Copyright: © 2022, The Author(s).Purpose: Primary Health Care (PHC) is the coordinator of health care in Brazil and needs to be strengthened in the diagnostic field to increase health care quality. Aiming to improve the diagnostic tools currently available in PHC, this work describes the process of development and validation of two point-of-care biomedical devices for screening patients with syphilis or different kinds of cancer. Methods: The development of these devices followed nine stages of action based on the requirements established by the Ministry of Health. During development, both systems followed the stages of circuit planning, software simulation to verify the components used, cost assessment for the acquisition of features, simulation in contact matrix, development of the embedded system, and planning of the printed circuit board and storage box. Results: Both devices underwent preliminary functionality tests to assess their quality. The performance tests applied on the device to diagnose syphilis performed 8,733,194 requests, with a flow of 2426 requests/second, reaching the desired parameters of robustness, integrity, durability, and stability. In addition, functioning tests on the cancer-screening device indicated the ability to detect standard fluorescence in a minimal (150 uL) sample volume. Conclusions: Together, the methodology used for developing the devices resulted in promising equipment to improve the diagnosis and meet the requirements for executing technologies for testing and triaging patients in PHC.publishersversionpublishe

A infância representada no livro escolar: tipos de textos e estereótipos sociais

Esta investigação inscreve-se dominantemente no âmbito dos estudos da criança e ancora a sua área específica nas questões linguísticas, assumindo os pressupostos teóricos e metodológicos da análise do discurso (de tradição francófona), considerando também contributos de áreas conexas. Analisa textos de manuais/livros escolares usados no sistema de ensino português, pretendendo tornar visíveis as imagens que estes constroem das crianças e da infância, bem como os recursos linguísticos mais relevantes associados a tal construção. Procura desvendar a representatividade das tipologias textuais nos manuais e de que forma estas contribuem para a construção das referidas imagens. Conclui que as crianças dos textos são seres sem voz e sem poder, consumidoras, mas não coprodutoras de cultura, com os textos inculcando valores conformadores da manutenção da ordem social estabelecida, sendo a forma como as tipologias textuais estão organizadas contribuidora para se alcançar esse propósito.This research forms primarily part of the child studies and is based on its specific field of linguistic issues, assuming the theoretical and methodological assumptions of the speech analysis (of French-speaking tradition), having also regard the inputs of related fields. It analyses texts from handbooks/textbooks used on the Portuguese educational system, intending to reveal pictures that these books construct about children and childhood, as well as the most relevant linguistic resources associated with such construction. This paper aims at unravelling the representation of the text typologies in the handbooks and how these can contribute for building of such pictures. From this, one can conclude that children from the texts are voiceless and have no power, they are consumers but not co-producers of culture, with these texts instilling conservative values for maintaining the established social order, but also that the way texts typologies are organized to contribute for reaching that propose.Esta investigación se ensere en el ámbito de los estudios del niño y más precisamente en la área de las cuestiones lingüísticas, asumiendo los presupuestos teóricos e metodológicos de la análisis del discurso (de tradición francófona), considerando también aportes de las áreas conexas. Analiza textos de manuales/libros escolares usados en el sistema de enseñanza portugués, pretendiendo tornar visibles las imágenes que este construyen de los niños y de la infancia, bien como los recursos lingüísticos más relevantes asociados a esa construcción. Busca desvendar la representatividad de las tipologías textuales en los manuales y de qué forma contribuyen para la construcción de las referidas imágenes. Concluye que los niños de los textos son seres sin voz y sin poder, consumidores, pero no coproductores de cultura y que los textos inculcan valores conformadores de manutención del orden social establecido, mas también que la forma como las tipologías textuales están organizadas contribuye para alcanzar ese propósito.CIEC - Centro de Investigação em Estudos da Criança, IE, UMinho (UI 317 da FCT), Portugal. Fundos Nacionais através da FCT (Fundação para a Ciência e a Tecnologia) e cofinanciado pelo Fundo Europeu de Desenvolvimento Regional (FEDER) através do COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) no âmbito do CIEC (Centro de Investigação em Estudos da Criança, da Universidade do Minho) com a referência POCI-01-0145-FEDER-007562info:eu-repo/semantics/publishedVersio