147 research outputs found
Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis
Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1ÎČ and tumour necrosis factor (TNF). It was hypothesised that these variants could influence rheumatoid arthritis (RA) susceptibility and may interact with functional single nucleotide polymorphisms (SNPs) in the genes for IL1, IL6 and TNF.
Methods: Genotyping was performed in 988 unrelated healthy controls and 965 patients with RA. Stratified analysis was used to test for interactions. Single gene effects and evidence of epistasis were investigated using the MantelâHaenszel (MâH) test and the linkage disequilibrium (LD)-based statistic.
Results: No association of SELS â105 genotype and RA susceptibility was detected. Stratification of SELS â105 genotypes by IL1 â511 genotypes showed that the disease risk (comparing AA/GA to GG at the SELS â105 locus) in individuals with the GG/AG genotype at the IL1ÎČ â511 locus was significantly lower than that in individuals having the AA genotype at the IL1ÎČ â511 locus (odds ratio (OR): 0.9 and 2.3, respectively; pâ=â0.004 by MâH test). Significant epistasis was also detected using the LD-based statistic (pâ=â<0.001). No interaction was observed between SELS â105 and IL6 or TNF variants.
Conclusion: Our results reveal evidence of strong epistasis in two genes in the IL1 production pathway and highlight the potential importance of geneâgene interactions in the pathogenesis of RA
Differential cross section and recoil polarization measurements for the gamma p to K+ Lambda reaction using CLAS at Jefferson Lab
We present measurements of the differential cross section and Lambda recoil
polarization for the gamma p to K+ Lambda reaction made using the CLAS detector
at Jefferson Lab. These measurements cover the center-of-mass energy range from
1.62 to 2.84 GeV and a wide range of center-of-mass K+ production angles.
Independent analyses were performed using the K+ p pi- and K+ p (missing pi -)
final-state topologies; results from these analyses were found to exhibit good
agreement. These differential cross section measurements show excellent
agreement with previous CLAS and LEPS results and offer increased precision and
a 300 MeV increase in energy coverage. The recoil polarization data agree well
with previous results and offer a large increase in precision and a 500 MeV
extension in energy range. The increased center-of-mass energy range that these
data represent will allow for independent study of non-resonant K+ Lambda
photoproduction mechanisms at all production angles.Comment: 22 pages, 16 figure
Tensor Correlations Measured in 3He(e,e'pp)n
We have measured the 3He(e,e'pp)n reaction at an incident energy of 4.7 GeV
over a wide kinematic range. We identified spectator correlated pp and pn
nucleon pairs using kinematic cuts and measured their relative and total
momentum distributions. This is the first measurement of the ratio of pp to pn
pairs as a function of pair total momentum, . For pair relative
momenta between 0.3 and 0.5 GeV/c, the ratio is very small at low and
rises to approximately 0.5 at large . This shows the dominance of
tensor over central correlations at this relative momentum.Comment: 4 pages, 4 figures, submitted to PR
Measurement of the nuclear multiplicity ratio for hadronization at CLAS
The influence of cold nuclear matter on lepto-production of hadrons in
semi-inclusive deep inelastic scattering is measured using the CLAS detector in
Hall B at Jefferson Lab and a 5.014 GeV electron beam. We report the
multiplicity ratios for targets of C, Fe, and Pb relative to deuterium as a
function of the fractional virtual photon energy transferred to the
and the transverse momentum squared of the . We find that the
multiplicity ratios for are reduced in the nuclear medium at high
and low , with a trend for the transverse momentum to be
broadened in the nucleus for large .Comment: Submitted to Phys. Lett.
Coherent Photoproduction of pi^+ from 3^He
We have measured the differential cross section for the
He reaction. This reaction was studied using
the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Lab. Real photons
produced with the Hall-B bremsstrahlung tagging system in the energy range from
0.50 to 1.55 GeV were incident on a cryogenic liquid He target. The
differential cross sections for the He
reaction were measured as a function of photon-beam energy and pion-scattering
angle. Theoretical predictions to date cannot explain the large cross sections
except at backward angles, showing that additional components must be added to
the model.Comment: 11 pages, 16 figure
Measurement of the Nucleon Structure Function F2 in the Nuclear Medium and Evaluation of its Moments
We report on the measurement of inclusive electron scattering off a carbon
target performed with CLAS at Jefferson Laboratory. A combination of three
different beam energies 1.161, 2.261 and 4.461 GeV allowed us to reach an
invariant mass of the final-state hadronic system W~2.4 GeV with four-momentum
transfers Q2 ranging from 0.2 to 5 GeV2. These data, together with previous
measurements of the inclusive electron scattering off proton and deuteron,
which cover a similar continuous two-dimensional region of Q2 and Bjorken
variable x, permit the study of nuclear modifications of the nucleon structure.
By using these, as well as other world data, we evaluated the F2 structure
function and its moments. Using an OPE-based twist expansion, we studied the
Q2-evolution of the moments, obtaining a separation of the leading-twist and
the total higher-twist terms. The carbon-to-deuteron ratio of the leading-twist
contributions to the F2 moments exhibits the well known EMC effect, compatible
with that discovered previously in x-space. The total higher-twist term in the
carbon nucleus appears, although with large systematic uncertainites, to be
smaller with respect to the deuteron case for n<7, suggesting partial parton
deconfinement in nuclear matter. We speculate that the spatial extension of the
nucleon is changed when it is immersed in the nuclear medium.Comment: 37 pages, 15 figure
Precise Measurements of Beam Spin Asymmetries in Semi-Inclusive production
We present studies of single-spin asymmetries for neutral pion
electroproduction in semi-inclusive deep-inelastic scattering of 5.776 GeV
polarized electrons from an unpolarized hydrogen target, using the CEBAF Large
Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Accelerator
Facility. A substantial amplitude has been measured in the
distribution of the cross section asymmetry as a function of the azimuthal
angle of the produced neutral pion. The dependence of this amplitude
on Bjorken and on the pion transverse momentum is extracted with
significantly higher precision than previous data and is compared to model
calculations.Comment: to be submitted PL
A Bayesian analysis of pentaquark signals from CLAS data
We examine the results of two measurements by the CLAS collaboration, one of
which claimed evidence for a pentaquark, whilst the other found no
such evidence. The unique feature of these two experiments was that they were
performed with the same experimental setup. Using a Bayesian analysis we find
that the results of the two experiments are in fact compatible with each other,
but that the first measurement did not contain sufficient information to
determine unambiguously the existence of a . Further, we suggest a
means by which the existence of a new candidate particle can be tested in a
rigorous manner.Comment: 5 pages, 3 figure
First measurement of direct photoproduction on the proton
We report on the results of the first measurement of exclusive
meson photoproduction on protons for GeV and GeV. Data were collected with the CLAS detector at the Thomas
Jefferson National Accelerator Facility. The resonance was detected via its
decay in the channel by performing a partial wave analysis of the
reaction . Clear evidence of the meson
was found in the interference between and waves at GeV. The -wave differential cross section integrated in the mass range of
the was found to be a factor of 50 smaller than the cross section
for the meson. This is the first time the meson has been
measured in a photoproduction experiment
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